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The map label for this gene is hisA

Identifier: 87199031

GI number: 87199031

Start: 1051232

End: 1051957

Strand: Direct

Name: hisA

Synonym: Saro_1009

Alternate gene names: 87199031

Gene position: 1051232-1051957 (Clockwise)

Preceding gene: 87199030

Following gene: 87199032

Centisome position: 29.52

GC content: 65.01

Gene sequence:

>726_bases
ATGATCGTCTTTCCCGCCATTGACCTGAAAGCTGGCCAGGTCGTTCGCCTCGCCGAAGGAGACATGGACCGCGCCACGGT
CTACGGCGACAACCCGGCCCACCAGGCAAGCCTGTTCGCGCAGGCGGGGTCGCAATACCTCCACGTCGTCGATCTCGATG
GCTCGTTCGCAGGGCGCGCTGAAAACCGCGAGGCGGTGGAAGGCATCCTCAAGTCCTTCCCCGGTCACGTTCAACTGGGC
GGCGGCATCCGCACGCGCGAGGCCGTTTCGGGCTGGTTCGACCTCGGTGTCAGCCGCGTCGTCATGGGCACTGCCGCATT
GAAGGACCCTCAGTTCGTCAAGGACATGGCGAAGGAATTCCCCGGCGGCATCGTCGTCGCAGTCGATGCGCGCGACGGCA
TGGTCGCAACCGAGGGCTGGGCCGACGTTTCCGATGTCTCGGTCGTCGACCTCGCACGCCGCTTCGAGGATGCCGGCGTT
GCCAGCCTGCTGTTCACCGACATCGGTCGTGACGGCCTGCTCAAGGGCGTGAATCTCGACGCGACGGTCGAACTCGCGCG
CCGCGTCGACATTCCGGTGATCGCCAGCGGCGGCGTGAAGGGCATCGACGACATCCGCATGCTCAAGATCCACGAGGGCG
ACGGAATTGAAGGTGTCATCACCGGCCGGGCGCTCTATGATGGACGTCTCGATCTGAAGGCCGCGATCGAGATGGCAGAG
GCCTGA

Upstream 100 bases:

>100_bases
TTCATCGTGGCCTCGGGCGAGGCCGATCTTGCCTGCCGCATCACCCATGTGCCGAAGGAAGCCTTCCGTTCCGCGTGATC
GCCTGCTAGGCGCGCGGGCC

Downstream 100 bases:

>100_bases
TTCCATGACTGTCCGCGTCCGCGTCATTCCCTGTCTCGACGTTGCCGATGGCCGCGTGGTCAAGGGCGTCAATTTCGTCG
ACCTGCGCGATGCGGGAGAT

Product: 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Products: NA

Alternate protein names: Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MIVFPAIDLKAGQVVRLAEGDMDRATVYGDNPAHQASLFAQAGSQYLHVVDLDGSFAGRAENREAVEGILKSFPGHVQLG
GGIRTREAVSGWFDLGVSRVVMGTAALKDPQFVKDMAKEFPGGIVVAVDARDGMVATEGWADVSDVSVVDLARRFEDAGV
ASLLFTDIGRDGLLKGVNLDATVELARRVDIPVIASGGVKGIDDIRMLKIHEGDGIEGVITGRALYDGRLDLKAAIEMAE
A

Sequences:

>Translated_241_residues
MIVFPAIDLKAGQVVRLAEGDMDRATVYGDNPAHQASLFAQAGSQYLHVVDLDGSFAGRAENREAVEGILKSFPGHVQLG
GGIRTREAVSGWFDLGVSRVVMGTAALKDPQFVKDMAKEFPGGIVVAVDARDGMVATEGWADVSDVSVVDLARRFEDAGV
ASLLFTDIGRDGLLKGVNLDATVELARRVDIPVIASGGVKGIDDIRMLKIHEGDGIEGVITGRALYDGRLDLKAAIEMAE
A
>Mature_241_residues
MIVFPAIDLKAGQVVRLAEGDMDRATVYGDNPAHQASLFAQAGSQYLHVVDLDGSFAGRAENREAVEGILKSFPGHVQLG
GGIRTREAVSGWFDLGVSRVVMGTAALKDPQFVKDMAKEFPGGIVVAVDARDGMVATEGWADVSDVSVVDLARRFEDAGV
ASLLFTDIGRDGLLKGVNLDATVELARRVDIPVIASGGVKGIDDIRMLKIHEGDGIEGVITGRALYDGRLDLKAAIEMAE
A

Specific function: Histidine biosynthesis; fourth step. [C]

COG id: COG0106

COG function: function code E; Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hisA/hisF family

Homologues:

Organism=Escherichia coli, GI87082028, Length=242, Percent_Identity=35.9504132231405, Blast_Score=134, Evalue=6e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS4_NOVAD (Q2G9L9)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_496288.1
- HSSP:   P16250
- ProteinModelPortal:   Q2G9L9
- SMR:   Q2G9L9
- STRING:   Q2G9L9
- GeneID:   3915791
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_1009
- NMPDR:   fig|48935.1.peg.3113
- eggNOG:   COG0106
- HOGENOM:   HBG541613
- OMA:   SIIYTDI
- PhylomeDB:   Q2G9L9
- ProtClustDB:   PRK00748
- BioCyc:   NARO279238:SARO_1009-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01014
- InterPro:   IPR013785
- InterPro:   IPR006062
- InterPro:   IPR006063
- InterPro:   IPR023016
- InterPro:   IPR011060
- Gene3D:   G3DSA:3.20.20.70
- TIGRFAMs:   TIGR00007

Pfam domain/function: PF00977 His_biosynth; SSF51366 RibP_bind_barrel

EC number: =5.3.1.16

Molecular weight: Translated: 25504; Mature: 25504

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: NA

Important sites: ACT_SITE 8-8 ACT_SITE 129-129

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVFPAIDLKAGQVVRLAEGDMDRATVYGDNPAHQASLFAQAGSQYLHVVDLDGSFAGRA
CEEECEECCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
ENREAVEGILKSFPGHVQLGGGIRTREAVSGWFDLGVSRVVMGTAALKDPQFVKDMAKEF
CCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PGGIVVAVDARDGMVATEGWADVSDVSVVDLARRFEDAGVASLLFTDIGRDGLLKGVNLD
CCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCEECCCCC
ATVELARRVDIPVIASGGVKGIDDIRMLKIHEGDGIEGVITGRALYDGRLDLKAAIEMAE
HHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEECCEEECCCCCHHHHHHHHC
A
C
>Mature Secondary Structure
MIVFPAIDLKAGQVVRLAEGDMDRATVYGDNPAHQASLFAQAGSQYLHVVDLDGSFAGRA
CEEECEECCCCCCEEEEECCCCCCEEEECCCCHHHHHHHHHCCCCEEEEEECCCCCCCCC
ENREAVEGILKSFPGHVQLGGGIRTREAVSGWFDLGVSRVVMGTAALKDPQFVKDMAKEF
CCHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHC
PGGIVVAVDARDGMVATEGWADVSDVSVVDLARRFEDAGVASLLFTDIGRDGLLKGVNLD
CCCEEEEEECCCCEEEECCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCCCCCEECCCCC
ATVELARRVDIPVIASGGVKGIDDIRMLKIHEGDGIEGVITGRALYDGRLDLKAAIEMAE
HHHHHHHHCCCCEEECCCCCCCCCEEEEEEECCCCCEEEEECCEEECCCCCHHHHHHHHC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA