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The map label for this gene is metC [H]

Identifier: 86750030

GI number: 86750030

Start: 3321442

End: 3322638

Strand: Direct

Name: metC [H]

Synonym: RPB_2913

Alternate gene names: 86750030

Gene position: 3321442-3322638 (Clockwise)

Preceding gene: 86750025

Following gene: 86750037

Centisome position: 62.3

GC content: 67.84

Gene sequence:

>1197_bases
ATGAACTCTTCCGATCACGGCGACCCGGCATCGCCGCTCAGCCCGCAGACCCGGCTGGTCACCTCCGGCCGCGACACCAA
GGCGCAGAAGGGCTTCGTCAATCCCCCGGTGGTGCGCGGCTCGACGGTATTGTACCCGACGGCCGAAGACCTGCACGCGC
ACCGCGGCGAGTATTCGTATGGACGCCACGGCACGCCGACCACGAGGGCGCTGCAGCAGGCGCTGATGGCGCTGGAAGGC
CCGCAATGCGCCGGCGTCGGCCTGGCGCCGTCCGGCGTCTCGGCGATCTCGACCGCCCTGCTGGCGGTGCTGAAAGCCGG
CGATCATGTCCTGGTGTGTGACAACGCCTATCGCCCGACCCGGCTGTTCTGCGACCAGATGCTGAAGCGCTACGGCATCG
AGACCAGCTATTTCGATCCCTTGATCGGGGCCGGAATCGCCGCGCACCTCAAGCCCAATACGGCCGTGGTGATGGTCGAG
GCGCCCGGCTCGCAGTCCTTCGAAATGCCCGACATTCCGGCGATCGCCGAGGTCGCGCATGCGCATGGCGCGCTGGTGAT
CGACGACAACACCTGGGCGACGCCGCTGTATCACCGCTCGCTCGATCAGGGCGTCGACATCTCGATCCAGGCCGGCACCA
AATATATCGGCGGCCATTCCGACATCATGTTCGGCACCATCGCAGCCAACAAAAGGGCGTGGCCGCAGGTGGCCGAGGGG
ATTCGCCAGCTCGGCGTCTGCGCCGGGCCGGACGACGTGTTCCTGGCGCTGCGCGGCCTGCGCACGCTGGCGGTGCGGCT
GGCGCAGCATCAGCAATCCGGGCTGGAGATGGCGCGCTGGCTCGGCGAGCGCCCCGAGGTGCAGCGCGTGCTGCACCCGG
CGCTGGAAAGCGACCCGGGACACGCGATCTGGAAGCGCGATTTCACCGGCGCGTCCGGCCTGTTCTCGATCGTGCTGCAG
CCCGCGCCGCAGAAGGCCGTCGATGCGCTGCTCGACACCGTGAAGCTGTTCGGCATGGGCTATTCCTGGGGAGGATTCGA
GAGTTTGGCGATCCCGTTCGACTGCACGACGTATCGCAGCGCGACGCAATGGAACCCCGGTGGACCGGCGCTGCGGCTGC
ATATCGGGCTCGAGAGCACCGACGATCTCAAGGCCGATCTGGAACGCGGCTTCGCGGCGTTCAACGCGGCGCGCTGA

Upstream 100 bases:

>100_bases
ACGGCCGTCTTCCCAAGCCTGCTATTAGGCAGATCGTTTCGGCAGCCGCCCGGCGCTCGTTGCGCGATCACCATGGCGGT
TAATTCATCAGCGAGCCAGT

Downstream 100 bases:

>100_bases
GCGCGCGCTATTTGATTTGATACCCGGAAGCGTCATCCTGAGGTGCCCATCGAACCGCGCATCAAGCGCGGTGCGATGGG
CCTCGAAGGATGAGCCACAG

Product: cystathionine beta-lyase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MNSSDHGDPASPLSPQTRLVTSGRDTKAQKGFVNPPVVRGSTVLYPTAEDLHAHRGEYSYGRHGTPTTRALQQALMALEG
PQCAGVGLAPSGVSAISTALLAVLKAGDHVLVCDNAYRPTRLFCDQMLKRYGIETSYFDPLIGAGIAAHLKPNTAVVMVE
APGSQSFEMPDIPAIAEVAHAHGALVIDDNTWATPLYHRSLDQGVDISIQAGTKYIGGHSDIMFGTIAANKRAWPQVAEG
IRQLGVCAGPDDVFLALRGLRTLAVRLAQHQQSGLEMARWLGERPEVQRVLHPALESDPGHAIWKRDFTGASGLFSIVLQ
PAPQKAVDALLDTVKLFGMGYSWGGFESLAIPFDCTTYRSATQWNPGGPALRLHIGLESTDDLKADLERGFAAFNAAR

Sequences:

>Translated_398_residues
MNSSDHGDPASPLSPQTRLVTSGRDTKAQKGFVNPPVVRGSTVLYPTAEDLHAHRGEYSYGRHGTPTTRALQQALMALEG
PQCAGVGLAPSGVSAISTALLAVLKAGDHVLVCDNAYRPTRLFCDQMLKRYGIETSYFDPLIGAGIAAHLKPNTAVVMVE
APGSQSFEMPDIPAIAEVAHAHGALVIDDNTWATPLYHRSLDQGVDISIQAGTKYIGGHSDIMFGTIAANKRAWPQVAEG
IRQLGVCAGPDDVFLALRGLRTLAVRLAQHQQSGLEMARWLGERPEVQRVLHPALESDPGHAIWKRDFTGASGLFSIVLQ
PAPQKAVDALLDTVKLFGMGYSWGGFESLAIPFDCTTYRSATQWNPGGPALRLHIGLESTDDLKADLERGFAAFNAAR
>Mature_398_residues
MNSSDHGDPASPLSPQTRLVTSGRDTKAQKGFVNPPVVRGSTVLYPTAEDLHAHRGEYSYGRHGTPTTRALQQALMALEG
PQCAGVGLAPSGVSAISTALLAVLKAGDHVLVCDNAYRPTRLFCDQMLKRYGIETSYFDPLIGAGIAAHLKPNTAVVMVE
APGSQSFEMPDIPAIAEVAHAHGALVIDDNTWATPLYHRSLDQGVDISIQAGTKYIGGHSDIMFGTIAANKRAWPQVAEG
IRQLGVCAGPDDVFLALRGLRTLAVRLAQHQQSGLEMARWLGERPEVQRVLHPALESDPGHAIWKRDFTGASGLFSIVLQ
PAPQKAVDALLDTVKLFGMGYSWGGFESLAIPFDCTTYRSATQWNPGGPALRLHIGLESTDDLKADLERGFAAFNAAR

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=299, Percent_Identity=34.1137123745819, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI299473759, Length=299, Percent_Identity=31.1036789297659, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI25453487, Length=298, Percent_Identity=30.2013422818792, Blast_Score=137, Evalue=1e-32,
Organism=Escherichia coli, GI1789383, Length=387, Percent_Identity=46.2532299741602, Blast_Score=341, Evalue=6e-95,
Organism=Escherichia coli, GI1790375, Length=384, Percent_Identity=31.7708333333333, Blast_Score=163, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17560056, Length=356, Percent_Identity=33.9887640449438, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI17538055, Length=297, Percent_Identity=32.6599326599327, Blast_Score=164, Evalue=7e-41,
Organism=Caenorhabditis elegans, GI71980708, Length=393, Percent_Identity=28.2442748091603, Blast_Score=157, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6321170, Length=336, Percent_Identity=46.1309523809524, Blast_Score=320, Evalue=3e-88,
Organism=Saccharomyces cerevisiae, GI6319307, Length=352, Percent_Identity=29.2613636363636, Blast_Score=144, Evalue=2e-35,
Organism=Saccharomyces cerevisiae, GI6321904, Length=381, Percent_Identity=26.509186351706, Blast_Score=100, Evalue=3e-22,
Organism=Saccharomyces cerevisiae, GI6323333, Length=384, Percent_Identity=25.5208333333333, Blast_Score=95, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6321254, Length=407, Percent_Identity=25.3071253071253, Blast_Score=82, Evalue=2e-16,
Organism=Drosophila melanogaster, GI19922554, Length=346, Percent_Identity=33.8150289017341, Blast_Score=194, Evalue=1e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 42663; Mature: 42663

Theoretical pI: Translated: 6.75; Mature: 6.75

Prosite motif: PS00868 CYS_MET_METAB_PP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSDHGDPASPLSPQTRLVTSGRDTKAQKGFVNPPVVRGSTVLYPTAEDLHAHRGEYSY
CCCCCCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCCCCCCEEEECCHHHHHHCCCCCCC
GRHGTPTTRALQQALMALEGPQCAGVGLAPSGVSAISTALLAVLKAGDHVLVCDNAYRPT
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCH
RLFCDQMLKRYGIETSYFDPLIGAGIAAHLKPNTAVVMVEAPGSQSFEMPDIPAIAEVAH
HHHHHHHHHHHCCCCHHCCHHHHCCEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHH
AHGALVIDDNTWATPLYHRSLDQGVDISIQAGTKYIGGHSDIMFGTIAANKRAWPQVAEG
HCCEEEECCCCCCCHHHHHHHCCCCEEEEECCCEEECCCCCEEEEEEECCCCCCHHHHHH
IRQLGVCAGPDDVFLALRGLRTLAVRLAQHQQSGLEMARWLGERPEVQRVLHPALESDPG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
HAIWKRDFTGASGLFSIVLQPAPQKAVDALLDTVKLFGMGYSWGGFESLAIPFDCTTYRS
CEEEECCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCC
ATQWNPGGPALRLHIGLESTDDLKADLERGFAAFNAAR
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNSSDHGDPASPLSPQTRLVTSGRDTKAQKGFVNPPVVRGSTVLYPTAEDLHAHRGEYSY
CCCCCCCCCCCCCCCCCEEEECCCCCHHCCCCCCCCCCCCCEEEECCHHHHHHCCCCCCC
GRHGTPTTRALQQALMALEGPQCAGVGLAPSGVSAISTALLAVLKAGDHVLVCDNAYRPT
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCH
RLFCDQMLKRYGIETSYFDPLIGAGIAAHLKPNTAVVMVEAPGSQSFEMPDIPAIAEVAH
HHHHHHHHHHHCCCCHHCCHHHHCCEEEEECCCEEEEEEECCCCCCCCCCCCCHHHHHHH
AHGALVIDDNTWATPLYHRSLDQGVDISIQAGTKYIGGHSDIMFGTIAANKRAWPQVAEG
HCCEEEECCCCCCCHHHHHHHCCCCEEEEECCCEEECCCCCEEEEEEECCCCCCHHHHHH
IRQLGVCAGPDDVFLALRGLRTLAVRLAQHQQSGLEMARWLGERPEVQRVLHPALESDPG
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCC
HAIWKRDFTGASGLFSIVLQPAPQKAVDALLDTVKLFGMGYSWGGFESLAIPFDCTTYRS
CEEEECCCCCCCHHHHEEECCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCC
ATQWNPGGPALRLHIGLESTDDLKADLERGFAAFNAAR
CCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]