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The map label for this gene is capI [H]

Identifier: 85858261

GI number: 85858261

Start: 418318

End: 419337

Strand: Direct

Name: capI [H]

Synonym: SYN_01112

Alternate gene names: 85858261

Gene position: 418318-419337 (Clockwise)

Preceding gene: 85858260

Following gene: 85858262

Centisome position: 13.16

GC content: 60.69

Gene sequence:

>1020_bases
ATGACTGAAAGAGGAAACATACTGGTCACCGGCGCCGCGGGATTCATCGGCTTTCATCTGTCGCGGCGGCTGCTGGCGGC
GGGACATTCGGTCGTCGGCCTGGACAACCTGAACGACTACTACGACGTCCGCCTGAAGGAGGCCCGCCTGGCCCGCCTGA
CGCCCCATCCCAATTTCCGGTTTGTCCGCCAGGGTCTGGAAGAGCGGGAGAAACTGCACGCCCTCTTTGCCGCGGAGAGC
TTCGCGACCGTCGTCAACCTGGCCGCCCAGGCGGGGGTGCGCTATTCCCTGACCAATCCCTACGCCTACATCGACAGCAA
CATCGTCGGCTTTGTCAATCTCCTCGAAGGGTGCCGCCATTACGGAGTCCGGCACCTGGTTTACGCCTCCTCCAGTTCCG
TCTACGGCGCCAACACGGCGATGCCCTTCTCCGTACACCATAACGTGGATCATCCCGTTTCCCTGTATGCCGCCACCAAA
AAGGCCAACGAGCTGATGGCGCACACCTATTCCAGCCTCTACGGAATACCCGCCACGGGCCTTCGCTTTTTCACGGTTTA
CGGCCCCTGGGGCCGCCCGGACATGGCCCTGTTTCTTTTTACCCGGGCGATTCTCGAAGGCCGTCCCATCGATGTCTTCA
ACTACGGAAAAATGCGGAGGGACTTCACCTATGTCGATGACATCGTCGAGGGGGTGGTGCGGGTGATGGACCGAATTCCC
GAGGGCAATCCGGCCTGGAGCGGCGACCATCCCGATCCCGGAACCAGCTATGCCCCCTATAAAATTTACAACATCGGGAA
CAACAACCCCGTGGAACTGCTCTCCTTCATCGAGGCGCTGGAGGACTGCCTGGGGAAAAAGGCCGAAAAGAACTTCCTGC
CCCTGCAGGCCGGCGATGTACCCGCCACCTATGCCGATGTGGACGACCTGATGCGGGATGTGGGCTTCCAGCCGTCCACC
CCCATCGAGGAAGGCATCCGGCGGTTTGTGACGTGGTATCGGGAGTATTACGCGCTGTAA

Upstream 100 bases:

>100_bases
GCTGACTCTGGGCAGACCGGTGGTGCTGGATGTCAAGGGAATCTTTGACCGGCAGGCCCTGGCGGATGCCGGAATCCGCC
TGTGGAGACTCTGATCCGCC

Downstream 100 bases:

>100_bases
TCATCGGCCAGGCAACGGTCAAAGGTATTGATGCTTTTCAACTCTCTTGAATTTGCCCTGTTCTTTTCCCTGACCGGTCT
GGTTTATTTTCTCTCGCCAT

Product: UDP-N-acetylglucosamine 4-epimerase

Products: dTDP-4-dehydro-6-deoxy-D-glucose; H2O [C]

Alternate protein names: NA

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MTERGNILVTGAAGFIGFHLSRRLLAAGHSVVGLDNLNDYYDVRLKEARLARLTPHPNFRFVRQGLEEREKLHALFAAES
FATVVNLAAQAGVRYSLTNPYAYIDSNIVGFVNLLEGCRHYGVRHLVYASSSSVYGANTAMPFSVHHNVDHPVSLYAATK
KANELMAHTYSSLYGIPATGLRFFTVYGPWGRPDMALFLFTRAILEGRPIDVFNYGKMRRDFTYVDDIVEGVVRVMDRIP
EGNPAWSGDHPDPGTSYAPYKIYNIGNNNPVELLSFIEALEDCLGKKAEKNFLPLQAGDVPATYADVDDLMRDVGFQPST
PIEEGIRRFVTWYREYYAL

Sequences:

>Translated_339_residues
MTERGNILVTGAAGFIGFHLSRRLLAAGHSVVGLDNLNDYYDVRLKEARLARLTPHPNFRFVRQGLEEREKLHALFAAES
FATVVNLAAQAGVRYSLTNPYAYIDSNIVGFVNLLEGCRHYGVRHLVYASSSSVYGANTAMPFSVHHNVDHPVSLYAATK
KANELMAHTYSSLYGIPATGLRFFTVYGPWGRPDMALFLFTRAILEGRPIDVFNYGKMRRDFTYVDDIVEGVVRVMDRIP
EGNPAWSGDHPDPGTSYAPYKIYNIGNNNPVELLSFIEALEDCLGKKAEKNFLPLQAGDVPATYADVDDLMRDVGFQPST
PIEEGIRRFVTWYREYYAL
>Mature_338_residues
TERGNILVTGAAGFIGFHLSRRLLAAGHSVVGLDNLNDYYDVRLKEARLARLTPHPNFRFVRQGLEEREKLHALFAAESF
ATVVNLAAQAGVRYSLTNPYAYIDSNIVGFVNLLEGCRHYGVRHLVYASSSSVYGANTAMPFSVHHNVDHPVSLYAATKK
ANELMAHTYSSLYGIPATGLRFFTVYGPWGRPDMALFLFTRAILEGRPIDVFNYGKMRRDFTYVDDIVEGVVRVMDRIPE
GNPAWSGDHPDPGTSYAPYKIYNIGNNNPVELLSFIEALEDCLGKKAEKNFLPLQAGDVPATYADVDDLMRDVGFQPSTP
IEEGIRRFVTWYREYYAL

Specific function: Required for the biosynthesis of type 1 capsular polysaccharide [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sugar epimerase family [H]

Homologues:

Organism=Homo sapiens, GI42516563, Length=339, Percent_Identity=26.5486725663717, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI7657641, Length=338, Percent_Identity=25.4437869822485, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI56237023, Length=357, Percent_Identity=25.4901960784314, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI56118217, Length=357, Percent_Identity=25.4901960784314, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI189083684, Length=357, Percent_Identity=25.4901960784314, Blast_Score=102, Evalue=5e-22,
Organism=Escherichia coli, GI1788353, Length=354, Percent_Identity=27.4011299435028, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI48994969, Length=351, Percent_Identity=26.2108262108262, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1786974, Length=349, Percent_Identity=24.9283667621776, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1788589, Length=354, Percent_Identity=24.0112994350282, Blast_Score=73, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI71982035, Length=350, Percent_Identity=26.2857142857143, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI71982038, Length=352, Percent_Identity=26.1363636363636, Blast_Score=104, Evalue=6e-23,
Organism=Caenorhabditis elegans, GI17539532, Length=339, Percent_Identity=25.6637168141593, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17568069, Length=352, Percent_Identity=25, Blast_Score=92, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI115532424, Length=345, Percent_Identity=24.0579710144928, Blast_Score=72, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319493, Length=356, Percent_Identity=25.8426966292135, Blast_Score=79, Evalue=7e-16,
Organism=Drosophila melanogaster, GI19923002, Length=351, Percent_Identity=26.7806267806268, Blast_Score=110, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356223, Length=343, Percent_Identity=25.3644314868805, Blast_Score=100, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040
- InterPro:   IPR008089 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 4.2.1.46 [C]

Molecular weight: Translated: 38005; Mature: 37873

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTERGNILVTGAAGFIGFHLSRRLLAAGHSVVGLDNLNDYYDVRLKEARLARLTPHPNFR
CCCCCCEEEEECHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHEEHHHHHHCCCCCCCHH
FVRQGLEEREKLHALFAAESFATVVNLAAQAGVRYSLTNPYAYIDSNIVGFVNLLEGCRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCHHHHHHHHHHHHH
YGVRHLVYASSSSVYGANTAMPFSVHHNVDHPVSLYAATKKANELMAHTYSSLYGIPATG
HCCCEEEEECCCCCCCCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCC
LRFFTVYGPWGRPDMALFLFTRAILEGRPIDVFNYGKMRRDFTYVDDIVEGVVRVMDRIP
EEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEECCCCHHCCHHHHHHHHHHHHHHHHHCC
EGNPAWSGDHPDPGTSYAPYKIYNIGNNNPVELLSFIEALEDCLGKKAEKNFLPLQAGDV
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHCCCCCEECCCC
PATYADVDDLMRDVGFQPSTPIEEGIRRFVTWYREYYAL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TERGNILVTGAAGFIGFHLSRRLLAAGHSVVGLDNLNDYYDVRLKEARLARLTPHPNFR
CCCCCEEEEECHHHHHHHHHHHHHHCCCCEEECCCCCCHHHHEEHHHHHHCCCCCCCHH
FVRQGLEEREKLHALFAAESFATVVNLAAQAGVRYSLTNPYAYIDSNIVGFVNLLEGCRH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCEEEECCCHHHHHHHHHHHHH
YGVRHLVYASSSSVYGANTAMPFSVHHNVDHPVSLYAATKKANELMAHTYSSLYGIPATG
HCCCEEEEECCCCCCCCCCCCCEEEECCCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCCC
LRFFTVYGPWGRPDMALFLFTRAILEGRPIDVFNYGKMRRDFTYVDDIVEGVVRVMDRIP
EEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEECCCCHHCCHHHHHHHHHHHHHHHHHCC
EGNPAWSGDHPDPGTSYAPYKIYNIGNNNPVELLSFIEALEDCLGKKAEKNFLPLQAGDV
CCCCCCCCCCCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHCCHHHCCCCCEECCCC
PATYADVDDLMRDVGFQPSTPIEEGIRRFVTWYREYYAL
CCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NAD+ [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.019 {NAD+}} 0.034 {dTDPglucose}} [C]

Substrates: dTDPglucose [C]

Specific reaction: dTDPglucose --> dTDP-4-dehydro-6-deoxy-D-glucose + H2O [C]

General reaction: Elimination (of H2O C-O bond cleavage [C]

Inhibitor: TDP; TTP [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7961465 [H]