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The map label for this gene is cysG2 [H]

Identifier: 86750297

GI number: 86750297

Start: 3643089

End: 3643838

Strand: Direct

Name: cysG2 [H]

Synonym: RPB_3186

Alternate gene names: 86750297

Gene position: 3643089-3643838 (Clockwise)

Preceding gene: 86750296

Following gene: 86750299

Centisome position: 68.33

GC content: 71.6

Gene sequence:

>750_bases
ATGCCGACCGCTTCGACCTCCTCTTTCATGCCCGGCAGCGTCGCCCTCGTCGGCGCCGGCCCCGGCGATGCCGACCTGCT
GACGCTGCGCGCCATCAAGCGGCTGCAGGAGGCCGACGTCGTGCTCTACGATGATCTCGCCGGCGAGGAGTTCATGGCCT
TCCTCAAAGCCGACGTCGAACTCGTGGCCGTCGGCAAACGCGCCGGCCACCCCTCGCCGCGCCAGGACGAGGTCAGCCGC
CTGATCGTCGCCCATGCGCAGCGCGGCCAGCGCGTGGTGCGACTCAAGGCCGGCGACCCGACGGTGTTCGCCAGATCCGA
CGAGGAACTACGCGCCGCCCGCGACGCCGGCATCGAGATCGAGATCGTCCCGGGTATCACCACCGCAACCGCCGCCGCGG
CTGCGCTCGGCGCGTCGCTGACCAAGCGCGGCGTCGCCCGCCGCGTGCAGCTCGTCACCGGCCACGACGTCGACGGCCGC
CTGCCCGGCGACCTCGACATCACCGCACTCGCCGATCCGGCGGCGACCACCTGCATCTATATGGGCAAGGCGACCTTCCC
GACGCTGGTCGCGCGGCTGATCGCTGCGGGACTGAGCCCGCAGACGCCGGCCGCGATCGTCGAAAGCCTCGGCTCGCCGG
AGACGCGCATCTTTCGCGGCTCCGTCACCGAGCTCGCGAGCCGGCTCGCCACCGATCCACCGCCGGGCGCCTGCATCATC
CTCTACGGACAGGCGTTCGCGACGTCCTGA

Upstream 100 bases:

>100_bases
ATGCCGCCGGTGCGCCGACCAGCGAGACCGGCAGCCGGCGCGGCCACGTGAGCGGGACGTTCTTCCACCTGATCGACGTC
GCGCAGGAGCCCGTCGCCTG

Downstream 100 bases:

>100_bases
GACTCAGGGCTTCATCACCACCTTGATGCAGCCGTCCTGCTTGTCGCGGAACGTCTTGTACAGCTCCGGGCCATCCTCCA
GCGTGGCGCGATGGGTGATG

Product: uroporphyrin-III C-methyltransferase

Products: NA

Alternate protein names: Uroporphyrinogen-III C-methyltransferase; Urogen III methylase; SUMT; Uroporphyrinogen III methylase; UROM; Precorrin-2 dehydrogenase; Sirohydrochlorin ferrochelatase [H]

Number of amino acids: Translated: 249; Mature: 248

Protein sequence:

>249_residues
MPTASTSSFMPGSVALVGAGPGDADLLTLRAIKRLQEADVVLYDDLAGEEFMAFLKADVELVAVGKRAGHPSPRQDEVSR
LIVAHAQRGQRVVRLKAGDPTVFARSDEELRAARDAGIEIEIVPGITTATAAAAALGASLTKRGVARRVQLVTGHDVDGR
LPGDLDITALADPAATTCIYMGKATFPTLVARLIAAGLSPQTPAAIVESLGSPETRIFRGSVTELASRLATDPPPGACII
LYGQAFATS

Sequences:

>Translated_249_residues
MPTASTSSFMPGSVALVGAGPGDADLLTLRAIKRLQEADVVLYDDLAGEEFMAFLKADVELVAVGKRAGHPSPRQDEVSR
LIVAHAQRGQRVVRLKAGDPTVFARSDEELRAARDAGIEIEIVPGITTATAAAAALGASLTKRGVARRVQLVTGHDVDGR
LPGDLDITALADPAATTCIYMGKATFPTLVARLIAAGLSPQTPAAIVESLGSPETRIFRGSVTELASRLATDPPPGACII
LYGQAFATS
>Mature_248_residues
PTASTSSFMPGSVALVGAGPGDADLLTLRAIKRLQEADVVLYDDLAGEEFMAFLKADVELVAVGKRAGHPSPRQDEVSRL
IVAHAQRGQRVVRLKAGDPTVFARSDEELRAARDAGIEIEIVPGITTATAAAAALGASLTKRGVARRVQLVTGHDVDGRL
PGDLDITALADPAATTCIYMGKATFPTLVARLIAAGLSPQTPAAIVESLGSPETRIFRGSVTELASRLATDPPPGACIIL
YGQAFATS

Specific function: Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into si

COG id: COG0007

COG function: function code H; Uroporphyrinogen-III methylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the precorrin methyltransferase family [H]

Homologues:

Organism=Escherichia coli, GI1789768, Length=229, Percent_Identity=42.3580786026201, Blast_Score=177, Evalue=7e-46,
Organism=Saccharomyces cerevisiae, GI6322922, Length=226, Percent_Identity=30.0884955752212, Blast_Score=99, Evalue=5e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000878
- InterPro:   IPR014777
- InterPro:   IPR014776
- InterPro:   IPR006366
- InterPro:   IPR016040
- InterPro:   IPR019478
- InterPro:   IPR006367
- InterPro:   IPR003043 [H]

Pfam domain/function: PF10414 CysG_dimeriser; PF00590 TP_methylase [H]

EC number: =2.1.1.107; =1.3.1.76; =4.99.1.4 [H]

Molecular weight: Translated: 25851; Mature: 25720

Theoretical pI: Translated: 5.77; Mature: 5.77

Prosite motif: PS00839 SUMT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTASTSSFMPGSVALVGAGPGDADLLTLRAIKRLQEADVVLYDDLAGEEFMAFLKADVE
CCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCEE
LVAVGKRAGHPSPRQDEVSRLIVAHAQRGQRVVRLKAGDPTVFARSDEELRAARDAGIEI
EEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHCCCEE
EIVPGITTATAAAAALGASLTKRGVARRVQLVTGHDVDGRLPGDLDITALADPAATTCIY
EEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEECCCCHHEEEE
MGKATFPTLVARLIAAGLSPQTPAAIVESLGSPETRIFRGSVTELASRLATDPPPGACII
ECCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEECCCHHHHHHHHCCCCCCCEEEE
LYGQAFATS
EECCHHCCC
>Mature Secondary Structure 
PTASTSSFMPGSVALVGAGPGDADLLTLRAIKRLQEADVVLYDDLAGEEFMAFLKADVE
CCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHCCEE
LVAVGKRAGHPSPRQDEVSRLIVAHAQRGQRVVRLKAGDPTVFARSDEELRAARDAGIEI
EEEECCCCCCCCCCHHHHHHHHHHHHHCCCEEEEEECCCCEEEECCCHHHHHHHHCCCEE
EIVPGITTATAAAAALGASLTKRGVARRVQLVTGHDVDGRLPGDLDITALADPAATTCIY
EEECCCHHHHHHHHHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCEEEEECCCCHHEEEE
MGKATFPTLVARLIAAGLSPQTPAAIVESLGSPETRIFRGSVTELASRLATDPPPGACII
ECCCHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCCEEECCCHHHHHHHHCCCCCCCEEEE
LYGQAFATS
EECCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA