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The map label for this gene is ribB [H]

Identifier: 87199599

GI number: 87199599

Start: 1638340

End: 1639614

Strand: Reverse

Name: ribB [H]

Synonym: Saro_1582

Alternate gene names: 87199599

Gene position: 1639614-1638340 (Counterclockwise)

Preceding gene: 87199600

Following gene: 87199598

Centisome position: 46.04

GC content: 63.84

Gene sequence:

>1275_bases
ATGGCACAGGATATTGTAGCACGCGCTCGTCAGCTCATCGAAGACCGGATCATCTCGCGGGCCGCGCTGGCGCGTGCCGC
CGGGCTGCATCCCAATACGTTGCGCGATGCGCTTTCGCCCGACTGGAACCCCACCGTCGATACGCTGACCAAGCTGGAGC
GGGCAATGGACGATAGCGAGGACGACGACTTCGCCCTCGCCTCGGTCGAAGAAATCATCGCCGAAGTCCGCAACGGCCGC
ATGGTGGTGCTGGTCGACGACGAGGACCGCGAGAACGAGGGCGATCTGCTTATTCCGGCACAAATGGCCACGCCCGAGAC
GATCAACTTCATGGCAACGCACGGTCGTGGCCTCATCTGTCTGTGCCTTACCAGCGACCGCGCCAGCAATCTTGGCCTCG
AACTGATGAGCCGGCATAACGGCACCCGTCATGGAACAGCCTTCACTGTATCCATCGAGGCCCGCGAGGGTGTCGATACC
GGCATTTCCGCCGCAGACCGCGCCCGCACCATTGCCGTTGCCGTCGATGCGACGAAGACCCGCGACGATCTGGTGACGCC
CGGCCACGTCTTCCCGCTGATCGCACGTGACGGCGGCGTCTTGGTCCGCGCCGGACACACCGAGGCAGCAGTCGACCTTC
CGCGCCTTGCCGGCCTCAATCCCTCGGGCGTGATCTGCGAGATCATGAACGACGATGGCACCATGGCGCGCCTCGACGAT
CTCATTCCCTTCGCCCGCAAGCATGGCCTGAAGATCGGCACGATCCGCGACCTGATTGAATATCGCCGCCGCCACGACCA
CCTTGTCGAATGCGCGAACCAGGCTCCGTTCCACACCGATTACGGCGGCGAATGGACGATCAAGACCTATCGCAACAAGG
TGGACGGATCGGCCCACCTCGTGCTCCAGAAGGGCGCGGTCGTGCCGGGCAAGCCCACGCTAGTGCGCATGCATGCGATC
TCGGTCCTGTCCGATGTTCTCGGCCAGCCGGGACCGCGCAAGCGCATCCTGCAGCGCGCCATGACCGCGATCGGCGAGGC
AGGCTCCGGGGTGATCGTGCTGCTCATGCCGACCGACCCGCAGCAACTGATGAACGAAGTTGCCGGAACGGCCGGACACG
ACATGGAACTGCGCAGCTATGGCATCGGCGCGCAGATCCTTGCCGATCTGGGCGTGCATGACATGGTCCTGCTAACCAAT
TCGCACCACAACCTTGTTGCGCTCGAAGGCTACGGGCTGAGCATCGTCGGCGAACAGGCCATTCCGGAGGCCTGA

Upstream 100 bases:

>100_bases
TGTGAATGACCGCCAGCGAAACAGCTCCACCCATCACGAAAGTGACATTCAAATGTGATGAGGCTTGACGAGTGATACGT
TAATGTGCCACCCAATGTGT

Downstream 100 bases:

>100_bases
GCGGCCTCGCTCCGATGCGCCCGTGAAGAAGAAGCGACGCTATCTGACGGCGACGATGGCCGATGGTTACGTGAAGACCA
TCGGCCCCACGACCGACAGC

Product: GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 424; Mature: 423

Protein sequence:

>424_residues
MAQDIVARARQLIEDRIISRAALARAAGLHPNTLRDALSPDWNPTVDTLTKLERAMDDSEDDDFALASVEEIIAEVRNGR
MVVLVDDEDRENEGDLLIPAQMATPETINFMATHGRGLICLCLTSDRASNLGLELMSRHNGTRHGTAFTVSIEAREGVDT
GISAADRARTIAVAVDATKTRDDLVTPGHVFPLIARDGGVLVRAGHTEAAVDLPRLAGLNPSGVICEIMNDDGTMARLDD
LIPFARKHGLKIGTIRDLIEYRRRHDHLVECANQAPFHTDYGGEWTIKTYRNKVDGSAHLVLQKGAVVPGKPTLVRMHAI
SVLSDVLGQPGPRKRILQRAMTAIGEAGSGVIVLLMPTDPQQLMNEVAGTAGHDMELRSYGIGAQILADLGVHDMVLLTN
SHHNLVALEGYGLSIVGEQAIPEA

Sequences:

>Translated_424_residues
MAQDIVARARQLIEDRIISRAALARAAGLHPNTLRDALSPDWNPTVDTLTKLERAMDDSEDDDFALASVEEIIAEVRNGR
MVVLVDDEDRENEGDLLIPAQMATPETINFMATHGRGLICLCLTSDRASNLGLELMSRHNGTRHGTAFTVSIEAREGVDT
GISAADRARTIAVAVDATKTRDDLVTPGHVFPLIARDGGVLVRAGHTEAAVDLPRLAGLNPSGVICEIMNDDGTMARLDD
LIPFARKHGLKIGTIRDLIEYRRRHDHLVECANQAPFHTDYGGEWTIKTYRNKVDGSAHLVLQKGAVVPGKPTLVRMHAI
SVLSDVLGQPGPRKRILQRAMTAIGEAGSGVIVLLMPTDPQQLMNEVAGTAGHDMELRSYGIGAQILADLGVHDMVLLTN
SHHNLVALEGYGLSIVGEQAIPEA
>Mature_423_residues
AQDIVARARQLIEDRIISRAALARAAGLHPNTLRDALSPDWNPTVDTLTKLERAMDDSEDDDFALASVEEIIAEVRNGRM
VVLVDDEDRENEGDLLIPAQMATPETINFMATHGRGLICLCLTSDRASNLGLELMSRHNGTRHGTAFTVSIEAREGVDTG
ISAADRARTIAVAVDATKTRDDLVTPGHVFPLIARDGGVLVRAGHTEAAVDLPRLAGLNPSGVICEIMNDDGTMARLDDL
IPFARKHGLKIGTIRDLIEYRRRHDHLVECANQAPFHTDYGGEWTIKTYRNKVDGSAHLVLQKGAVVPGKPTLVRMHAIS
VLSDVLGQPGPRKRILQRAMTAIGEAGSGVIVLLMPTDPQQLMNEVAGTAGHDMELRSYGIGAQILADLGVHDMVLLTNS
HHNLVALEGYGLSIVGEQAIPEA

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=198, Percent_Identity=52.5252525252525, Blast_Score=215, Evalue=4e-57,
Organism=Saccharomyces cerevisiae, GI6320695, Length=207, Percent_Identity=39.6135265700483, Blast_Score=163, Evalue=4e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 45818; Mature: 45687

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQDIVARARQLIEDRIISRAALARAAGLHPNTLRDALSPDWNPTVDTLTKLERAMDDSE
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
DDDFALASVEEIIAEVRNGRMVVLVDDEDRENEGDLLIPAQMATPETINFMATHGRGLIC
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEECCCCEEE
LCLTSDRASNLGLELMSRHNGTRHGTAFTVSIEAREGVDTGISAADRARTIAVAVDATKT
EEEECCCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEEECCCC
RDDLVTPGHVFPLIARDGGVLVRAGHTEAAVDLPRLAGLNPSGVICEIMNDDGTMARLDD
CCCCCCCCCEEEEEECCCCEEEEECCCHHHHCCHHHCCCCCCCEEEEEECCCCCHHHHHH
LIPFARKHGLKIGTIRDLIEYRRRHDHLVECANQAPFHTDYGGEWTIKTYRNKVDGSAHL
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEE
VLQKGAVVPGKPTLVRMHAISVLSDVLGQPGPRKRILQRAMTAIGEAGSGVIVLLMPTDP
EEECCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCH
QQLMNEVAGTAGHDMELRSYGIGAQILADLGVHDMVLLTNSHHNLVALEGYGLSIVGEQA
HHHHHHHCCCCCCCCCHHHCCCCHHHHHHCCCCEEEEEECCCCCEEEEECCCEEEECCCC
IPEA
CCCC
>Mature Secondary Structure 
AQDIVARARQLIEDRIISRAALARAAGLHPNTLRDALSPDWNPTVDTLTKLERAMDDSE
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
DDDFALASVEEIIAEVRNGRMVVLVDDEDRENEGDLLIPAQMATPETINFMATHGRGLIC
CCCHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCEEEEECCCCCCCEEEEEECCCCEEE
LCLTSDRASNLGLELMSRHNGTRHGTAFTVSIEAREGVDTGISAADRARTIAVAVDATKT
EEEECCCCCCCCHHHHHHCCCCCCCEEEEEEEECCCCCCCCCCCCCCCEEEEEEEECCCC
RDDLVTPGHVFPLIARDGGVLVRAGHTEAAVDLPRLAGLNPSGVICEIMNDDGTMARLDD
CCCCCCCCCEEEEEECCCCEEEEECCCHHHHCCHHHCCCCCCCEEEEEECCCCCHHHHHH
LIPFARKHGLKIGTIRDLIEYRRRHDHLVECANQAPFHTDYGGEWTIKTYRNKVDGSAHL
HHHHHHHCCCEEHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCEEE
VLQKGAVVPGKPTLVRMHAISVLSDVLGQPGPRKRILQRAMTAIGEAGSGVIVLLMPTDP
EEECCCCCCCCCCEEHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEEEECCCH
QQLMNEVAGTAGHDMELRSYGIGAQILADLGVHDMVLLTNSHHNLVALEGYGLSIVGEQA
HHHHHHHCCCCCCCCCHHHCCCCHHHHHHCCCCEEEEEECCCCCEEEEECCCEEEECCCC
IPEA
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1339274 [H]