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The map label for this gene is nadC [H]

Identifier: 86748230

GI number: 86748230

Start: 1271688

End: 1272563

Strand: Reverse

Name: nadC [H]

Synonym: RPB_1105

Alternate gene names: 86748230

Gene position: 1272563-1271688 (Counterclockwise)

Preceding gene: 86748231

Following gene: 86748222

Centisome position: 23.87

GC content: 68.95

Gene sequence:

>876_bases
ATGATTGCAACGACTTTGCTGCATCCCGACGCCTTCCTGTCGCCGCTGGCGATCGAGGAGGCCGTCGGCCGCGCGCTCGA
CGAAGATCTCGGCCGCGCCGGAGATGTGACTTCGATCGCCACGATCCCGGAGGCGACCCAGGCGCACGCGGTCATGGTCG
CGCGCCAGGCCGGCGTGATCGCCGGGCTGCCGCTGGCGGTCGCGGCGTTTCAGAGGCTGTCGCCCGACATCGCCATCACC
GCCCATGTCCGCGACGGCGACGCGGTCGCGGCGGGCGTCAACGTGCTGACGCTGTCGGGGCCGGCACGGGCGATCTTGTC
CGGCGAGCGCACCGCGCTGAACTTCGTCGGCCGGCTGTCGGGCATCGCGACGCTGACCGCGGACTATGTCCGCCACACCT
CCGGCACCAAGATGCGGATCTGCTGCACCCGCAAGACGACGCCGGGGCTGCGCGCGCTGGAGAAATACGCGGTGCGCTGC
GGTGGCGGCTTCAACCATCGCTTCGGGCTCGACGACGCGGTGCTGATCAAGGACAATCACATCGCGGTCGCCGGCGGCAT
CCGCCCGGTGCTCGACAGCGCGCGGGCGAAGATCGGCCATCTGGTGAAGATTGAGATCGAGGTCGACACGCTCGATCAGT
TGCAAGAGGTGCTCGACACCGGCATGGCCGACGTCGTGCTGCTCGACAACATGGACATCGACGCGCTGAAACGCGCCGTG
GCGATGGCGCAGGGTCGCGTCGTGCTGGAGGCTTCCGGCGGCGTCACCCGCGAGTCGATCAGCAGCATCGCCGCCACCGG
CGTCGACTACGCATCCGCCGGCGCGCTGACTCACTCCGCGCCGAATTTCGACGTCGCGCTGGATATCGACGCGTAG

Upstream 100 bases:

>100_bases
GCGGCACTGAGCAAAGGCGCCAACATTCTGCGGTTTCCGACCCGGGCCCGCACCGCGTCGGCCTGATCCCTCCCCGTCTG
CCTGCTCAGGAGCAGTTCCC

Downstream 100 bases:

>100_bases
TTCATTGCGCAACCTCTCCCGCTTGCGGGAGAGGTCGGATCGCGCAGCGATCCGGGTGAGGGCTCTCCTCTCCGCGCAAC
GTGGCCTCACTGCTGGGGGC

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MIATTLLHPDAFLSPLAIEEAVGRALDEDLGRAGDVTSIATIPEATQAHAVMVARQAGVIAGLPLAVAAFQRLSPDIAIT
AHVRDGDAVAAGVNVLTLSGPARAILSGERTALNFVGRLSGIATLTADYVRHTSGTKMRICCTRKTTPGLRALEKYAVRC
GGGFNHRFGLDDAVLIKDNHIAVAGGIRPVLDSARAKIGHLVKIEIEVDTLDQLQEVLDTGMADVVLLDNMDIDALKRAV
AMAQGRVVLEASGGVTRESISSIAATGVDYASAGALTHSAPNFDVALDIDA

Sequences:

>Translated_291_residues
MIATTLLHPDAFLSPLAIEEAVGRALDEDLGRAGDVTSIATIPEATQAHAVMVARQAGVIAGLPLAVAAFQRLSPDIAIT
AHVRDGDAVAAGVNVLTLSGPARAILSGERTALNFVGRLSGIATLTADYVRHTSGTKMRICCTRKTTPGLRALEKYAVRC
GGGFNHRFGLDDAVLIKDNHIAVAGGIRPVLDSARAKIGHLVKIEIEVDTLDQLQEVLDTGMADVVLLDNMDIDALKRAV
AMAQGRVVLEASGGVTRESISSIAATGVDYASAGALTHSAPNFDVALDIDA
>Mature_291_residues
MIATTLLHPDAFLSPLAIEEAVGRALDEDLGRAGDVTSIATIPEATQAHAVMVARQAGVIAGLPLAVAAFQRLSPDIAIT
AHVRDGDAVAAGVNVLTLSGPARAILSGERTALNFVGRLSGIATLTADYVRHTSGTKMRICCTRKTTPGLRALEKYAVRC
GGGFNHRFGLDDAVLIKDNHIAVAGGIRPVLDSARAKIGHLVKIEIEVDTLDQLQEVLDTGMADVVLLDNMDIDALKRAV
AMAQGRVVLEASGGVTRESISSIAATGVDYASAGALTHSAPNFDVALDIDA

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=285, Percent_Identity=32.9824561403509, Blast_Score=139, Evalue=2e-33,
Organism=Escherichia coli, GI1786299, Length=276, Percent_Identity=42.3913043478261, Blast_Score=196, Evalue=2e-51,
Organism=Saccharomyces cerevisiae, GI6321162, Length=255, Percent_Identity=34.1176470588235, Blast_Score=143, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30244; Mature: 30244

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIATTLLHPDAFLSPLAIEEAVGRALDEDLGRAGDVTSIATIPEATQAHAVMVARQAGVI
CCEEEEECCHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHEEEEHHCCCE
AGLPLAVAAFQRLSPDIAITAHVRDGDAVAAGVNVLTLSGPARAILSGERTALNFVGRLS
ECCHHHHHHHHHCCCCEEEEEEECCCCEEEECEEEEEECCCHHHHHCCCHHHHHHHHHHH
GIATLTADYVRHTSGTKMRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAVLIKDNH
HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
IAVAGGIRPVLDSARAKIGHLVKIEIEVDTLDQLQEVLDTGMADVVLLDNMDIDALKRAV
EEEECCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
AMAQGRVVLEASGGVTRESISSIAATGVDYASAGALTHSAPNFDVALDIDA
HHHCCCEEEEECCCCCHHHHHHHHHCCCCHHCCCCEECCCCCCEEEEEECC
>Mature Secondary Structure
MIATTLLHPDAFLSPLAIEEAVGRALDEDLGRAGDVTSIATIPEATQAHAVMVARQAGVI
CCEEEEECCHHHHCHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCHHHHHEEEEHHCCCE
AGLPLAVAAFQRLSPDIAITAHVRDGDAVAAGVNVLTLSGPARAILSGERTALNFVGRLS
ECCHHHHHHHHHCCCCEEEEEEECCCCEEEECEEEEEECCCHHHHHCCCHHHHHHHHHHH
GIATLTADYVRHTSGTKMRICCTRKTTPGLRALEKYAVRCGGGFNHRFGLDDAVLIKDNH
HHHHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCC
IAVAGGIRPVLDSARAKIGHLVKIEIEVDTLDQLQEVLDTGMADVVLLDNMDIDALKRAV
EEEECCCHHHHHHHHHHHCCEEEEEEEECCHHHHHHHHHCCCEEEEEECCCCHHHHHHHH
AMAQGRVVLEASGGVTRESISSIAATGVDYASAGALTHSAPNFDVALDIDA
HHHCCCEEEEECCCCCHHHHHHHHHCCCCHHCCCCEECCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7721706 [H]