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The map label for this gene is algA [H]

Identifier: 87198766

GI number: 87198766

Start: 786182

End: 787222

Strand: Direct

Name: algA [H]

Synonym: Saro_0742

Alternate gene names: 87198766

Gene position: 786182-787222 (Clockwise)

Preceding gene: 87198765

Following gene: 87198767

Centisome position: 22.07

GC content: 65.03

Gene sequence:

>1041_bases
ATGACCGATACAGTTCCTGTCGTACTATGTGGGGGCAGCGGCACCCGCCTCTGGCCCCGGTCGCGCAAGCAGAAGCCCAA
GCCTTTTCTTCCCCTCGTCGGCGAAAACACGCTTTTCGCCCAGACCGTGCTGCGTTGCGGGCGGGATGCCGGCTTTTCGC
CGCCTGTCGTGGTAACCGGGGCGGCGCATCTTGCGCATGTCGAGGAGCAGCTTCCGGATCGCGCCAGCACACGGATCATC
GTCGAACCGGAAGGCCGCAACACGGCGGCGGCCATCGCCCTGGCGGCACTGTCCTTGCCCGAGGACGCGGTGATGCTGGT
CTGTCCGAGCGACCATCACATCGGCGATTGCGAAGCGTTCCAGGCAGCGGCTCGCGAAGCAGTTGCACTGGCGGTCGAGG
GCTGGCTGGTCTCCTTCGGCATCGTGCCGACTGCGCCCGAGACAGGGTTCGGCTATCTCAAGCAGGGTGAGCCGATTGCA
GGCACTGTCGGGCGAAGGGTCCAGCGCTTTGTCGAGAAGCCCGATCTTGCACGTGCCATGGAATTTCTCGCGAGCGGAGA
ATATGCCTGGAACGGCGGTATTTTCGCCTTCCGCGCGGGCACCTTCATCGACGAACTCGGCAAGTACCGCCCGGCCATCC
TCGCCGCAGTCCGCGACGCGGTAGGCCGGGGCAAGTGGGACGGCATGCGGTTCCACCCCGATGCGGCCGCCTTCTCGCGG
GTTGAAAGCGAGTCCGTCGACTATGCGGTCATGGAGAATACCGACAAGGCCGCCATGGTGCCTGCGGTCATGGCGTGGTC
GGATATCGGCAACTGGCAGGCGCTCCACGAGGCGCTCGACCGCGACGAACACGGCAACGCCGTTCGCGGTCCGGCGGAAC
TTCGCGACTGTTCGAACGTCCTGGTGATGAGCGACGGTCCTCGGGTGTCGGTGGTCGGTGCATCCAATCTCGTCGTCGTG
GTCGATGGCGACGAAGTGCTGGTGTGCACGCCCGAAGGTGCTCAGTCCGTGGGCAAGTTGTCCGGAGCCGCCAATCAATG
A

Upstream 100 bases:

>100_bases
TCGCTACCACTTCGGTCGCCGATCTGCTGGCAATGATGGTGGATTGTCCCTAGAAGCCGGCCAAAACGGGCGCGCGGCAA
AACTCAGATCAAGGCAGCAA

Downstream 100 bases:

>100_bases
CCAAGTTGACCAAGCGTCTGGTGGAGAAGCCGTGGGGCAAGGATACGCTGCCTGCCCCCTTCACCGCGCCCGCAGGAAGC
CGGATCGGCGAGGTTTGGTT

Product: mannose-1-phosphate guanylyltransferase (GDP)

Products: NA

Alternate protein names: Mannose-6-phosphate isomerase; Phosphohexomutase; Phosphomannose isomerase; PMI; Mannose-1-phosphate guanylyltransferase; GDP-mannose pyrophosphorylase; GMP; GMPP; GTP--mannose-1-phosphate guanylyltransferase [H]

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MTDTVPVVLCGGSGTRLWPRSRKQKPKPFLPLVGENTLFAQTVLRCGRDAGFSPPVVVTGAAHLAHVEEQLPDRASTRII
VEPEGRNTAAAIALAALSLPEDAVMLVCPSDHHIGDCEAFQAAAREAVALAVEGWLVSFGIVPTAPETGFGYLKQGEPIA
GTVGRRVQRFVEKPDLARAMEFLASGEYAWNGGIFAFRAGTFIDELGKYRPAILAAVRDAVGRGKWDGMRFHPDAAAFSR
VESESVDYAVMENTDKAAMVPAVMAWSDIGNWQALHEALDRDEHGNAVRGPAELRDCSNVLVMSDGPRVSVVGASNLVVV
VDGDEVLVCTPEGAQSVGKLSGAANQ

Sequences:

>Translated_346_residues
MTDTVPVVLCGGSGTRLWPRSRKQKPKPFLPLVGENTLFAQTVLRCGRDAGFSPPVVVTGAAHLAHVEEQLPDRASTRII
VEPEGRNTAAAIALAALSLPEDAVMLVCPSDHHIGDCEAFQAAAREAVALAVEGWLVSFGIVPTAPETGFGYLKQGEPIA
GTVGRRVQRFVEKPDLARAMEFLASGEYAWNGGIFAFRAGTFIDELGKYRPAILAAVRDAVGRGKWDGMRFHPDAAAFSR
VESESVDYAVMENTDKAAMVPAVMAWSDIGNWQALHEALDRDEHGNAVRGPAELRDCSNVLVMSDGPRVSVVGASNLVVV
VDGDEVLVCTPEGAQSVGKLSGAANQ
>Mature_345_residues
TDTVPVVLCGGSGTRLWPRSRKQKPKPFLPLVGENTLFAQTVLRCGRDAGFSPPVVVTGAAHLAHVEEQLPDRASTRIIV
EPEGRNTAAAIALAALSLPEDAVMLVCPSDHHIGDCEAFQAAAREAVALAVEGWLVSFGIVPTAPETGFGYLKQGEPIAG
TVGRRVQRFVEKPDLARAMEFLASGEYAWNGGIFAFRAGTFIDELGKYRPAILAAVRDAVGRGKWDGMRFHPDAAAFSRV
ESESVDYAVMENTDKAAMVPAVMAWSDIGNWQALHEALDRDEHGNAVRGPAELRDCSNVLVMSDGPRVSVVGASNLVVVV
DGDEVLVCTPEGAQSVGKLSGAANQ

Specific function: Produces a precursor for alginate polymerization. The alginate layer provides a protective barrier against host immune defenses and antibiotics [H]

COG id: COG0836

COG function: function code M; Mannose-1-phosphate guanylyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mannose-6-phosphate isomerase type 2 family [H]

Homologues:

Organism=Escherichia coli, GI1788362, Length=345, Percent_Identity=44.9275362318841, Blast_Score=239, Evalue=2e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR006375
- InterPro:   IPR001538
- InterPro:   IPR005835
- InterPro:   IPR014710 [H]

Pfam domain/function: PF01050 MannoseP_isomer; PF00483 NTP_transferase [H]

EC number: =5.3.1.8; =2.7.7.13 [H]

Molecular weight: Translated: 36784; Mature: 36653

Theoretical pI: Translated: 4.99; Mature: 4.99

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTVPVVLCGGSGTRLWPRSRKQKPKPFLPLVGENTLFAQTVLRCGRDAGFSPPVVVTG
CCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEC
AAHLAHVEEQLPDRASTRIIVEPEGRNTAAAIALAALSLPEDAVMLVCPSDHHIGDCEAF
CHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHH
QAAAREAVALAVEGWLVSFGIVPTAPETGFGYLKQGEPIAGTVGRRVQRFVEKPDLARAM
HHHHHHHHHHEEECEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
EFLASGEYAWNGGIFAFRAGTFIDELGKYRPAILAAVRDAVGRGKWDGMRFHPDAAAFSR
HHHHCCCCEECCCEEEEECCHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHH
VESESVDYAVMENTDKAAMVPAVMAWSDIGNWQALHEALDRDEHGNAVRGPAELRDCSNV
HHHCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCE
LVMSDGPRVSVVGASNLVVVVDGDEVLVCTPEGAQSVGKLSGAANQ
EEECCCCEEEEEECCCEEEEECCCEEEEECCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
TDTVPVVLCGGSGTRLWPRSRKQKPKPFLPLVGENTLFAQTVLRCGRDAGFSPPVVVTG
CCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCEEEEC
AAHLAHVEEQLPDRASTRIIVEPEGRNTAAAIALAALSLPEDAVMLVCPSDHHIGDCEAF
CHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCHHHH
QAAAREAVALAVEGWLVSFGIVPTAPETGFGYLKQGEPIAGTVGRRVQRFVEKPDLARAM
HHHHHHHHHHEEECEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHH
EFLASGEYAWNGGIFAFRAGTFIDELGKYRPAILAAVRDAVGRGKWDGMRFHPDAAAFSR
HHHHCCCCEECCCEEEEECCHHHHHHHCCCHHHHHHHHHHHCCCCCCCEEECCCHHHHHH
VESESVDYAVMENTDKAAMVPAVMAWSDIGNWQALHEALDRDEHGNAVRGPAELRDCSNV
HHHCCCCEEEECCCCCHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCHHHHCCCCE
LVMSDGPRVSVVGASNLVVVVDGDEVLVCTPEGAQSVGKLSGAANQ
EEECCCCEEEEEECCCEEEEECCCEEEEECCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12775688 [H]