Click here to switch to the map view.

The map label for this gene is capL [H]

Identifier: 85858260

GI number: 85858260

Start: 417025

End: 418311

Strand: Direct

Name: capL [H]

Synonym: SYN_01113

Alternate gene names: 85858260

Gene position: 417025-418311 (Clockwise)

Preceding gene: 85858259

Following gene: 85858261

Centisome position: 13.12

GC content: 63.01

Gene sequence:

>1287_bases
GTGCGAATGAATAGAGTTGTTTCAGTGATAGGCCTTGGATACGTCGGGTTGCCGGTGGCCGTGGCTTTTGGAAAACGGAA
AAGGACGGTCGGCTTCGACATCAATTCGACCCGCATTGCCGAGCTCCGCAAGGGACACGACCGCACCGGCGAGGTGACGC
CCGAGGATCTGGCTGCCGCGGATATCCTCTTCACCAGTGACATCAACGAGCTGCGGCAGGCCGATTTTCATATCGTCGCC
GTCCCCACGCCGGTGGATAACGCCAATCAGCCCGATCTGACCCCCGTCCTGCGCGCGTCGGAAACCGCGGGGAAGGCCCT
GAAGAAGGGGGATATCGTCGTCTATGAATCGACGGTCTATCCCGGCGTCACGGAAGAGGAATGCGTGCCGATCCTCGAAC
GGGTTTCCGGCCTGACCTGCGGGACCGATTTCACCGTCGGGTACAGCCCGGAACGGATCAACCCCGGCGATAAGGAGCAC
ACCTTCACTAAAATCAAAAAGGTCGTCTCCGGCCAGGACGCCGAAACGCTGGAGATCGTGGCCTCGGTTTACGAGTCCGT
GGTGACGGCCGGCGTCCATCGCGCCCCGACGATCAAGGTTGCCGAGGCGGCCAAGGTCATCGAGAACACCCAGCGCGACC
TGAACATCGCCCTGATGAACGAACTGGCCCTGATCTTCGATCGGCTGGGCATCGACACCGGCGACGTCCTGGAGGCGGCG
GGCACCAAATGGAACTTCCTCGGCTTCCGGCCGGGGCTGGTCGGCGGGCACTGCATCGGCGTCGATCCCTATTACCTGAC
CCACAAGGCCGAGATGATCGGCTACATCCCCCAGGTGATCCTCGCCGGCCGCCGCATCAACGATTCCATGGGGAAATACA
TCGCCCAGCAGGCCGTCAGGGAGATGATCCTTGCCGGCCACAATGTCCTGGACGCCCGCGTCACGGTGCTGGGGCTGACA
TTCAAGGAAGACTGCCCCGACCTGCGCAACTCCCGCGTCATCGACATCATCCGGGAGCTGGAGGGGTACGGCGTTCAGTT
GCAGGTCTCCGACCCGATGGCTGATGGGGAGGAGGCCCGGCACGAATACGGTGTCGCTCTGACCCCCCTTGACCGGCTGC
TGCCCGCCTCCGCAGTGATCGTGGCCGTTGCGCATCAGGCCTATCGCGGCATGACGCCGGATCAACTCGCGGCGCTGACT
CTGGGCAGACCGGTGGTGCTGGATGTCAAGGGAATCTTTGACCGGCAGGCCCTGGCGGATGCCGGAATCCGCCTGTGGAG
ACTCTGA

Upstream 100 bases:

>100_bases
CTTTCCGACCGGAAGACTTTACCGAAGATAATGCTTTTGCAAGGGAAATCATGAAAAGCGGCATTGAATTGCATCTGTCT
GAATTATCCTGAGAGCGGAG

Downstream 100 bases:

>100_bases
TCCGCCATGACTGAAAGAGGAAACATACTGGTCACCGGCGCCGCGGGATTCATCGGCTTTCATCTGTCGCGGCGGCTGCT
GGCGGCGGGACATTCGGTCG

Product: UDP-N-acetyl-D-galactosamine 6-dehydrogenase

Products: UDP-N-acetyl-D-mannosaminuronic-acid; NADH; Proton [C]

Alternate protein names: NA

Number of amino acids: Translated: 428; Mature: 428

Protein sequence:

>428_residues
MRMNRVVSVIGLGYVGLPVAVAFGKRKRTVGFDINSTRIAELRKGHDRTGEVTPEDLAAADILFTSDINELRQADFHIVA
VPTPVDNANQPDLTPVLRASETAGKALKKGDIVVYESTVYPGVTEEECVPILERVSGLTCGTDFTVGYSPERINPGDKEH
TFTKIKKVVSGQDAETLEIVASVYESVVTAGVHRAPTIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTGDVLEAA
GTKWNFLGFRPGLVGGHCIGVDPYYLTHKAEMIGYIPQVILAGRRINDSMGKYIAQQAVREMILAGHNVLDARVTVLGLT
FKEDCPDLRNSRVIDIIRELEGYGVQLQVSDPMADGEEARHEYGVALTPLDRLLPASAVIVAVAHQAYRGMTPDQLAALT
LGRPVVLDVKGIFDRQALADAGIRLWRL

Sequences:

>Translated_428_residues
MRMNRVVSVIGLGYVGLPVAVAFGKRKRTVGFDINSTRIAELRKGHDRTGEVTPEDLAAADILFTSDINELRQADFHIVA
VPTPVDNANQPDLTPVLRASETAGKALKKGDIVVYESTVYPGVTEEECVPILERVSGLTCGTDFTVGYSPERINPGDKEH
TFTKIKKVVSGQDAETLEIVASVYESVVTAGVHRAPTIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTGDVLEAA
GTKWNFLGFRPGLVGGHCIGVDPYYLTHKAEMIGYIPQVILAGRRINDSMGKYIAQQAVREMILAGHNVLDARVTVLGLT
FKEDCPDLRNSRVIDIIRELEGYGVQLQVSDPMADGEEARHEYGVALTPLDRLLPASAVIVAVAHQAYRGMTPDQLAALT
LGRPVVLDVKGIFDRQALADAGIRLWRL
>Mature_428_residues
MRMNRVVSVIGLGYVGLPVAVAFGKRKRTVGFDINSTRIAELRKGHDRTGEVTPEDLAAADILFTSDINELRQADFHIVA
VPTPVDNANQPDLTPVLRASETAGKALKKGDIVVYESTVYPGVTEEECVPILERVSGLTCGTDFTVGYSPERINPGDKEH
TFTKIKKVVSGQDAETLEIVASVYESVVTAGVHRAPTIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTGDVLEAA
GTKWNFLGFRPGLVGGHCIGVDPYYLTHKAEMIGYIPQVILAGRRINDSMGKYIAQQAVREMILAGHNVLDARVTVLGLT
FKEDCPDLRNSRVIDIIRELEGYGVQLQVSDPMADGEEARHEYGVALTPLDRLLPASAVIVAVAHQAYRGMTPDQLAALT
LGRPVVLDVKGIFDRQALADAGIRLWRL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0677

COG function: function code M; UDP-N-acetyl-D-mannosaminuronate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI48994968, Length=430, Percent_Identity=30, Blast_Score=146, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: 1.1.1.- [C]

Molecular weight: Translated: 46573; Mature: 46573

Theoretical pI: Translated: 5.49; Mature: 5.49

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRMNRVVSVIGLGYVGLPVAVAFGKRKRTVGFDINSTRIAELRKGHDRTGEVTPEDLAAA
CCHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHH
DILFTSDINELRQADFHIVAVPTPVDNANQPDLTPVLRASETAGKALKKGDIVVYESTVY
HEEECCCHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHCCHHHHHHHHCCCEEEEECCCC
PGVTEEECVPILERVSGLTCGTDFTVGYSPERINPGDKEHTFTKIKKVVSGQDAETLEIV
CCCCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
ASVYESVVTAGVHRAPTIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTGDVLEAA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
GTKWNFLGFRPGLVGGHCIGVDPYYLTHKAEMIGYIPQVILAGRRINDSMGKYIAQQAVR
CCCEEEEECCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EMILAGHNVLDARVTVLGLTFKEDCPDLRNSRVIDIIRELEGYGVQLQVSDPMADGEEAR
HHHHHCCCHHEEEEEEEEEEHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHH
HEYGVALTPLDRLLPASAVIVAVAHQAYRGMTPDQLAALTLGRPVVLDVKGIFDRQALAD
HHCCCEECCHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHH
AGIRLWRL
CCEEEECC
>Mature Secondary Structure
MRMNRVVSVIGLGYVGLPVAVAFGKRKRTVGFDINSTRIAELRKGHDRTGEVTPEDLAAA
CCHHHHHHHHHCCHHHHHHHHHHCCCCCEEECCCCCHHHHHHHCCCCCCCCCCHHHHHHH
DILFTSDINELRQADFHIVAVPTPVDNANQPDLTPVLRASETAGKALKKGDIVVYESTVY
HEEECCCHHHHHHCCEEEEEECCCCCCCCCCCCCHHHHCCHHHHHHHHCCCEEEEECCCC
PGVTEEECVPILERVSGLTCGTDFTVGYSPERINPGDKEHTFTKIKKVVSGQDAETLEIV
CCCCHHHHHHHHHHHCCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHCCCCHHHHHHH
ASVYESVVTAGVHRAPTIKVAEAAKVIENTQRDLNIALMNELALIFDRLGIDTGDVLEAA
HHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHC
GTKWNFLGFRPGLVGGHCIGVDPYYLTHKAEMIGYIPQVILAGRRINDSMGKYIAQQAVR
CCCEEEEECCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
EMILAGHNVLDARVTVLGLTFKEDCPDLRNSRVIDIIRELEGYGVQLQVSDPMADGEEAR
HHHHHCCCHHEEEEEEEEEEHHHCCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCCHHHH
HEYGVALTPLDRLLPASAVIVAVAHQAYRGMTPDQLAALTLGRPVVLDVKGIFDRQALAD
HHCCCEECCHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHHCCCCEEEEECHHHHHHHHHH
AGIRLWRL
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-N-acetyl-D-mannosamine; NAD [C]

Specific reaction: UDP-N-acetyl-D-mannosamine + NAD = UDP-N-acetyl-D-mannosaminuronic-acid + NADH + Proton [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]