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The map label for this gene is lysC [H]

Identifier: 86607716

GI number: 86607716

Start: 227576

End: 229426

Strand: Reverse

Name: lysC [H]

Synonym: CYB_0217

Alternate gene names: 86607716

Gene position: 229426-227576 (Counterclockwise)

Preceding gene: 86607717

Following gene: 86607706

Centisome position: 7.53

GC content: 62.83

Gene sequence:

>1851_bases
ATGGAACGCAGCTTAATCGTTCAAAAGTACGGCGGTACCTCTGTCGGCTCTGTCGAGCGTATCCAAGCCGTGGCCCAACG
GGTGGCCCACACGGTGAAGGCAGGGCATCGGGTGGTGGTGGTGGTCTCGGCGATGGGGGATGAAACCGATCGCCTTGTGG
GCTTGGGGGAGCAGATCTTGCAGGGATCCCCGACCACGCCGGCCCAGTTGCGGGAATGGGATATGCTCCTTTCCACCGGT
GAGCAGGTGAGCATTGCCCTGGTGGCCTTGGCGCTGCAACGCTTGGGGTGTCCTGCCCTTTCCCTGACGGCAGCCCAGGT
GGGCATTGTCACCACTCGGGATCACAGCCGGGCCCGCATTTTGCACATCCACACCGACCGCCTGTGGCAGCACCTGGAGC
GGGAAGAGGTGGTGGTGGTGGCCGGGTTTCAGGGCATCACCAGCCTGGCGGAGCTGGAGATCACCACCCTAGGTCGGGGG
GGATCCGACACCACGGCGGTGGCCTTGGCAGTGGCTTTGGGAGCAGAGCTGTGTGAGATCTACACCGATGTGCCGGGGAT
CTTCACCACGGATCCGCGTAAGGTGCCTGAGGCCAGGCTGTTGCCGGAGATCACCAGTGATGAAATGTTGGAGCTGGCCA
GCTTGGGGGCCCAGGTGCTGCATCCCCGCTCGGTGGAAATTGCCCGCAACTACGGTGTGAAGCTGCGGGTGCGCTCCAGC
TTGGAGCCATTGCAGGCGGGATGCGAGGGCACTCTCATTCTTTCTCCTCCCCCCCGTCCTCGTGCTGCCGACAGCAGTAT
CGAGCTGGGCCTGGCGGTGGATACGGTGGAGCTGGATCGGGATCAGGCCAAGTTGGTGTTGGTGGGGGTGCCGGATCGCC
CTGGCATTGCCGCCCAACTCTTTCAGGGGATCGCGGCAGCAGGGGTGAATGTGGATTTGATTTTGCAGTCCCTCCAGTTC
ACAGCCTCTTGCGCCAGCGGGACGGACTCCTTGCCGCAGGGATCCGTGCCCCAGCCCACCAATGACATTGCCTTTACGGT
CAGTCGGTCGCAGGTGGCCGAGGCTGCAGCCGTTGCCCGGCAGATTGGCCAAGAGCTGCAGTGTGCAGCGGTGATTGTGG
ATGAGGCGGTGGCCAAAGTCAGCATTGCCGGGGTGGGGATGATGGGCCGACCCGGAATTGCGGCGCAAATGTTCCAGGTG
CTGGCCGAGGCCGGGATCAATTTGCAGATGATCTCCATGTCAGAGATCAAGGTGAGCTGTGTGGTGGCTGCGGAGCGGGC
CGGGGATGCCGCCTTGGCTCTGGGAGAGTCGTTCCAGGTGATCCCCCACTTGCATCGGGCAAAGATGCCGGCTGCTCCTC
AAGACAGCCACCCGGTACGCGGTGTTGCCTTGGATTTGAAGCAATCGCGGCTGGGCCTTCGCAAAGTGCCGGATCGTCCG
GGAACTGCCGCCCATTTGTTTGGGCGCTTGGCGGCTGCTGGGATCATCGTGGACACCATCATCCAAAGCCAGCGGGGCTA
CCACAACGGGATCCCCAGTACCGACATTGCCTTTACCGTGCCTCAGGATCAAGCGATGGCTGCTGAGGCAGTCTGCCGGC
AGGTGGCCGAAGAGCTCCAGGCGGCAGGAGTTGACGCGGATCACGACATTGCCAAGGTCAGCATTGTCGGCGCCGAGATG
GAAACCTACCCTGGCGTGGCTGCTCGCCTGTTTGCAGCCCTAGCCGAAGCCGGAATCAACATCGAGATGATCGCCACCTC
GGAGATCAAGGTGAGCTGTGTAGTGCGCCGGGATCGAGGGATCCCGGCCTTGCAAGCTATTCACCGCGCTTTCCGGCTGG
ACTGCCCCTAG

Upstream 100 bases:

>100_bases
TGCTGATCCTGCTGCCGGTGCCGCCGTTTTTGCAAAATGGGCTGGGCTTGGCCTAGATCCGGGGTAGGATCCAAACCGCC
CCTGACCTCGTTCTTCTCTC

Downstream 100 bases:

>100_bases
CCTGCCTTAGGGTTGAGCCGCCAGCAGCAAGGGAAAATGATGGGCGTTGGGGGCGTGCATCACCTGGATCCCCAGATTGG
CGCGGTTGAGGAGATCGGCG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MERSLIVQKYGGTSVGSVERIQAVAQRVAHTVKAGHRVVVVVSAMGDETDRLVGLGEQILQGSPTTPAQLREWDMLLSTG
EQVSIALVALALQRLGCPALSLTAAQVGIVTTRDHSRARILHIHTDRLWQHLEREEVVVVAGFQGITSLAELEITTLGRG
GSDTTAVALAVALGAELCEIYTDVPGIFTTDPRKVPEARLLPEITSDEMLELASLGAQVLHPRSVEIARNYGVKLRVRSS
LEPLQAGCEGTLILSPPPRPRAADSSIELGLAVDTVELDRDQAKLVLVGVPDRPGIAAQLFQGIAAAGVNVDLILQSLQF
TASCASGTDSLPQGSVPQPTNDIAFTVSRSQVAEAAAVARQIGQELQCAAVIVDEAVAKVSIAGVGMMGRPGIAAQMFQV
LAEAGINLQMISMSEIKVSCVVAAERAGDAALALGESFQVIPHLHRAKMPAAPQDSHPVRGVALDLKQSRLGLRKVPDRP
GTAAHLFGRLAAAGIIVDTIIQSQRGYHNGIPSTDIAFTVPQDQAMAAEAVCRQVAEELQAAGVDADHDIAKVSIVGAEM
ETYPGVAARLFAALAEAGINIEMIATSEIKVSCVVRRDRGIPALQAIHRAFRLDCP

Sequences:

>Translated_616_residues
MERSLIVQKYGGTSVGSVERIQAVAQRVAHTVKAGHRVVVVVSAMGDETDRLVGLGEQILQGSPTTPAQLREWDMLLSTG
EQVSIALVALALQRLGCPALSLTAAQVGIVTTRDHSRARILHIHTDRLWQHLEREEVVVVAGFQGITSLAELEITTLGRG
GSDTTAVALAVALGAELCEIYTDVPGIFTTDPRKVPEARLLPEITSDEMLELASLGAQVLHPRSVEIARNYGVKLRVRSS
LEPLQAGCEGTLILSPPPRPRAADSSIELGLAVDTVELDRDQAKLVLVGVPDRPGIAAQLFQGIAAAGVNVDLILQSLQF
TASCASGTDSLPQGSVPQPTNDIAFTVSRSQVAEAAAVARQIGQELQCAAVIVDEAVAKVSIAGVGMMGRPGIAAQMFQV
LAEAGINLQMISMSEIKVSCVVAAERAGDAALALGESFQVIPHLHRAKMPAAPQDSHPVRGVALDLKQSRLGLRKVPDRP
GTAAHLFGRLAAAGIIVDTIIQSQRGYHNGIPSTDIAFTVPQDQAMAAEAVCRQVAEELQAAGVDADHDIAKVSIVGAEM
ETYPGVAARLFAALAEAGINIEMIATSEIKVSCVVRRDRGIPALQAIHRAFRLDCP
>Mature_616_residues
MERSLIVQKYGGTSVGSVERIQAVAQRVAHTVKAGHRVVVVVSAMGDETDRLVGLGEQILQGSPTTPAQLREWDMLLSTG
EQVSIALVALALQRLGCPALSLTAAQVGIVTTRDHSRARILHIHTDRLWQHLEREEVVVVAGFQGITSLAELEITTLGRG
GSDTTAVALAVALGAELCEIYTDVPGIFTTDPRKVPEARLLPEITSDEMLELASLGAQVLHPRSVEIARNYGVKLRVRSS
LEPLQAGCEGTLILSPPPRPRAADSSIELGLAVDTVELDRDQAKLVLVGVPDRPGIAAQLFQGIAAAGVNVDLILQSLQF
TASCASGTDSLPQGSVPQPTNDIAFTVSRSQVAEAAAVARQIGQELQCAAVIVDEAVAKVSIAGVGMMGRPGIAAQMFQV
LAEAGINLQMISMSEIKVSCVVAAERAGDAALALGESFQVIPHLHRAKMPAAPQDSHPVRGVALDLKQSRLGLRKVPDRP
GTAAHLFGRLAAAGIIVDTIIQSQRGYHNGIPSTDIAFTVPQDQAMAAEAVCRQVAEELQAAGVDADHDIAKVSIVGAEM
ETYPGVAARLFAALAEAGINIEMIATSEIKVSCVVRRDRGIPALQAIHRAFRLDCP

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=487, Percent_Identity=28.5420944558522, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1790455, Length=283, Percent_Identity=33.5689045936396, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1790376, Length=108, Percent_Identity=39.8148148148148, Blast_Score=73, Evalue=4e-14,
Organism=Saccharomyces cerevisiae, GI6320893, Length=408, Percent_Identity=27.9411764705882, Blast_Score=118, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 64988; Mature: 64988

Theoretical pI: Translated: 5.62; Mature: 5.62

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERSLIVQKYGGTSVGSVERIQAVAQRVAHTVKAGHRVVVVVSAMGDETDRLVGLGEQIL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHCCHHHH
QGSPTTPAQLREWDMLLSTGEQVSIALVALALQRLGCPALSLTAAQVGIVTTRDHSRARI
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHEEEEEECCCCCEEE
LHIHTDRLWQHLEREEVVVVAGFQGITSLAELEITTLGRGGSDTTAVALAVALGAELCEI
EEEEHHHHHHHCCCCCEEEEECCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHH
YTDVPGIFTTDPRKVPEARLLPEITSDEMLELASLGAQVLHPRSVEIARNYGVKLRVRSS
HHCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCHHHCCCCCEEHHHCCCEEEEECCC
LEPLQAGCEGTLILSPPPRPRAADSSIELGLAVDTVELDRDQAKLVLVGVPDRPGIAAQL
CCHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEECCCCCCHHHHH
FQGIAAAGVNVDLILQSLQFTASCASGTDSLPQGSVPQPTNDIAFTVSRSQVAEAAAVAR
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHH
QIGQELQCAAVIVDEAVAKVSIAGVGMMGRPGIAAQMFQVLAEAGINLQMISMSEIKVSC
HHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCEEEEE
VVAAERAGDAALALGESFQVIPHLHRAKMPAAPQDSHPVRGVALDLKQSRLGLRKVPDRP
EEEECCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHCCCCCCCCCCC
GTAAHLFGRLAAAGIIVDTIIQSQRGYHNGIPSTDIAFTVPQDQAMAAEAVCRQVAEELQ
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
AAGVDADHDIAKVSIVGAEMETYPGVAARLFAALAEAGINIEMIATSEIKVSCVVRRDRG
HCCCCCCCCEEEEEEEECCHHHCCCHHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCC
IPALQAIHRAFRLDCP
CHHHHHHHHHHCCCCC
>Mature Secondary Structure
MERSLIVQKYGGTSVGSVERIQAVAQRVAHTVKAGHRVVVVVSAMGDETDRLVGLGEQIL
CCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCHHHHHHCCHHHH
QGSPTTPAQLREWDMLLSTGEQVSIALVALALQRLGCPALSLTAAQVGIVTTRDHSRARI
CCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCEEHHHHEEEEEECCCCCEEE
LHIHTDRLWQHLEREEVVVVAGFQGITSLAELEITTLGRGGSDTTAVALAVALGAELCEI
EEEEHHHHHHHCCCCCEEEEECCCCHHHHHHEEEEEECCCCCCHHHHHHHHHHHHHHHHH
YTDVPGIFTTDPRKVPEARLLPEITSDEMLELASLGAQVLHPRSVEIARNYGVKLRVRSS
HHCCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHCCHHHCCCCCEEHHHCCCEEEEECCC
LEPLQAGCEGTLILSPPPRPRAADSSIELGLAVDTVELDRDQAKLVLVGVPDRPGIAAQL
CCHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEEEEECCCCCEEEEEECCCCCCHHHHH
FQGIAAAGVNVDLILQSLQFTASCASGTDSLPQGSVPQPTNDIAFTVSRSQVAEAAAVAR
HHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHH
QIGQELQCAAVIVDEAVAKVSIAGVGMMGRPGIAAQMFQVLAEAGINLQMISMSEIKVSC
HHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHHHCCCCEEEEEECCEEEEE
VVAAERAGDAALALGESFQVIPHLHRAKMPAAPQDSHPVRGVALDLKQSRLGLRKVPDRP
EEEECCCCCEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCEEEEECHHHCCCCCCCCCCC
GTAAHLFGRLAAAGIIVDTIIQSQRGYHNGIPSTDIAFTVPQDQAMAAEAVCRQVAEELQ
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCCHHHHHHHHHHHHHHHHHH
AAGVDADHDIAKVSIVGAEMETYPGVAARLFAALAEAGINIEMIATSEIKVSCVVRRDRG
HCCCCCCCCEEEEEEEECCHHHCCCHHHHHHHHHHHCCCCEEEEEECCEEEEEEEECCCC
IPALQAIHRAFRLDCP
CHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]