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The map label for this gene is clpP [H]

Identifier: 86749681

GI number: 86749681

Start: 2941340

End: 2941978

Strand: Direct

Name: clpP [H]

Synonym: RPB_2563

Alternate gene names: 86749681

Gene position: 2941340-2941978 (Clockwise)

Preceding gene: 86749680

Following gene: 86749682

Centisome position: 55.17

GC content: 63.69

Gene sequence:

>639_bases
ATGCGCGATCCGGTGGAAACCTACATGAACCTCGTGCCGATGGTGGTCGAGCAGACCAACCGCGGCGAACGGGCCTACGA
CATCTTCTCGCGCCTCCTGAAAGAGCGGATCATCTTCCTGACCGGACCGGTCGAGGACGGCATGTCGACTTTGGTCGTCG
CCCAGCTGCTGTTTCTCGAAGCCGAGAATCCGAAGAAGGAAATCTCGATGTACATCAACTCGCCGGGCGGGGTGGTGACG
TCGGGCCTGGCGATCTACGACACCATGCAGTTCATCCGCCCGCCGGTGTCGACGCTGTGCACCGGCCAGGCCGCCTCGAT
GGGGTCGCTGCTGCTGGCCGCCGGCCACAAGGATATGCGGTTCTCTCTGCCGAACGCCCGGATCATGGTGCATCAGCCGT
CCGGCGGCTTCCAGGGCCAGGCCACCGACATCATGCTGCACGCCCAGGAAATCCTGAACCTGAAGAAGCGCCTCAACGAG
ATCTACGTCCATCACACCGGCCAGACCTACAAGGCGATCGAGGACGCGCTGGAGCGCGACAAGTTCCTCACCGCCGACAT
GGCGCGCGATTTCGGGATCGTGGACAAGGTGATCGACAAGCGCGCCGAGGAGTCGGCCCCCGGCCCGAAGGTGGCCTGA

Upstream 100 bases:

>100_bases
TGAGCACTCGCTTCACGTCCTGCATCACGGGACGATCGCTCGCTGCGAGGCCTGTGTTTCGGGCCCGCGAGCGTCGTCTT
CGACAACCTTCAGGTGAATT

Downstream 100 bases:

>100_bases
TCGGGGTTCCCGATCGGTTCTGAACCTCGTGAAACCCTCAGGGACACCCTGGATGTTCCGCTTTCGTCCCATGTCTCCCG
TGGCAAACGCGCAACTCTGC

Product: endopeptidase Clp

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 212; Mature: 212

Protein sequence:

>212_residues
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFLTGPVEDGMSTLVVAQLLFLEAENPKKEISMYINSPGGVVT
SGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLAAGHKDMRFSLPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNE
IYVHHTGQTYKAIEDALERDKFLTADMARDFGIVDKVIDKRAEESAPGPKVA

Sequences:

>Translated_212_residues
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFLTGPVEDGMSTLVVAQLLFLEAENPKKEISMYINSPGGVVT
SGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLAAGHKDMRFSLPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNE
IYVHHTGQTYKAIEDALERDKFLTADMARDFGIVDKVIDKRAEESAPGPKVA
>Mature_212_residues
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFLTGPVEDGMSTLVVAQLLFLEAENPKKEISMYINSPGGVVT
SGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLAAGHKDMRFSLPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNE
IYVHHTGQTYKAIEDALERDKFLTADMARDFGIVDKVIDKRAEESAPGPKVA

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=190, Percent_Identity=63.6842105263158, Blast_Score=263, Evalue=7e-71,
Organism=Escherichia coli, GI1786641, Length=200, Percent_Identity=63.5, Blast_Score=279, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17538017, Length=186, Percent_Identity=60.2150537634409, Blast_Score=244, Evalue=2e-65,
Organism=Drosophila melanogaster, GI20129427, Length=202, Percent_Identity=63.3663366336634, Blast_Score=273, Evalue=6e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23541; Mature: 23541

Theoretical pI: Translated: 6.36; Mature: 6.36

Prosite motif: PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFLTGPVEDGMSTLVVAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHC
AENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLAAGHKDMR
CCCCHHEEEEEECCCCCHHHCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCCCCE
FSLPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNEIYVHHTGQTYKAIEDALERD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHH
KFLTADMARDFGIVDKVIDKRAEESAPGPKVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRDPVETYMNLVPMVVEQTNRGERAYDIFSRLLKERIIFLTGPVEDGMSTLVVAQLLFLE
CCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHEEEEECCHHHHHHHHHHHHHHHHC
AENPKKEISMYINSPGGVVTSGLAIYDTMQFIRPPVSTLCTGQAASMGSLLLAAGHKDMR
CCCCHHEEEEEECCCCCHHHCCHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHCCCCCCE
FSLPNARIMVHQPSGGFQGQATDIMLHAQEILNLKKRLNEIYVHHTGQTYKAIEDALERD
EECCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHH
KFLTADMARDFGIVDKVIDKRAEESAPGPKVA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA