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The map label for this gene is hisC

Identifier: 85375110

GI number: 85375110

Start: 2307123

End: 2308226

Strand: Direct

Name: hisC

Synonym: ELI_11415

Alternate gene names: 85375110

Gene position: 2307123-2308226 (Clockwise)

Preceding gene: 85375107

Following gene: 85375111

Centisome position: 75.58

GC content: 65.85

Gene sequence:

>1104_bases
ATGTCAGACACGCGCCCTCAGATAAAAACTTGGATCGAAGGTATTCACGCCTATGTGCCCGGCAAGGCGACCGGCGCGCA
GGGGCAGGCGCTGATCAAGCTGTCGGCCAACGAAAATCCGCTGGGATGTTCGCCGAAGGCGCTCGAAGCACTCGACGCGC
CCGGCAATCCGGCGACCTATCCCGATCCCGATGCCAAGGCGCTGCGCGCGAAACTGGCCGAGGTTCACGGGCTCGATGCC
GGGCGGATCGTCTGCGGGACCGGGTCCGATGAATTGCTCAACCTTGCCGCGCAGGCCTTTGCGGGGCCGGGCGACGAAGT
GCTGTTCAGCACCTACAGCTTCTCGGTTTACGACATCGCGGCGCGGCGCTGCGGGGCGACGCCGGTCGAGGCGCCTGATG
CCGACTACGCCGCCGACGTCGATGCGCTGCTGGCGGCGGTCACGGACAAGACGCGCGTAGTCTTCGTCGCCAATCCCAAC
AATCCGACCGGCAGCTTCCTGCCCCGCGACGAGATTGCAAGGCTTCACGCGGGCTTGCCGCAAGATGTGCTGTTCGTGCT
CGATCAGGCTTATGCCGAATATTTGACACCGGAGGAGGACGATGGCGGCTTCGCCCTCGCCGCCGCACATGAGAACGTGC
TCGTTACGCGCACTTTCTCCAAGGCTTACGGCTTGGCCGGCGAGCGGATCGGCTGGGCCACCGGCGCGCCGCATTTCATC
GATGCGCTCAACCGCGTCCGCGGGCCATTCAATGTCACCAACAGCGGTCAGGCGGCAGCGCTGGCAGGCGTCGATGACCA
GAATTTCATCGACCGGACGCGCGACCACAACACCCGCGAACTGACGCGCTTCACCGACGCCATGGCCGCGCTCGGCAATC
ACGGCATCCGCCCGCTGCCCAGCAAAGCCAATTTCGCGCTGGTCCTGTTCGAAGGGACACTCGCGGCAGAGACGGCGCTG
AGCGCGCTTGCAGATGCAGGCTACGCCGTGCGGCACTTACCGGGCCAGGGCCTGCCGCATGGGCTGCGGATCACCATCGG
CACCGCCGAGGACATGGACCGCATCGCGCGAACCATCGCCGAGGCGGCCGAGGCAGCACAATGA

Upstream 100 bases:

>100_bases
CTTCGACAAGCTCAGCACGAACGGGTTTGGAGCAAACCCCTCTATCCGTTCGCCCTGAGCTTGTCGAAGGGCTGTATTTC
TTTATGGGCTGAAACCCGCA

Downstream 100 bases:

>100_bases
CGATCCGCCGCGTTGCCATCATCGGCCTTGGCCTCTTGGGCGGTTCGCTCAGCCTCGCCCTGCGCGAGAAGCTGCCCGGA
ATCGCGACGACCGGCTACGA

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 367; Mature: 366

Protein sequence:

>367_residues
MSDTRPQIKTWIEGIHAYVPGKATGAQGQALIKLSANENPLGCSPKALEALDAPGNPATYPDPDAKALRAKLAEVHGLDA
GRIVCGTGSDELLNLAAQAFAGPGDEVLFSTYSFSVYDIAARRCGATPVEAPDADYAADVDALLAAVTDKTRVVFVANPN
NPTGSFLPRDEIARLHAGLPQDVLFVLDQAYAEYLTPEEDDGGFALAAAHENVLVTRTFSKAYGLAGERIGWATGAPHFI
DALNRVRGPFNVTNSGQAAALAGVDDQNFIDRTRDHNTRELTRFTDAMAALGNHGIRPLPSKANFALVLFEGTLAAETAL
SALADAGYAVRHLPGQGLPHGLRITIGTAEDMDRIARTIAEAAEAAQ

Sequences:

>Translated_367_residues
MSDTRPQIKTWIEGIHAYVPGKATGAQGQALIKLSANENPLGCSPKALEALDAPGNPATYPDPDAKALRAKLAEVHGLDA
GRIVCGTGSDELLNLAAQAFAGPGDEVLFSTYSFSVYDIAARRCGATPVEAPDADYAADVDALLAAVTDKTRVVFVANPN
NPTGSFLPRDEIARLHAGLPQDVLFVLDQAYAEYLTPEEDDGGFALAAAHENVLVTRTFSKAYGLAGERIGWATGAPHFI
DALNRVRGPFNVTNSGQAAALAGVDDQNFIDRTRDHNTRELTRFTDAMAALGNHGIRPLPSKANFALVLFEGTLAAETAL
SALADAGYAVRHLPGQGLPHGLRITIGTAEDMDRIARTIAEAAEAAQ
>Mature_366_residues
SDTRPQIKTWIEGIHAYVPGKATGAQGQALIKLSANENPLGCSPKALEALDAPGNPATYPDPDAKALRAKLAEVHGLDAG
RIVCGTGSDELLNLAAQAFAGPGDEVLFSTYSFSVYDIAARRCGATPVEAPDADYAADVDALLAAVTDKTRVVFVANPNN
PTGSFLPRDEIARLHAGLPQDVLFVLDQAYAEYLTPEEDDGGFALAAAHENVLVTRTFSKAYGLAGERIGWATGAPHFID
ALNRVRGPFNVTNSGQAAALAGVDDQNFIDRTRDHNTRELTRFTDAMAALGNHGIRPLPSKANFALVLFEGTLAAETALS
ALADAGYAVRHLPGQGLPHGLRITIGTAEDMDRIARTIAEAAEAAQ

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=352, Percent_Identity=26.1363636363636, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1788627, Length=161, Percent_Identity=28.5714285714286, Blast_Score=65, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17567369, Length=199, Percent_Identity=22.1105527638191, Blast_Score=66, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322075, Length=364, Percent_Identity=27.4725274725275, Blast_Score=105, Evalue=1e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_ERYLH (Q2N7G6)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_459172.1
- HSSP:   Q9X0D0
- ProteinModelPortal:   Q2N7G6
- SMR:   Q2N7G6
- STRING:   Q2N7G6
- GeneID:   3870451
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_11415
- NMPDR:   fig|314225.3.peg.738
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   YDIAARR
- ProtClustDB:   PRK02731
- BioCyc:   ELIT314225:ELI_11415-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 38652; Mature: 38520

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDTRPQIKTWIEGIHAYVPGKATGAQGQALIKLSANENPLGCSPKALEALDAPGNPATY
CCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCC
PDPDAKALRAKLAEVHGLDAGRIVCGTGSDELLNLAAQAFAGPGDEVLFSTYSFSVYDIA
CCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
ARRCGATPVEAPDADYAADVDALLAAVTDKTRVVFVANPNNPTGSFLPRDEIARLHAGLP
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCC
QDVLFVLDQAYAEYLTPEEDDGGFALAAAHENVLVTRTFSKAYGLAGERIGWATGAPHFI
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEHHHHHCCCCCCCCCCCCCCHHH
DALNRVRGPFNVTNSGQAAALAGVDDQNFIDRTRDHNTRELTRFTDAMAALGNHGIRPLP
HHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
SKANFALVLFEGTLAAETALSALADAGYAVRHLPGQGLPHGLRITIGTAEDMDRIARTIA
CCCCEEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECHHHHHHHHHHHH
EAAEAAQ
HHHHHCC
>Mature Secondary Structure 
SDTRPQIKTWIEGIHAYVPGKATGAQGQALIKLSANENPLGCSPKALEALDAPGNPATY
CCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCC
PDPDAKALRAKLAEVHGLDAGRIVCGTGSDELLNLAAQAFAGPGDEVLFSTYSFSVYDIA
CCCCHHHHHHHHHHHHCCCCCEEEECCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHH
ARRCGATPVEAPDADYAADVDALLAAVTDKTRVVFVANPNNPTGSFLPRDEIARLHAGLP
HHHCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCHHHHHHHHCCCC
QDVLFVLDQAYAEYLTPEEDDGGFALAAAHENVLVTRTFSKAYGLAGERIGWATGAPHFI
HHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCEEEEEEHHHHHCCCCCCCCCCCCCCHHH
DALNRVRGPFNVTNSGQAAALAGVDDQNFIDRTRDHNTRELTRFTDAMAALGNHGIRPLP
HHHHHCCCCCCCCCCCCEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCC
SKANFALVLFEGTLAAETALSALADAGYAVRHLPGQGLPHGLRITIGTAEDMDRIARTIA
CCCCEEEEEEECCHHHHHHHHHHHHCCCCEEECCCCCCCCCEEEEEECHHHHHHHHHHHH
EAAEAAQ
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA