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The map label for this gene is coaBC [H]

Identifier: 86608462

GI number: 86608462

Start: 1018038

End: 1019276

Strand: Direct

Name: coaBC [H]

Synonym: CYB_0983

Alternate gene names: 86608462

Gene position: 1018038-1019276 (Clockwise)

Preceding gene: 86608458

Following gene: 86608468

Centisome position: 33.41

GC content: 61.82

Gene sequence:

>1239_bases
ATGGATCCCTTTTGGTCGGGGCGGCGTCTCCTCATTGGGGTGAGCGGGGGGATTGCTGCTTACAAAACGGCAGCTTTGGT
GTCTGCTCTGGTGCAGCAGGGAGCAGAGCTCAAGGTGGTTTTGACAAAAGCTGCGGAACATTTTATTTCTCCTTTGACTT
TTGCCACCTTGTCCCGCCAGCCGGCTTTTACGGATGCCGCCTTTTGGCAGGCAACACGAGGACGACCGCTGCACATCGAG
TTGGGGGAATGGGCGGAGGCTCTCCTCATTGCACCCTTGTCGGCCAACACCTTGGGCAAGTTGGCTCATGGGCTGGCGGA
TAATTTGCTCACCAATGTGGTTTTGGCTTCCCGGTGTCCGGTGGCGGTGGCACCGGCTATGAATACGCAGATGTGGAAGG
CGGAGAAGGTGGCCGAGAATTGGCAGCGGCTACACCAGGATCCCCGTTTTTGGGCCTTGCCGACGGCCAGTGGCCGCCTG
GCCTGTGATGCGGTGGGGGAAGGGCGCATGTTGGAGCCGGAGGCGCTGCAGGAGTATGTGCGGGCTTTGCTCTGGACAGG
GGGGAAAAAAGATTGGCAGGGCAAGCGGGTGTTGGTGACGGCGGGGGGGACACGGGAGCCCATCGACGCGGTGCGTTTTA
TCGGCAACCCGGCCAGTGGTCGGATGGGCGTGGCATTGGCGGTGGCGGCGGCCTGCCGAGGAGCGACGGTGACGCTGGTT
CATGGGCCGTTGGGGATCCCTTTTGAGCCGGAACCCTTTGGCATTCGGGCCATTCGAGTGGAAACGGCAGCCCAACTGGA
GGCGGCTTTGCAGGCGGAATTTCCCCAGGCGGATCTCTTGTGGATGGCTGCTGCTGTGGGGGATGTGCGCCCCTCTCAGG
TTTACGCGGGGAAGCTGCCCAAAGCCGATCTACCCCAGATGTTGCCGTTGGAGCCGATCCCTGACCTGCTGGCAGCTCTG
GCCCGCCACAAACGCCCTGGCCAACGCCTCATCGGCTTTGCCGCCCAAAGTGGGGATCCCTTGCCGCCGGCCAGAGAGAA
GCTCCGCCAGAAGGGCCTGGATGCTATTGTGGCCAACCCCATCGACCAACCGGATAGCGGCTTTGGCAGCAGCCACAACC
AAGGCTATTGGATCCCCCAGCAGGGAAGTCCAGAGCGGATCCCATTGGCAACCAAGCCAACCCTGGCCCACCGGCTGCTG
GATCTGGCCCGGCAATTGGAGTTGGGCTACTTTAGTTAA

Upstream 100 bases:

>100_bases
TCCAAGTCAAAGTATCTTTGGGCGAGGGATCCCCGCTTTGCCGCCGGAATTGAGCAAAAGCAGGGAAACTGGAAACAAGG
CTGTTTGCGTGTCACTCGAT

Downstream 100 bases:

>100_bases
ACTCCCTCTCCCTCTGGAAGAGGGGCCGGGGGTGGGGGCTGTGCGGTACAGAACGCTAAACTTCCCGGAATAGCTGTTCG
CGAACTGCCTCAAGAACCTG

Product: bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase

Products: NA

Alternate protein names: DNA/pantothenate metabolism flavoprotein; Phosphopantothenoylcysteine decarboxylase; PPCDC; CoaC; Phosphopantothenate--cysteine ligase; CoaB; PPC synthetase; PPCS; Phosphopantothenoylcysteine synthase [H]

Number of amino acids: Translated: 412; Mature: 412

Protein sequence:

>412_residues
MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQPAFTDAAFWQATRGRPLHIE
LGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCPVAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRL
ACDAVGEGRMLEPEALQEYVRALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV
HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLPKADLPQMLPLEPIPDLLAAL
ARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANPIDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLL
DLARQLELGYFS

Sequences:

>Translated_412_residues
MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQPAFTDAAFWQATRGRPLHIE
LGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCPVAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRL
ACDAVGEGRMLEPEALQEYVRALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV
HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLPKADLPQMLPLEPIPDLLAAL
ARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANPIDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLL
DLARQLELGYFS
>Mature_412_residues
MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQPAFTDAAFWQATRGRPLHIE
LGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCPVAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRL
ACDAVGEGRMLEPEALQEYVRALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV
HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLPKADLPQMLPLEPIPDLLAAL
ARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANPIDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLL
DLARQLELGYFS

Specific function: Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine [H]

COG id: COG0452

COG function: function code H; Phosphopantothenoylcysteine synthetase/decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the PPC synthetase family [H]

Homologues:

Organism=Homo sapiens, GI71725351, Length=184, Percent_Identity=39.1304347826087, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI87082301, Length=399, Percent_Identity=38.5964912280702, Blast_Score=230, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17560194, Length=202, Percent_Identity=33.6633663366337, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6322762, Length=187, Percent_Identity=35.2941176470588, Blast_Score=94, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6322925, Length=90, Percent_Identity=40, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6324629, Length=89, Percent_Identity=39.3258426966292, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24657262, Length=182, Percent_Identity=35.7142857142857, Blast_Score=91, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005252
- InterPro:   IPR007085
- InterPro:   IPR003382 [H]

Pfam domain/function: PF04127 DFP; PF02441 Flavoprotein [H]

EC number: =4.1.1.36; =6.3.2.5 [H]

Molecular weight: Translated: 44326; Mature: 44326

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQ
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHHCCC
PAFTDAAFWQATRGRPLHIELGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCP
CCCCHHHHHHHCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRLACDAVGEGRMLEPEALQEYV
EEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHH
RALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV
HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEE
HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLP
ECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCCC
KADLPQMLPLEPIPDLLAALARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANP
CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCCCCHHHHHHHHCCCCEEECCC
IDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLLDLARQLELGYFS
CCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MDPFWSGRRLLIGVSGGIAAYKTAALVSALVQQGAELKVVLTKAAEHFISPLTFATLSRQ
CCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHCHHHHHHHCCC
PAFTDAAFWQATRGRPLHIELGEWAEALLIAPLSANTLGKLAHGLADNLLTNVVLASRCP
CCCCHHHHHHHCCCCEEEEECCCCCCCCEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
VAVAPAMNTQMWKAEKVAENWQRLHQDPRFWALPTASGRLACDAVGEGRMLEPEALQEYV
EEECCCCCCHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEECCCCCCCCHHHHHHHH
RALLWTGGKKDWQGKRVLVTAGGTREPIDAVRFIGNPASGRMGVALAVAAACRGATVTLV
HHHHHCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCCCCCHHHHHHHHHHHCCCEEEEE
HGPLGIPFEPEPFGIRAIRVETAAQLEAALQAEFPQADLLWMAAAVGDVRPSQVYAGKLP
ECCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHCCCCC
KADLPQMLPLEPIPDLLAALARHKRPGQRLIGFAAQSGDPLPPAREKLRQKGLDAIVANP
CCCCCCCCCCCCHHHHHHHHHHCCCCCHHHEEECCCCCCCCCHHHHHHHHCCCCEEECCC
IDQPDSGFGSSHNQGYWIPQQGSPERIPLATKPTLAHRLLDLARQLELGYFS
CCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]