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The map label for this gene is gyrA [H]

Identifier: 86609072

GI number: 86609072

Start: 1679987

End: 1682515

Strand: Reverse

Name: gyrA [H]

Synonym: CYB_1609

Alternate gene names: 86609072

Gene position: 1682515-1679987 (Counterclockwise)

Preceding gene: 86609076

Following gene: 86609071

Centisome position: 55.22

GC content: 62.59

Gene sequence:

>2529_bases
ATGAGCGACAACGAATCGACGGCGCGCATCATCTCCACCGACCTGCAGCGGGAGATGTCGCAGTCCTACCTGGAATACGC
CATGAGCGTGATCGTCGGGAGGGCTTTGCCAGATGCGCGGGATGGCCTGAAGCCGGTGCACCGCCGCATTCTCTACGCTA
TGCACGAGTTGGGCCTGACGGCGGATCGCCCCTTCCGCAAGTGTGCCCGCGTGGTGGGGGATGTGATCGGGAAATACCAT
CCCCATGGGGATCAGGCCGTCTATGATGCGCTGGTGCGCATGGCCCAGGATTTCTCCATGCGGGAGCGCCTGGTGGATGG
GCATGGCAACTTCGGCTCTGTGGACAACGATCCGCCGGCGGCCATGCGCTACACCGAGTGTCGGCTGACTGCCTTTGCCC
AAGAAGCCCTGCTGCAGGATATCGACGCCAACACTGTCGATTTTGTCGGCAACTACGACGGATCCCAGCAAGAACCCCTG
GTGCTGCCGGCGCGGATCCCGCAACTGCTCCTGAACGGCTCTTCCGGCATTGCCGTGGGCATGGCCACCAACATCCCGCC
TCACAACTTGAGCGAATTGGTGGACGGCCTGATCGCCCTCATCCACAACCCCAACCTGACCAGCCTGGAGTTGATGCAGT
GGATCCCGGCCCCCGACTTCCCCACCGGGGCGCTGATCATGGGCCAGGAGGGCATCCGCGAAGCCTACACCACCGGGCGC
AGCTCCATCACCCTGCGGGGGGTGGCCAGGGTGGAGACGATCGAGCAGCGGGGCCGACCGGTTCGAGACGCCATCATTAT
CACCGAGCTGCCCTACCAGACCAACAAGGCAGCCATGATTGAGAAGATCGCCGAGCTGGTCAACGAGAAAAAACTGGAAG
GCATTGCCGACATCCGCGACGAGAGCGACCGCAGCGGCATGCGGGTGGTGATCGAGCTAAAGCGGGATGCCCAGCCGCAG
GTGGTGCTTAACAACCTCTACAAGCAAACCCCCCTGCAGGCCAACTTCGGGGTCAACATGCTGGCCATCCTCAACGGCGA
GCCGCGCACCCTGACCCTGCGGGACGCGCTGCAGGCTTTTCTGGATTTTCGGGAAGAGGTGATCGAGCGGCGCACCCGCT
ACGAGCTGCAAAAAGCCGAAGAGCGGGATCACCTGCTGCAGGGCTATCTCTTGGCTTTGGGGCAGTTGGATCGGGTGATT
GCCCTCATTCGGGGAGCCGCCGATACCGCCACAGCCCGAGAGGAATTGCAGGCGGTGTTGGGCCTGAGCGAAGCCCAAGC
CGACGGGATCCTGCAGATGCAGCTGCGCCGCCTCACCGCCCTGGAAGCGGAAAAAATCCAGGCCGAGCACGAAGACTTGG
TGAGGCAAATTGCCGACCTGCGGGATATTCTGGCCCGCCGAGAACGGGTGATGCAGATCATCAGCGAAGAGCTGCAGCAG
CTCAAAGCCCGCTTTGCCAGCCCGCGCCGTTCCCGCCTCTGTTTGGAGGATGGGGAGCTGGGAACGGATGATCTGATCGA
AAATCGGGAGACGGTTATCTTTCTAACCGAGCAGGGCTATATCAAGCGCATGGGCCTTGAGGAGTTCCAGGTGCAGGGGC
GAGCCACCCGCGGCAAAGCCGGCGCCCGCATCAAAGAAGACGATGCCATCGAACAGTTTTTTGCCTGTCGCAGCCACGAC
ACCATCCTCTTTTTCACCAATCGGGGCGTAGTCTATACCCTGCCCGCCCACCAGATCCCCCAGGGGAGCCGCGCCGCCCG
CGGCAGCGCCATCGTTCAGTTGCTGCCGATCACCCGGGAAGAGCGGGTTACGTCCATGGTGCCGGTGAGCCAGTTCAGCG
ACGACGAATATCTGGTGATGCTCACCCGCGGCGGCTACATCAAAAAAACGGCCCTCAGCGCCTTTGCCAATGTACGCTCC
AACGGCCTGATTGCCATCTCTCTGGAAGAAAACGACGAACTGCGCTGGGTGCGCCGCGCCCGCTCCAGCGATGATGTGGT
CATGGCGACCCGCCAAGGCATGTCCATTCGCTTCCCGGCGGATGACGAGCAACTGCGCCCTCTGGGACGGGCCACCCGGG
GCGTGCGGGCCATTACCCTCAACGCCGGCGATGACATCGTCAGCATGGATATTATCTCTGCCGAATCGGTGATGGCTGCC
GAGCGAGAGGGGGAGAAGCTGGCTAACCCTTGGGTGCTGGTGATCACCAAAGAAGGGCGGGGCAAGCGCTCGGCCATCGA
CAATTTCCGCCAGCAAAACCGCGGCGGCAAGGGGGTGATCGCCACCAAGTTCCGCCAAGCGTCGGACGAGCTGGCGGCCC
TGCGCATCGTCAATGCCGAAGACGAGATCCTGTTGGTAACCGCCAGGGGCATTGTCATGCGCCAGTTGGCCAAGGCTATT
CCCACCCAGTCCCGCGAGGCGACCGGGGTGCTGGTGCAGCGCCTGGATCCGGAAGACAGCATTGTGGGAGTTACAGTGGT
ACCCGCTGCCTTGGTTGCCGAGGAGGAGACCTCAGAAGCCAGCGCTTGA

Upstream 100 bases:

>100_bases
GGTAGTTTACTCTGCCACGGCCAAGGTTGGCTTCTCGATAAACTTCCATGAACCCACTGCGCCAAGGCCGACTGGGATCC
CTTACGGATAACCCAACCCC

Downstream 100 bases:

>100_bases
TCCCCGGCCGTTACTTAGGTACGGCATTTGCCGCCGCAGAAGGGTGGGATCCCGTACCGGAGGGGGTGAGGATGGGGTGT
TACCTTTGGGATAGCCCAAA

Product: DNA gyrase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 842; Mature: 841

Protein sequence:

>842_residues
MSDNESTARIISTDLQREMSQSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMHELGLTADRPFRKCARVVGDVIGKYH
PHGDQAVYDALVRMAQDFSMRERLVDGHGNFGSVDNDPPAAMRYTECRLTAFAQEALLQDIDANTVDFVGNYDGSQQEPL
VLPARIPQLLLNGSSGIAVGMATNIPPHNLSELVDGLIALIHNPNLTSLELMQWIPAPDFPTGALIMGQEGIREAYTTGR
SSITLRGVARVETIEQRGRPVRDAIIITELPYQTNKAAMIEKIAELVNEKKLEGIADIRDESDRSGMRVVIELKRDAQPQ
VVLNNLYKQTPLQANFGVNMLAILNGEPRTLTLRDALQAFLDFREEVIERRTRYELQKAEERDHLLQGYLLALGQLDRVI
ALIRGAADTATAREELQAVLGLSEAQADGILQMQLRRLTALEAEKIQAEHEDLVRQIADLRDILARRERVMQIISEELQQ
LKARFASPRRSRLCLEDGELGTDDLIENRETVIFLTEQGYIKRMGLEEFQVQGRATRGKAGARIKEDDAIEQFFACRSHD
TILFFTNRGVVYTLPAHQIPQGSRAARGSAIVQLLPITREERVTSMVPVSQFSDDEYLVMLTRGGYIKKTALSAFANVRS
NGLIAISLEENDELRWVRRARSSDDVVMATRQGMSIRFPADDEQLRPLGRATRGVRAITLNAGDDIVSMDIISAESVMAA
EREGEKLANPWVLVITKEGRGKRSAIDNFRQQNRGGKGVIATKFRQASDELAALRIVNAEDEILLVTARGIVMRQLAKAI
PTQSREATGVLVQRLDPEDSIVGVTVVPAALVAEEETSEASA

Sequences:

>Translated_842_residues
MSDNESTARIISTDLQREMSQSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMHELGLTADRPFRKCARVVGDVIGKYH
PHGDQAVYDALVRMAQDFSMRERLVDGHGNFGSVDNDPPAAMRYTECRLTAFAQEALLQDIDANTVDFVGNYDGSQQEPL
VLPARIPQLLLNGSSGIAVGMATNIPPHNLSELVDGLIALIHNPNLTSLELMQWIPAPDFPTGALIMGQEGIREAYTTGR
SSITLRGVARVETIEQRGRPVRDAIIITELPYQTNKAAMIEKIAELVNEKKLEGIADIRDESDRSGMRVVIELKRDAQPQ
VVLNNLYKQTPLQANFGVNMLAILNGEPRTLTLRDALQAFLDFREEVIERRTRYELQKAEERDHLLQGYLLALGQLDRVI
ALIRGAADTATAREELQAVLGLSEAQADGILQMQLRRLTALEAEKIQAEHEDLVRQIADLRDILARRERVMQIISEELQQ
LKARFASPRRSRLCLEDGELGTDDLIENRETVIFLTEQGYIKRMGLEEFQVQGRATRGKAGARIKEDDAIEQFFACRSHD
TILFFTNRGVVYTLPAHQIPQGSRAARGSAIVQLLPITREERVTSMVPVSQFSDDEYLVMLTRGGYIKKTALSAFANVRS
NGLIAISLEENDELRWVRRARSSDDVVMATRQGMSIRFPADDEQLRPLGRATRGVRAITLNAGDDIVSMDIISAESVMAA
EREGEKLANPWVLVITKEGRGKRSAIDNFRQQNRGGKGVIATKFRQASDELAALRIVNAEDEILLVTARGIVMRQLAKAI
PTQSREATGVLVQRLDPEDSIVGVTVVPAALVAEEETSEASA
>Mature_841_residues
SDNESTARIISTDLQREMSQSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMHELGLTADRPFRKCARVVGDVIGKYHP
HGDQAVYDALVRMAQDFSMRERLVDGHGNFGSVDNDPPAAMRYTECRLTAFAQEALLQDIDANTVDFVGNYDGSQQEPLV
LPARIPQLLLNGSSGIAVGMATNIPPHNLSELVDGLIALIHNPNLTSLELMQWIPAPDFPTGALIMGQEGIREAYTTGRS
SITLRGVARVETIEQRGRPVRDAIIITELPYQTNKAAMIEKIAELVNEKKLEGIADIRDESDRSGMRVVIELKRDAQPQV
VLNNLYKQTPLQANFGVNMLAILNGEPRTLTLRDALQAFLDFREEVIERRTRYELQKAEERDHLLQGYLLALGQLDRVIA
LIRGAADTATAREELQAVLGLSEAQADGILQMQLRRLTALEAEKIQAEHEDLVRQIADLRDILARRERVMQIISEELQQL
KARFASPRRSRLCLEDGELGTDDLIENRETVIFLTEQGYIKRMGLEEFQVQGRATRGKAGARIKEDDAIEQFFACRSHDT
ILFFTNRGVVYTLPAHQIPQGSRAARGSAIVQLLPITREERVTSMVPVSQFSDDEYLVMLTRGGYIKKTALSAFANVRSN
GLIAISLEENDELRWVRRARSSDDVVMATRQGMSIRFPADDEQLRPLGRATRGVRAITLNAGDDIVSMDIISAESVMAAE
REGEKLANPWVLVITKEGRGKRSAIDNFRQQNRGGKGVIATKFRQASDELAALRIVNAEDEILLVTARGIVMRQLAKAIP
TQSREATGVLVQRLDPEDSIVGVTVVPAALVAEEETSEASA

Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=344, Percent_Identity=26.453488372093, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1788562, Length=849, Percent_Identity=44.1696113074205, Blast_Score=722, Evalue=0.0,
Organism=Escherichia coli, GI1789396, Length=678, Percent_Identity=36.8731563421829, Blast_Score=391, Evalue=1e-110,
Organism=Caenorhabditis elegans, GI17535065, Length=360, Percent_Identity=27.7777777777778, Blast_Score=83, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6324241, Length=180, Percent_Identity=26.6666666666667, Blast_Score=72, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR005743
- InterPro:   IPR006691
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760 [H]

Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]

EC number: =5.99.1.3 [H]

Molecular weight: Translated: 93592; Mature: 93461

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNESTARIISTDLQREMSQSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMHELGLT
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCC
ADRPFRKCARVVGDVIGKYHPHGDQAVYDALVRMAQDFSMRERLVDGHGNFGSVDNDPPA
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AMRYTECRLTAFAQEALLQDIDANTVDFVGNYDGSQQEPLVLPARIPQLLLNGSSGIAVG
CEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHCCCCCCEEEE
MATNIPPHNLSELVDGLIALIHNPNLTSLELMQWIPAPDFPTGALIMGQEGIREAYTTGR
EECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEECCHHHHHHHHCCC
SSITLRGVARVETIEQRGRPVRDAIIITELPYQTNKAAMIEKIAELVNEKKLEGIADIRD
CCEEEEHHHHHHHHHHCCCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCC
ESDRSGMRVVIELKRDAQPQVVLNNLYKQTPLQANFGVNMLAILNGEPRTLTLRDALQAF
CCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEHHHHHHHH
LDFREEVIERRTRYELQKAEERDHLLQGYLLALGQLDRVIALIRGAADTATAREELQAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GLSEAQADGILQMQLRRLTALEAEKIQAEHEDLVRQIADLRDILARRERVMQIISEELQQ
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKARFASPRRSRLCLEDGELGTDDLIENRETVIFLTEQGYIKRMGLEEFQVQGRATRGKA
HHHHHCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEECCCHHHHCCCHHHHHCCCCCCCCC
GARIKEDDAIEQFFACRSHDTILFFTNRGVVYTLPAHQIPQGSRAARGSAIVQLLPITRE
CCCCCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
ERVTSMVPVSQFSDDEYLVMLTRGGYIKKTALSAFANVRSNGLIAISLEENDELRWVRRA
HHHHHHCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHC
RSSDDVVMATRQGMSIRFPADDEQLRPLGRATRGVRAITLNAGDDIVSMDIISAESVMAA
CCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHHHHHHH
EREGEKLANPWVLVITKEGRGKRSAIDNFRQQNRGGKGVIATKFRQASDELAALRIVNAE
HHCCHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHCCCEEEEEEECCC
DEILLVTARGIVMRQLAKAIPTQSREATGVLVQRLDPEDSIVGVTVVPAALVAEEETSEA
CCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHEECCCCCCEEEEEHHHHHHHHCCCCCCC
SA
CC
>Mature Secondary Structure 
SDNESTARIISTDLQREMSQSYLEYAMSVIVGRALPDARDGLKPVHRRILYAMHELGLT
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHCCC
ADRPFRKCARVVGDVIGKYHPHGDQAVYDALVRMAQDFSMRERLVDGHGNFGSVDNDPPA
CCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
AMRYTECRLTAFAQEALLQDIDANTVDFVGNYDGSQQEPLVLPARIPQLLLNGSSGIAVG
CEEHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCEEEHHHHHHHHCCCCCCEEEE
MATNIPPHNLSELVDGLIALIHNPNLTSLELMQWIPAPDFPTGALIMGQEGIREAYTTGR
EECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCEEEECCHHHHHHHHCCC
SSITLRGVARVETIEQRGRPVRDAIIITELPYQTNKAAMIEKIAELVNEKKLEGIADIRD
CCEEEEHHHHHHHHHHCCCCCHHEEEEEECCCCCCHHHHHHHHHHHHHHHHHCCHHHHCC
ESDRSGMRVVIELKRDAQPQVVLNNLYKQTPLQANFGVNMLAILNGEPRTLTLRDALQAF
CCCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEEEECCCCCEEEHHHHHHHH
LDFREEVIERRTRYELQKAEERDHLLQGYLLALGQLDRVIALIRGAADTATAREELQAVL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
GLSEAQADGILQMQLRRLTALEAEKIQAEHEDLVRQIADLRDILARRERVMQIISEELQQ
CCCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LKARFASPRRSRLCLEDGELGTDDLIENRETVIFLTEQGYIKRMGLEEFQVQGRATRGKA
HHHHHCCCCCCCCCCCCCCCCCHHHHCCCCEEEEEECCCHHHHCCCHHHHHCCCCCCCCC
GARIKEDDAIEQFFACRSHDTILFFTNRGVVYTLPAHQIPQGSRAARGSAIVQLLPITRE
CCCCCCHHHHHHHHHHCCCCEEEEEECCCEEEECCCCCCCCCCCCCCCCEEEEEECCCHH
ERVTSMVPVSQFSDDEYLVMLTRGGYIKKTALSAFANVRSNGLIAISLEENDELRWVRRA
HHHHHHCCHHHCCCCCEEEEEECCCCHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHC
RSSDDVVMATRQGMSIRFPADDEQLRPLGRATRGVRAITLNAGDDIVSMDIISAESVMAA
CCCCCEEEEECCCCEEECCCCHHHHHHHHHHCCCEEEEEEECCCCEEEEEEHHHHHHHHH
EREGEKLANPWVLVITKEGRGKRSAIDNFRQQNRGGKGVIATKFRQASDELAALRIVNAE
HHCCHHHCCCEEEEEECCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHCCCEEEEEEECCC
DEILLVTARGIVMRQLAKAIPTQSREATGVLVQRLDPEDSIVGVTVVPAALVAEEETSEA
CCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHEECCCCCCEEEEEHHHHHHHHCCCCCCC
SA
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8590279; 8905231 [H]