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The map label for this gene is mprA [H]

Identifier: 86608522

GI number: 86608522

Start: 1084594

End: 1085283

Strand: Direct

Name: mprA [H]

Synonym: CYB_1044

Alternate gene names: 86608522

Gene position: 1084594-1085283 (Clockwise)

Preceding gene: 86608521

Following gene: 86608524

Centisome position: 35.6

GC content: 58.41

Gene sequence:

>690_bases
ATGAAGCGTGTACTGGTCGTAGATGACGATCCCCTCTCCCTGAAGGTGCTGAGCCGCCACCTGACTCAGCATGGCTATCG
GGTTTGTACAGGCGCTTCGGGTGTGGAAGGATTGCGTCTGTTTGCCCAAGAGCAGCCGGATGTGGTGGTTTCAGATGTGG
TGATGCCGGAAATGGACGGCTTTGAGTTTTGCCGACAACTGCGCCAACAGCGCGGCGGCGAGCTCGTCCCCTTCATTTTT
CTCTCTTCGCGGGGAGAGATCGATGACCGAGTTCAGGGCTATGAGCGGGGGGCGGATGACTACATCATCAAGCCCTTTGA
ACCCCTGGAACTGGTGGCCAAAATCGAGGCCCAGATTGAACGCTCCCGCCGCACCCAATCGGAAATTTTGCGGCTAATCC
AACAGCAGTCCCAGCCAAAACCCGAAGCGGACCCCCGCCCCACCCCACCCGAATTGCCCCTGACCCCTGCCGAAGAGCGG
GTCTTTCGGGAAGTCATTCGCGGCTTCACCAACAAGCAAATCGGCGAGAAGCTGTTCATCAGCCCGCGCACCGTGCAAAC
TCACCTGACCAACATCCTCAGCAAGCTTTCTTTGGAAAATCGCTCGCAACTGGTGCGTTTTGCCTACGAACGGGGCTACA
CCGCCGAAGAGGAGCCGGGCCAGAAGGGATCCCTTTCAGGCCAGGTGTAG

Upstream 100 bases:

>100_bases
CCCCAGCCAAATGACGAATCCTGTCCGTCTCCCTAAAATAGCGACAGATAACAGGTGAATAGCGCTTTACCCTTTTCCCT
AACAGCCTCCTCGAGTCCTC

Downstream 100 bases:

>100_bases
CCTCAAAACAGCACGTGGCGCTTTTCGCACCCGGCAGGGGATCCGCTCCTTGCCCAAGCGGACAAATGCCTCGTAGCGAT
GGCAGCCGGAGAACCCATAA

Product: LuxR family DNA-binding response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 229; Mature: 229

Protein sequence:

>229_residues
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDGFEFCRQLRQQRGGELVPFIF
LSSRGEIDDRVQGYERGADDYIIKPFEPLELVAKIEAQIERSRRTQSEILRLIQQQSQPKPEADPRPTPPELPLTPAEER
VFREVIRGFTNKQIGEKLFISPRTVQTHLTNILSKLSLENRSQLVRFAYERGYTAEEEPGQKGSLSGQV

Sequences:

>Translated_229_residues
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDGFEFCRQLRQQRGGELVPFIF
LSSRGEIDDRVQGYERGADDYIIKPFEPLELVAKIEAQIERSRRTQSEILRLIQQQSQPKPEADPRPTPPELPLTPAEER
VFREVIRGFTNKQIGEKLFISPRTVQTHLTNILSKLSLENRSQLVRFAYERGYTAEEEPGQKGSLSGQV
>Mature_229_residues
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDGFEFCRQLRQQRGGELVPFIF
LSSRGEIDDRVQGYERGADDYIIKPFEPLELVAKIEAQIERSRRTQSEILRLIQQQSQPKPEADPRPTPPELPLTPAEER
VFREVIRGFTNKQIGEKLFISPRTVQTHLTNILSKLSLENRSQLVRFAYERGYTAEEEPGQKGSLSGQV

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=234, Percent_Identity=29.4871794871795, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI1789809, Length=119, Percent_Identity=42.0168067226891, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=29.3333333333333, Blast_Score=91, Evalue=8e-20,
Organism=Escherichia coli, GI1790299, Length=164, Percent_Identity=34.7560975609756, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1786599, Length=225, Percent_Identity=28.4444444444444, Blast_Score=88, Evalue=4e-19,
Organism=Escherichia coli, GI1790860, Length=209, Percent_Identity=30.622009569378, Blast_Score=87, Evalue=9e-19,
Organism=Escherichia coli, GI1786784, Length=120, Percent_Identity=32.5, Blast_Score=86, Evalue=2e-18,
Organism=Escherichia coli, GI87082012, Length=127, Percent_Identity=29.9212598425197, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788905, Length=129, Percent_Identity=37.2093023255814, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786911, Length=127, Percent_Identity=36.2204724409449, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1788550, Length=111, Percent_Identity=35.1351351351351, Blast_Score=78, Evalue=6e-16,
Organism=Escherichia coli, GI1787229, Length=119, Percent_Identity=36.1344537815126, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788521, Length=213, Percent_Identity=29.1079812206573, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI1790863, Length=119, Percent_Identity=31.0924369747899, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI2367329, Length=128, Percent_Identity=36.71875, Blast_Score=70, Evalue=9e-14,
Organism=Escherichia coli, GI145693157, Length=123, Percent_Identity=30.0813008130081, Blast_Score=69, Evalue=2e-13,
Organism=Escherichia coli, GI1787375, Length=130, Percent_Identity=29.2307692307692, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1786747, Length=162, Percent_Identity=25.9259259259259, Blast_Score=68, Evalue=5e-13,
Organism=Escherichia coli, GI1790552, Length=220, Percent_Identity=26.8181818181818, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1790437, Length=125, Percent_Identity=28.8, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788222, Length=219, Percent_Identity=27.8538812785388, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI145693140, Length=108, Percent_Identity=29.6296296296296, Blast_Score=62, Evalue=4e-11,
Organism=Escherichia coli, GI1788713, Length=146, Percent_Identity=30.1369863013699, Blast_Score=61, Evalue=6e-11,
Organism=Escherichia coli, GI1788712, Length=210, Percent_Identity=22.8571428571429, Blast_Score=61, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26059; Mature: 26059

Theoretical pI: Translated: 5.84; Mature: 5.84

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDG
CCEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCEEEHHHHCCCCCH
FEFCRQLRQQRGGELVPFIFLSSRGEIDDRVQGYERGADDYIIKPFEPLELVAKIEAQIE
HHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHH
RSRRTQSEILRLIQQQSQPKPEADPRPTPPELPLTPAEERVFREVIRGFTNKQIGEKLFI
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCHHHCC
SPRTVQTHLTNILSKLSLENRSQLVRFAYERGYTAEEEPGQKGSLSGQV
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRVLVVDDDPLSLKVLSRHLTQHGYRVCTGASGVEGLRLFAQEQPDVVVSDVVMPEMDG
CCEEEEECCCCCHHHHHHHHHHHCCCEEECCCCCHHHHHHHHCCCCCEEEHHHHCCCCCH
FEFCRQLRQQRGGELVPFIFLSSRGEIDDRVQGYERGADDYIIKPFEPLELVAKIEAQIE
HHHHHHHHHHCCCCEEEEEEECCCCCHHHHHHHHHCCCCCCEECCCHHHHHHHHHHHHHH
RSRRTQSEILRLIQQQSQPKPEADPRPTPPELPLTPAEERVFREVIRGFTNKQIGEKLFI
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCHHHCHHHCC
SPRTVQTHLTNILSKLSLENRSQLVRFAYERGYTAEEEPGQKGSLSGQV
CCHHHHHHHHHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA