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The map label for this gene is hmgA

Identifier: 86748033

GI number: 86748033

Start: 1044169

End: 1045515

Strand: Direct

Name: hmgA

Synonym: RPB_0907

Alternate gene names: 86748033

Gene position: 1044169-1045515 (Clockwise)

Preceding gene: 86748032

Following gene: 86748034

Centisome position: 19.58

GC content: 64.37

Gene sequence:

>1347_bases
ATGAATATCAACGCCGCACCGCAGATCATTGGCCACGGTTCGCAGGGCGTCACGCCCGGCTACATGTCGGGCTTCGGCAA
TTCGTTCGAAACCGAAGCTCTCCCCGGCGCGCTGCCGATCGGCCGCAACTCGCCGCAGCGCGCGGCTTACGGCCTCTATG
CCGAGCAATTATCAGGCTCGCCGTTCACCGCGCCGCGCGGCGCCAATGAGCGAAGCTGGCTGTATCGCATCCGCCCCTCG
GTGAAGCACTCCGGCCGCTTTACCAAGGCGGACATGGGCCTGTGGCGCTCGGCGCCGTGTCTCGAATACGACATGCCGAT
CGCGCAGCTGCGCTGGGACGCGCCGTCGATGCCGCAGGAGGATCTGACGTTCCTGCAAGGCGTGCGAACGATGACGACCG
CCGGCGATGTGAATACGCAGGCCGGCATGGCGACGCATATGTATCTGATCACCCAATCGATGGTCGATCAGCATTTCTAC
AATGCCGACGGTGAATTGATGTTCGTGCCGCAGCAGGGCAGCCTGCGGCTGGTCACGGAATTCGGCGTCATCAGCATCGA
GCCCGCCGAAATCGCGGTGATCCCGCGCGGCGTCAAGTTTCGCGTCGAACTGGTCGACGGCCCGGCGCGCGGCTATTTGT
GTGAGAATTACGGCGGCGCCTTCACGCTGCCGGAGCGCGGCCCGATCGGCGCCAATTGCCTGGCCAATTCGCGCGATTTC
CTGACGCCGGTGGCGGCCTATGAGGACAGGGACGTGCCGACCGAATTGTTCGTGAAATGGGGCGGGGCGCTGTGGCAGAC
CACGCTGCCGCATTCGCCGATCGATGTGGTCGCGTGGCATGGCAACTACGCGCCGTACAAATACGATCTGCGCACCTTCT
CGCCGGTCGGCGCGATCGGCTTCGATCATCCCGATCCGTCGATCTTCACCGTGCTGACGTCGCCGTCGGAAACCGCCGGC
ACCGCCAATATAGACTTCGTGATCTTCCCCGAGCGCTGGATGGTGGCGGAAAACACCTTCCGGCCGCCCTGGTACCACAT
GAATATCATGTCGGAGTTCATGGGGTTGATCTGCGGCGTCTACGACGCCAAGCCGCAGGGCTTCGTCCCCGGCGGCGCGT
CGCTGCACAACATGATGCTGCCGCACGGGCCGGATCGCGAGGCGTTCGATCATGCCTCGAACGGCGAGCTGAAGCCGGTG
AAACTCACCGGCACGATGGCCTTCATGTTCGAGACCCGCTATCCGCAGCGCGTCACCGAATATGCCGCGACCGCCGGCAC
GCTGCAGGACGACTACGCCGATTGCTGGCGCGGCCTGGAGAAGCGCTTCGACCCGAGCCGGCCATGA

Upstream 100 bases:

>100_bases
TCTGGACCGCCGAGCGCGATCGCGAGATGTGGGCCGCGCTGCAAGGATAATCCGAACCACCCGCTTTCCCCAGCCATGCA
CCCACGTGTTGGAGGATGAC

Downstream 100 bases:

>100_bases
CCAAGACCGCTGATCACGACGCCGCGGTGCTGTACGGTTACTTCCGGTCCTCCGCGGCCTATCGGGTGCGCATCGCGCTC
AATCTGAAGGGCGTCGTCGT

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MNINAAPQIIGHGSQGVTPGYMSGFGNSFETEALPGALPIGRNSPQRAAYGLYAEQLSGSPFTAPRGANERSWLYRIRPS
VKHSGRFTKADMGLWRSAPCLEYDMPIAQLRWDAPSMPQEDLTFLQGVRTMTTAGDVNTQAGMATHMYLITQSMVDQHFY
NADGELMFVPQQGSLRLVTEFGVISIEPAEIAVIPRGVKFRVELVDGPARGYLCENYGGAFTLPERGPIGANCLANSRDF
LTPVAAYEDRDVPTELFVKWGGALWQTTLPHSPIDVVAWHGNYAPYKYDLRTFSPVGAIGFDHPDPSIFTVLTSPSETAG
TANIDFVIFPERWMVAENTFRPPWYHMNIMSEFMGLICGVYDAKPQGFVPGGASLHNMMLPHGPDREAFDHASNGELKPV
KLTGTMAFMFETRYPQRVTEYAATAGTLQDDYADCWRGLEKRFDPSRP

Sequences:

>Translated_448_residues
MNINAAPQIIGHGSQGVTPGYMSGFGNSFETEALPGALPIGRNSPQRAAYGLYAEQLSGSPFTAPRGANERSWLYRIRPS
VKHSGRFTKADMGLWRSAPCLEYDMPIAQLRWDAPSMPQEDLTFLQGVRTMTTAGDVNTQAGMATHMYLITQSMVDQHFY
NADGELMFVPQQGSLRLVTEFGVISIEPAEIAVIPRGVKFRVELVDGPARGYLCENYGGAFTLPERGPIGANCLANSRDF
LTPVAAYEDRDVPTELFVKWGGALWQTTLPHSPIDVVAWHGNYAPYKYDLRTFSPVGAIGFDHPDPSIFTVLTSPSETAG
TANIDFVIFPERWMVAENTFRPPWYHMNIMSEFMGLICGVYDAKPQGFVPGGASLHNMMLPHGPDREAFDHASNGELKPV
KLTGTMAFMFETRYPQRVTEYAATAGTLQDDYADCWRGLEKRFDPSRP
>Mature_448_residues
MNINAAPQIIGHGSQGVTPGYMSGFGNSFETEALPGALPIGRNSPQRAAYGLYAEQLSGSPFTAPRGANERSWLYRIRPS
VKHSGRFTKADMGLWRSAPCLEYDMPIAQLRWDAPSMPQEDLTFLQGVRTMTTAGDVNTQAGMATHMYLITQSMVDQHFY
NADGELMFVPQQGSLRLVTEFGVISIEPAEIAVIPRGVKFRVELVDGPARGYLCENYGGAFTLPERGPIGANCLANSRDF
LTPVAAYEDRDVPTELFVKWGGALWQTTLPHSPIDVVAWHGNYAPYKYDLRTFSPVGAIGFDHPDPSIFTVLTSPSETAG
TANIDFVIFPERWMVAENTFRPPWYHMNIMSEFMGLICGVYDAKPQGFVPGGASLHNMMLPHGPDREAFDHASNGELKPV
KLTGTMAFMFETRYPQRVTEYAATAGTLQDDYADCWRGLEKRFDPSRP

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family

Homologues:

Organism=Homo sapiens, GI115527117, Length=439, Percent_Identity=49.8861047835991, Blast_Score=415, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI17507969, Length=428, Percent_Identity=51.6355140186916, Blast_Score=424, Evalue=1e-119,
Organism=Drosophila melanogaster, GI24583650, Length=435, Percent_Identity=50.5747126436782, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HGD_RHOP2 (Q2J1P2)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_484529.1
- STRING:   Q2J1P2
- GeneID:   3909087
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_0907
- eggNOG:   COG3508
- HOGENOM:   HBG293508
- OMA:   RNCMSEF
- ProtClustDB:   PRK05341
- BioCyc:   RPAL316058:RPB_0907-MONOMER
- HAMAP:   MF_00334
- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950
- PANTHER:   PTHR11056
- TIGRFAMs:   TIGR01015

Pfam domain/function: PF04209 HgmA; SSF51182 RmlC_like_cupin

EC number: =1.13.11.5

Molecular weight: Translated: 49545; Mature: 49545

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNINAAPQIIGHGSQGVTPGYMSGFGNSFETEALPGALPIGRNSPQRAAYGLYAEQLSGS
CCCCCCCCEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
PFTAPRGANERSWLYRIRPSVKHSGRFTKADMGLWRSAPCLEYDMPIAQLRWDAPSMPQE
CCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHCCCCCCCCEEECCCHHHEECCCCCCCHH
DLTFLQGVRTMTTAGDVNTQAGMATHMYLITQSMVDQHFYNADGELMFVPQQGSLRLVTE
HHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEE
FGVISIEPAEIAVIPRGVKFRVELVDGPARGYLCENYGGAFTLPERGPIGANCLANSRDF
CCEEEECCCEEEEECCCEEEEEEEECCCCCCCEEECCCCEEECCCCCCCCCHHCCCCCHH
LTPVAAYEDRDVPTELFVKWGGALWQTTLPHSPIDVVAWHGNYAPYKYDLRTFSPVGAIG
CCHHHHCCCCCCCHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCC
FDHPDPSIFTVLTSPSETAGTANIDFVIFPERWMVAENTFRPPWYHMNIMSEFMGLICGV
CCCCCCCEEEEEECCCCCCCCCEEEEEEECCCEEEECCCCCCCEEEHHHHHHHHHHHHHH
YDAKPQGFVPGGASLHNMMLPHGPDREAFDHASNGELKPVKLTGTMAFMFETRYPQRVTE
CCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCEEEEEEECEEEEEEECCCHHHHHH
YAATAGTLQDDYADCWRGLEKRFDPSRP
HHHHCCCCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNINAAPQIIGHGSQGVTPGYMSGFGNSFETEALPGALPIGRNSPQRAAYGLYAEQLSGS
CCCCCCCCEEECCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCC
PFTAPRGANERSWLYRIRPSVKHSGRFTKADMGLWRSAPCLEYDMPIAQLRWDAPSMPQE
CCCCCCCCCCCCEEEEECCCCCCCCCEEEHHHCCCCCCCCEEECCCHHHEECCCCCCCHH
DLTFLQGVRTMTTAGDVNTQAGMATHMYLITQSMVDQHFYNADGELMFVPQQGSLRLVTE
HHHHHHHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCEEEEEE
FGVISIEPAEIAVIPRGVKFRVELVDGPARGYLCENYGGAFTLPERGPIGANCLANSRDF
CCEEEECCCEEEEECCCEEEEEEEECCCCCCCEEECCCCEEECCCCCCCCCHHCCCCCHH
LTPVAAYEDRDVPTELFVKWGGALWQTTLPHSPIDVVAWHGNYAPYKYDLRTFSPVGAIG
CCHHHHCCCCCCCHHHHHHHCCCEEECCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCC
FDHPDPSIFTVLTSPSETAGTANIDFVIFPERWMVAENTFRPPWYHMNIMSEFMGLICGV
CCCCCCCEEEEEECCCCCCCCCEEEEEEECCCEEEECCCCCCCEEEHHHHHHHHHHHHHH
YDAKPQGFVPGGASLHNMMLPHGPDREAFDHASNGELKPVKLTGTMAFMFETRYPQRVTE
CCCCCCCCCCCCCCHHHCCCCCCCCHHHHCCCCCCCEEEEEEECEEEEEEECCCHHHHHH
YAATAGTLQDDYADCWRGLEKRFDPSRP
HHHHCCCCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA