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The map label for this gene is hemL

Identifier: 85860193

GI number: 85860193

Start: 2393928

End: 2395226

Strand: Direct

Name: hemL

Synonym: SYN_00583

Alternate gene names: 85860193

Gene position: 2393928-2395226 (Clockwise)

Preceding gene: 85860192

Following gene: 85860194

Centisome position: 75.3

GC content: 59.43

Gene sequence:

>1299_bases
ATGACAAAATCCTTATCGGAACAACTTTTTGAAACCGCGGAAGGTCTTCTTCCCGGCGGGGTGAACAGTCCCGTGAGGGC
GTTCCGGGCTGTCGGAGGGGTTCCCCGTTTTATCGACCGGGCAGAAGGTTCCCGGATCTATGATATTGACGGCAGGGAAT
ACATCGATTATGTCGGATCATGGGGTCCGATGATCCTTGGCCACAGCCATCCGCAGGTCGTGGAGGCGATCCGGAAGGCC
GTCGAACGTGGAACCAGTTACGGCGCTCCGACCCCCGGAGAAATTGCCCTGGCGAGGACCATTATTGAAGCCTTTCCCTC
CATGGAGATGATCCGGATGGTCAGCTCCGGCACGGAAGCCGTCATGAGCGCCATCCGCCTGGCCCGCGGATTCACGGGCA
GAGATAAAATTCTCAAATTCGAGGGCTGTTATCACGGCCATGGCGATTCGCTCCTGGTCAAAGCCGGTTCCGGAGTCGCT
ACCCTGGGAATCCCCGGCAGCCCCGGCGTGCCGGCATGCCTCGCCGAACTGACGATCACCGTCCCTTTCAATTCCAACGA
AGCCTTCCGCAAAGCCGTGGATCGCCACGGCAAAGAACTGGCCTGCGTCATTGTGGAACCCGTCGCGGCGAACATGGGCG
TTGTCAACCCCCGGCCGGGATTTCTGGAAACCCTCCGGGAACTGACCCGAAAGGCCGGGATCGTCCTCATCTTTGACGAG
GTCATCACCGGTTTTCGCCTTGCCTATGGCGGATTCCAGAAACTCTGCCGCCTCGAACCCGACCTGACCTGCCTGGGGAA
GATCATCGGTGGCGGACTTCCCGTCGGCGCCTTCGGCGGCAAACGGACAATCATGGACTTTCTGGCCCCCAATGGACCCG
TCTACCAGGCGGGCACCCTCTCCGGCAATCCCCTGGCCATGTCGGCCGGGCTGGCCACCCTGGAAACGCTGCGCAGCCGG
AGGGATGACTACGCCGCTTTGGACAGGCGCACGGCAGACCTCTGCGCCGCCATGGGAAAACTCTTCAGGACCGCGGAGCT
TCCTGTACGCATCAACCGGGCAGGCTCCCTGTTCACGGTGTTCTTTACGGATTCCGATGTATTCGATTACGAAACAGCCA
GTCACTGCAACTTGGAACGGTATGCCCGCTTCTTCAAGGGCATGCTGGATCGGGGCGTCTATCTTGCGCCGTCCGCTTTC
GAAGCGGCCTTTGTTTCCTTTGCCCATTCCGATGAAGATTTAGAGAAAACGCTGCAGGCCTGCGCTGAAACCATAAAAAC
TTTGGGAGGTAACCCATGA

Upstream 100 bases:

>100_bases
CGAATCAGGTGCGGGAGATGGCGCAGGCGGCAGATCTTGACGATTATCAGATCCTCGTCAGCGAAACCGAGTATAAAAAA
AGCAGCATGGTCTATTTCAC

Downstream 100 bases:

>100_bases
AAAAAGCATTTATCACCGGCATTACAGGACAGGACGGCTCCTATCTGGCTGAATTTCTCCTCGGGAAAGGCTATGAAGTC
CACGGCCTGATCCGGCGCTC

Product: glutamate-1-semialdehyde 2,1-aminomutase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT

Number of amino acids: Translated: 432; Mature: 431

Protein sequence:

>432_residues
MTKSLSEQLFETAEGLLPGGVNSPVRAFRAVGGVPRFIDRAEGSRIYDIDGREYIDYVGSWGPMILGHSHPQVVEAIRKA
VERGTSYGAPTPGEIALARTIIEAFPSMEMIRMVSSGTEAVMSAIRLARGFTGRDKILKFEGCYHGHGDSLLVKAGSGVA
TLGIPGSPGVPACLAELTITVPFNSNEAFRKAVDRHGKELACVIVEPVAANMGVVNPRPGFLETLRELTRKAGIVLIFDE
VITGFRLAYGGFQKLCRLEPDLTCLGKIIGGGLPVGAFGGKRTIMDFLAPNGPVYQAGTLSGNPLAMSAGLATLETLRSR
RDDYAALDRRTADLCAAMGKLFRTAELPVRINRAGSLFTVFFTDSDVFDYETASHCNLERYARFFKGMLDRGVYLAPSAF
EAAFVSFAHSDEDLEKTLQACAETIKTLGGNP

Sequences:

>Translated_432_residues
MTKSLSEQLFETAEGLLPGGVNSPVRAFRAVGGVPRFIDRAEGSRIYDIDGREYIDYVGSWGPMILGHSHPQVVEAIRKA
VERGTSYGAPTPGEIALARTIIEAFPSMEMIRMVSSGTEAVMSAIRLARGFTGRDKILKFEGCYHGHGDSLLVKAGSGVA
TLGIPGSPGVPACLAELTITVPFNSNEAFRKAVDRHGKELACVIVEPVAANMGVVNPRPGFLETLRELTRKAGIVLIFDE
VITGFRLAYGGFQKLCRLEPDLTCLGKIIGGGLPVGAFGGKRTIMDFLAPNGPVYQAGTLSGNPLAMSAGLATLETLRSR
RDDYAALDRRTADLCAAMGKLFRTAELPVRINRAGSLFTVFFTDSDVFDYETASHCNLERYARFFKGMLDRGVYLAPSAF
EAAFVSFAHSDEDLEKTLQACAETIKTLGGNP
>Mature_431_residues
TKSLSEQLFETAEGLLPGGVNSPVRAFRAVGGVPRFIDRAEGSRIYDIDGREYIDYVGSWGPMILGHSHPQVVEAIRKAV
ERGTSYGAPTPGEIALARTIIEAFPSMEMIRMVSSGTEAVMSAIRLARGFTGRDKILKFEGCYHGHGDSLLVKAGSGVAT
LGIPGSPGVPACLAELTITVPFNSNEAFRKAVDRHGKELACVIVEPVAANMGVVNPRPGFLETLRELTRKAGIVLIFDEV
ITGFRLAYGGFQKLCRLEPDLTCLGKIIGGGLPVGAFGGKRTIMDFLAPNGPVYQAGTLSGNPLAMSAGLATLETLRSRR
DDYAALDRRTADLCAAMGKLFRTAELPVRINRAGSLFTVFFTDSDVFDYETASHCNLERYARFFKGMLDRGVYLAPSAFE
AAFVSFAHSDEDLEKTLQACAETIKTLGGNP

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=305, Percent_Identity=29.5081967213115, Blast_Score=102, Evalue=9e-22,
Organism=Homo sapiens, GI13994255, Length=319, Percent_Identity=28.2131661442006, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI284507298, Length=219, Percent_Identity=29.6803652968037, Blast_Score=67, Evalue=3e-11,
Organism=Escherichia coli, GI1786349, Length=418, Percent_Identity=57.4162679425837, Blast_Score=488, Evalue=1e-139,
Organism=Escherichia coli, GI1789016, Length=308, Percent_Identity=31.1688311688312, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI145693181, Length=353, Percent_Identity=30.028328611898, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI1789759, Length=293, Percent_Identity=31.0580204778157, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI1788044, Length=296, Percent_Identity=30.0675675675676, Blast_Score=107, Evalue=2e-24,
Organism=Escherichia coli, GI1787560, Length=286, Percent_Identity=30.7692307692308, Blast_Score=106, Evalue=4e-24,
Organism=Escherichia coli, GI1786991, Length=379, Percent_Identity=26.1213720316623, Blast_Score=92, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=306, Percent_Identity=26.797385620915, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI25144274, Length=148, Percent_Identity=33.7837837837838, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=422, Percent_Identity=26.0663507109005, Blast_Score=108, Evalue=2e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=304, Percent_Identity=24.0131578947368, Blast_Score=71, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GSA_SYNAS (Q2LVW6)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_462395.1
- ProteinModelPortal:   Q2LVW6
- SMR:   Q2LVW6
- STRING:   Q2LVW6
- GeneID:   3883628
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_00583
- NMPDR:   fig|56780.10.peg.2341
- eggNOG:   COG0001
- HOGENOM:   HBG725944
- OMA:   DKVIKFE
- PhylomeDB:   Q2LVW6
- BioCyc:   SACI56780:SYN_00583-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00375
- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- TIGRFAMs:   TIGR00713

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =5.4.3.8

Molecular weight: Translated: 46457; Mature: 46326

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKSLSEQLFETAEGLLPGGVNSPVRAFRAVGGVPRFIDRAEGSRIYDIDGREYIDYVGS
CCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHCC
WGPMILGHSHPQVVEAIRKAVERGTSYGAPTPGEIALARTIIEAFPSMEMIRMVSSGTEA
CCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCHHH
VMSAIRLARGFTGRDKILKFEGCYHGHGDSLLVKAGSGVATLGIPGSPGVPACLAELTIT
HHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEECCCCCCCHHHHEEHEEEE
VPFNSNEAFRKAVDRHGKELACVIVEPVAANMGVVNPRPGFLETLRELTRKAGIVLIFDE
EECCCCHHHHHHHHHCCCEEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEHHH
VITGFRLAYGGFQKLCRLEPDLTCLGKIIGGGLPVGAFGGKRTIMDFLAPNGPVYQAGTL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEECCCC
SGNPLAMSAGLATLETLRSRRDDYAALDRRTADLCAAMGKLFRTAELPVRINRAGSLFTV
CCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEE
FFTDSDVFDYETASHCNLERYARFFKGMLDRGVYLAPSAFEAAFVSFAHSDEDLEKTLQA
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCHHHHHHHHHH
CAETIKTLGGNP
HHHHHHHHCCCC
>Mature Secondary Structure 
TKSLSEQLFETAEGLLPGGVNSPVRAFRAVGGVPRFIDRAEGSRIYDIDGREYIDYVGS
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCHHHHHHCCCCEEEECCCHHHHHHHCC
WGPMILGHSHPQVVEAIRKAVERGTSYGAPTPGEIALARTIIEAFPSMEMIRMVSSGTEA
CCCEEECCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHCCHHH
VMSAIRLARGFTGRDKILKFEGCYHGHGDSLLVKAGSGVATLGIPGSPGVPACLAELTIT
HHHHHHHHHCCCCCCCEEEEECCCCCCCCEEEEECCCCEEEECCCCCCCHHHHEEHEEEE
VPFNSNEAFRKAVDRHGKELACVIVEPVAANMGVVNPRPGFLETLRELTRKAGIVLIFDE
EECCCCHHHHHHHHHCCCEEEEEEEECHHCCCCCCCCCCCHHHHHHHHHHHCCEEEEHHH
VITGFRLAYGGFQKLCRLEPDLTCLGKIIGGGLPVGAFGGKRTIMDFLAPNGPVYQAGTL
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCEEECCCC
SGNPLAMSAGLATLETLRSRRDDYAALDRRTADLCAAMGKLFRTAELPVRINRAGSLFTV
CCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEE
FFTDSDVFDYETASHCNLERYARFFKGMLDRGVYLAPSAFEAAFVSFAHSDEDLEKTLQA
EEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCEEECCHHHHHHHHHHHCCHHHHHHHHHH
CAETIKTLGGNP
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA