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The map label for this gene is sucD [H]

Identifier: 86747405

GI number: 86747405

Start: 315585

End: 316469

Strand: Reverse

Name: sucD [H]

Synonym: RPB_0279

Alternate gene names: 86747405

Gene position: 316469-315585 (Counterclockwise)

Preceding gene: 86747406

Following gene: 86747404

Centisome position: 5.94

GC content: 65.42

Gene sequence:

>885_bases
ATGTCCATCCTGATCGACGCCAACACCAAAGTCATCTGCCAGGGCTTCACCGGCAAGAACGGCACCTTCCATTCCGAGGC
CGCGGTGGCCTACGGCACCAAGATGGTCGGCGGCACCTCGCCGGGCAAAGGCGGCACCACGCATCTCGGCCTGCCGGTGT
TCGACACCGTGCGCGAGGCGCGCGACAAGACTGGCGCCGATGCGTCGGTGATCTATGTGCCACCGCCGGGTGCTGCGGAT
GCGATCTGCGAGGCGATCGACGCCGAGATCCCGCTGATCGTCTGCATCACCGAGGGCATCCCGGTGCTCGACATGGTGCG
GGTCAAGCGCTCGCTGGTCGGCTCCAAGTCGCGGCTGATCGGGCCGAACTGCCCGGGTGTGATGACCGCGGGCGAATGCA
AGATCGGCATCATGCCGGCCAACATCTTCAAGCCCGGCTCGGTCGGCATCGTGTCGCGCTCCGGCACCCTGACCTATGAG
GCGGTGTTCCAGACCACCAGCGAGGGTCTGGGCCAGACCACCGCGGTCGGCATCGGCGGCGATCCGGTCAAAGGCACCGA
ATTCATCGACGTGCTGGAGATGTTCCTGGCCGACGACAAGACCGAGTCGATCATTATGATCGGCGAGATCGGCGGCTCCG
CCGAGGAAGAGGCTGCCCAGTTCCTGATCGACGAGGCCAAGCGTGGCCGCAAGAAGCCGATGGTCGGATTCATCGCCGGC
GTCACCGCCCCTCCGGGTCGGCGTATGGGGCATGCCGGTGCGATCATTTCGGGGGGCAAAGGCGACGCGGCGTCGAAAAC
CGCCGCGATGGAAGCCGCTGGCATCACGGTTTCGCCGTCGCCGGCGCGTCTCGGCAAAACGCTTGCCGAAAAATTGAAGT
CCTAA

Upstream 100 bases:

>100_bases
TGCCGCGCAGAAGATCGTCAATGCCGTCAAGGGAGCCTGAGGCCGCCCCGGCCTCGCTCGCTTCCGACCAACCCGTTCGA
CCGCGAAAGCAACCCCGCCT

Downstream 100 bases:

>100_bases
TTCAAACCTTGTTTCATTACGAGCTTACATTTCCCTAGAATCCGATAAAAGGTGCACTATGTTGCTGATCCGGTAACCGG
ATCAGCTTATCGCGTGTTCA

Product: succinyl-CoA synthetase, alpha subunit

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 294; Mature: 293

Protein sequence:

>294_residues
MSILIDANTKVICQGFTGKNGTFHSEAAVAYGTKMVGGTSPGKGGTTHLGLPVFDTVREARDKTGADASVIYVPPPGAAD
AICEAIDAEIPLIVCITEGIPVLDMVRVKRSLVGSKSRLIGPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYE
AVFQTTSEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEEAAQFLIDEAKRGRKKPMVGFIAG
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS

Sequences:

>Translated_294_residues
MSILIDANTKVICQGFTGKNGTFHSEAAVAYGTKMVGGTSPGKGGTTHLGLPVFDTVREARDKTGADASVIYVPPPGAAD
AICEAIDAEIPLIVCITEGIPVLDMVRVKRSLVGSKSRLIGPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYE
AVFQTTSEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEEAAQFLIDEAKRGRKKPMVGFIAG
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS
>Mature_293_residues
SILIDANTKVICQGFTGKNGTFHSEAAVAYGTKMVGGTSPGKGGTTHLGLPVFDTVREARDKTGADASVIYVPPPGAADA
ICEAIDAEIPLIVCITEGIPVLDMVRVKRSLVGSKSRLIGPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYEA
VFQTTSEGLGQTTAVGIGGDPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEEAAQFLIDEAKRGRKKPMVGFIAGV
TAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=292, Percent_Identity=68.1506849315068, Blast_Score=343, Evalue=9e-95,
Organism=Homo sapiens, GI38569423, Length=260, Percent_Identity=29.2307692307692, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI38569421, Length=260, Percent_Identity=29.2307692307692, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1786949, Length=293, Percent_Identity=68.9419795221843, Blast_Score=387, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17550194, Length=289, Percent_Identity=65.3979238754325, Blast_Score=359, Evalue=1e-99,
Organism=Caenorhabditis elegans, GI17553126, Length=292, Percent_Identity=64.041095890411, Blast_Score=356, Evalue=6e-99,
Organism=Caenorhabditis elegans, GI17551266, Length=260, Percent_Identity=27.3076923076923, Blast_Score=82, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI17557344, Length=223, Percent_Identity=28.6995515695067, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6324716, Length=297, Percent_Identity=55.2188552188552, Blast_Score=305, Evalue=6e-84,
Organism=Drosophila melanogaster, GI21356559, Length=292, Percent_Identity=61.3013698630137, Blast_Score=358, Evalue=3e-99,
Organism=Drosophila melanogaster, GI28574296, Length=293, Percent_Identity=64.1638225255973, Blast_Score=342, Evalue=2e-94,
Organism=Drosophila melanogaster, GI281363477, Length=264, Percent_Identity=28.030303030303, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363475, Length=264, Percent_Identity=28.030303030303, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI281363473, Length=264, Percent_Identity=28.030303030303, Blast_Score=80, Evalue=1e-15,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30063; Mature: 29932

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSILIDANTKVICQGFTGKNGTFHSEAAVAYGTKMVGGTSPGKGGTTHLGLPVFDTVREA
CEEEEECCCEEEEEECCCCCCCCCCCHHHHHCCEECCCCCCCCCCCEEECCCHHHHHHHH
RDKTGADASVIYVPPPGAADAICEAIDAEIPLIVCITEGIPVLDMVRVKRSLVGSKSRLI
HHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCC
GPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYEAVFQTTSEGLGQTTAVGIGG
CCCCCCCEECCCEEEEEEECCCCCCCCEEEEECCCCEEEHHHHHHHHCCCCCEEEEECCC
DPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEEAAQFLIDEAKRGRKKPMVGFIAG
CCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCEEECCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
SILIDANTKVICQGFTGKNGTFHSEAAVAYGTKMVGGTSPGKGGTTHLGLPVFDTVREA
EEEEECCCEEEEEECCCCCCCCCCCHHHHHCCEECCCCCCCCCCCEEECCCHHHHHHHH
RDKTGADASVIYVPPPGAADAICEAIDAEIPLIVCITEGIPVLDMVRVKRSLVGSKSRLI
HHCCCCCCEEEEECCCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCCCC
GPNCPGVMTAGECKIGIMPANIFKPGSVGIVSRSGTLTYEAVFQTTSEGLGQTTAVGIGG
CCCCCCCEECCCEEEEEEECCCCCCCCEEEEECCCCEEEHHHHHHHHCCCCCEEEEECCC
DPVKGTEFIDVLEMFLADDKTESIIMIGEIGGSAEEEAAQFLIDEAKRGRKKPMVGFIAG
CCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEC
VTAPPGRRMGHAGAIISGGKGDAASKTAAMEAAGITVSPSPARLGKTLAEKLKS
CCCCCCCCCCCCCEEEECCCCCCCHHHHHHHHCCEEECCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]