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The map label for this gene is lmrA [H]

Identifier: 87198995

GI number: 87198995

Start: 1018702

End: 1019349

Strand: Direct

Name: lmrA [H]

Synonym: Saro_0973

Alternate gene names: 87198995

Gene position: 1018702-1019349 (Clockwise)

Preceding gene: 87198993

Following gene: 87198997

Centisome position: 28.6

GC content: 64.04

Gene sequence:

>648_bases
TTGCCATACTATAATGATCGCCATATAACGGCGAGGTGTTTTACGGACAAGGAGTCTTCGGTGCCCAGGAAAAGCGACGC
ACGCGCCAAGGCGATTGCCACTGCGGAACGGCTTTTCTGCACGTCGGGGTATGCGGCCACCGGTCTCGCGCGCATCCTTG
AGGAGAGCGGCGCACCGAAGGGATCGTTCTATTTCCACTTTCCTCGCGGGAAGGCCGAACTGGCCGAGGAAGTGATCGAA
GCCTACCGCGCCCGCACGACCGCCCTGTTCCGCGTGCTGGTCGAACGGGCGAAGGGTGACCCGCGAGCCTTCGTGACCTC
GTTGGCGCAGGGCATCGCTGGCGAGATGGAACGGTCGGGCTGGTCCATGGGCTGCGTGGCGATGGCATTGGCGCAGGAAG
TCGCGCCTGCCGATGCGGCGCTCACCGACGCATTGGAGCGCGTGTTTGCCGAATGGGCGAGAATTATGGCCGAAGGCATC
CGGCGTCCGGACGAGGTGTCCACCGCCGCCGAGGTGCAAACGCGGGCGCTGGCGCTTCTGGCAGCGCTGGAAGGTGCGCG
GGTGATTGCCCGGACCATGCGTTCAAGGGAGCCGTTCGAAGCCGTGGTCCACCAGTTTCGCTGTAGCGGACTCATTCCCA
GGGTTTGA

Upstream 100 bases:

>100_bases
TCGGGGCGGGCGAGGCACTGGCTGCCTGCGCGAAGGCAGGAAACAGGACGAGGGGAAGAAGCAGGTTGCGCATCATGGCA
TTGGTCCTTTTATATGGCAA

Downstream 100 bases:

>100_bases
TGTCGCCGGGTGCTAGCCTGCGGATGATTTCGAGGCGGCGGGTCTGGCGCGTCTCGAGGCCGAGCGTCATCAAGGGCTGC
GGGCGTTCGACGAACTGCCG

Product: TetR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 214

Protein sequence:

>215_residues
MPYYNDRHITARCFTDKESSVPRKSDARAKAIATAERLFCTSGYAATGLARILEESGAPKGSFYFHFPRGKAELAEEVIE
AYRARTTALFRVLVERAKGDPRAFVTSLAQGIAGEMERSGWSMGCVAMALAQEVAPADAALTDALERVFAEWARIMAEGI
RRPDEVSTAAEVQTRALALLAALEGARVIARTMRSREPFEAVVHQFRCSGLIPRV

Sequences:

>Translated_215_residues
MPYYNDRHITARCFTDKESSVPRKSDARAKAIATAERLFCTSGYAATGLARILEESGAPKGSFYFHFPRGKAELAEEVIE
AYRARTTALFRVLVERAKGDPRAFVTSLAQGIAGEMERSGWSMGCVAMALAQEVAPADAALTDALERVFAEWARIMAEGI
RRPDEVSTAAEVQTRALALLAALEGARVIARTMRSREPFEAVVHQFRCSGLIPRV
>Mature_214_residues
PYYNDRHITARCFTDKESSVPRKSDARAKAIATAERLFCTSGYAATGLARILEESGAPKGSFYFHFPRGKAELAEEVIEA
YRARTTALFRVLVERAKGDPRAFVTSLAQGIAGEMERSGWSMGCVAMALAQEVAPADAALTDALERVFAEWARIMAEGIR
RPDEVSTAAEVQTRALALLAALEGARVIARTMRSREPFEAVVHQFRCSGLIPRV

Specific function: Acts as repressor of the lincomycin-resistance (lmrAB) and yxaGH operons [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH tetR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI145693141, Length=186, Percent_Identity=26.8817204301075, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009057
- InterPro:   IPR015893
- InterPro:   IPR011075
- InterPro:   IPR001647 [H]

Pfam domain/function: PF00440 TetR_N [H]

EC number: NA

Molecular weight: Translated: 23571; Mature: 23440

Theoretical pI: Translated: 8.63; Mature: 8.63

Prosite motif: PS50977 HTH_TETR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPYYNDRHITARCFTDKESSVPRKSDARAKAIATAERLFCTSGYAATGLARILEESGAPK
CCCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
GSFYFHFPRGKAELAEEVIEAYRARTTALFRVLVERAKGDPRAFVTSLAQGIAGEMERSG
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
WSMGCVAMALAQEVAPADAALTDALERVFAEWARIMAEGIRRPDEVSTAAEVQTRALALL
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AALEGARVIARTMRSREPFEAVVHQFRCSGLIPRV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
PYYNDRHITARCFTDKESSVPRKSDARAKAIATAERLFCTSGYAATGLARILEESGAPK
CCCCCCCEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCC
GSFYFHFPRGKAELAEEVIEAYRARTTALFRVLVERAKGDPRAFVTSLAQGIAGEMERSG
CCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCC
WSMGCVAMALAQEVAPADAALTDALERVFAEWARIMAEGIRRPDEVSTAAEVQTRALALL
CHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
AALEGARVIARTMRSREPFEAVVHQFRCSGLIPRV
HHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9274031; 9384377 [H]