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The map label for this gene is fghA [H]

Identifier: 85375107

GI number: 85375107

Start: 2304466

End: 2305308

Strand: Direct

Name: fghA [H]

Synonym: ELI_11400

Alternate gene names: 85375107

Gene position: 2304466-2305308 (Clockwise)

Preceding gene: 85375106

Following gene: 85375110

Centisome position: 75.5

GC content: 61.09

Gene sequence:

>843_bases
ATGAAACTCGAAACCTTGAGCGAAAATCGCAGCCACGGCGGCGTGCAGGGCGTCTATTCTCATCATTCCGAAGTGATCGG
CACCGAGATGACATTTTCGGTCTATCTCCCGCCACACAGCGAAGGCGAGACATTGCCTGTGCTGTGGTATCTCTCCGGCC
TCACCTGCACCCATGCCAATGTCACCGAGAAGGGCGAGTTCCGCGCAGCATGCGCCGAGCATGGCATCGCCTTCATCGCC
CCCGACACCTCCCCGCGCGGCGAAGATGTGCCCGACGCGGAGGAGGAATACGATTTCGGCAAGGGCGCGGGGTTCTACGT
CGATGCGACCGAGGAGCCATGGCGCAAGCACTACCGCATGCGCAGCTATATCGAGCGCGAACTGCCCGAATTGGTCGCTG
CCAACTTCCCGCTCGAAATGAGCCGTCAGTCGATCACCGGCCATTCGATGGGCGGCCACGGCGCACTAAGCATCGGCTTG
CGCAATCCCGACCACTTCCGCTCAATCAGCGCCTTCAGTCCCATCGTCGCACCCAGCCAGGTGCCCTGGGGCGAGAAGGC
GCTGGGCCGCTATCTGGGCGATGATCGGTCAAGCTGGCGCGAATACGACGCCGTCGCGCTGATCGAAGACGGCACACGGC
ACGATCACATCCTCGTTGACCAGGGCACCGCGGACGATTTTCTCGAAGACCAGCTTAAGACCAGCCTGCTTTCCCTCGCC
TGCGCCAAGGCCGGAATGGAACCGACAATCCGCATGCAGGAAGGCTATGACCACTCCTATTATTTCATCTCAACCTTCAT
GGCCGAGCACGTCGCGTGGCATGCGGAGAGGTTGAAGGCCTAG

Upstream 100 bases:

>100_bases
CCTGAGCTTGTCGAAGGGCTGTACTTTTTTTGGTGCGGTGCCGGAAAGAAGAAGAACAGGGCTTCGACAAGCTCAGCCCG
AACGGGTAGTTGAGTTGGGT

Downstream 100 bases:

>100_bases
CGGCTAACCTCGAACAGCGCATATTCCGCGCGCCAGTTGGCGCCGCCGCCACCGATTTCGCGCTCGCGCGTGAAATACCA
GCGGTCTTCGATCCTGACGC

Product: esterase D

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKLETLSENRSHGGVQGVYSHHSEVIGTEMTFSVYLPPHSEGETLPVLWYLSGLTCTHANVTEKGEFRAACAEHGIAFIA
PDTSPRGEDVPDAEEEYDFGKGAGFYVDATEEPWRKHYRMRSYIERELPELVAANFPLEMSRQSITGHSMGGHGALSIGL
RNPDHFRSISAFSPIVAPSQVPWGEKALGRYLGDDRSSWREYDAVALIEDGTRHDHILVDQGTADDFLEDQLKTSLLSLA
CAKAGMEPTIRMQEGYDHSYYFISTFMAEHVAWHAERLKA

Sequences:

>Translated_280_residues
MKLETLSENRSHGGVQGVYSHHSEVIGTEMTFSVYLPPHSEGETLPVLWYLSGLTCTHANVTEKGEFRAACAEHGIAFIA
PDTSPRGEDVPDAEEEYDFGKGAGFYVDATEEPWRKHYRMRSYIERELPELVAANFPLEMSRQSITGHSMGGHGALSIGL
RNPDHFRSISAFSPIVAPSQVPWGEKALGRYLGDDRSSWREYDAVALIEDGTRHDHILVDQGTADDFLEDQLKTSLLSLA
CAKAGMEPTIRMQEGYDHSYYFISTFMAEHVAWHAERLKA
>Mature_280_residues
MKLETLSENRSHGGVQGVYSHHSEVIGTEMTFSVYLPPHSEGETLPVLWYLSGLTCTHANVTEKGEFRAACAEHGIAFIA
PDTSPRGEDVPDAEEEYDFGKGAGFYVDATEEPWRKHYRMRSYIERELPELVAANFPLEMSRQSITGHSMGGHGALSIGL
RNPDHFRSISAFSPIVAPSQVPWGEKALGRYLGDDRSSWREYDAVALIEDGTRHDHILVDQGTADDFLEDQLKTSLLSLA
CAKAGMEPTIRMQEGYDHSYYFISTFMAEHVAWHAERLKA

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=283, Percent_Identity=50.1766784452297, Blast_Score=301, Evalue=4e-82,
Organism=Escherichia coli, GI1786551, Length=277, Percent_Identity=50.9025270758123, Blast_Score=306, Evalue=7e-85,
Organism=Escherichia coli, GI1788477, Length=278, Percent_Identity=47.4820143884892, Blast_Score=261, Evalue=3e-71,
Organism=Caenorhabditis elegans, GI17510185, Length=283, Percent_Identity=52.6501766784452, Blast_Score=283, Evalue=6e-77,
Organism=Saccharomyces cerevisiae, GI6322393, Length=297, Percent_Identity=40.7407407407407, Blast_Score=223, Evalue=2e-59,
Organism=Drosophila melanogaster, GI45551932, Length=284, Percent_Identity=47.1830985915493, Blast_Score=280, Evalue=6e-76,
Organism=Drosophila melanogaster, GI24648347, Length=284, Percent_Identity=47.1830985915493, Blast_Score=280, Evalue=1e-75,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 31280; Mature: 31280

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLETLSENRSHGGVQGVYSHHSEVIGTEMTFSVYLPPHSEGETLPVLWYLSGLTCTHAN
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEEEECCCEEECCC
VTEKGEFRAACAEHGIAFIAPDTSPRGEDVPDAEEEYDFGKGAGFYVDATEEPWRKHYRM
CCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHCCCCCCCCEEEECCCCHHHHHHHH
RSYIERELPELVAANFPLEMSRQSITGHSMGGHGALSIGLRNPDHFRSISAFSPIVAPSQ
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCC
VPWGEKALGRYLGDDRSSWREYDAVALIEDGTRHDHILVDQGTADDFLEDQLKTSLLSLA
CCCCHHHHHHHHCCCHHHHHHHCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
CAKAGMEPTIRMQEGYDHSYYFISTFMAEHVAWHAERLKA
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKLETLSENRSHGGVQGVYSHHSEVIGTEMTFSVYLPPHSEGETLPVLWYLSGLTCTHAN
CCCCCCCCCCCCCCCHHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEEEEECCCEEECCC
VTEKGEFRAACAEHGIAFIAPDTSPRGEDVPDAEEEYDFGKGAGFYVDATEEPWRKHYRM
CCCCCHHHHHHHHCCEEEEECCCCCCCCCCCCCHHHCCCCCCCCEEEECCCCHHHHHHHH
RSYIERELPELVAANFPLEMSRQSITGHSMGGHGALSIGLRNPDHFRSISAFSPIVAPSQ
HHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCC
VPWGEKALGRYLGDDRSSWREYDAVALIEDGTRHDHILVDQGTADDFLEDQLKTSLLSLA
CCCCHHHHHHHHCCCHHHHHHHCEEEEEECCCCCCEEEEECCCHHHHHHHHHHHHHHHHH
CAKAGMEPTIRMQEGYDHSYYFISTFMAEHVAWHAERLKA
HHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]