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The map label for this gene is era [H]

Identifier: 86749731

GI number: 86749731

Start: 2996661

End: 2997584

Strand: Direct

Name: era [H]

Synonym: RPB_2613

Alternate gene names: 86749731

Gene position: 2996661-2997584 (Clockwise)

Preceding gene: 86749730

Following gene: 86749732

Centisome position: 56.21

GC content: 64.72

Gene sequence:

>924_bases
ATGCCTGAAATCACTGATGCGGCTCCGGCCGCCACCCGCTGCGGCTTCGTCGCGCTGATCGGCGCCCCGAATGTCGGCAA
GTCCACGCTGGTCAACGCGCTGGTCGGCTCCAAGGTCACCATCGTGTCGCGCAAGGTGCAGACCACGCGCGCGCTGATTC
GCGGTATCGTCATCGAAAGCGGGTCGCAGATCGTGCTGGTCGATACGCCCGGCATCTTCGCGCCGAAGCGAAGGCTCGAC
CGCGCCATGGTACGGACGGCCTGGACCGGCGCCCACGACGCCGACGCGGTCTGCGTGTTGCTCGACGCCCGTGCCGGCAT
CGACGAGCAGGCGGAGACGATTTTCGGCAATCTCGAAAATGTCGGCCACCCGAAGGTGCTGGTGCTCAACAAGATCGATC
TGGTGCCGCGCGAGAAGCTGCTGGCGCTGACGCAGGCGGCCAACGAGCGGCTCCGCTTCGACGAGACCTTCATGGTGTCG
GCGCTGTCCGGCGACGGCGTCGACGATCTGCGTCGCGGATTGGCCGCGCGCGTCCCCGTCGGTCCGTTCCACTATCCCGA
AGACCAGATGTCGGATGCCCCGCTGCGGCATCTGGCGGCCGAGATCACCCGCGAGAAGATCTTCCGGAAACTGCACCAGG
AACTGCCGTACCAGTCCACGGTCGAGACCGATGTCTGGACCGAACGCAAGGACGGTTCAGTGCGGATCGAGCAGACCATC
TTCGTCGAGCGCGAGAGCCAGCGAAAGATCGTGCTCGGCAAGGGCGGCGCGACGATCAAGTCGATCGGCGCCGAAGCCCG
CAAGGAAATCGGCGAGATCCTCGAACAGAAGGTCCATCTGTTCCTGTTCGTCAAAGTGCGCGAAGACTGGGAGAACGACC
CGGACCGCTACCGCGAGATGGGCCTCGAATTTCCGAAGGAATAG

Upstream 100 bases:

>100_bases
CTCGATCCCGCCGAAGGTGTCGGCGGCAGCAAGCGCGCCGCGGAGAAAGTCGCCGCCTCGGTGATGCTGGCCCGCGAAGG
CGTCAGCGCTGGCGGTAACG

Downstream 100 bases:

>100_bases
CGGCGCCGCAATGAGCGTTCCCAAGAATGTCTATTGGTTCGAGGTGCTGCTGCTGGCATCGCTGACGCTCGACTGCATCT
CCGTCGCGTTTCAGGATCGC

Product: GTP-binding protein Era

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 306

Protein sequence:

>307_residues
MPEITDAAPAATRCGFVALIGAPNVGKSTLVNALVGSKVTIVSRKVQTTRALIRGIVIESGSQIVLVDTPGIFAPKRRLD
RAMVRTAWTGAHDADAVCVLLDARAGIDEQAETIFGNLENVGHPKVLVLNKIDLVPREKLLALTQAANERLRFDETFMVS
ALSGDGVDDLRRGLAARVPVGPFHYPEDQMSDAPLRHLAAEITREKIFRKLHQELPYQSTVETDVWTERKDGSVRIEQTI
FVERESQRKIVLGKGGATIKSIGAEARKEIGEILEQKVHLFLFVKVREDWENDPDRYREMGLEFPKE

Sequences:

>Translated_307_residues
MPEITDAAPAATRCGFVALIGAPNVGKSTLVNALVGSKVTIVSRKVQTTRALIRGIVIESGSQIVLVDTPGIFAPKRRLD
RAMVRTAWTGAHDADAVCVLLDARAGIDEQAETIFGNLENVGHPKVLVLNKIDLVPREKLLALTQAANERLRFDETFMVS
ALSGDGVDDLRRGLAARVPVGPFHYPEDQMSDAPLRHLAAEITREKIFRKLHQELPYQSTVETDVWTERKDGSVRIEQTI
FVERESQRKIVLGKGGATIKSIGAEARKEIGEILEQKVHLFLFVKVREDWENDPDRYREMGLEFPKE
>Mature_306_residues
PEITDAAPAATRCGFVALIGAPNVGKSTLVNALVGSKVTIVSRKVQTTRALIRGIVIESGSQIVLVDTPGIFAPKRRLDR
AMVRTAWTGAHDADAVCVLLDARAGIDEQAETIFGNLENVGHPKVLVLNKIDLVPREKLLALTQAANERLRFDETFMVSA
LSGDGVDDLRRGLAARVPVGPFHYPEDQMSDAPLRHLAAEITREKIFRKLHQELPYQSTVETDVWTERKDGSVRIEQTIF
VERESQRKIVLGKGGATIKSIGAEARKEIGEILEQKVHLFLFVKVREDWENDPDRYREMGLEFPKE

Specific function: An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism [H]

COG id: COG1159

COG function: function code R; GTPase

Gene ontology:

Cell location: Cytoplasm. Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH type-2 domain [H]

Homologues:

Organism=Homo sapiens, GI24307899, Length=330, Percent_Identity=32.1212121212121, Blast_Score=138, Evalue=6e-33,
Organism=Escherichia coli, GI1788919, Length=293, Percent_Identity=39.9317406143345, Blast_Score=200, Evalue=9e-53,
Organism=Escherichia coli, GI87082120, Length=160, Percent_Identity=33.125, Blast_Score=75, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17532761, Length=139, Percent_Identity=34.5323741007194, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI24646434, Length=308, Percent_Identity=27.2727272727273, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005662
- InterPro:   IPR015946
- InterPro:   IPR009019
- InterPro:   IPR004044
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF07650 KH_2; PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 34082; Mature: 33950

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS50823 KH_TYPE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEITDAAPAATRCGFVALIGAPNVGKSTLVNALVGSKVTIVSRKVQTTRALIRGIVIES
CCCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHEEC
GSQIVLVDTPGIFAPKRRLDRAMVRTAWTGAHDADAVCVLLDARAGIDEQAETIFGNLEN
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHC
VGHPKVLVLNKIDLVPREKLLALTQAANERLRFDETFMVSALSGDGVDDLRRGLAARVPV
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCHHHCCCC
GPFHYPEDQMSDAPLRHLAAEITREKIFRKLHQELPYQSTVETDVWTERKDGSVRIEQTI
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEE
FVERESQRKIVLGKGGATIKSIGAEARKEIGEILEQKVHLFLFVKVREDWENDPDRYREM
EEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCHHHHHHC
GLEFPKE
CCCCCCC
>Mature Secondary Structure 
PEITDAAPAATRCGFVALIGAPNVGKSTLVNALVGSKVTIVSRKVQTTRALIRGIVIES
CCCCCCCCCHHHCCEEEEECCCCCCHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHEEC
GSQIVLVDTPGIFAPKRRLDRAMVRTAWTGAHDADAVCVLLDARAGIDEQAETIFGNLEN
CCEEEEEECCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCHHHHHHHHHHHC
VGHPKVLVLNKIDLVPREKLLALTQAANERLRFDETFMVSALSGDGVDDLRRGLAARVPV
CCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHCHHHCCCC
GPFHYPEDQMSDAPLRHLAAEITREKIFRKLHQELPYQSTVETDVWTERKDGSVRIEQTI
CCCCCCHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEEEE
FVERESQRKIVLGKGGATIKSIGAEARKEIGEILEQKVHLFLFVKVREDWENDPDRYREM
EEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHEEEEEEEEEECCCCCCHHHHHHC
GLEFPKE
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12597275; 9870699 [H]