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The map label for this gene is hemH

Identifier: 86751640

GI number: 86751640

Start: 5136270

End: 5137307

Strand: Reverse

Name: hemH

Synonym: RPB_4542

Alternate gene names: 86751640

Gene position: 5137307-5136270 (Counterclockwise)

Preceding gene: 86751641

Following gene: 86751639

Centisome position: 96.35

GC content: 64.45

Gene sequence:

>1038_bases
ATGACGGTGATTGTCCCCATTCACGGCCCTGCACCCGCTCTGGCACCTGCGCCCGAGCGCGTCGGCGTATTGCTGGTCAA
TCTCGGCACCCCCGACAGCTGCGACACCAAGGGCGTGCGGGTCTATTTGCGCGAGTTCCTGTCGGACCCGCGGGTGATCG
AGAATCAGGGGATCTTCTGGAAGCTGGCGCTGAACGGCATCATCCTGAACACCCGTCCGGCCCGCAAGGCCAAGGACTAC
CAGAAGATCTGGAACCAGGAGAAGAACGAGTCGCCGCTGAAGACCATCACCCGCGCGCAGGCCGAGAAGCTCGCCGCGTC
GCTGAGCGATCGCAGCCACCTGGTGGTGGACTGGGCGATGCGTTACGGCAACCCGTCGATGCGCGACCGGATCGAGGCGC
TGGTGGCGCAAGGCTGCTCGCGGCTGCTGGTGGTGCCCCTCTATCCACAATATTCGGCGGCGACCTCGGCCACCGTGTGC
GACCAGGCGTTTCGCGTGCTGCGCGAATTGCGCGCCCAGCCGACGCTGCGGGTGACACCGCCTTACTACCGCGACGACGC
CTATATCGACGCGCTGGCGAATTCGATCCATGCGCATCTGGCGACGCTGCCGTTCAAGCCGGAGATGATCGTCGCCTCTT
TTCACGGCATGCCGCAGGCCTATATCGAGAAGGGCGATCCGTATCAGTCGCAATGCGTCGCCACCGTCGATGCGCTGCGC
GAGCGGATGGGGCTGGACGACAAGAAGCTGCTGCTGACGTTCCAGTCGCGGTTCGGCTTCGACCAGTGGCTGCAGCCCTA
CACCGACAAGACCATCGAGAAGCTCGCCAAGGACGGCGTGCGCAAGCTCGCCGTGGTGATGCCCGGCTTCGCCGCGGACT
GCCTCGAGACGCTGGAAGAAATCGCGCAGGAGAATGCCGAGATCTTCATGCACAATGGCGGCGAGGAGTTCTCCGCGATC
CCCTGCCTCAACGACAGCGCCGACGGCATCGCGGTGATCCGGCAACTGGTGATGCGCGAACTGGAAGGTTGGCTGTAG

Upstream 100 bases:

>100_bases
ATACGTATGGTGTGAGGCGCCCCGGCGCGGCGTTCGGCCGCCGCGCGGTCATCGCGTCGTCTTGACAACAATAGGCCAAA
GCGCGAAGCCAATCAGCATC

Downstream 100 bases:

>100_bases
GCGGCGGGATTTGCCGCCGGCCGTCGACGGTTGCATCCGCGGCATCCCAACGCCGCACACCCCGGCGATCAGGCTCGCTT
TCCCCGCGCTCGAACCTTAC

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTVIVPIHGPAPALAPAPERVGVLLVNLGTPDSCDTKGVRVYLREFLSDPRVIENQGIFWKLALNGIILNTRPARKAKDY
QKIWNQEKNESPLKTITRAQAEKLAASLSDRSHLVVDWAMRYGNPSMRDRIEALVAQGCSRLLVVPLYPQYSAATSATVC
DQAFRVLRELRAQPTLRVTPPYYRDDAYIDALANSIHAHLATLPFKPEMIVASFHGMPQAYIEKGDPYQSQCVATVDALR
ERMGLDDKKLLLTFQSRFGFDQWLQPYTDKTIEKLAKDGVRKLAVVMPGFAADCLETLEEIAQENAEIFMHNGGEEFSAI
PCLNDSADGIAVIRQLVMRELEGWL

Sequences:

>Translated_345_residues
MTVIVPIHGPAPALAPAPERVGVLLVNLGTPDSCDTKGVRVYLREFLSDPRVIENQGIFWKLALNGIILNTRPARKAKDY
QKIWNQEKNESPLKTITRAQAEKLAASLSDRSHLVVDWAMRYGNPSMRDRIEALVAQGCSRLLVVPLYPQYSAATSATVC
DQAFRVLRELRAQPTLRVTPPYYRDDAYIDALANSIHAHLATLPFKPEMIVASFHGMPQAYIEKGDPYQSQCVATVDALR
ERMGLDDKKLLLTFQSRFGFDQWLQPYTDKTIEKLAKDGVRKLAVVMPGFAADCLETLEEIAQENAEIFMHNGGEEFSAI
PCLNDSADGIAVIRQLVMRELEGWL
>Mature_344_residues
TVIVPIHGPAPALAPAPERVGVLLVNLGTPDSCDTKGVRVYLREFLSDPRVIENQGIFWKLALNGIILNTRPARKAKDYQ
KIWNQEKNESPLKTITRAQAEKLAASLSDRSHLVVDWAMRYGNPSMRDRIEALVAQGCSRLLVVPLYPQYSAATSATVCD
QAFRVLRELRAQPTLRVTPPYYRDDAYIDALANSIHAHLATLPFKPEMIVASFHGMPQAYIEKGDPYQSQCVATVDALRE
RMGLDDKKLLLTFQSRFGFDQWLQPYTDKTIEKLAKDGVRKLAVVMPGFAADCLETLEEIAQENAEIFMHNGGEEFSAIP
CLNDSADGIAVIRQLVMRELEGWL

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family

Homologues:

Organism=Homo sapiens, GI60499021, Length=320, Percent_Identity=24.6875, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI60499025, Length=306, Percent_Identity=25.4901960784314, Blast_Score=95, Evalue=9e-20,
Organism=Escherichia coli, GI1786681, Length=318, Percent_Identity=40.5660377358491, Blast_Score=243, Evalue=9e-66,
Organism=Drosophila melanogaster, GI17864156, Length=337, Percent_Identity=23.4421364985163, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEMH_RHOP2 (Q2IRD5)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_488136.1
- ProteinModelPortal:   Q2IRD5
- SMR:   Q2IRD5
- STRING:   Q2IRD5
- GeneID:   3912359
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_4542
- eggNOG:   COG0276
- HOGENOM:   HBG697135
- OMA:   DFEANGK
- ProtClustDB:   PRK00035
- BioCyc:   RPAL316058:RPB_4542-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00323
- InterPro:   IPR001015
- InterPro:   IPR019772
- PANTHER:   PTHR11108
- TIGRFAMs:   TIGR00109

Pfam domain/function: PF00762 Ferrochelatase

EC number: =4.99.1.1

Molecular weight: Translated: 38583; Mature: 38452

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVIVPIHGPAPALAPAPERVGVLLVNLGTPDSCDTKGVRVYLREFLSDPRVIENQGIFW
CEEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEECCCCCEE
KLALNGIILNTRPARKAKDYQKIWNQEKNESPLKTITRAQAEKLAASLSDRSHLVVDWAM
EEEECCEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHH
RYGNPSMRDRIEALVAQGCSRLLVVPLYPQYSAATSATVCDQAFRVLRELRAQPTLRVTP
HCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
PYYRDDAYIDALANSIHAHLATLPFKPEMIVASFHGMPQAYIEKGDPYQSQCVATVDALR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHH
ERMGLDDKKLLLTFQSRFGFDQWLQPYTDKTIEKLAKDGVRKLAVVMPGFAADCLETLEE
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IAQENAEIFMHNGGEEFSAIPCLNDSADGIAVIRQLVMRELEGWL
HHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVIVPIHGPAPALAPAPERVGVLLVNLGTPDSCDTKGVRVYLREFLSDPRVIENQGIFW
EEEEECCCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCEECCCCCEE
KLALNGIILNTRPARKAKDYQKIWNQEKNESPLKTITRAQAEKLAASLSDRSHLVVDWAM
EEEECCEEECCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHH
RYGNPSMRDRIEALVAQGCSRLLVVPLYPQYSAATSATVCDQAFRVLRELRAQPTLRVTP
HCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEEECC
PYYRDDAYIDALANSIHAHLATLPFKPEMIVASFHGMPQAYIEKGDPYQSQCVATVDALR
CCCCCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCHHHHCCCCCHHHHHHHHHHHHH
ERMGLDDKKLLLTFQSRFGFDQWLQPYTDKTIEKLAKDGVRKLAVVMPGFAADCLETLEE
HHHCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
IAQENAEIFMHNGGEEFSAIPCLNDSADGIAVIRQLVMRELEGWL
HHHCCCEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA