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The map label for this gene is dgoD [H]

Identifier: 86360959

GI number: 86360959

Start: 242109

End: 243299

Strand: Reverse

Name: dgoD [H]

Synonym: RHE_PF00229

Alternate gene names: 86360959

Gene position: 243299-242109 (Counterclockwise)

Preceding gene: 86360960

Following gene: 86360951

Centisome position: 37.87

GC content: 61.38

Gene sequence:

>1191_bases
ATGATGAAGATCGACAGAATGCGAGTGTTCATGACCCGCGATAAGGACCGTCCCCGCGTGATCGTCGCACTCGATACCGA
TGATGGGCTGACCGGCTGGGGTGAGTGCTACAACCACGGCCCTGACAAGGCGCTGCCGCCGTTGCTCGATTATCTCTACG
GATTTCTCTCCGGACAGGATCCGACACGCGTCGAATACCTCGTCAATCTGCTGATCCAGCAAAGTCGATTCCCGCCCGGC
GCGCTCGGCCTTGCCGCAATCTCCGCGCTTGATCATTGCCTGTGGGATCTGGCGGCCAAGGCTGCGAACGTGCCGGTTTA
CAAGCTTCTCGGCGGCGAGGTCCGTGACCGCATCAAGGTCTATGCCGGAGTCTACACCGCGCCCGACGCGCCGGCCGCCC
GCGACGAATTCGACCGCCTGAAGGAGGAGTGGGGTTTCACCGCCTTCAAGCTCAGCCCCTGGCGGATCGACATGCATGCC
CATCGCTGGGGGAATGTCGTGAAGGCGTCAGCGGATTATTTCCGGTCGCTGCGCGAGACGGTGAATGACGAATACGAGAT
TGCCTTCGATGCTCATGCCAAGATTTTCGAACCGATCGCCGCAAGGCAACTCGGCAATGCGCTGGCGCCCTATGACCCGC
TGTTCTACGAAGAGCCGCTGCGTCCTGAGAATATCGAGGCCTGGGGCGATCTGAAACAGGGGCTCAATTGCGTGCTCGCA
ACCGGCGAGTCACTCTATAACAGGAACGAATTCCTGCGGCTGCTGCAGGTCAAGGGCGCCGACCTGATCCAGCCCGATAT
CTGCGTCGTCGGGGGAATCAGCGAAATGCGCCGCATCGCCACGCTGGCCGAAGCCTATTTCGTCGGCGTCGCTCCGCACA
ACCCGATGGGGCCGCTGGCGACGGCGGTCAATGTGCATTTTTCGGCCGCGGCCCAGAATTTCCGCATCCTCGAATACCGG
CTGCCAAAGGGCCAGGCCTATGTCTATGGCGGCCTCGACATCGAGAAGCGGCAGGGGGAAACACGCTACGTCGTGGACCC
CTATCTGCCGAAAGACGGTTATCTCGAACTGCGCCCCGACCGGCCCGGATGGGGAGTCGAAATGGATGAAAAGGCGATGG
AGGAGGAAGGCTATATCCATTGGCAGCGGCGCGTGCCGAAGCGGCCGGACGGCTCTTATGCCTTCGCCTGA

Upstream 100 bases:

>100_bases
GGAGGCCGCCGACTCCTACAATCCCGGAACCTACAACGAGCATCTCTACGTGCAGACGCGCGTGGCGCGCCGCAGCTATT
TCAATCGCTAGAAGGACAGA

Downstream 100 bases:

>100_bases
GGGTGTTACACGCTAAACCAGAGCTGGCCGCCGGAATGAGGCAGCCAGCTCCTGGGCGAAGTTTGCAGGCATTGTAGGAA
CATCGCGATCCCATGCCAAG

Product: putative isomerase protein

Products: NA

Alternate protein names: GalD [H]

Number of amino acids: Translated: 396; Mature: 396

Protein sequence:

>396_residues
MMKIDRMRVFMTRDKDRPRVIVALDTDDGLTGWGECYNHGPDKALPPLLDYLYGFLSGQDPTRVEYLVNLLIQQSRFPPG
ALGLAAISALDHCLWDLAAKAANVPVYKLLGGEVRDRIKVYAGVYTAPDAPAARDEFDRLKEEWGFTAFKLSPWRIDMHA
HRWGNVVKASADYFRSLRETVNDEYEIAFDAHAKIFEPIAARQLGNALAPYDPLFYEEPLRPENIEAWGDLKQGLNCVLA
TGESLYNRNEFLRLLQVKGADLIQPDICVVGGISEMRRIATLAEAYFVGVAPHNPMGPLATAVNVHFSAAAQNFRILEYR
LPKGQAYVYGGLDIEKRQGETRYVVDPYLPKDGYLELRPDRPGWGVEMDEKAMEEEGYIHWQRRVPKRPDGSYAFA

Sequences:

>Translated_396_residues
MMKIDRMRVFMTRDKDRPRVIVALDTDDGLTGWGECYNHGPDKALPPLLDYLYGFLSGQDPTRVEYLVNLLIQQSRFPPG
ALGLAAISALDHCLWDLAAKAANVPVYKLLGGEVRDRIKVYAGVYTAPDAPAARDEFDRLKEEWGFTAFKLSPWRIDMHA
HRWGNVVKASADYFRSLRETVNDEYEIAFDAHAKIFEPIAARQLGNALAPYDPLFYEEPLRPENIEAWGDLKQGLNCVLA
TGESLYNRNEFLRLLQVKGADLIQPDICVVGGISEMRRIATLAEAYFVGVAPHNPMGPLATAVNVHFSAAAQNFRILEYR
LPKGQAYVYGGLDIEKRQGETRYVVDPYLPKDGYLELRPDRPGWGVEMDEKAMEEEGYIHWQRRVPKRPDGSYAFA
>Mature_396_residues
MMKIDRMRVFMTRDKDRPRVIVALDTDDGLTGWGECYNHGPDKALPPLLDYLYGFLSGQDPTRVEYLVNLLIQQSRFPPG
ALGLAAISALDHCLWDLAAKAANVPVYKLLGGEVRDRIKVYAGVYTAPDAPAARDEFDRLKEEWGFTAFKLSPWRIDMHA
HRWGNVVKASADYFRSLRETVNDEYEIAFDAHAKIFEPIAARQLGNALAPYDPLFYEEPLRPENIEAWGDLKQGLNCVLA
TGESLYNRNEFLRLLQVKGADLIQPDICVVGGISEMRRIATLAEAYFVGVAPHNPMGPLATAVNVHFSAAAQNFRILEYR
LPKGQAYVYGGLDIEKRQGETRYVVDPYLPKDGYLELRPDRPGWGVEMDEKAMEEEGYIHWQRRVPKRPDGSYAFA

Specific function: Catalyzes the dehydration of D-galactonate to 2-keto-3- deoxy-D-galactonate [H]

COG id: COG4948

COG function: function code MR; L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mandelate racemase/muconate lactonizing enzyme family. GalD subfamily [H]

Homologues:

Organism=Homo sapiens, GI42544119, Length=357, Percent_Identity=24.6498599439776, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI186972148, Length=357, Percent_Identity=24.6498599439776, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI48994953, Length=379, Percent_Identity=32.9815303430079, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1787864, Length=398, Percent_Identity=28.1407035175879, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI226510960, Length=366, Percent_Identity=25.1366120218579, Blast_Score=96, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018110
- InterPro:   IPR013342
- InterPro:   IPR013341
- InterPro:   IPR001354 [H]

Pfam domain/function: PF01188 MR_MLE; PF02746 MR_MLE_N [H]

EC number: =4.2.1.6 [H]

Molecular weight: Translated: 44801; Mature: 44801

Theoretical pI: Translated: 5.50; Mature: 5.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKIDRMRVFMTRDKDRPRVIVALDTDDGLTGWGECYNHGPDKALPPLLDYLYGFLSGQD
CCCCCCEEEEEECCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCC
PTRVEYLVNLLIQQSRFPPGALGLAAISALDHCLWDLAAKAANVPVYKLLGGEVRDRIKV
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHEE
YAGVYTAPDAPAARDEFDRLKEEWGFTAFKLSPWRIDMHAHRWGNVVKASADYFRSLRET
EEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCEEEEEEHHHCCCEEEHHHHHHHHHHHH
VNDEYEIAFDAHAKIFEPIAARQLGNALAPYDPLFYEEPLRPENIEAWGDLKQGLNCVLA
CCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEE
TGESLYNRNEFLRLLQVKGADLIQPDICVVGGISEMRRIATLAEAYFVGVAPHNPMGPLA
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHEEECCCCCCCCCHH
TAVNVHFSAAAQNFRILEYRLPKGQAYVYGGLDIEKRQGETRYVVDPYLPKDGYLELRPD
HHEEEEEHHHCCCEEEEEEECCCCCEEEEECCEEHHCCCCEEEEECCCCCCCCCEEECCC
RPGWGVEMDEKAMEEEGYIHWQRRVPKRPDGSYAFA
CCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCC
>Mature Secondary Structure
MMKIDRMRVFMTRDKDRPRVIVALDTDDGLTGWGECYNHGPDKALPPLLDYLYGFLSGQD
CCCCCCEEEEEECCCCCCEEEEEEECCCCCCCHHHHHCCCCCCCCHHHHHHHHHHHCCCC
PTRVEYLVNLLIQQSRFPPGALGLAAISALDHCLWDLAAKAANVPVYKLLGGEVRDRIKV
CHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCHHHHHHHEE
YAGVYTAPDAPAARDEFDRLKEEWGFTAFKLSPWRIDMHAHRWGNVVKASADYFRSLRET
EEEEEECCCCCCHHHHHHHHHHHHCCEEEEECCEEEEEEHHHCCCEEEHHHHHHHHHHHH
VNDEYEIAFDAHAKIFEPIAARQLGNALAPYDPLFYEEPLRPENIEAWGDLKQGLNCVLA
CCCCEEEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCEEEEE
TGESLYNRNEFLRLLQVKGADLIQPDICVVGGISEMRRIATLAEAYFVGVAPHNPMGPLA
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEECCHHHHHHHHHHHHHHEEECCCCCCCCCHH
TAVNVHFSAAAQNFRILEYRLPKGQAYVYGGLDIEKRQGETRYVVDPYLPKDGYLELRPD
HHEEEEEHHHCCCEEEEEEECCCCCEEEEECCEEHHCCCCEEEEECCCCCCCCCEEECCC
RPGWGVEMDEKAMEEEGYIHWQRRVPKRPDGSYAFA
CCCCCCCCCHHHHHHCCCEEEECCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA