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The map label for this gene is gudP [H]

Identifier: 86751783

GI number: 86751783

Start: 5299921

End: 5301207

Strand: Reverse

Name: gudP [H]

Synonym: RPB_4685

Alternate gene names: 86751783

Gene position: 5301207-5299921 (Counterclockwise)

Preceding gene: 86751788

Following gene: 86751778

Centisome position: 99.43

GC content: 67.99

Gene sequence:

>1287_bases
TTGGACGGGCATTCCACGCCGAAGGGCGCCTGGAGGATCACCTTCCTCCTGTTCCTGTTCATGGTGGTCAACTTCGCCGA
CAAGATCGTCGTCGGCCTCGCCGGCGTGCCGATCACCCAAGAGCTCGGTCTCACACCCGAACAGTTCGGCCTGCTCGGCT
CGTCGTTTTTCTTCCTGTTCTCGATCACGGCGGTCGTCGTCGGCTTCGTCGTCAACCGGGTCGACACCCGTTGGGTGCTG
TTGGTGCTGGCCCTGATCTGGGCGGTGGCGCAGTTTCCGATGGTCGGCACCGTCAGCTTCACCACGCTCTTGATCTGCCG
CATCATCCTCGGCGCCGGCGAAGGCCCGGCCTTCGCGGTCGCGGCGCATGCGATCTACAAATGGTTTCCCGACCACAAGC
GGACGCTGCCCACCGCGATCCTGTCGCAGGGCTCGGCGTTCGGCGTGATCCTGGCGGTACCGGCGCTGAACTGGATCATC
GTCAACCATTCCTGGCACTACGCGTTCGGCGCGCTCGGCATTGTCGGGCTGATGTGGGCGGCGGCGTGGCTCGCGCTCGG
CAAGGAAGGCCCGCTGGTGCCGACCGCGGCGATGGCGGCGGCGGAGACTCGGATCCCCTATGCGCGGCTGCTGACCTCGC
GCACCTTCATCGGCTGCGTCGCGGCGACGTTCGGTGCGTATTGGGCGCTGTCGCTGGGACTGACCTGGTTCACCACCTAC
ATCATCAGCGGGCTCGGCTTCAGCCAGCACCAGGCCGGCCTGATCTCGATCACGCCCTGGGTGTTCGGCGCCGCCGTCGT
GATGCTGACCGGCTGGCTGTCGCAGTTGCTGATGGGGCGCGGCGCGTCGAGCCGGCTGGCCCGCGGCGTGCTCGGCGCGG
CCCCGCTGGTGCTCGGCGGACTGATCCTGCTGACGATGCCGTTGATCGACAATCCGACCGGGCGGATCGCCGCGCTGGTG
ATCGGCTCGGGGTTGTGCGGATCGATCTACGTGGTGTGCCCGCCGATGATCGCCGAGTTCGCCCCGGTGTCGCAGCGCGG
CGCCGCGATCGCGATCTACGGTGCGCTGTACACGCTCGCCGGCATCGTGGCGCCGCTGGTGATGGGCAGCGTCGTCCAGC
ACGCCGCGTCGCTGAACGAGGGCTATCTCACCGGCTACGTGATCAACGGCGCGGTGATGATCGTCTCCGGCCTGCTCGGC
CTGCTGCTGCTGTGGCCGAACACCGAGCGCGCGAGGCTGCTGAGCAGCTCGGACGTCGCGCCTGTCGGCCTTCGCAAGCC
GGCGTGA

Upstream 100 bases:

>100_bases
GACATTCTGACGAATGCGTGATTGCATTCCCGCCCGATCGGCGGCAGCATCGCAACAGGTTCGCAATAAGAACCGGCAAT
GACGTCATCGGGAGGCCGCC

Downstream 100 bases:

>100_bases
ATTCTCTTCCGTCATGGCCGGGTGTTCGTCCCGCCTGCACGGCCGAAGCCGCGTCGGAACGGCGAAGGCCGGGTATCGAG
CCTCGCACCAGCGGCCTGCC

Product: major facilitator transporter

Products: NA

Alternate protein names: D-glucarate permease [H]

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MDGHSTPKGAWRITFLLFLFMVVNFADKIVVGLAGVPITQELGLTPEQFGLLGSSFFFLFSITAVVVGFVVNRVDTRWVL
LVLALIWAVAQFPMVGTVSFTTLLICRIILGAGEGPAFAVAAHAIYKWFPDHKRTLPTAILSQGSAFGVILAVPALNWII
VNHSWHYAFGALGIVGLMWAAAWLALGKEGPLVPTAAMAAAETRIPYARLLTSRTFIGCVAATFGAYWALSLGLTWFTTY
IISGLGFSQHQAGLISITPWVFGAAVVMLTGWLSQLLMGRGASSRLARGVLGAAPLVLGGLILLTMPLIDNPTGRIAALV
IGSGLCGSIYVVCPPMIAEFAPVSQRGAAIAIYGALYTLAGIVAPLVMGSVVQHAASLNEGYLTGYVINGAVMIVSGLLG
LLLLWPNTERARLLSSSDVAPVGLRKPA

Sequences:

>Translated_428_residues
MDGHSTPKGAWRITFLLFLFMVVNFADKIVVGLAGVPITQELGLTPEQFGLLGSSFFFLFSITAVVVGFVVNRVDTRWVL
LVLALIWAVAQFPMVGTVSFTTLLICRIILGAGEGPAFAVAAHAIYKWFPDHKRTLPTAILSQGSAFGVILAVPALNWII
VNHSWHYAFGALGIVGLMWAAAWLALGKEGPLVPTAAMAAAETRIPYARLLTSRTFIGCVAATFGAYWALSLGLTWFTTY
IISGLGFSQHQAGLISITPWVFGAAVVMLTGWLSQLLMGRGASSRLARGVLGAAPLVLGGLILLTMPLIDNPTGRIAALV
IGSGLCGSIYVVCPPMIAEFAPVSQRGAAIAIYGALYTLAGIVAPLVMGSVVQHAASLNEGYLTGYVINGAVMIVSGLLG
LLLLWPNTERARLLSSSDVAPVGLRKPA
>Mature_428_residues
MDGHSTPKGAWRITFLLFLFMVVNFADKIVVGLAGVPITQELGLTPEQFGLLGSSFFFLFSITAVVVGFVVNRVDTRWVL
LVLALIWAVAQFPMVGTVSFTTLLICRIILGAGEGPAFAVAAHAIYKWFPDHKRTLPTAILSQGSAFGVILAVPALNWII
VNHSWHYAFGALGIVGLMWAAAWLALGKEGPLVPTAAMAAAETRIPYARLLTSRTFIGCVAATFGAYWALSLGLTWFTTY
IISGLGFSQHQAGLISITPWVFGAAVVMLTGWLSQLLMGRGASSRLARGVLGAAPLVLGGLILLTMPLIDNPTGRIAALV
IGSGLCGSIYVVCPPMIAEFAPVSQRGAAIAIYGALYTLAGIVAPLVMGSVVQHAASLNEGYLTGYVINGAVMIVSGLLG
LLLLWPNTERARLLSSSDVAPVGLRKPA

Specific function: Uptake of D-glucarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI21322234, Length=380, Percent_Identity=24.7368421052632, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI9945322, Length=364, Percent_Identity=22.5274725274725, Blast_Score=71, Evalue=2e-12,
Organism=Homo sapiens, GI9966811, Length=389, Percent_Identity=21.3367609254499, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI6912666, Length=259, Percent_Identity=25.0965250965251, Blast_Score=67, Evalue=4e-11,
Organism=Escherichia coli, GI87082320, Length=383, Percent_Identity=25.065274151436, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1789515, Length=406, Percent_Identity=26.3546798029557, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1789152, Length=405, Percent_Identity=23.2098765432099, Blast_Score=101, Evalue=8e-23,
Organism=Escherichia coli, GI2367379, Length=324, Percent_Identity=26.2345679012346, Blast_Score=96, Evalue=3e-21,
Organism=Escherichia coli, GI2367193, Length=440, Percent_Identity=23.6363636363636, Blast_Score=71, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17554962, Length=338, Percent_Identity=24.2603550295858, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24648416, Length=424, Percent_Identity=23.1132075471698, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356189, Length=424, Percent_Identity=23.1132075471698, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24639764, Length=376, Percent_Identity=22.3404255319149, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI19922400, Length=357, Percent_Identity=25.7703081232493, Blast_Score=68, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24654215, Length=357, Percent_Identity=25.7703081232493, Blast_Score=68, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 45148; Mature: 45148

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGHSTPKGAWRITFLLFLFMVVNFADKIVVGLAGVPITQELGLTPEQFGLLGSSFFFLF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHH
SITAVVVGFVVNRVDTRWVLLVLALIWAVAQFPMVGTVSFTTLLICRIILGAGEGPAFAV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
AAHAIYKWFPDHKRTLPTAILSQGSAFGVILAVPALNWIIVNHSWHYAFGALGIVGLMWA
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHH
AAWLALGKEGPLVPTAAMAAAETRIPYARLLTSRTFIGCVAATFGAYWALSLGLTWFTTY
HHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IISGLGFSQHQAGLISITPWVFGAAVVMLTGWLSQLLMGRGASSRLARGVLGAAPLVLGG
HHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LILLTMPLIDNPTGRIAALVIGSGLCGSIYVVCPPMIAEFAPVSQRGAAIAIYGALYTLA
HHHHHHHHCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHCCCCCCCCEEEHHHHHHHHH
GIVAPLVMGSVVQHAASLNEGYLTGYVINGAVMIVSGLLGLLLLWPNTERARLLSSSDVA
HHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCC
PVGLRKPA
CCCCCCCC
>Mature Secondary Structure
MDGHSTPKGAWRITFLLFLFMVVNFADKIVVGLAGVPITQELGLTPEQFGLLGSSFFFLF
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHH
SITAVVVGFVVNRVDTRWVLLVLALIWAVAQFPMVGTVSFTTLLICRIILGAGEGPAFAV
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHH
AAHAIYKWFPDHKRTLPTAILSQGSAFGVILAVPALNWIIVNHSWHYAFGALGIVGLMWA
HHHHHHHHCCCCHHHHHHHHHCCCCCCCCEEEECCCEEEEEECCHHHHHHHHHHHHHHHH
AAWLALGKEGPLVPTAAMAAAETRIPYARLLTSRTFIGCVAATFGAYWALSLGLTWFTTY
HHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IISGLGFSQHQAGLISITPWVFGAAVVMLTGWLSQLLMGRGASSRLARGVLGAAPLVLGG
HHHCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
LILLTMPLIDNPTGRIAALVIGSGLCGSIYVVCPPMIAEFAPVSQRGAAIAIYGALYTLA
HHHHHHHHCCCCCCCEEEEEECCCCCCCCEEECCHHHHHHCCCCCCCCEEEHHHHHHHHH
GIVAPLVMGSVVQHAASLNEGYLTGYVINGAVMIVSGLLGLLLLWPNTERARLLSSSDVA
HHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCC
PVGLRKPA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]