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The map label for this gene is lysA [H]

Identifier: 85859277

GI number: 85859277

Start: 1464467

End: 1465750

Strand: Direct

Name: lysA [H]

Synonym: SYN_02160

Alternate gene names: 85859277

Gene position: 1464467-1465750 (Clockwise)

Preceding gene: 85859276

Following gene: 85859278

Centisome position: 46.06

GC content: 50.47

Gene sequence:

>1284_bases
ATGAATGATTTTCTATATAAAGATCAACAGTTGTGGTGTGAGAACATTCCCGTCTCTCAAATAGCAGAGGAAGTGGGGAC
GCCGTTTTACCTTTACAGCCACGCGACCCTGAGGAATCATTTTCGCGTGTTTGCCGAGGCTTTCGCGAAGGTGCCCTCCA
TCATCTGTTTTGCGGTCAAGGCCAATTCCAACCTGGCGGTGCTCAGGGTCCTGATCGCCGAAGGTGGCGGGGTCGATATC
GTGTCGGGCGGCGAGCTGTACCGTGCTCTTCAGGCCGGAGTGGAACCGGGAAAAGTCGTGTATTCCGGGGTGGGAAAGCG
CGTGGATGAAATCGAATACGCCCTTCGTTCCGGAATTCTCATGTTCAATGTTGAATCGCTGCAGGAACTGGAGGTCATCA
ATCGATGTGCACAGAATCTGGGTGTCAGCGCGGGCATTGCCCTGAGGGTCAATCCGGATGTGGATCCCAAGACGCATCCT
CATATTTCAACAGGCCTCAAAGAAAACAAATTCGGAATCGATATTGAGCGCTCTCTGGAAACCTATCGTCACGCAAGGTC
TCTCCAGCATCTTGATATCAGAGGGGTAAGCTGTCATATCGGCTCACAGGTTACTCGGTTGTCGCCATTTCTTGAGGCCC
TGGAAAGACTTTCGCTGTTGGTTCATCAACTGAAACGGGAAGATTTCGACATCCGCTATGTAGATCTGGGGGGCGGGCTC
GGAATTACCTATAATCAGGAAATGCCGCCTCATCCCTCGGAATACGCGAAAGCCATTTTAGAAACATCCCGGGATCTGGA
TTGTACGTTCATATTTGAGCCGGGAAGGGTGATCGTCGGCAACGCCGGGATACTTGTCACCCGGGTTCTTTATACAAAAA
GCAATGATAACAAGAATTTCATTATCGTCGATGCGGGAATGAACGATCTCGTCCGGCCGAGCCTCTACAACTCATTTCAT
GCGATCCGGCCGGTCATCGAGGAAAACCGTAAAGAGATCATCGCCGATGTTGTCGGTCCCATCTGTGAATCCGGTGATTA
TCTGGCCAAAGCCAGAAAACTAAAAGACTTCCATCGGGGAGACCTTCTTGCTGTATTCAGTGCCGGCGCATACGGGTTCA
CGATGGCGTCCAATTATAATTCACGACCGAGGATTCCGGAAATCATGGTCAGGGAGGATCAGTATTATGTTGTGCGCAGA
CGGGAAACCTATGCCGATTTAATTTCGCATGAGGAAATCCCTGCGTTTTTGAAAAACAAGGCGATATCCCGAACAGGAAA
GTGA

Upstream 100 bases:

>100_bases
GCGGATGCAGTCAAATGATGATCAGTCAATATTTCTGCCTTGTCGAAAATCAGGGAAATCAGCCGGAGCTTGAAGAAAGA
GCCTGGACGGTGCAATAAAT

Downstream 100 bases:

>100_bases
AGGAGGGCAACAGGAAAAGTATGTTTAAAGGAGCTATTGTCGCGATTGTGACGCCATTTAAGAATGGCGAGATTGATGAA
CCGGCATTGAGGGATTTGAT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNDFLYKDQQLWCENIPVSQIAEEVGTPFYLYSHATLRNHFRVFAEAFAKVPSIICFAVKANSNLAVLRVLIAEGGGVDI
VSGGELYRALQAGVEPGKVVYSGVGKRVDEIEYALRSGILMFNVESLQELEVINRCAQNLGVSAGIALRVNPDVDPKTHP
HISTGLKENKFGIDIERSLETYRHARSLQHLDIRGVSCHIGSQVTRLSPFLEALERLSLLVHQLKREDFDIRYVDLGGGL
GITYNQEMPPHPSEYAKAILETSRDLDCTFIFEPGRVIVGNAGILVTRVLYTKSNDNKNFIIVDAGMNDLVRPSLYNSFH
AIRPVIEENRKEIIADVVGPICESGDYLAKARKLKDFHRGDLLAVFSAGAYGFTMASNYNSRPRIPEIMVREDQYYVVRR
RETYADLISHEEIPAFLKNKAISRTGK

Sequences:

>Translated_427_residues
MNDFLYKDQQLWCENIPVSQIAEEVGTPFYLYSHATLRNHFRVFAEAFAKVPSIICFAVKANSNLAVLRVLIAEGGGVDI
VSGGELYRALQAGVEPGKVVYSGVGKRVDEIEYALRSGILMFNVESLQELEVINRCAQNLGVSAGIALRVNPDVDPKTHP
HISTGLKENKFGIDIERSLETYRHARSLQHLDIRGVSCHIGSQVTRLSPFLEALERLSLLVHQLKREDFDIRYVDLGGGL
GITYNQEMPPHPSEYAKAILETSRDLDCTFIFEPGRVIVGNAGILVTRVLYTKSNDNKNFIIVDAGMNDLVRPSLYNSFH
AIRPVIEENRKEIIADVVGPICESGDYLAKARKLKDFHRGDLLAVFSAGAYGFTMASNYNSRPRIPEIMVREDQYYVVRR
RETYADLISHEEIPAFLKNKAISRTGK
>Mature_427_residues
MNDFLYKDQQLWCENIPVSQIAEEVGTPFYLYSHATLRNHFRVFAEAFAKVPSIICFAVKANSNLAVLRVLIAEGGGVDI
VSGGELYRALQAGVEPGKVVYSGVGKRVDEIEYALRSGILMFNVESLQELEVINRCAQNLGVSAGIALRVNPDVDPKTHP
HISTGLKENKFGIDIERSLETYRHARSLQHLDIRGVSCHIGSQVTRLSPFLEALERLSLLVHQLKREDFDIRYVDLGGGL
GITYNQEMPPHPSEYAKAILETSRDLDCTFIFEPGRVIVGNAGILVTRVLYTKSNDNKNFIIVDAGMNDLVRPSLYNSFH
AIRPVIEENRKEIIADVVGPICESGDYLAKARKLKDFHRGDLLAVFSAGAYGFTMASNYNSRPRIPEIMVREDQYYVVRR
RETYADLISHEEIPAFLKNKAISRTGK

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=382, Percent_Identity=25.6544502617801, Blast_Score=104, Evalue=1e-22,
Organism=Homo sapiens, GI22538418, Length=368, Percent_Identity=25.5434782608696, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI21361583, Length=368, Percent_Identity=25.5434782608696, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI16506287, Length=381, Percent_Identity=23.3595800524934, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789203, Length=437, Percent_Identity=29.9771167048055, Blast_Score=177, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17562780, Length=412, Percent_Identity=23.0582524271845, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6322664, Length=378, Percent_Identity=25.3968253968254, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24586472, Length=338, Percent_Identity=24.2603550295858, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 47847; Mature: 47847

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFLYKDQQLWCENIPVSQIAEEVGTPFYLYSHATLRNHFRVFAEAFAKVPSIICFAVK
CCCCCCCCHHHHHCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEE
ANSNLAVLRVLIAEGGGVDIVSGGELYRALQAGVEPGKVVYSGVGKRVDEIEYALRSGIL
CCCCCEEEEEEECCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCEE
MFNVESLQELEVINRCAQNLGVSAGIALRVNPDVDPKTHPHISTGLKENKFGIDIERSLE
EEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHHHH
TYRHARSLQHLDIRGVSCHIGSQVTRLSPFLEALERLSLLVHQLKREDFDIRYVDLGGGL
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCE
GITYNQEMPPHPSEYAKAILETSRDLDCTFIFEPGRVIVGNAGILVTRVLYTKSNDNKNF
EEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCEEEEEEEEECCCCCCEE
IIVDAGMNDLVRPSLYNSFHAIRPVIEENRKEIIADVVGPICESGDYLAKARKLKDFHRG
EEEECCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DLLAVFSAGAYGFTMASNYNSRPRIPEIMVREDQYYVVRRRETYADLISHEEIPAFLKNK
CEEEEEECCCCEEEEECCCCCCCCCCCEEEECCCEEEEECHHHHHHHHCCHHHHHHHHHH
AISRTGK
HHHCCCC
>Mature Secondary Structure
MNDFLYKDQQLWCENIPVSQIAEEVGTPFYLYSHATLRNHFRVFAEAFAKVPSIICFAVK
CCCCCCCCHHHHHCCCCHHHHHHHHCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEEEEEE
ANSNLAVLRVLIAEGGGVDIVSGGELYRALQAGVEPGKVVYSGVGKRVDEIEYALRSGIL
CCCCCEEEEEEECCCCCEEEECCHHHHHHHHCCCCCCHHHHHHHCCHHHHHHHHHHCCEE
MFNVESLQELEVINRCAQNLGVSAGIALRVNPDVDPKTHPHISTGLKENKFGIDIERSLE
EEEHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCHHCCCCCCCCCCCHHHHHH
TYRHARSLQHLDIRGVSCHIGSQVTRLSPFLEALERLSLLVHQLKREDFDIRYVDLGGGL
HHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCE
GITYNQEMPPHPSEYAKAILETSRDLDCTFIFEPGRVIVGNAGILVTRVLYTKSNDNKNF
EEEECCCCCCCHHHHHHHHHHCCCCCCEEEEECCCEEEEECCCEEEEEEEEECCCCCCEE
IIVDAGMNDLVRPSLYNSFHAIRPVIEENRKEIIADVVGPICESGDYLAKARKLKDFHRG
EEEECCCCHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCC
DLLAVFSAGAYGFTMASNYNSRPRIPEIMVREDQYYVVRRRETYADLISHEEIPAFLKNK
CEEEEEECCCCEEEEECCCCCCCCCCCEEEECCCEEEEECHHHHHHHHCCHHHHHHHHHH
AISRTGK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10952301 [H]