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The map label for this gene is fabG [C]

Identifier: 86750299

GI number: 86750299

Start: 3645198

End: 3646127

Strand: Direct

Name: fabG [C]

Synonym: RPB_3188

Alternate gene names: 86750299

Gene position: 3645198-3646127 (Clockwise)

Preceding gene: 86750297

Following gene: 86750306

Centisome position: 68.37

GC content: 68.6

Gene sequence:

>930_bases
ATGCATCCATACCAAGCAACTAAGCGAACCGCGCTGATCACCGGAGCCAATTCGGGCCTCGGCAAAGCCGTCGCAACGGC
ACTCGCGGCCGAGGATGCGCGCGTCGGTCTGGTCGCGCGCGACCGCGAACGCGGCGAGACGGCGCTCGCGGACATCCGGG
CCGCCACCGGAAACAACGACCTGCATCTGTTCGTCGCCGATCTGGCCGATCAGTCGGCGATCCGCGCGCTGGCGCAGGCG
GTGCATCGGCGTTTCGACCGCCTGCATCTGCTGATCAACAATGCCGGCACCGCTTTCCCCGCGCGGCGGCTCAGCCCGGA
CGGGATCGAATGCGCCTTCGCCGTGAACCACCTCGGCCCGTTCCTCCTCACCAATCTGCTGCTGGATCTGCTCCGCGCCA
GCGCGCCGGCGCGGATCGTCAATGTCGGCACCCGCATCAGCACCGCGCTGGATTTCGAGGACCTGAATTGGGAGCGGCGG
CCGTATCGCATGATGCAGGGCTACGGCCAGTCCAAGCTCGGCAATCTGCACTTCACCTTCGAACTGGCGCGCCGTCTGCA
AGGCAGCGGCGTCACCGTCAATTGCGTGTTCCCGGGCGTGTTCAAATCCAATCTCGGCGGCACCGACGGCGCCCAGGGCG
CCTTGCTGAAGCTGTTCGCGCGCTGGGGCGGCTGGGCGATCCCGTCGCCGGAGCGGGCGGCGCGCCGCGTGCTGTATCTC
GCCAACGCACCGGAACTGGCCACGGTGAGCGGCCAGTATTTCGGCGACCGCAAGATCATCCCGGCGCCGGCCCAGGCGCT
CGATGTCGAAGCCAATCGCCGGCTGTGGCAGATCAGCGAAGCGCTGACGGCCCCGGGACCGGAACCCGCCCCGCGCGAGC
GCCCCTCCACCGGCCCCGCCCACGATCGACCGATCACCACCGATCGATGA

Upstream 100 bases:

>100_bases
TATGATCTCATCGGCAAATCCGGCCGACCGTTCGCCAGCCGTCGACCGACCTCAGCCGCCTGTGCGACCTTTTGCCCGCC
GAGTCCCGGAGGCCAGCTCG

Downstream 100 bases:

>100_bases
GAGACGAAGGGCCCTATCTTTCAGCGTGTCGGGTCGTGCCGCGGCGCGTTTCGGATTACGCTCAGGTGGACCTGGATCAC
TCCCACTCGATGGTCCCCGG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MHPYQATKRTALITGANSGLGKAVATALAAEDARVGLVARDRERGETALADIRAATGNNDLHLFVADLADQSAIRALAQA
VHRRFDRLHLLINNAGTAFPARRLSPDGIECAFAVNHLGPFLLTNLLLDLLRASAPARIVNVGTRISTALDFEDLNWERR
PYRMMQGYGQSKLGNLHFTFELARRLQGSGVTVNCVFPGVFKSNLGGTDGAQGALLKLFARWGGWAIPSPERAARRVLYL
ANAPELATVSGQYFGDRKIIPAPAQALDVEANRRLWQISEALTAPGPEPAPRERPSTGPAHDRPITTDR

Sequences:

>Translated_309_residues
MHPYQATKRTALITGANSGLGKAVATALAAEDARVGLVARDRERGETALADIRAATGNNDLHLFVADLADQSAIRALAQA
VHRRFDRLHLLINNAGTAFPARRLSPDGIECAFAVNHLGPFLLTNLLLDLLRASAPARIVNVGTRISTALDFEDLNWERR
PYRMMQGYGQSKLGNLHFTFELARRLQGSGVTVNCVFPGVFKSNLGGTDGAQGALLKLFARWGGWAIPSPERAARRVLYL
ANAPELATVSGQYFGDRKIIPAPAQALDVEANRRLWQISEALTAPGPEPAPRERPSTGPAHDRPITTDR
>Mature_309_residues
MHPYQATKRTALITGANSGLGKAVATALAAEDARVGLVARDRERGETALADIRAATGNNDLHLFVADLADQSAIRALAQA
VHRRFDRLHLLINNAGTAFPARRLSPDGIECAFAVNHLGPFLLTNLLLDLLRASAPARIVNVGTRISTALDFEDLNWERR
PYRMMQGYGQSKLGNLHFTFELARRLQGSGVTVNCVFPGVFKSNLGGTDGAQGALLKLFARWGGWAIPSPERAARRVLYL
ANAPELATVSGQYFGDRKIIPAPAQALDVEANRRLWQISEALTAPGPEPAPRERPSTGPAHDRPITTDR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI225579078, Length=305, Percent_Identity=44.9180327868852, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI10190746, Length=291, Percent_Identity=41.9243986254296, Blast_Score=171, Evalue=6e-43,
Organism=Homo sapiens, GI19923931, Length=264, Percent_Identity=45.4545454545455, Blast_Score=168, Evalue=7e-42,
Organism=Homo sapiens, GI166795268, Length=277, Percent_Identity=40.072202166065, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI186928839, Length=276, Percent_Identity=40.2173913043478, Blast_Score=161, Evalue=6e-40,
Organism=Homo sapiens, GI146231950, Length=294, Percent_Identity=37.4149659863946, Blast_Score=144, Evalue=1e-34,
Organism=Homo sapiens, GI7706523, Length=290, Percent_Identity=34.8275862068965, Blast_Score=135, Evalue=6e-32,
Organism=Homo sapiens, GI193804850, Length=286, Percent_Identity=32.8671328671329, Blast_Score=112, Evalue=3e-25,
Organism=Homo sapiens, GI13375997, Length=169, Percent_Identity=30.1775147928994, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI1787335, Length=199, Percent_Identity=25.6281407035176, Blast_Score=68, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17558006, Length=284, Percent_Identity=32.0422535211268, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI72001364, Length=308, Percent_Identity=32.4675324675325, Blast_Score=111, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17532805, Length=300, Percent_Identity=30, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17505416, Length=287, Percent_Identity=28.5714285714286, Blast_Score=97, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17532791, Length=275, Percent_Identity=26.1818181818182, Blast_Score=96, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI193207620, Length=297, Percent_Identity=27.6094276094276, Blast_Score=95, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI71992402, Length=293, Percent_Identity=28.3276450511945, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17535059, Length=294, Percent_Identity=27.5510204081633, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI115533174, Length=283, Percent_Identity=32.5088339222615, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI115533172, Length=283, Percent_Identity=32.5088339222615, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17562910, Length=259, Percent_Identity=27.4131274131274, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17551412, Length=269, Percent_Identity=28.6245353159851, Blast_Score=77, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI32565532, Length=132, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71994604, Length=201, Percent_Identity=30.8457711442786, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71994600, Length=197, Percent_Identity=29.9492385786802, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6324148, Length=307, Percent_Identity=25.4071661237785, Blast_Score=68, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322227, Length=274, Percent_Identity=25.1824817518248, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586328, Length=283, Percent_Identity=39.5759717314488, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI22024069, Length=281, Percent_Identity=40.5693950177936, Blast_Score=162, Evalue=2e-40,
Organism=Drosophila melanogaster, GI45553409, Length=284, Percent_Identity=36.6197183098592, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24647948, Length=284, Percent_Identity=36.6197183098592, Blast_Score=158, Evalue=4e-39,
Organism=Drosophila melanogaster, GI24647946, Length=284, Percent_Identity=36.6197183098592, Blast_Score=157, Evalue=8e-39,
Organism=Drosophila melanogaster, GI19921754, Length=285, Percent_Identity=38.5964912280702, Blast_Score=154, Evalue=6e-38,
Organism=Drosophila melanogaster, GI161076371, Length=283, Percent_Identity=39.2226148409894, Blast_Score=150, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28573296, Length=284, Percent_Identity=39.7887323943662, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI45554248, Length=274, Percent_Identity=35.4014598540146, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24640117, Length=274, Percent_Identity=35.4014598540146, Blast_Score=138, Evalue=6e-33,
Organism=Drosophila melanogaster, GI24656154, Length=289, Percent_Identity=33.5640138408304, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI19922628, Length=289, Percent_Identity=33.5640138408304, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24647931, Length=298, Percent_Identity=30.8724832214765, Blast_Score=103, Evalue=1e-22,
Organism=Drosophila melanogaster, GI20129347, Length=292, Percent_Identity=27.7397260273973, Blast_Score=96, Evalue=4e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 33481; Mature: 33481

Theoretical pI: Translated: 10.36; Mature: 10.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHPYQATKRTALITGANSGLGKAVATALAAEDARVGLVARDRERGETALADIRAATGNND
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
LHLFVADLADQSAIRALAQAVHRRFDRLHLLINNAGTAFPARRLSPDGIECAFAVNHLGP
EEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCEEEHHHHHCCH
FLLTNLLLDLLRASAPARIVNVGTRISTALDFEDLNWERRPYRMMQGYGQSKLGNLHFTF
HHHHHHHHHHHHCCCCCEEEECCCHHHHEECHHHCCCCCCHHHHHHCCCCCCCCCEEEHH
ELARRLQGSGVTVNCVFPGVFKSNLGGTDGAQGALLKLFARWGGWAIPSPERAARRVLYL
HHHHHHCCCCEEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCEEEEE
ANAPELATVSGQYFGDRKIIPAPAQALDVEANRRLWQISEALTAPGPEPAPRERPSTGPA
ECCCCEEEECCCCCCCCEECCCCHHHHCCHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
HDRPITTDR
CCCCCCCCC
>Mature Secondary Structure
MHPYQATKRTALITGANSGLGKAVATALAAEDARVGLVARDRERGETALADIRAATGNND
CCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCHHHHHHHHCCCCCC
LHLFVADLADQSAIRALAQAVHRRFDRLHLLINNAGTAFPARRLSPDGIECAFAVNHLGP
EEEEEECCCCHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCCEEEHHHHHCCH
FLLTNLLLDLLRASAPARIVNVGTRISTALDFEDLNWERRPYRMMQGYGQSKLGNLHFTF
HHHHHHHHHHHHCCCCCEEEECCCHHHHEECHHHCCCCCCHHHHHHCCCCCCCCCEEEHH
ELARRLQGSGVTVNCVFPGVFKSNLGGTDGAQGALLKLFARWGGWAIPSPERAARRVLYL
HHHHHHCCCCEEEEEEECCHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCHHHHHCEEEEE
ANAPELATVSGQYFGDRKIIPAPAQALDVEANRRLWQISEALTAPGPEPAPRERPSTGPA
ECCCCEEEECCCCCCCCEECCCCHHHHCCHHCCHHHHHHHHHCCCCCCCCCCCCCCCCCC
HDRPITTDR
CCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]