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The map label for this gene is mutY [H]

Identifier: 87198982

GI number: 87198982

Start: 1006872

End: 1007951

Strand: Direct

Name: mutY [H]

Synonym: Saro_0960

Alternate gene names: 87198982

Gene position: 1006872-1007951 (Clockwise)

Preceding gene: 87198979

Following gene: 87198983

Centisome position: 28.27

GC content: 69.44

Gene sequence:

>1080_bases
ATGCAGGCCAGAGGACAAGCCACAGCCAAGTTCGATCCGCAGGCGATCGCGCCCGCCTTGCTCGACTGGTACGATGCCCA
TGCACGCAAGCTGCCGTGGCGGCGGTTGCCGGGAGAAGCGCGGCAGGACCCCTACCGGGTGTGGCTGTCCGAGGTCATGC
TGCAGCAGACGACCGTGGCGGCGGTGGGCCCCTATTTCGAGAAGTTCACGCGTTTGTGGCCGACGGTTGGCGACCTGGCG
GCGGCGGACGACGGCGATGTCATGGCTGCCTGGGCCGGGCTGGGTTATTATGCCCGGGCCCGCAACCTGCTGGCATGTGC
GCGGGCGGTGGCGGCCATGGGCGGGACTTTCCCCGATAGCGAGGACGGTCTTCGCGCGCTGCCCGGACTGGGCGAATATA
CGGCGGCGGCGGTGGCTGCGATCGCGTTCGGCCGTCGGGCGGTGGTGGTCGATGCCAATGTCGAGCGCGTCATTGCCCGG
CTTTTCGCCATCGATGAGCCCTTGCCGGCGGGGAAAGCGGCGATCCGGCTGGCGGCGGGGCAAGTGACTCCGGAGGAGCG
GGCGGGCGATTTCGCCCAGGCGATGATGGACCTTGGCGCTACGGTGTGCACCGCGCGGTCGCCCCGGTGCATGTTGTGTC
CACTGCGCGAACATTGCCGCGCGCTTGCCGAAGGTGCGCCCGAGCGCCTGCCGGTGAAGGCCGCGCGCAAGGCAAAGCCG
GTGCGGCAGGGGCGCGCCTACTGGATCGAGCGCGAGGGCAGGGTGCTGCTGGTGCGGCGGCCGGGGCGCGGGATGCTGGG
CGGAATGCGCGCGCTGCCCGACGACGGCTGGTCGGCGCGAGGCGACGGCGCCGACGCCATCGGCGGCGAATGGCGCGGGG
GCGGCGTGGTTCGCCACGGCTTCACGCATTTCGATCTCGAATTGCAATTGATGCTTTGCGTTCAGGCGGAAGCGGCTAGT
CTGCCCGGCCTGAACGATATCGAGGGAGAATGGTGGCCAGTCGACGAGATCGAGGCCGCCGGATTGCCGACCGTTTTCGC
CAAGGCGGCGCGGCTGGCGATTGCCGAAAGGATTGGCTGA

Upstream 100 bases:

>100_bases
GGCTTTCCTGCCGTGCCGCCGGCGGCCTTGCGGGATTTGCGTTTCGCGGCGTCCGAAGGGGTGCTTTCCATCTTGCCCGC
CGCCATGCCATAGCGGCGCG

Downstream 100 bases:

>100_bases
CAAGATGCGGCAGATGGCGGTTTCAAGGCGCGGGCTGATCGGATCGCTGGGGGCGCTGGCCGGCTGTGCGCTGATGCCGC
GACTGGCGTGGGCGAGCGCG

Product: A/G-specific DNA-adenine glycosylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MQARGQATAKFDPQAIAPALLDWYDAHARKLPWRRLPGEARQDPYRVWLSEVMLQQTTVAAVGPYFEKFTRLWPTVGDLA
AADDGDVMAAWAGLGYYARARNLLACARAVAAMGGTFPDSEDGLRALPGLGEYTAAAVAAIAFGRRAVVVDANVERVIAR
LFAIDEPLPAGKAAIRLAAGQVTPEERAGDFAQAMMDLGATVCTARSPRCMLCPLREHCRALAEGAPERLPVKAARKAKP
VRQGRAYWIEREGRVLLVRRPGRGMLGGMRALPDDGWSARGDGADAIGGEWRGGGVVRHGFTHFDLELQLMLCVQAEAAS
LPGLNDIEGEWWPVDEIEAAGLPTVFAKAARLAIAERIG

Sequences:

>Translated_359_residues
MQARGQATAKFDPQAIAPALLDWYDAHARKLPWRRLPGEARQDPYRVWLSEVMLQQTTVAAVGPYFEKFTRLWPTVGDLA
AADDGDVMAAWAGLGYYARARNLLACARAVAAMGGTFPDSEDGLRALPGLGEYTAAAVAAIAFGRRAVVVDANVERVIAR
LFAIDEPLPAGKAAIRLAAGQVTPEERAGDFAQAMMDLGATVCTARSPRCMLCPLREHCRALAEGAPERLPVKAARKAKP
VRQGRAYWIEREGRVLLVRRPGRGMLGGMRALPDDGWSARGDGADAIGGEWRGGGVVRHGFTHFDLELQLMLCVQAEAAS
LPGLNDIEGEWWPVDEIEAAGLPTVFAKAARLAIAERIG
>Mature_359_residues
MQARGQATAKFDPQAIAPALLDWYDAHARKLPWRRLPGEARQDPYRVWLSEVMLQQTTVAAVGPYFEKFTRLWPTVGDLA
AADDGDVMAAWAGLGYYARARNLLACARAVAAMGGTFPDSEDGLRALPGLGEYTAAAVAAIAFGRRAVVVDANVERVIAR
LFAIDEPLPAGKAAIRLAAGQVTPEERAGDFAQAMMDLGATVCTARSPRCMLCPLREHCRALAEGAPERLPVKAARKAKP
VRQGRAYWIEREGRVLLVRRPGRGMLGGMRALPDDGWSARGDGADAIGGEWRGGGVVRHGFTHFDLELQLMLCVQAEAAS
LPGLNDIEGEWWPVDEIEAAGLPTVFAKAARLAIAERIG

Specific function: Adenine glycosylase active on G-A mispairs. MutY also corrects error-prone DNA synthesis past GO lesions which are due to the oxidatively damaged form of guanine:7,8-dihydro-8- oxoguanine (8-oxo-dGTP) [H]

COG id: COG1194

COG function: function code L; A/G-specific DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Nth/MutY family [H]

Homologues:

Organism=Homo sapiens, GI115298650, Length=410, Percent_Identity=33.9024390243902, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI115298654, Length=410, Percent_Identity=33.9024390243902, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI115298652, Length=410, Percent_Identity=33.9024390243902, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI115298648, Length=410, Percent_Identity=33.9024390243902, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI190358497, Length=410, Percent_Identity=33.9024390243902, Blast_Score=179, Evalue=3e-45,
Organism=Homo sapiens, GI6912520, Length=410, Percent_Identity=33.9024390243902, Blast_Score=179, Evalue=3e-45,
Organism=Escherichia coli, GI1789331, Length=300, Percent_Identity=41.6666666666667, Blast_Score=216, Evalue=1e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011257
- InterPro:   IPR004036
- InterPro:   IPR004035
- InterPro:   IPR003651
- InterPro:   IPR003265
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR023170
- InterPro:   IPR005760
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF10576 EndIII_4Fe-2S; PF00633 HHH; PF00730 HhH-GPD [H]

EC number: 3.2.2.20

Molecular weight: Translated: 38690; Mature: 38690

Theoretical pI: Translated: 7.81; Mature: 7.81

Prosite motif: PS00764 ENDONUCLEASE_III_1 ; PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQARGQATAKFDPQAIAPALLDWYDAHARKLPWRRLPGEARQDPYRVWLSEVMLQQTTVA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVGPYFEKFTRLWPTVGDLAAADDGDVMAAWAGLGYYARARNLLACARAVAAMGGTFPDS
HHHHHHHHHHHHCCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EDGLRALPGLGEYTAAAVAAIAFGRRAVVVDANVERVIARLFAIDEPLPAGKAAIRLAAG
CCCHHHCCCCCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCCCHHHEEEECC
QVTPEERAGDFAQAMMDLGATVCTARSPRCMLCPLREHCRALAEGAPERLPVKAARKAKP
CCCCHHHCCHHHHHHHHCCHHHCCCCCCCEEECCHHHHHHHHHCCCCCCCCHHHHHHCCH
VRQGRAYWIEREGRVLLVRRPGRGMLGGMRALPDDGWSARGDGADAIGGEWRGGGVVRHG
HHCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECC
FTHFDLELQLMLCVQAEAASLPGLNDIEGEWWPVDEIEAAGLPTVFAKAARLAIAERIG
CEEECEEEEEEEEEEHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MQARGQATAKFDPQAIAPALLDWYDAHARKLPWRRLPGEARQDPYRVWLSEVMLQQTTVA
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
AVGPYFEKFTRLWPTVGDLAAADDGDVMAAWAGLGYYARARNLLACARAVAAMGGTFPDS
HHHHHHHHHHHHCCCHHHHCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
EDGLRALPGLGEYTAAAVAAIAFGRRAVVVDANVERVIARLFAIDEPLPAGKAAIRLAAG
CCCHHHCCCCCHHHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHCCCCCCCHHHEEEECC
QVTPEERAGDFAQAMMDLGATVCTARSPRCMLCPLREHCRALAEGAPERLPVKAARKAKP
CCCCHHHCCHHHHHHHHCCHHHCCCCCCCEEECCHHHHHHHHHCCCCCCCCHHHHHHCCH
VRQGRAYWIEREGRVLLVRRPGRGMLGGMRALPDDGWSARGDGADAIGGEWRGGGVVRHG
HHCCCEEEEECCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEECC
FTHFDLELQLMLCVQAEAASLPGLNDIEGEWWPVDEIEAAGLPTVFAKAARLAIAERIG
CEEECEEEEEEEEEEHHHHCCCCCCCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2197596; 2001994; 9278503; 9846876 [H]