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The map label for this gene is nuoF1 [H]

Identifier: 86749697

GI number: 86749697

Start: 2959313

End: 2960638

Strand: Direct

Name: nuoF1 [H]

Synonym: RPB_2579

Alternate gene names: 86749697

Gene position: 2959313-2960638 (Clockwise)

Preceding gene: 86749696

Following gene: 86749698

Centisome position: 55.5

GC content: 65.76

Gene sequence:

>1326_bases
ATGCTGGACGACAAGGACCGCATCTTCCGGAACCTGTACGGGCTCGACGATTGGGGCCTCAAGGGCGCGCGCCGTCGCGG
GCAGTGGGAAGGCACCAAGGCGATCATCGACAAGGGTCGCGACTGGATCATCAGCGAGATGAAGGCGTCCGGCCTGCGCG
GCCGCGGCGGCGCCGGCTTTCCGACCGGCCTGAAATGGTCGTTCATGCCGAAGGACAATGCCGACGGCAGGCCGAGCTAT
CTCGTCGTCAATGCCGACGAGTCCGAACCTGGTACCTGCAAAGACCGCGAGATCATGCGGCACGATCCGCACACGCTGGT
CGAGGGCTGCCTGATTGCCGGCTGCGCGATGGGTGCGCATGTCGGCTACATCTACGTCCGCGGCGAATTCATCCGCGAGC
GCGAGCATCTGCAAGCCGCGATCGATCAGGCCTACGAGGCCAAGCTGATCGGCAAGGACAACGTCCACGGTTATCCGTTC
GACCTGTATGTCGCACATGGTGCCGGCGCTTATATCTGCGGTGAAGAAACGGCCCTATTGGAAAGCCTCGAAGGCAAGAA
GGGCCAGCCGCGGCTGAAGCCGCCGTTCCCGGCCAATGTCGGCCTGTACGGCTGCCCGACCACGGTCAACAACGTCGAGT
CGATCGCGGTGGCGCCCGACATCCTGCGCCGCGGCGCGTCCTGGTTCGCCGGCATCGGCCGGGCGAACAATGTCGGCACC
AAGCTTTACGGCATCTCCGGCCACGTCAACACGCCCTGCGTCGTCGAAGAGGCGATGAGCATTCCGTTCCGCGAGCTGAT
CGAGAAGCACGGCGGCGGCATCCGCGGCGGCTGGGACAATCTGCTGGCGATCATTCCCGGCGGCGCGTCGTGCCCGCTGA
TTCCGGCGGCGGATTGCGAAGAACTGATCATGGATTTCGACGGCACCCGCGCGGTGAAGTCGAGCTTCGGCACCGCCGGC
GTCATCGTGATGGACAAGTCCACCGACGTCGTCGCCGCGATCGCCCGCATCAGCTACTTCTTCAAACACGAGAGCTGCGG
CCAGTGCACGCCGTGCCGCGAAGGCACCGGCTGGATGTGGCGCGTGCTCGACCGCATGGTGCACGGCCGCGCCCACAAGC
GCGAGATCGACATGCTGCTGGAAGTCACCAAGCAGGTCGAAGGCCACACCATCTGCGCGCTCGGCGACGCCGCGGCCTGG
CCGATCCAGGGCCTGATCCGCGCCTTCCGGCCCGAGATCGAGCGCCGCATCGACGATTTCTCGCGCAAGGCCACGCTCGA
CGATCAGGGCGTGCTCGATCCGGCGCATATGGTGGCGGCGGAGTAA

Upstream 100 bases:

>100_bases
GACACTCGAATCGAGCCTGCTGTGGGCGCTCACCTTCGGTGGATGCGCTGCTGGCCTCGCTTACATGCAATCGAATCGCT
GACAGGGAACGCCGCAAGCC

Downstream 100 bases:

>100_bases
CAGCCATGATCAAGATCATCGTCGACGGCAAGGAAGTCGAGGTTCCGCCGGAATACACGCTGCTGCAGGCCTGTGAGTCG
GCCGGCGCGGAGATTCCGCG

Product: NADH dehydrogenase I subunit F

Products: NA

Alternate protein names: NADH dehydrogenase I subunit F 1; NDH-1 subunit F 1 [H]

Number of amino acids: Translated: 441; Mature: 441

Protein sequence:

>441_residues
MLDDKDRIFRNLYGLDDWGLKGARRRGQWEGTKAIIDKGRDWIISEMKASGLRGRGGAGFPTGLKWSFMPKDNADGRPSY
LVVNADESEPGTCKDREIMRHDPHTLVEGCLIAGCAMGAHVGYIYVRGEFIREREHLQAAIDQAYEAKLIGKDNVHGYPF
DLYVAHGAGAYICGEETALLESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPDILRRGASWFAGIGRANNVGT
KLYGISGHVNTPCVVEEAMSIPFRELIEKHGGGIRGGWDNLLAIIPGGASCPLIPAADCEELIMDFDGTRAVKSSFGTAG
VIVMDKSTDVVAAIARISYFFKHESCGQCTPCREGTGWMWRVLDRMVHGRAHKREIDMLLEVTKQVEGHTICALGDAAAW
PIQGLIRAFRPEIERRIDDFSRKATLDDQGVLDPAHMVAAE

Sequences:

>Translated_441_residues
MLDDKDRIFRNLYGLDDWGLKGARRRGQWEGTKAIIDKGRDWIISEMKASGLRGRGGAGFPTGLKWSFMPKDNADGRPSY
LVVNADESEPGTCKDREIMRHDPHTLVEGCLIAGCAMGAHVGYIYVRGEFIREREHLQAAIDQAYEAKLIGKDNVHGYPF
DLYVAHGAGAYICGEETALLESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPDILRRGASWFAGIGRANNVGT
KLYGISGHVNTPCVVEEAMSIPFRELIEKHGGGIRGGWDNLLAIIPGGASCPLIPAADCEELIMDFDGTRAVKSSFGTAG
VIVMDKSTDVVAAIARISYFFKHESCGQCTPCREGTGWMWRVLDRMVHGRAHKREIDMLLEVTKQVEGHTICALGDAAAW
PIQGLIRAFRPEIERRIDDFSRKATLDDQGVLDPAHMVAAE
>Mature_441_residues
MLDDKDRIFRNLYGLDDWGLKGARRRGQWEGTKAIIDKGRDWIISEMKASGLRGRGGAGFPTGLKWSFMPKDNADGRPSY
LVVNADESEPGTCKDREIMRHDPHTLVEGCLIAGCAMGAHVGYIYVRGEFIREREHLQAAIDQAYEAKLIGKDNVHGYPF
DLYVAHGAGAYICGEETALLESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPDILRRGASWFAGIGRANNVGT
KLYGISGHVNTPCVVEEAMSIPFRELIEKHGGGIRGGWDNLLAIIPGGASCPLIPAADCEELIMDFDGTRAVKSSFGTAG
VIVMDKSTDVVAAIARISYFFKHESCGQCTPCREGTGWMWRVLDRMVHGRAHKREIDMLLEVTKQVEGHTICALGDAAAW
PIQGLIRAFRPEIERRIDDFSRKATLDDQGVLDPAHMVAAE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocat

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI20149568, Length=420, Percent_Identity=67.6190476190476, Blast_Score=600, Evalue=1e-171,
Organism=Homo sapiens, GI260656005, Length=420, Percent_Identity=67.6190476190476, Blast_Score=599, Evalue=1e-171,
Organism=Escherichia coli, GI1788620, Length=416, Percent_Identity=42.3076923076923, Blast_Score=311, Evalue=6e-86,
Organism=Caenorhabditis elegans, GI17531727, Length=430, Percent_Identity=66.046511627907, Blast_Score=593, Evalue=1e-170,
Organism=Drosophila melanogaster, GI19920794, Length=425, Percent_Identity=67.5294117647059, Blast_Score=609, Evalue=1e-174,
Organism=Drosophila melanogaster, GI45550452, Length=430, Percent_Identity=64.8837209302326, Blast_Score=576, Evalue=1e-164,
Organism=Drosophila melanogaster, GI24653819, Length=423, Percent_Identity=46.0992907801418, Blast_Score=396, Evalue=1e-110,
Organism=Drosophila melanogaster, GI24653817, Length=423, Percent_Identity=42.789598108747, Blast_Score=359, Evalue=2e-99,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR011537
- InterPro:   IPR011538
- InterPro:   IPR019554 [H]

Pfam domain/function: PF01512 Complex1_51K; PF10589 NADH_4Fe-4S; PF10531 SLBB [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 48280; Mature: 48280

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDKDRIFRNLYGLDDWGLKGARRRGQWEGTKAIIDKGRDWIISEMKASGLRGRGGAGF
CCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKDNADGRPSYLVVNADESEPGTCKDREIMRHDPHTLVEGCLIAGCAMGAH
CCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCC
VGYIYVRGEFIREREHLQAAIDQAYEAKLIGKDNVHGYPFDLYVAHGAGAYICGEETALL
EEEEEEECHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPDILRRGASWFAGIGRANNVGT
HHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHCCHHHHHCCCHHHHCCCCCCCCCC
KLYGISGHVNTPCVVEEAMSIPFRELIEKHGGGIRGGWDNLLAIIPGGASCPLIPAADCE
EEEEECCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHH
ELIMDFDGTRAVKSSFGTAGVIVMDKSTDVVAAIARISYFFKHESCGQCTPCREGTGWMW
HHHHCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
RVLDRMVHGRAHKREIDMLLEVTKQVEGHTICALGDAAAWPIQGLIRAFRPEIERRIDDF
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
SRKATLDDQGVLDPAHMVAAE
HHHCCCCCCCCCCHHHHHCCC
>Mature Secondary Structure
MLDDKDRIFRNLYGLDDWGLKGARRRGQWEGTKAIIDKGRDWIISEMKASGLRGRGGAGF
CCCCHHHHHHHHCCCCCCCCCCHHHCCCCCCHHHHHHCCCHHHHHHHHHCCCCCCCCCCC
PTGLKWSFMPKDNADGRPSYLVVNADESEPGTCKDREIMRHDPHTLVEGCLIAGCAMGAH
CCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCC
VGYIYVRGEFIREREHLQAAIDQAYEAKLIGKDNVHGYPFDLYVAHGAGAYICGEETALL
EEEEEEECHHHHHHHHHHHHHHHHHHEEECCCCCCCCCCEEEEEECCCCEEEECCHHHHH
ESLEGKKGQPRLKPPFPANVGLYGCPTTVNNVESIAVAPDILRRGASWFAGIGRANNVGT
HHHCCCCCCCCCCCCCCCCCCCEECCCCCCCCHHHHCCHHHHHCCCHHHHCCCCCCCCCC
KLYGISGHVNTPCVVEEAMSIPFRELIEKHGGGIRGGWDNLLAIIPGGASCPLIPAADCE
EEEEECCCCCCCHHHHHHHCCCHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHH
ELIMDFDGTRAVKSSFGTAGVIVMDKSTDVVAAIARISYFFKHESCGQCTPCREGTGWMW
HHHHCCCCCHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHH
RVLDRMVHGRAHKREIDMLLEVTKQVEGHTICALGDAAAWPIQGLIRAFRPEIERRIDDF
HHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHH
SRKATLDDQGVLDPAHMVAAE
HHHCCCCCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11481430 [H]