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The map label for this gene is hisN [H]

Identifier: 87198997

GI number: 87198997

Start: 1020437

End: 1021216

Strand: Direct

Name: hisN [H]

Synonym: Saro_0975

Alternate gene names: 87198997

Gene position: 1020437-1021216 (Clockwise)

Preceding gene: 87198995

Following gene: 87198998

Centisome position: 28.65

GC content: 67.18

Gene sequence:

>780_bases
ATGAAACTCGACCAAGACATTGCCCTGGCGATGCGGCTCGCCGATGCGGCGGCTGCCGCCATCCGTCCTCATTTTCGCAC
TGTCATCGCAGAGCGGAAGGGCGATGCGACGCCCGTGACACTCGCGGATCGCGCGGCGGAAGAAGCCATGCGGCGAATTC
TTACCGCCGAAGCGGCGCGCGACACGGTGATCGGCGAGGAATTCGGCGCGACGGCGGGGACCTCGGGCCGTAGCTGGGTG
CTCGATCCCATTGACGGTACCGCCGGCTTCCTGGCCGGCCGACCGATCTTCGGCACGCTGATTGCCCTCGTGGTGGAAGG
CTTCCCCGTGCTTGGCGTGATCGACCAGCCCATCACCGGGGAGCGGTGGATCGGCGCGACCGGGATGGCCACCACGCTGA
ACGGCAAGCCGGTGCGCACCCGCCCTTGCCGCGAACTGGCCGAGGCGACGCTGGCGACGACTGGTCCGCACTATTTCGAC
GACCATGACGGCGGACACTTCATGGGCCTGGCCGCCAAGACCGACCACAGGCGGATGGTCATGGGCGGCGATTGCTACAA
CTATGCCATGCTTGCCACCGGGCAGCTCGACGTGGTGTGCGAGGCCAACCTCAAGCTGCACGACTGGGCTGCGCTGGTGC
CCATCGTCGAGGGAGCCGGGGGAACCATGGCGGACTGGAATGGCGATCCGCTTCACGCCGGATCGGACGGCCACGTGATC
GCTCTGGGCGATCCGGCGCGTCTCGACGACGTTGTCGAGGCCTTGGCCTGCGGTCATTGA

Upstream 100 bases:

>100_bases
ACTGTCACGCCTTAACTAAAGATGGAACGCGTAGATTGTCCAATACGGATTTGGTTAAGCGCAATTGACGTTCGGGGGCC
GGGGAGGGCACAGGCAGGAC

Downstream 100 bases:

>100_bases
CGACTCCATGCGCAGTCGGTTGTTCTTCTTCTACGGAACGCTGACGCAGGACCATGACACGGTGATGAACCGGCAGATCC
TGCCCTTTCTTCAGGGCGGG

Product: inositol monophosphatase

Products: NA

Alternate protein names: HolPase; Histidinol-phosphate phosphatase [H]

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MKLDQDIALAMRLADAAAAAIRPHFRTVIAERKGDATPVTLADRAAEEAMRRILTAEAARDTVIGEEFGATAGTSGRSWV
LDPIDGTAGFLAGRPIFGTLIALVVEGFPVLGVIDQPITGERWIGATGMATTLNGKPVRTRPCRELAEATLATTGPHYFD
DHDGGHFMGLAAKTDHRRMVMGGDCYNYAMLATGQLDVVCEANLKLHDWAALVPIVEGAGGTMADWNGDPLHAGSDGHVI
ALGDPARLDDVVEALACGH

Sequences:

>Translated_259_residues
MKLDQDIALAMRLADAAAAAIRPHFRTVIAERKGDATPVTLADRAAEEAMRRILTAEAARDTVIGEEFGATAGTSGRSWV
LDPIDGTAGFLAGRPIFGTLIALVVEGFPVLGVIDQPITGERWIGATGMATTLNGKPVRTRPCRELAEATLATTGPHYFD
DHDGGHFMGLAAKTDHRRMVMGGDCYNYAMLATGQLDVVCEANLKLHDWAALVPIVEGAGGTMADWNGDPLHAGSDGHVI
ALGDPARLDDVVEALACGH
>Mature_259_residues
MKLDQDIALAMRLADAAAAAIRPHFRTVIAERKGDATPVTLADRAAEEAMRRILTAEAARDTVIGEEFGATAGTSGRSWV
LDPIDGTAGFLAGRPIFGTLIALVVEGFPVLGVIDQPITGERWIGATGMATTLNGKPVRTRPCRELAEATLATTGPHYFD
DHDGGHFMGLAAKTDHRRMVMGGDCYNYAMLATGQLDVVCEANLKLHDWAALVPIVEGAGGTMADWNGDPLHAGSDGHVI
ALGDPARLDDVVEALACGH

Specific function: Catalyzes the dephosphorylation of histidinol-phosphate to histidinol, the direct precursor of histidine [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the inositol monophosphatase family [H]

Homologues:

Organism=Escherichia coli, GI1788882, Length=231, Percent_Identity=30.3030303030303, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI193202572, Length=239, Percent_Identity=25.9414225941423, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI193202570, Length=243, Percent_Identity=25.9259259259259, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320493, Length=209, Percent_Identity=28.7081339712919, Blast_Score=66, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24664922, Length=248, Percent_Identity=26.6129032258064, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011809
- InterPro:   IPR020583
- InterPro:   IPR000760
- InterPro:   IPR020550 [H]

Pfam domain/function: PF00459 Inositol_P [H]

EC number: =3.1.3.15 [H]

Molecular weight: Translated: 27291; Mature: 27291

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLDQDIALAMRLADAAAAAIRPHFRTVIAERKGDATPVTLADRAAEEAMRRILTAEAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
DTVIGEEFGATAGTSGRSWVLDPIDGTAGFLAGRPIFGTLIALVVEGFPVLGVIDQPITG
HHHCCHHHCCCCCCCCCEEEECCCCCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCC
ERWIGATGMATTLNGKPVRTRPCRELAEATLATTGPHYFDDHDGGHFMGLAAKTDHRRMV
CCEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEE
MGGDCYNYAMLATGQLDVVCEANLKLHDWAALVPIVEGAGGTMADWNGDPLHAGSDGHVI
ECCCCCCEEEEECCCEEEEEECCCEEEHHHHEEHHEECCCCCCCCCCCCCCCCCCCCCEE
ALGDPARLDDVVEALACGH
EECCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MKLDQDIALAMRLADAAAAAIRPHFRTVIAERKGDATPVTLADRAAEEAMRRILTAEAAR
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHHH
DTVIGEEFGATAGTSGRSWVLDPIDGTAGFLAGRPIFGTLIALVVEGFPVLGVIDQPITG
HHHCCHHHCCCCCCCCCEEEECCCCCCCHHHCCCCHHHHHHHHHHCCCCEEEEECCCCCC
ERWIGATGMATTLNGKPVRTRPCRELAEATLATTGPHYFDDHDGGHFMGLAAKTDHRRMV
CCEECCCCCEEECCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEECCCCCEEE
MGGDCYNYAMLATGQLDVVCEANLKLHDWAALVPIVEGAGGTMADWNGDPLHAGSDGHVI
ECCCCCCEEEEECCCEEEEEECCCEEEHHHHEEHHEECCCCCCCCCCCCCCCCCCCCCEE
ALGDPARLDDVVEALACGH
EECCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8626508 [H]