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The map label for this gene is qor [C]

Identifier: 86749442

GI number: 86749442

Start: 2670208

End: 2671221

Strand: Reverse

Name: qor [C]

Synonym: RPB_2322

Alternate gene names: 86749442

Gene position: 2671221-2670208 (Counterclockwise)

Preceding gene: 86749445

Following gene: 86749409

Centisome position: 50.1

GC content: 69.03

Gene sequence:

>1014_bases
ATGAAGGCCGTAGGCTACGCCAAATCCCTCCCGATCGACGACGCCGACGCGCTGATCGATGTCGACGTCGCCAGGCCGGA
GCCAGGCCCGCGCGACCTGCGCGTCGCCGTGAAGGCGATCTCGGTCAATCCGGTCGACTTCAAGGTCCGCAAGCGCGCCG
CGCCGCCGGCCGGCCAGATCAAGATTCTGGGCTACGACGCCGCCGGCGTGGTCGAGTCCGTGGGCAGCGAGGTGACGCTG
TTCCGGCCCGGCGACGAGGTGTTCTACGCCGGTTCGATCGGCCGCCAGGGCACCAATGCCGAATTGCATCTGGTCGACGA
GCGCATCGTCGGCCGCAAGCCGACGACACTGTCGTTCGCGCAGGCGGCGGCGCTGCCGCTGACCTCGATTACCGCGTGGG
AACTGCTGTTCGACCGGCTCGGCGTGCGGCCCGGCAAGGCGCACGACCCGCGCACGCTGCTGATCACCGGCGGCGCCGGC
GGCGTCGGCTCGATCCTGATCCAGCTGGCGCGCCGGCTCACCGCGCTGACCGTGGTGGCGACCGCGTCGCGGCCGCAGAC
GCAGGCCTGGTGCCGCGAGCTCGGCGCCGATGCGGTGATCGATCACAGCCGGGCGATGCAGCCGCAGATCGACGCCTTGA
AGCTGCCGCCGGTGGCGCTGATCGCCAGCCTCACCAACACCGATCAGCATTTCCCGGCGCTGGTCGAGATCCTGGCGCCC
CAGGGCAAGGTGGCGCTGATCGACGACCCGGCGACGCTGAACCCGATGCTGCTGAAGCCGAAATCGGCGTCGCTGCATTG
GGAGGCGATGTTCGCGCGCTCGACCTACACCACGCCCGACATGATCGCGCAGCACGACCTGTTGAACGAAGTCGCAGACC
TGATCGACGCCGGCGTGCTGCGCACCACGCTCGACCAGACCTTCGGGACGATCAATGCCGCGAATTTGAGACGCGCCCAC
GCGCTGCTGGAGAGCGGCAAATCGGTCGGCAAGATCGTGCTGGAGGGGTGGTAG

Upstream 100 bases:

>100_bases
ATGCGTGTGGGCACTATACCTCGCCGGCCGCGACGCTTGCAATTGACCGGGGGCGTGACACCTAGAGGACGCAAGCGCCG
TCAGCACAGGAGCACCGTTC

Downstream 100 bases:

>100_bases
TCGGCGCGCGCCGTGCCCGCGTCGCCCTCACCCCACCCCTCTCCCGCAAGCGGGAGAGGGAGCAGGCTGTGCGTGCTGTG
CGGGCCGCGGACCAATGCGA

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 337

Protein sequence:

>337_residues
MKAVGYAKSLPIDDADALIDVDVARPEPGPRDLRVAVKAISVNPVDFKVRKRAAPPAGQIKILGYDAAGVVESVGSEVTL
FRPGDEVFYAGSIGRQGTNAELHLVDERIVGRKPTTLSFAQAAALPLTSITAWELLFDRLGVRPGKAHDPRTLLITGGAG
GVGSILIQLARRLTALTVVATASRPQTQAWCRELGADAVIDHSRAMQPQIDALKLPPVALIASLTNTDQHFPALVEILAP
QGKVALIDDPATLNPMLLKPKSASLHWEAMFARSTYTTPDMIAQHDLLNEVADLIDAGVLRTTLDQTFGTINAANLRRAH
ALLESGKSVGKIVLEGW

Sequences:

>Translated_337_residues
MKAVGYAKSLPIDDADALIDVDVARPEPGPRDLRVAVKAISVNPVDFKVRKRAAPPAGQIKILGYDAAGVVESVGSEVTL
FRPGDEVFYAGSIGRQGTNAELHLVDERIVGRKPTTLSFAQAAALPLTSITAWELLFDRLGVRPGKAHDPRTLLITGGAG
GVGSILIQLARRLTALTVVATASRPQTQAWCRELGADAVIDHSRAMQPQIDALKLPPVALIASLTNTDQHFPALVEILAP
QGKVALIDDPATLNPMLLKPKSASLHWEAMFARSTYTTPDMIAQHDLLNEVADLIDAGVLRTTLDQTFGTINAANLRRAH
ALLESGKSVGKIVLEGW
>Mature_337_residues
MKAVGYAKSLPIDDADALIDVDVARPEPGPRDLRVAVKAISVNPVDFKVRKRAAPPAGQIKILGYDAAGVVESVGSEVTL
FRPGDEVFYAGSIGRQGTNAELHLVDERIVGRKPTTLSFAQAAALPLTSITAWELLFDRLGVRPGKAHDPRTLLITGGAG
GVGSILIQLARRLTALTVVATASRPQTQAWCRELGADAVIDHSRAMQPQIDALKLPPVALIASLTNTDQHFPALVEILAP
QGKVALIDDPATLNPMLLKPKSASLHWEAMFARSTYTTPDMIAQHDLLNEVADLIDAGVLRTTLDQTFGTINAANLRRAH
ALLESGKSVGKIVLEGW

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI47519420, Length=335, Percent_Identity=29.5522388059701, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI194239676, Length=195, Percent_Identity=31.2820512820513, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI194239674, Length=194, Percent_Identity=31.4432989690722, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI13236495, Length=194, Percent_Identity=31.4432989690722, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI24308257, Length=302, Percent_Identity=25.1655629139073, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI22538446, Length=333, Percent_Identity=26.7267267267267, Blast_Score=66, Evalue=6e-11,
Organism=Homo sapiens, GI22538444, Length=333, Percent_Identity=26.7267267267267, Blast_Score=66, Evalue=6e-11,
Organism=Escherichia coli, GI1790485, Length=189, Percent_Identity=32.2751322751323, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI71987554, Length=171, Percent_Identity=35.672514619883, Blast_Score=86, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI17507255, Length=249, Percent_Identity=30.5220883534137, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35965; Mature: 35965

Theoretical pI: Translated: 7.24; Mature: 7.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAVGYAKSLPIDDADALIDVDVARPEPGPRDLRVAVKAISVNPVDFKVRKRAAPPAGQI
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHEEEEEEEEECCCCCEEEHHCCCCCCCCE
KILGYDAAGVVESVGSEVTLFRPGDEVFYAGSIGRQGTNAELHLVDERIVGRKPTTLSFA
EEEEECHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCEEEEECHHHCCCCCCCHHHH
QAAALPLTSITAWELLFDRLGVRPGKAHDPRTLLITGGAGGVGSILIQLARRLTALTVVA
HHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHEEEEE
TASRPQTQAWCRELGADAVIDHSRAMQPQIDALKLPPVALIASLTNTDQHFPALVEILAP
ECCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCC
QGKVALIDDPATLNPMLLKPKSASLHWEAMFARSTYTTPDMIAQHDLLNEVADLIDAGVL
CCCEEEEECCCCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
RTTLDQTFGTINAANLRRAHALLESGKSVGKIVLEGW
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECC
>Mature Secondary Structure
MKAVGYAKSLPIDDADALIDVDVARPEPGPRDLRVAVKAISVNPVDFKVRKRAAPPAGQI
CCCCCCCCCCCCCCCCCEEEEEECCCCCCCHHEEEEEEEEECCCCCEEEHHCCCCCCCCE
KILGYDAAGVVESVGSEVTLFRPGDEVFYAGSIGRQGTNAELHLVDERIVGRKPTTLSFA
EEEEECHHHHHHHCCCCEEEECCCCCEEEECCCCCCCCCCEEEEECHHHCCCCCCCHHHH
QAAALPLTSITAWELLFDRLGVRPGKAHDPRTLLITGGAGGVGSILIQLARRLTALTVVA
HHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHEEEEE
TASRPQTQAWCRELGADAVIDHSRAMQPQIDALKLPPVALIASLTNTDQHFPALVEILAP
ECCCCHHHHHHHHHCCCCEECCCCCCCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHCC
QGKVALIDDPATLNPMLLKPKSASLHWEAMFARSTYTTPDMIAQHDLLNEVADLIDAGVL
CCCEEEEECCCCCCCEEECCCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHH
RTTLDQTFGTINAANLRRAHALLESGKSVGKIVLEGW
HHHHHHHHCCCCHHHHHHHHHHHHCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]