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The map label for this gene is rsh [H]

Identifier: 85374708

GI number: 85374708

Start: 1923470

End: 1925563

Strand: Reverse

Name: rsh [H]

Synonym: ELI_09405

Alternate gene names: 85374708

Gene position: 1925563-1923470 (Counterclockwise)

Preceding gene: 85374710

Following gene: 85374704

Centisome position: 63.08

GC content: 62.18

Gene sequence:

>2094_bases
ATGCTGCGCCAATATGAATTGATCGAGCGGGTCAAGGAATACGACCCTGATGCCGACGAGGCGCTGCTCAACCGTGCCTA
TGTCTATACCGTCCAGAAGCATGGCAGCCAGAAGCGCGCCAGCGGTGATCCCTATTTCAGCCACCCGGTCGAAGTTGCCG
GCTTGATGACGGACCTCAAGCTGGACCAGGATTCGATCATCACCGCACTGCTCCACGACACCGTGGAAGATACGCTCGCG
ACGATCGAGGATATCGAAGCCAATTTCGGCAAGGATGTCGCGCGGCTTGTCGACGGGGTGACCAAGCTTTCCAAGATCGA
GCAGATGCCGGAGAACGAGCGAGCGGCGGAGAACCTGCGCAAGTTCCTGCTGGCGATGAGCGAAGACATCCGCGTGCTGC
TGGTGAAACTGGGCGACCGGCTGCACAATATGCGCACCCTTCATTTCATCAAGAATCCGGAAAAACGCCAGCGGATCGCG
CGCGAAACGATGGATATCTATGCCCCGCTGGCCGAGCGGATCGGCATGTACGAATATATGCGCGAAATGCAGGCACTCGC
TTTCGAACAGCTCGAGCCGGATGCATTCCAGACCATCACCGGCCGGCTCGAGCAAATCCGCAAGCAGGATGGCGGACAGG
TCGATGCGATTGCGTTGCAGATCAAGCAGGCGCTGGCCGAGGCGGGGCTGCAGGTCGAAGTCTCCGGCCGCGAAAAGCAT
CCCTATTCGATCTGGCGCAAGATGGCCGAGCGCCACGTGAGCTTCGAGCAGGTGACCGATATCTTCGCCTTCCGCATCAT
CACCGAAAGCATCGGCGATTGCTACCGCGCGATGGGTATGCTGCACACGACGTGGCAGTTCATTCCCGGCCGGTTCAAAG
ACTATATCTCGACGCCCAAGAGCAACGGCTATCGCAGCCTGCATACTTCATTGATCTTCGACAATTCGATGCGGGTCGAG
GTACAGATCCGTACCCGTGACATGCATCATCGCAATGAGTTCGGCCTAGCGGCGCACTGGGCCTACAAGCAGAACGACAC
GCCCGACGGCTCGGTCGGCTGGCTGCGCGACCTGATCGAGATCGTCGATGCCAGCCACGACGCCGAGGAGCTGCTCGAAC
ACACGCGTATGGCGATCTACCAGGATCGTATCTTCGCCTTCACGCCCAAAGGCGCGCTGTTCCAACTGCCCAAGGGCGCA
ACGCCGGTCGATTTCGCCTTTGCGGTCCATACGGACCTGGGCGCCCAGACAGTCGGTGCGAAGATCAACGGGCGGCACAT
GCCGCTACGCACGGTGCTCAACAATGGCGACGTGGTGGAGATCATCAAGGGCAGCGAGGCCGAGCCGCAGATGAGCTGGC
TGGGCTTCGTCGTGACCGGCAAGGCGCGGGCCGCGATCCGCCGCGCCGTGCGGCTCAAGGAACGCGCCGAAGTGGCCGAG
CTGGGCGGCAAGCTGTTCGACGAAATTGCCGACCGCGTGCCCGCGAAGATCGGCAAGAAGGCCATTCGCGAAGCGGTCAA
ACGCCTGGAAATGCACGATGCGGAAGAGCTGATGTACGCCATCGGCGCGGCGGAGGTGGAGGATCGCGACGTGATGGAAG
CGCTGGTGCCCGGCTGCACCGCCGACTTCGAAGACGAAGCGCCGGACTGGTCGAAACGGGACAAGGCGATCTCCATCCGC
GGCCTGACCCCCGGCGTAGGCTTCAAGCTCGCCGAGTGTTGCCACCCGGTCCCGGGGGACCGCATCGTCGGCACCCGCAA
GACGGGCGAGGGCGTAGAGGTCCACACGATCGACTGCCTGACGCTCGCCAGCGGCATCGACAGCGACTGGATCGACCTGC
AATGGGGCAAGCGCAGCCACGGTGCGGTGGGGCGCTTGCGGGTGACGCTCTACGATCGCCCCGGCACGCTGGCGGAAATG
GCCGGCATCTTCGCCAAGAACCACGTCAATGTGATGAGTCTGCAGCAGACTGCGCTCGACCATCCTTTTACAAGCTACGA
GATCGACCTTGAGGTGCAGGACCTGGCGCATCTCACCCGGATGCTGAGTGCGCTCAGGGCAAGCGACGCTGTGGCGCATG
CGGAGCGGGGTTAG

Upstream 100 bases:

>100_bases
AAACACTGCGACGATAGCGCCACAATCTGCTTTCGATAGGACCAAAAAGCCGTTTTGCGTTGCAATATCGCGCGATTGAG
CCACATTCGAAGGCGGGAAG

Downstream 100 bases:

>100_bases
AGCAACTCCAGTTCGAGCGTGACAGGGTCGCCCTCGGCAAGATCTTCAGCCCGCATCACTTTCTTGCTGACGAGCAGAAT
CCATTCCGATTGCTTGTCCT

Product: guanosine polyphosphate pyrophosphohydrolase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase [H]

Number of amino acids: Translated: 697; Mature: 697

Protein sequence:

>697_residues
MLRQYELIERVKEYDPDADEALLNRAYVYTVQKHGSQKRASGDPYFSHPVEVAGLMTDLKLDQDSIITALLHDTVEDTLA
TIEDIEANFGKDVARLVDGVTKLSKIEQMPENERAAENLRKFLLAMSEDIRVLLVKLGDRLHNMRTLHFIKNPEKRQRIA
RETMDIYAPLAERIGMYEYMREMQALAFEQLEPDAFQTITGRLEQIRKQDGGQVDAIALQIKQALAEAGLQVEVSGREKH
PYSIWRKMAERHVSFEQVTDIFAFRIITESIGDCYRAMGMLHTTWQFIPGRFKDYISTPKSNGYRSLHTSLIFDNSMRVE
VQIRTRDMHHRNEFGLAAHWAYKQNDTPDGSVGWLRDLIEIVDASHDAEELLEHTRMAIYQDRIFAFTPKGALFQLPKGA
TPVDFAFAVHTDLGAQTVGAKINGRHMPLRTVLNNGDVVEIIKGSEAEPQMSWLGFVVTGKARAAIRRAVRLKERAEVAE
LGGKLFDEIADRVPAKIGKKAIREAVKRLEMHDAEELMYAIGAAEVEDRDVMEALVPGCTADFEDEAPDWSKRDKAISIR
GLTPGVGFKLAECCHPVPGDRIVGTRKTGEGVEVHTIDCLTLASGIDSDWIDLQWGKRSHGAVGRLRVTLYDRPGTLAEM
AGIFAKNHVNVMSLQQTALDHPFTSYEIDLEVQDLAHLTRMLSALRASDAVAHAERG

Sequences:

>Translated_697_residues
MLRQYELIERVKEYDPDADEALLNRAYVYTVQKHGSQKRASGDPYFSHPVEVAGLMTDLKLDQDSIITALLHDTVEDTLA
TIEDIEANFGKDVARLVDGVTKLSKIEQMPENERAAENLRKFLLAMSEDIRVLLVKLGDRLHNMRTLHFIKNPEKRQRIA
RETMDIYAPLAERIGMYEYMREMQALAFEQLEPDAFQTITGRLEQIRKQDGGQVDAIALQIKQALAEAGLQVEVSGREKH
PYSIWRKMAERHVSFEQVTDIFAFRIITESIGDCYRAMGMLHTTWQFIPGRFKDYISTPKSNGYRSLHTSLIFDNSMRVE
VQIRTRDMHHRNEFGLAAHWAYKQNDTPDGSVGWLRDLIEIVDASHDAEELLEHTRMAIYQDRIFAFTPKGALFQLPKGA
TPVDFAFAVHTDLGAQTVGAKINGRHMPLRTVLNNGDVVEIIKGSEAEPQMSWLGFVVTGKARAAIRRAVRLKERAEVAE
LGGKLFDEIADRVPAKIGKKAIREAVKRLEMHDAEELMYAIGAAEVEDRDVMEALVPGCTADFEDEAPDWSKRDKAISIR
GLTPGVGFKLAECCHPVPGDRIVGTRKTGEGVEVHTIDCLTLASGIDSDWIDLQWGKRSHGAVGRLRVTLYDRPGTLAEM
AGIFAKNHVNVMSLQQTALDHPFTSYEIDLEVQDLAHLTRMLSALRASDAVAHAERG
>Mature_697_residues
MLRQYELIERVKEYDPDADEALLNRAYVYTVQKHGSQKRASGDPYFSHPVEVAGLMTDLKLDQDSIITALLHDTVEDTLA
TIEDIEANFGKDVARLVDGVTKLSKIEQMPENERAAENLRKFLLAMSEDIRVLLVKLGDRLHNMRTLHFIKNPEKRQRIA
RETMDIYAPLAERIGMYEYMREMQALAFEQLEPDAFQTITGRLEQIRKQDGGQVDAIALQIKQALAEAGLQVEVSGREKH
PYSIWRKMAERHVSFEQVTDIFAFRIITESIGDCYRAMGMLHTTWQFIPGRFKDYISTPKSNGYRSLHTSLIFDNSMRVE
VQIRTRDMHHRNEFGLAAHWAYKQNDTPDGSVGWLRDLIEIVDASHDAEELLEHTRMAIYQDRIFAFTPKGALFQLPKGA
TPVDFAFAVHTDLGAQTVGAKINGRHMPLRTVLNNGDVVEIIKGSEAEPQMSWLGFVVTGKARAAIRRAVRLKERAEVAE
LGGKLFDEIADRVPAKIGKKAIREAVKRLEMHDAEELMYAIGAAEVEDRDVMEALVPGCTADFEDEAPDWSKRDKAISIR
GLTPGVGFKLAECCHPVPGDRIVGTRKTGEGVEVHTIDCLTLASGIDSDWIDLQWGKRSHGAVGRLRVTLYDRPGTLAEM
AGIFAKNHVNVMSLQQTALDHPFTSYEIDLEVQDLAHLTRMLSALRASDAVAHAERG

Specific function: Functions as a (p)ppGpp synthase. In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. Plays a role in ada

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Homo sapiens, GI38348360, Length=145, Percent_Identity=34.4827586206897, Blast_Score=70, Evalue=1e-11,
Organism=Escherichia coli, GI1790082, Length=702, Percent_Identity=36.8945868945869, Blast_Score=480, Evalue=1e-136,
Organism=Escherichia coli, GI1789147, Length=741, Percent_Identity=30.3643724696356, Blast_Score=367, Evalue=1e-102,
Organism=Drosophila melanogaster, GI24650996, Length=124, Percent_Identity=35.4838709677419, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 78468; Mature: 78468

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRQYELIERVKEYDPDADEALLNRAYVYTVQKHGSQKRASGDPYFSHPVEVAGLMTDLK
CCCHHHHHHHHHHCCCCHHHHHHHHHHEEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHCC
LDQDSIITALLHDTVEDTLATIEDIEANFGKDVARLVDGVTKLSKIEQMPENERAAENLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KFLLAMSEDIRVLLVKLGDRLHNMRTLHFIKNPEKRQRIARETMDIYAPLAERIGMYEYM
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REMQALAFEQLEPDAFQTITGRLEQIRKQDGGQVDAIALQIKQALAEAGLQVEVSGREKH
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCC
PYSIWRKMAERHVSFEQVTDIFAFRIITESIGDCYRAMGMLHTTWQFIPGRFKDYISTPK
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
SNGYRSLHTSLIFDNSMRVEVQIRTRDMHHRNEFGLAAHWAYKQNDTPDGSVGWLRDLIE
CCCCHHHHHHEEECCCEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
IVDASHDAEELLEHTRMAIYQDRIFAFTPKGALFQLPKGATPVDFAFAVHTDLGAQTVGA
HHCCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCEEEEEEECCCCCHHHCC
KINGRHMPLRTVLNNGDVVEIIKGSEAEPQMSWLGFVVTGKARAAIRRAVRLKERAEVAE
EECCCCCCHHHHHCCCCEEEEECCCCCCCCHHHEEEEEECHHHHHHHHHHHHHHHHHHHH
LGGKLFDEIADRVPAKIGKKAIREAVKRLEMHDAEELMYAIGAAEVEDRDVMEALVPGCT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCC
ADFEDEAPDWSKRDKAISIRGLTPGVGFKLAECCHPVPGDRIVGTRKTGEGVEVHTIDCL
CCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCEEECCCCCCCCEEEEEHHH
TLASGIDSDWIDLQWGKRSHGAVGRLRVTLYDRPGTLAEMAGIFAKNHVNVMSLQQTALD
HHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHC
HPFTSYEIDLEVQDLAHLTRMLSALRASDAVAHAERG
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MLRQYELIERVKEYDPDADEALLNRAYVYTVQKHGSQKRASGDPYFSHPVEVAGLMTDLK
CCCHHHHHHHHHHCCCCHHHHHHHHHHEEEEHHCCCCCCCCCCCCCCCCHHHHHHHHHCC
LDQDSIITALLHDTVEDTLATIEDIEANFGKDVARLVDGVTKLSKIEQMPENERAAENLR
CCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
KFLLAMSEDIRVLLVKLGDRLHNMRTLHFIKNPEKRQRIARETMDIYAPLAERIGMYEYM
HHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
REMQALAFEQLEPDAFQTITGRLEQIRKQDGGQVDAIALQIKQALAEAGLQVEVSGREKH
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCEEEECCCCCC
PYSIWRKMAERHVSFEQVTDIFAFRIITESIGDCYRAMGMLHTTWQFIPGRFKDYISTPK
CHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCC
SNGYRSLHTSLIFDNSMRVEVQIRTRDMHHRNEFGLAAHWAYKQNDTPDGSVGWLRDLIE
CCCCHHHHHHEEECCCEEEEEEEEECCCCCCCCCCCEEEEEECCCCCCCCCHHHHHHHHH
IVDASHDAEELLEHTRMAIYQDRIFAFTPKGALFQLPKGATPVDFAFAVHTDLGAQTVGA
HHCCCCCHHHHHHHHHHHHHHCCEEEECCCCCEEECCCCCCCCEEEEEEECCCCCHHHCC
KINGRHMPLRTVLNNGDVVEIIKGSEAEPQMSWLGFVVTGKARAAIRRAVRLKERAEVAE
EECCCCCCHHHHHCCCCEEEEECCCCCCCCHHHEEEEEECHHHHHHHHHHHHHHHHHHHH
LGGKLFDEIADRVPAKIGKKAIREAVKRLEMHDAEELMYAIGAAEVEDRDVMEALVPGCT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHCCCCC
ADFEDEAPDWSKRDKAISIRGLTPGVGFKLAECCHPVPGDRIVGTRKTGEGVEVHTIDCL
CCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHCCCCCCCCEEECCCCCCCCEEEEEHHH
TLASGIDSDWIDLQWGKRSHGAVGRLRVTLYDRPGTLAEMAGIFAKNHVNVMSLQQTALD
HHHCCCCCCCEEEECCCCCCCCCEEEEEEEECCCCHHHHHHHHHHHCCCHHHHHHHHHHC
HPFTSYEIDLEVQDLAHLTRMLSALRASDAVAHAERG
CCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA