Click here to switch to the map view.

The map label for this gene is ctaB

Identifier: 86751684

GI number: 86751684

Start: 5179911

End: 5180852

Strand: Reverse

Name: ctaB

Synonym: RPB_4586

Alternate gene names: 86751684

Gene position: 5180852-5179911 (Counterclockwise)

Preceding gene: 86751685

Following gene: 86751683

Centisome position: 97.17

GC content: 67.41

Gene sequence:

>942_bases
TTGTCGGTCATAGACACCAACCAGATCGATCTCGTCGCGCCCCGCATTTCCGAGGCCGGCGTCGCCGACTACATCGCGCT
GCTCAAGCCGCGGGTGATGTCGCTGGTGGTGTTCACCGCGCTGGTCGGCATGCTGCTGGCGCCGGGCGACTTTCACCCGG
TGCTGGCGATCACCGCGATGCTGTGCATCGCGGTCGGCGGCGGCGCGGCCGGCGCACTGAACATGTGGTACGAGGACGAC
ATCGACGGCCAGATGACGCGCACCGCCAACCGGCCGATCCCGCGCGGCCGCGTCACCCGGCCGGAAGCGCTGACCTTCGG
CATCACGCTGTCGTTCTTCTCGGTGATGACGCTCGGCATCCTGGTCAACTGGGTCGCCGGCGCGTTGCTCGCCTTCACCA
TCTTCTTCTACGTGGTGATCTATACGATGTGGCTGAAGCGCTCGACCGCGCAGAACATCGTGATCGGCGGCGCCGCCGGC
GCGCTGCCGCCGGTGGTGGCGTGGGCCGCGGTCACCGGCTCGCTGGCGGTGGAGCCGCTGCTGTTGTTCGCCATCATCTT
CTTCTGGACGCCGCCGCATTTCTGGGCGCTGGCGCTGTTCCGCAATGACGACTACGCCCGCGCCGGCGTGCCGATGCTGC
CGGTGGTCGCCGGTCAGGATCACACAAGGCTGCAGATCCTGCTCTACACCATCGTGCTGGTCGCGGTCGCGGCGGCGCCC
TGGCCGCTCGGCTATTTCAGCGCGATCTACGGCGTGGCGTCGCTGGCGCTCGGCGGCTGGATGCTGGTGCTCGCGCTGCG
GGTCTATCGCCATCGCACCGGCAGCGCCGCGCTGCGGGCGACGCGCAATCTGTTCAAGTTCTCGATCCTGTATCTGTTCG
CGCTGTTCTCGATCCTGTTGCTCGAGGTGGTGGCGAAGGCGGTGTGGCGATTGTTCGCCTGA

Upstream 100 bases:

>100_bases
AGTTCGAAGTGCTGCCGCAGGTCCGCTGAGGCGTTCGATCGAGAGCATCCGTCGCGGGTCGTCCGTCGGCGGATGCGTAT
AGAGAGACAGAGGTTCCGAA

Downstream 100 bases:

>100_bases
GGAGGTCCGGATGGACCAGCAGAGACCCGGCATCGTGCTCACCGAGGCGCAGAAGAAGCGCCAGCGCGAACGATCGATCG
CGATCGCCTTGGCGCTCGCC

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 313; Mature: 312

Protein sequence:

>313_residues
MSVIDTNQIDLVAPRISEAGVADYIALLKPRVMSLVVFTALVGMLLAPGDFHPVLAITAMLCIAVGGGAAGALNMWYEDD
IDGQMTRTANRPIPRGRVTRPEALTFGITLSFFSVMTLGILVNWVAGALLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAG
ALPPVVAWAAVTGSLAVEPLLLFAIIFFWTPPHFWALALFRNDDYARAGVPMLPVVAGQDHTRLQILLYTIVLVAVAAAP
WPLGYFSAIYGVASLALGGWMLVLALRVYRHRTGSAALRATRNLFKFSILYLFALFSILLLEVVAKAVWRLFA

Sequences:

>Translated_313_residues
MSVIDTNQIDLVAPRISEAGVADYIALLKPRVMSLVVFTALVGMLLAPGDFHPVLAITAMLCIAVGGGAAGALNMWYEDD
IDGQMTRTANRPIPRGRVTRPEALTFGITLSFFSVMTLGILVNWVAGALLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAG
ALPPVVAWAAVTGSLAVEPLLLFAIIFFWTPPHFWALALFRNDDYARAGVPMLPVVAGQDHTRLQILLYTIVLVAVAAAP
WPLGYFSAIYGVASLALGGWMLVLALRVYRHRTGSAALRATRNLFKFSILYLFALFSILLLEVVAKAVWRLFA
>Mature_312_residues
SVIDTNQIDLVAPRISEAGVADYIALLKPRVMSLVVFTALVGMLLAPGDFHPVLAITAMLCIAVGGGAAGALNMWYEDDI
DGQMTRTANRPIPRGRVTRPEALTFGITLSFFSVMTLGILVNWVAGALLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAGA
LPPVVAWAAVTGSLAVEPLLLFAIIFFWTPPHFWALALFRNDDYARAGVPMLPVVAGQDHTRLQILLYTIVLVAVAAAPW
PLGYFSAIYGVASLALGGWMLVLALRVYRHRTGSAALRATRNLFKFSILYLFALFSILLLEVVAKAVWRLFA

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=191, Percent_Identity=38.2198952879581, Blast_Score=115, Evalue=6e-26,
Organism=Escherichia coli, GI1786631, Length=276, Percent_Identity=32.9710144927536, Blast_Score=115, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=272, Percent_Identity=30.1470588235294, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6325085, Length=276, Percent_Identity=28.6231884057971, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI19921064, Length=289, Percent_Identity=31.4878892733564, Blast_Score=125, Evalue=5e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_RHOP2 (Q2IR91)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_488180.1
- STRING:   Q2IR91
- GeneID:   3912403
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_4586
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   LLKPRIM
- ProtClustDB:   PRK04375
- BioCyc:   RPAL316058:RPB_4586-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 34018; Mature: 33887

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x21d35b14)-; HASH(0x213a26e0)-; HASH(0x2139c0fc)-; HASH(0x217c10b0)-; HASH(0x2161034c)-; HASH(0x1f9d4cbc)-; HASH(0x217f8fa8)-; HASH(0x21eb8a24)-;

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVIDTNQIDLVAPRISEAGVADYIALLKPRVMSLVVFTALVGMLLAPGDFHPVLAITAM
CCCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LCIAVGGGAAGALNMWYEDDIDGQMTRTANRPIPRGRVTRPEALTFGITLSFFSVMTLGI
HHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LVNWVAGALLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAGALPPVVAWAAVTGSLAVEPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
LLFAIIFFWTPPHFWALALFRNDDYARAGVPMLPVVAGQDHTRLQILLYTIVLVAVAAAP
HHHHHHHHHCCHHHHEEHEEECCCCHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCC
WPLGYFSAIYGVASLALGGWMLVLALRVYRHRTGSAALRATRNLFKFSILYLFALFSILL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LEVVAKAVWRLFA
HHHHHHHHHHHCH
>Mature Secondary Structure 
SVIDTNQIDLVAPRISEAGVADYIALLKPRVMSLVVFTALVGMLLAPGDFHPVLAITAM
CCCCCCCCEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LCIAVGGGAAGALNMWYEDDIDGQMTRTANRPIPRGRVTRPEALTFGITLSFFSVMTLGI
HHHHHCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
LVNWVAGALLAFTIFFYVVIYTMWLKRSTAQNIVIGGAAGALPPVVAWAAVTGSLAVEPL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHH
LLFAIIFFWTPPHFWALALFRNDDYARAGVPMLPVVAGQDHTRLQILLYTIVLVAVAAAP
HHHHHHHHHCCHHHHEEHEEECCCCHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCC
WPLGYFSAIYGVASLALGGWMLVLALRVYRHRTGSAALRATRNLFKFSILYLFALFSILL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
LEVVAKAVWRLFA
HHHHHHHHHHHCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA