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The map label for this gene is kynA

Identifier: 85375655

GI number: 85375655

Start: 2840079

End: 2840870

Strand: Direct

Name: kynA

Synonym: ELI_14140

Alternate gene names: 85375655

Gene position: 2840079-2840870 (Clockwise)

Preceding gene: 85375654

Following gene: 85375656

Centisome position: 93.04

GC content: 63.01

Gene sequence:

>792_bases
ATGGCGCAAGACGTTACCTATTCCAGCTATCTCGATCTCGATCGCATCCTGGCGGCGCAGCACCCGGTGTCCGGCGCGCA
TGACGAGATGCTGTTCATCATCGTTCACCAGGCGAGCGAGCTGTGGCTGAAGCTATGCCTGCATGAGCTGTTCGCCGCGC
GCGATTGCATTGCCGCAGACAACCTCCGCCCCAGCTTCAAGATGCTCAGCCGCGTGGCGCGCGCGCAGACCCAGCTGATC
CAGAGCTGGGACGTGCTGAGCACCATGACGCCGCACGATTATTCGCAAATCCGCCCGCATCTCGGGCGCTCGAGCGGATT
CCAGTCGCCGCAATACCGGATGATGGAATTCCTGCTCGGCGGGCGCAATCCGGACATGGTTGCGATGCACGAACCGACGC
CGGAAATCGCGACGGCGCTGCGCGAGGAACTGGCGCGTACCAGCCTTTACGACGAGGCGATCCGCCTGCTGTCGCGGCGC
GGCTTCGCCATCCCCGATGAAGTGCTGGCGCGCAAGCTCGACGAAGTCTGGGTCCGGTCGGAAGAGGTCGAAGCGGCGTG
GGCTGAAATCTACCGGGACCCGCAGCAGCACTGGGATCTTTACGAACTGGCCGAGAAGCTGGTCGATCTCGAGTACCATT
TCCAGCGCTGGCGGTTCGGGCATCTGAAAACGGTCGAGCGGATCATCGGCTTCAAGCGCGGCACGGGCGGCACCAAGGGT
GTGCCGTATCTCGAAGGCGTGCTTAAACAGGCGTTCTTCCCCGAGCTGCTGAGCGTGAGGACGGCCATATGA

Upstream 100 bases:

>100_bases
TCAGAAAGCACCTCGACAAGCATCACCCGCAGACGCGCGTGATCGAGCAGTGAGCGGGCAGTAGTTTCAACCGAGACCAA
CTCGCGCTAGTGCCTGCCGC

Downstream 100 bases:

>100_bases
GGGTTGGGATATGAGCAGCTGGAAATCGCAACGGCGCATCTGGGATATTTCGCAGACGCTGCGCCCCGGTCTTCCGATAT
GGCCCGGCGATACCGAGTTC

Product: putative oxygenase oxidoreductase protein

Products: NA

Alternate protein names: TDO; Tryptamin 2,3-dioxygenase; Tryptophan oxygenase; TO; TRPO; Tryptophan pyrrolase; Tryptophanase

Number of amino acids: Translated: 263; Mature: 262

Protein sequence:

>263_residues
MAQDVTYSSYLDLDRILAAQHPVSGAHDEMLFIIVHQASELWLKLCLHELFAARDCIAADNLRPSFKMLSRVARAQTQLI
QSWDVLSTMTPHDYSQIRPHLGRSSGFQSPQYRMMEFLLGGRNPDMVAMHEPTPEIATALREELARTSLYDEAIRLLSRR
GFAIPDEVLARKLDEVWVRSEEVEAAWAEIYRDPQQHWDLYELAEKLVDLEYHFQRWRFGHLKTVERIIGFKRGTGGTKG
VPYLEGVLKQAFFPELLSVRTAI

Sequences:

>Translated_263_residues
MAQDVTYSSYLDLDRILAAQHPVSGAHDEMLFIIVHQASELWLKLCLHELFAARDCIAADNLRPSFKMLSRVARAQTQLI
QSWDVLSTMTPHDYSQIRPHLGRSSGFQSPQYRMMEFLLGGRNPDMVAMHEPTPEIATALREELARTSLYDEAIRLLSRR
GFAIPDEVLARKLDEVWVRSEEVEAAWAEIYRDPQQHWDLYELAEKLVDLEYHFQRWRFGHLKTVERIIGFKRGTGGTKG
VPYLEGVLKQAFFPELLSVRTAI
>Mature_262_residues
AQDVTYSSYLDLDRILAAQHPVSGAHDEMLFIIVHQASELWLKLCLHELFAARDCIAADNLRPSFKMLSRVARAQTQLIQ
SWDVLSTMTPHDYSQIRPHLGRSSGFQSPQYRMMEFLLGGRNPDMVAMHEPTPEIATALREELARTSLYDEAIRLLSRRG
FAIPDEVLARKLDEVWVRSEEVEAAWAEIYRDPQQHWDLYELAEKLVDLEYHFQRWRFGHLKTVERIIGFKRGTGGTKGV
PYLEGVLKQAFFPELLSVRTAI

Specific function: Catalyzes the oxidative cleavage of the L-tryptophan (L- Trp) pyrrole ring

COG id: COG3483

COG function: function code E; Tryptophan 2,3-dioxygenase (vermilion)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tryptophan 2,3-dioxygenase family

Homologues:

Organism=Homo sapiens, GI5032165, Length=127, Percent_Identity=38.5826771653543, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32564651, Length=127, Percent_Identity=38.5826771653543, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17552370, Length=127, Percent_Identity=38.5826771653543, Blast_Score=77, Evalue=7e-15,
Organism=Drosophila melanogaster, GI17530891, Length=330, Percent_Identity=29.6969696969697, Blast_Score=94, Evalue=8e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): T23O_ERYLH (Q2N5X1)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_459717.1
- ProteinModelPortal:   Q2N5X1
- STRING:   Q2N5X1
- GeneID:   3871638
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_14140
- NMPDR:   fig|314225.3.peg.190
- eggNOG:   COG3483
- HOGENOM:   HBG647485
- OMA:   HWELYEL
- BioCyc:   ELIT314225:ELI_14140-MONOMER
- InterPro:   IPR004981
- PANTHER:   PTHR10138

Pfam domain/function: PF03301 Trp_dioxygenase

EC number: =1.13.11.11

Molecular weight: Translated: 30341; Mature: 30210

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: BINDING 94-94 BINDING 98-98 BINDING 105-105 BINDING 235-235

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAQDVTYSSYLDLDRILAAQHPVSGAHDEMLFIIVHQASELWLKLCLHELFAARDCIAAD
CCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHC
NLRPSFKMLSRVARAQTQLIQSWDVLSTMTPHDYSQIRPHLGRSSGFQSPQYRMMEFLLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHC
GRNPDMVAMHEPTPEIATALREELARTSLYDEAIRLLSRRGFAIPDEVLARKLDEVWVRS
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EEVEAAWAEIYRDPQQHWDLYELAEKLVDLEYHFQRWRFGHLKTVERIIGFKRGTGGTKG
HHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VPYLEGVLKQAFFPELLSVRTAI
CHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
AQDVTYSSYLDLDRILAAQHPVSGAHDEMLFIIVHQASELWLKLCLHELFAARDCIAAD
CCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHC
NLRPSFKMLSRVARAQTQLIQSWDVLSTMTPHDYSQIRPHLGRSSGFQSPQYRMMEFLLG
CCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCCCCCHHHHHHHHHHC
GRNPDMVAMHEPTPEIATALREELARTSLYDEAIRLLSRRGFAIPDEVLARKLDEVWVRS
CCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
EEVEAAWAEIYRDPQQHWDLYELAEKLVDLEYHFQRWRFGHLKTVERIIGFKRGTGGTKG
HHHHHHHHHHHHCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
VPYLEGVLKQAFFPELLSVRTAI
CHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA