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The map label for this gene is rnc [H]

Identifier: 86749730

GI number: 86749730

Start: 2995853

End: 2996668

Strand: Direct

Name: rnc [H]

Synonym: RPB_2612

Alternate gene names: 86749730

Gene position: 2995853-2996668 (Clockwise)

Preceding gene: 86749729

Following gene: 86749731

Centisome position: 56.19

GC content: 69.12

Gene sequence:

>816_bases
ATGATCGAGGATGTGACCAGCATCGACAGTCCGCCGATGGCCAGCGATCCGGCTGGGTCGGAGCAGCCGGCCGAGCAGCC
TGCCGGCCGCAAGCGGCGCAGCAAGGCGAAGTCGAAGGCCGTGGCGGTCGCGATCGAACAGCGGATCGGACACAGCTTCG
CTGATCCGTCGCTGCTGAACACCGCTCTGACCCACGTCTCCGCCTTGAAGTCGGCGCGCAATCGCGCCGACAGCTACCAG
CGGCTGGAGTTTCTCGGCGACCACGTGCTCGGCCTCGTCGTCTCGGACATGCTTTACCGCGCGTTCCCGAACGCCGACGA
GGGCGAATTGTCGAAGCGTCTCGCCGATCTCGTGCGCAAGGAGACCTGCGCCGATGTCGCCCGCAGCCTCGATCTCGACG
AAGGCGTCAAGCTCGGCACCGTCGGCGCCGGCGCCGGCGCGCGGCTGCGCAAATCCGTGCTCGGCGACATCTGCGAGGCC
GTGATCGGCGCAGTGTTCCTCGACGGCGGCTATCCCGCCGCGGCCGAATTCGTGCAGCGCAACTGGACCGAGCGGATGCG
CAAGCCGACCCGCTCGCTGCGCGACCCCAAGACCGTGTTGCAGGAATGGGCCCAGGGCAAGGGCCTGCCGACGCCGGTCT
ATCGCGAAGTCGAGCGCACCGGGCCGCATCACGACCCGCAATTCCGCGTCGCCGTCAGCCTGCCGGGGCTCGATCCCGCC
GAAGGTGTCGGCGGCAGCAAGCGCGCCGCGGAGAAAGTCGCCGCCTCGGTGATGCTGGCCCGCGAAGGCGTCAGCGCTGG
CGGTAACGATGCCTGA

Upstream 100 bases:

>100_bases
CCCAGATGATCTTCTTCTCGATCGCCGAGGGTGAACACGCTTGGCAGATCTGGCGCTGGCCGACCGCGGTGCGCTGGAGC
CGCATCTTTTCGATCGTGCG

Downstream 100 bases:

>100_bases
AATCACTGATGCGGCTCCGGCCGCCACCCGCTGCGGCTTCGTCGCGCTGATCGGCGCCCCGAATGTCGGCAAGTCCACGC
TGGTCAACGCGCTGGTCGGC

Product: ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MIEDVTSIDSPPMASDPAGSEQPAEQPAGRKRRSKAKSKAVAVAIEQRIGHSFADPSLLNTALTHVSALKSARNRADSYQ
RLEFLGDHVLGLVVSDMLYRAFPNADEGELSKRLADLVRKETCADVARSLDLDEGVKLGTVGAGAGARLRKSVLGDICEA
VIGAVFLDGGYPAAAEFVQRNWTERMRKPTRSLRDPKTVLQEWAQGKGLPTPVYREVERTGPHHDPQFRVAVSLPGLDPA
EGVGGSKRAAEKVAASVMLAREGVSAGGNDA

Sequences:

>Translated_271_residues
MIEDVTSIDSPPMASDPAGSEQPAEQPAGRKRRSKAKSKAVAVAIEQRIGHSFADPSLLNTALTHVSALKSARNRADSYQ
RLEFLGDHVLGLVVSDMLYRAFPNADEGELSKRLADLVRKETCADVARSLDLDEGVKLGTVGAGAGARLRKSVLGDICEA
VIGAVFLDGGYPAAAEFVQRNWTERMRKPTRSLRDPKTVLQEWAQGKGLPTPVYREVERTGPHHDPQFRVAVSLPGLDPA
EGVGGSKRAAEKVAASVMLAREGVSAGGNDA
>Mature_271_residues
MIEDVTSIDSPPMASDPAGSEQPAEQPAGRKRRSKAKSKAVAVAIEQRIGHSFADPSLLNTALTHVSALKSARNRADSYQ
RLEFLGDHVLGLVVSDMLYRAFPNADEGELSKRLADLVRKETCADVARSLDLDEGVKLGTVGAGAGARLRKSVLGDICEA
VIGAVFLDGGYPAAAEFVQRNWTERMRKPTRSLRDPKTVLQEWAQGKGLPTPVYREVERTGPHHDPQFRVAVSLPGLDPA
EGVGGSKRAAEKVAASVMLAREGVSAGGNDA

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=183, Percent_Identity=30.6010928961749, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI155030234, Length=183, Percent_Identity=30.6010928961749, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1788920, Length=207, Percent_Identity=39.1304347826087, Blast_Score=143, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI17506883, Length=225, Percent_Identity=31.5555555555556, Blast_Score=86, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI193202651, Length=225, Percent_Identity=31.5555555555556, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17137682, Length=222, Percent_Identity=33.3333333333333, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 28918; Mature: 28918

Theoretical pI: Translated: 8.23; Mature: 8.23

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEDVTSIDSPPMASDPAGSEQPAEQPAGRKRRSKAKSKAVAVAIEQRIGHSFADPSLLN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
TALTHVSALKSARNRADSYQRLEFLGDHVLGLVVSDMLYRAFPNADEGELSKRLADLVRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ETCADVARSLDLDEGVKLGTVGAGAGARLRKSVLGDICEAVIGAVFLDGGYPAAAEFVQR
HHHHHHHHHCCHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NWTERMRKPTRSLRDPKTVLQEWAQGKGLPTPVYREVERTGPHHDPQFRVAVSLPGLDPA
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHH
EGVGGSKRAAEKVAASVMLAREGVSAGGNDA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MIEDVTSIDSPPMASDPAGSEQPAEQPAGRKRRSKAKSKAVAVAIEQRIGHSFADPSLLN
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
TALTHVSALKSARNRADSYQRLEFLGDHVLGLVVSDMLYRAFPNADEGELSKRLADLVRK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
ETCADVARSLDLDEGVKLGTVGAGAGARLRKSVLGDICEAVIGAVFLDGGYPAAAEFVQR
HHHHHHHHHCCHHCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NWTERMRKPTRSLRDPKTVLQEWAQGKGLPTPVYREVERTGPHHDPQFRVAVSLPGLDPA
HHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCHH
EGVGGSKRAAEKVAASVMLAREGVSAGGNDA
CCCCCHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA