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The map label for this gene is tdcB [H]

Identifier: 87199122

GI number: 87199122

Start: 1141884

End: 1143149

Strand: Direct

Name: tdcB [H]

Synonym: Saro_1100

Alternate gene names: 87199122

Gene position: 1141884-1143149 (Clockwise)

Preceding gene: 87199121

Following gene: 87199123

Centisome position: 32.06

GC content: 67.93

Gene sequence:

>1266_bases
ATGGAAAATGCAGCGCTCACGCCCGTAGTGCAGGGGGCCGCCGACGACGCGGACGCCCTGCTGACTCTCGCCGACGTTCG
TGCGGCGGCGGAGCGCATTGCCGGCCAGGTGGTGCGCACCCCGACCCTGCACAGCAAGACGCTGAGCGCGATTACCGGCG
CGAACATCTGGATCAAGTTCGAGAACCTGCAGTTCACCGCCGCCTACAAGGAGCGAGGTGCGCTCAATGCCCTGCTGCTC
CTTTCGCAGGAACAGCGCGCGCGGGGCGTGATCGCCGCGTCGGCGGGAAACCACGCGCAGGGGCTTTCCTACCACGGAAC
CCGCCTGGGCGTTCCCGTGACCATCGTCATGCCGCGCACGACGCCGACGGTGAAGATCATGCAGACCGAGGCCGTGGGCG
GCAAGGTCGTGCTCGAGGGCGAGACCTTCGACGAGGCCTATGCCCATGCGCGCAAGCTGGAGCGCGAACTGGGACTGACG
TTCGTCCACCCGTTCGACGAGCGCAATGTCGCGGCCGGACAGGGTACGGTCGCGCTCGAGATGCTCGAGGATGCGCCCGA
GATCGACATGCTGGCCGTTCCCATCGGTGGCGGTGGCCTGCTTTCGGGCATGGGCACGGCGGCGCGCGGGATCAAGCCGG
AGATCGGCCTGATCGGCGTGCAGGCACAGCTCTTCCCGTCGATGTTCGCGCGGCTCAAGCACCTCGATTTGCCATGCGGC
GGCGATACGCTGGCCGAGGGCATCGCGGTGAAGGAGCCGGGGGCGTTCACCTCCGCCGTGCTGCGCGATCTGGTCGACGA
TGTGGTGCTGGTGAACGAAGCCGCGCTGGAATCGGCCGTGGCGCTGCTGCTCCAGATCGAGAAGACCGTGGTCGAAGGCG
CGGGCGCCGCGGGGCTGGCGGCGGTGATGCAGAACCGGGAGCTGTTCGCGGGCCGCAACGTGGGCGTCGTGCTGACGGGC
GCGAACATCGATACGCGCCTGCTGGCCAACGTGCTGCTGCGCGATCTTGCACGGTCGGGGCGCCTCGGCCGCCTGCGCAT
CACATTGCAGGACCGTCCTGGCGCGCTGTTCAAGGTGGTCGAGGAGTTCAACCGTCACCAGGTGAACATCCTTGAAGTTT
GGCACCAGCGCATCTTCACTTCGCTGCCGGCCAAGGGCCTGACCGCCGAGATCGAGTGCGAGGCGCGCGATCGCGAGCAG
ATCGACCGGCTCGTCGCCGGGCTGCGCGGCAAGGGCTACGACGTCGAGCAGGTCGAACTGGGGTAG

Upstream 100 bases:

>100_bases
TGCCTGCCAGTGTTCTACTTCCGCCGCGTGGCCGGCGATCCGGGCGAATCCGGAAAAGCTTGAGGTTTCCTTCAAGCGCC
GTTTCCGTTAGGGCGCGCGG

Downstream 100 bases:

>100_bases
GGAAGGGCGCGGGCGTTAAGCTTCGTCCGCCAGCCTGTCCCGATTTCGGACTTCGCGCCGTTTCCGCGCGAAATAATCGG
CGCTGGCCAGGAACTTGACA

Product: threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 421; Mature: 421

Protein sequence:

>421_residues
MENAALTPVVQGAADDADALLTLADVRAAAERIAGQVVRTPTLHSKTLSAITGANIWIKFENLQFTAAYKERGALNALLL
LSQEQRARGVIAASAGNHAQGLSYHGTRLGVPVTIVMPRTTPTVKIMQTEAVGGKVVLEGETFDEAYAHARKLERELGLT
FVHPFDERNVAAGQGTVALEMLEDAPEIDMLAVPIGGGGLLSGMGTAARGIKPEIGLIGVQAQLFPSMFARLKHLDLPCG
GDTLAEGIAVKEPGAFTSAVLRDLVDDVVLVNEAALESAVALLLQIEKTVVEGAGAAGLAAVMQNRELFAGRNVGVVLTG
ANIDTRLLANVLLRDLARSGRLGRLRITLQDRPGALFKVVEEFNRHQVNILEVWHQRIFTSLPAKGLTAEIECEARDREQ
IDRLVAGLRGKGYDVEQVELG

Sequences:

>Translated_421_residues
MENAALTPVVQGAADDADALLTLADVRAAAERIAGQVVRTPTLHSKTLSAITGANIWIKFENLQFTAAYKERGALNALLL
LSQEQRARGVIAASAGNHAQGLSYHGTRLGVPVTIVMPRTTPTVKIMQTEAVGGKVVLEGETFDEAYAHARKLERELGLT
FVHPFDERNVAAGQGTVALEMLEDAPEIDMLAVPIGGGGLLSGMGTAARGIKPEIGLIGVQAQLFPSMFARLKHLDLPCG
GDTLAEGIAVKEPGAFTSAVLRDLVDDVVLVNEAALESAVALLLQIEKTVVEGAGAAGLAAVMQNRELFAGRNVGVVLTG
ANIDTRLLANVLLRDLARSGRLGRLRITLQDRPGALFKVVEEFNRHQVNILEVWHQRIFTSLPAKGLTAEIECEARDREQ
IDRLVAGLRGKGYDVEQVELG
>Mature_421_residues
MENAALTPVVQGAADDADALLTLADVRAAAERIAGQVVRTPTLHSKTLSAITGANIWIKFENLQFTAAYKERGALNALLL
LSQEQRARGVIAASAGNHAQGLSYHGTRLGVPVTIVMPRTTPTVKIMQTEAVGGKVVLEGETFDEAYAHARKLERELGLT
FVHPFDERNVAAGQGTVALEMLEDAPEIDMLAVPIGGGGLLSGMGTAARGIKPEIGLIGVQAQLFPSMFARLKHLDLPCG
GDTLAEGIAVKEPGAFTSAVLRDLVDDVVLVNEAALESAVALLLQIEKTVVEGAGAAGLAAVMQNRELFAGRNVGVVLTG
ANIDTRLLANVLLRDLARSGRLGRLRITLQDRPGALFKVVEEFNRHQVNILEVWHQRIFTSLPAKGLTAEIECEARDREQ
IDRLVAGLRGKGYDVEQVELG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=318, Percent_Identity=34.2767295597484, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI33469958, Length=276, Percent_Identity=27.536231884058, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI19923959, Length=144, Percent_Identity=30.5555555555556, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1789505, Length=317, Percent_Identity=35.6466876971609, Blast_Score=181, Evalue=1e-46,
Organism=Escherichia coli, GI1790207, Length=344, Percent_Identity=36.9186046511628, Blast_Score=166, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI71991565, Length=397, Percent_Identity=36.0201511335013, Blast_Score=243, Evalue=2e-64,
Organism=Caenorhabditis elegans, GI17537387, Length=363, Percent_Identity=35.2617079889807, Blast_Score=174, Evalue=8e-44,
Organism=Caenorhabditis elegans, GI17508781, Length=316, Percent_Identity=30.0632911392405, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6322631, Length=318, Percent_Identity=37.4213836477987, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6320930, Length=371, Percent_Identity=36.9272237196765, Blast_Score=172, Evalue=6e-44,
Organism=Saccharomyces cerevisiae, GI6319788, Length=205, Percent_Identity=24.8780487804878, Blast_Score=70, Evalue=8e-13,
Organism=Drosophila melanogaster, GI21355833, Length=363, Percent_Identity=40.771349862259, Blast_Score=217, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24645328, Length=267, Percent_Identity=37.4531835205993, Blast_Score=127, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 44871; Mature: 44871

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENAALTPVVQGAADDADALLTLADVRAAAERIAGQVVRTPTLHSKTLSAITGANIWIKF
CCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEE
ENLQFTAAYKERGALNALLLLSQEQRARGVIAASAGNHAQGLSYHGTRLGVPVTIVMPRT
ECEEEEEEHHHCCCCEEEEEECCHHHHCEEEEECCCCCCCCCCCCCCEECCEEEEEECCC
TPTVKIMQTEAVGGKVVLEGETFDEAYAHARKLERELGLTFVHPFDERNVAAGQGTVALE
CCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEE
MLEDAPEIDMLAVPIGGGGLLSGMGTAARGIKPEIGLIGVQAQLFPSMFARLKHLDLPCG
EHHCCCCCCEEEEECCCCHHHHCCCHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCC
GDTLAEGIAVKEPGAFTSAVLRDLVDDVVLVNEAALESAVALLLQIEKTVVEGAGAAGLA
CHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AVMQNRELFAGRNVGVVLTGANIDTRLLANVLLRDLARSGRLGRLRITLQDRPGALFKVV
HHHHCCHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHH
EEFNRHQVNILEVWHQRIFTSLPAKGLTAEIECEARDREQIDRLVAGLRGKGYDVEQVEL
HHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEC
G
C
>Mature Secondary Structure
MENAALTPVVQGAADDADALLTLADVRAAAERIAGQVVRTPTLHSKTLSAITGANIWIKF
CCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCEEEEEE
ENLQFTAAYKERGALNALLLLSQEQRARGVIAASAGNHAQGLSYHGTRLGVPVTIVMPRT
ECEEEEEEHHHCCCCEEEEEECCHHHHCEEEEECCCCCCCCCCCCCCEECCEEEEEECCC
TPTVKIMQTEAVGGKVVLEGETFDEAYAHARKLERELGLTFVHPFDERNVAAGQGTVALE
CCEEEEEEEECCCCEEEEECCCHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCEEEE
MLEDAPEIDMLAVPIGGGGLLSGMGTAARGIKPEIGLIGVQAQLFPSMFARLKHLDLPCG
EHHCCCCCCEEEEECCCCHHHHCCCHHHCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCC
GDTLAEGIAVKEPGAFTSAVLRDLVDDVVLVNEAALESAVALLLQIEKTVVEGAGAAGLA
CHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHH
AVMQNRELFAGRNVGVVLTGANIDTRLLANVLLRDLARSGRLGRLRITLQDRPGALFKVV
HHHHCCHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHH
EEFNRHQVNILEVWHQRIFTSLPAKGLTAEIECEARDREQIDRLVAGLRGKGYDVEQVEL
HHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEC
G
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA