Click here to switch to the map view.

The map label for this gene is dapA [H]

Identifier: 86749720

GI number: 86749720

Start: 2987118

End: 2988008

Strand: Direct

Name: dapA [H]

Synonym: RPB_2602

Alternate gene names: 86749720

Gene position: 2987118-2988008 (Clockwise)

Preceding gene: 86749719

Following gene: 86749721

Centisome position: 56.03

GC content: 65.77

Gene sequence:

>891_bases
ATGGCAGCCAAGACGAATTTCCGGGGGTCGTTCACCGCCTTGGTCACGCCTTTCAAGGATGGTGCGCTCGACGAGCAGGC
GTTTCGCAGTCTGGTCCAATGGCAGATCGCGGAAGGGACCCACGGACTGGTGCCGGTCGGGACCACAGGGGAAAGCCCGA
CGCTGAGCCATGACGAGCACCACAAGGTCGTGGAATGGTGCGTCGAGGAGGCGAAGGGACGGGTGCCGGTGATCGCGGGG
GCCGGATCGAACTCCACGCGCGAAGCCGTCGAACTCGCCAGGCACGCCGAGCAGGCGGGCGCGGACGCCGTCCTGGTGGT
GACGCCGTATTACAACAAGCCCACCCAGGAGGGCATGTATCAGCACTTCAAGGCGGTCAACGACGCGATCGGGATTCCGA
TCATCATCTACAACATCCCGCCGCGCTCCGTCGTCGACATGTCGGTCGACACCATGAGCCGGCTGTACGAGCTGAAGAAC
ATCGCCGGCGTCAAGGACGCCACCGCCAATCTCGGACGGGTGTCGCAGCAGCGCCACGCGATGGGCCCCGATTTCATCCA
GCTCTCCGGCGAGGACATGACCGCGCTGGCCTATATGGCAGCCGGCGGCCATGGCTGCATCTCGGTGGTGTCGAATATCG
CGCCGAAGCTCTGCGCCGACCTCATGGGCGCGGTACTGGCCGGCGACTATCCCGGCGCATTGAAGATTCAGGATCGCCTG
GTGCCGCTGCACGATGCGGTGTTCAAGGAGCCCGGCGTGGCGGGCGCCAAGCACGGCTTGACTCTGCTCGGCCGGATCCG
GGAAGAGGTGCGGCTGCCGCTGATGCCGGTGACCGAGCCGACCGGCGCCACGATCCGCGCCGCCATGATGCATGCCGGAC
TGCTGAACTGA

Upstream 100 bases:

>100_bases
CGCGATGGCCCTGAACAGCCTGTCGCCTGTCGCGGGCCTTTCGCGGCCGCGCGGCACCCGTTATGAAAGGTTCACAGGGA
CTGCGCGTCAGGAGAACAGT

Downstream 100 bases:

>100_bases
TTCACGCGGAATTGCAGGACAGGCTGCGCAACGACCAGGGCCGAGGGCGGTATGTTCAAGGAATTCCGTGAATTCGCGAT
GAAGGGCAACGTCGTCGACC

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MAAKTNFRGSFTALVTPFKDGALDEQAFRSLVQWQIAEGTHGLVPVGTTGESPTLSHDEHHKVVEWCVEEAKGRVPVIAG
AGSNSTREAVELARHAEQAGADAVLVVTPYYNKPTQEGMYQHFKAVNDAIGIPIIIYNIPPRSVVDMSVDTMSRLYELKN
IAGVKDATANLGRVSQQRHAMGPDFIQLSGEDMTALAYMAAGGHGCISVVSNIAPKLCADLMGAVLAGDYPGALKIQDRL
VPLHDAVFKEPGVAGAKHGLTLLGRIREEVRLPLMPVTEPTGATIRAAMMHAGLLN

Sequences:

>Translated_296_residues
MAAKTNFRGSFTALVTPFKDGALDEQAFRSLVQWQIAEGTHGLVPVGTTGESPTLSHDEHHKVVEWCVEEAKGRVPVIAG
AGSNSTREAVELARHAEQAGADAVLVVTPYYNKPTQEGMYQHFKAVNDAIGIPIIIYNIPPRSVVDMSVDTMSRLYELKN
IAGVKDATANLGRVSQQRHAMGPDFIQLSGEDMTALAYMAAGGHGCISVVSNIAPKLCADLMGAVLAGDYPGALKIQDRL
VPLHDAVFKEPGVAGAKHGLTLLGRIREEVRLPLMPVTEPTGATIRAAMMHAGLLN
>Mature_295_residues
AAKTNFRGSFTALVTPFKDGALDEQAFRSLVQWQIAEGTHGLVPVGTTGESPTLSHDEHHKVVEWCVEEAKGRVPVIAGA
GSNSTREAVELARHAEQAGADAVLVVTPYYNKPTQEGMYQHFKAVNDAIGIPIIIYNIPPRSVVDMSVDTMSRLYELKNI
AGVKDATANLGRVSQQRHAMGPDFIQLSGEDMTALAYMAAGGHGCISVVSNIAPKLCADLMGAVLAGDYPGALKIQDRLV
PLHDAVFKEPGVAGAKHGLTLLGRIREEVRLPLMPVTEPTGATIRAAMMHAGLLN

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=298, Percent_Identity=27.8523489932886, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI13540533, Length=306, Percent_Identity=27.1241830065359, Blast_Score=75, Evalue=7e-14,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=44.3298969072165, Blast_Score=257, Evalue=7e-70,
Organism=Escherichia coli, GI1789620, Length=286, Percent_Identity=33.9160839160839, Blast_Score=140, Evalue=1e-34,
Organism=Escherichia coli, GI87082415, Length=280, Percent_Identity=31.0714285714286, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1786463, Length=284, Percent_Identity=29.9295774647887, Blast_Score=135, Evalue=4e-33,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: =4.2.1.52 [H]

Molecular weight: Translated: 31596; Mature: 31464

Theoretical pI: Translated: 6.59; Mature: 6.59

Prosite motif: PS00665 DHDPS_1 ; PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKTNFRGSFTALVTPFKDGALDEQAFRSLVQWQIAEGTHGLVPVGTTGESPTLSHDEH
CCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHH
HKVVEWCVEEAKGRVPVIAGAGSNSTREAVELARHAEQAGADAVLVVTPYYNKPTQEGMY
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
QHFKAVNDAIGIPIIIYNIPPRSVVDMSVDTMSRLYELKNIAGVKDATANLGRVSQQRHA
HHHHHHHHCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
MGPDFIQLSGEDMTALAYMAAGGHGCISVVSNIAPKLCADLMGAVLAGDYPGALKIQDRL
CCCCEEEECCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCE
VPLHDAVFKEPGVAGAKHGLTLLGRIREEVRLPLMPVTEPTGATIRAAMMHAGLLN
ECHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure 
AAKTNFRGSFTALVTPFKDGALDEQAFRSLVQWQIAEGTHGLVPVGTTGESPTLSHDEH
CCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCHH
HKVVEWCVEEAKGRVPVIAGAGSNSTREAVELARHAEQAGADAVLVVTPYYNKPTQEGMY
HHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHH
QHFKAVNDAIGIPIIIYNIPPRSVVDMSVDTMSRLYELKNIAGVKDATANLGRVSQQRHA
HHHHHHHHCCCCCEEEEECCCCCEECCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
MGPDFIQLSGEDMTALAYMAAGGHGCISVVSNIAPKLCADLMGAVLAGDYPGALKIQDRL
CCCCEEEECCCCCEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCE
VPLHDAVFKEPGVAGAKHGLTLLGRIREEVRLPLMPVTEPTGATIRAAMMHAGLLN
ECHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA