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The map label for this gene is leuS [H]

Identifier: 85374704

GI number: 85374704

Start: 1918718

End: 1921228

Strand: Reverse

Name: leuS [H]

Synonym: ELI_09385

Alternate gene names: 85374704

Gene position: 1921228-1918718 (Counterclockwise)

Preceding gene: 85374708

Following gene: 85374680

Centisome position: 62.94

GC content: 63.92

Gene sequence:

>2511_bases
ATGTCCGAAACGCCAGAGACCCAATCCAGCGGCACCTTGCTGGACCAGCCCTTCCGCGAGAATTTCGACGCCATCGAGGC
CTATGCCCGCGACGTGTGGGCGGCGGAAAATGTCGACGCATGCGATCTCGATAGCGACAAGCCCAAGCGCTACGTGCTCG
GCATGTTCCCTTACCCCTCGGGCAATGCCCATATGGGTCACGTGCGGGTCTATGCGATTTCGGACGCTGTCGCGCGGCTC
TCGCGCTTTCGCGGGTTCGAGACATTGCACCCGCTGGGCTGGGATGCGTTCGGACTTCCGGCAGAGAATGCCGCGATCCA
GAACAATGCCGATCCCGCCGAGTGGACGCAGCGCAATATCGCGACGATGAAAGACGAGCAGTTCTCGCGGCTCGGCCTGT
CGTTCGACCTCGACCAGGAAATCAATTCCGCCTCGCCCGAGTTCTACAAGTGGACGCAGTGGCTGTTTCAGACGCTCTAC
GACCACGATCTGGTCTATCGCGCCAATGGCTGGGTCAACTGGGACCCCGTCGACCAGACCGTGCTCGCCAACGAACAGGT
GATCGACGGCAAGGGCTGGCGCTCCGGCGCGCCGGTCGAGCGGCGGCAGCTGCCGCAATGGTATGTCCGTATCACCAGGT
TCGCGCAGTCGCTGTGGGACGGGCTCGATACGTTGCAGGGGCATTGGTCCGATGAAGCGATCGCGGTCCAGCGCGGCTGG
ATCGGGCGCAGCGAAGGCGTCGAGATCGAATTCCCCGTGCTGGGCGAGGGCGGTCACACGATCAGGTGCTACACCACCCG
CGCCGACACGATTTTCGGCGTGACCTCGATCACGCTCGCGCCCGAACATCCGCTGGTGAAGGACCTCGCCGCGACCGAGG
TGCAGGGGAAGGTCGAGGAATACATCGCCTTCGCCACCAACCGCAGCGAGTTGGAGCGAGAAACGGCGGAGCGGACCGGC
GTTGCGTTGGGCGCCAAGGCGCGCAACCCGCTGACCGGCGAAGACTTGCCGATCTACATCAGCGAATACGTACTGGGCGG
CTATGGCACCGGCGCGATCATGAACGTGCCCGCACACGACGCGCGTGATTTCGATTTCGCCCGGACCAACGGCCTGCCGA
TCCGGCAGGTGATCCTGCCCGCGAAGGATGCGCCGGAAGGCGATCTGGACGAGGCTTATACCGACCCCGGCTTCATGACG
AATTCCGGCCAGTTCGACGGCATGTCGACGCATGAAGCCAAGCACGCAATCATCGATCACCTGGTCGAGCAGGGCCTCGG
CACGCGCAAGGTCAATTTCCGCCTGCGCGACTGGCTGATCTCGCGCCAGCGCTTCTGGGGTGCGCCGATCCCGATGGTGC
ATTCGGACGAACACGGTTGGGCCAAGGCGCCCGACCTGCCGGTCATGCTGCCGAAAGACGTCGATTTCAGCCAGGGCTCA
GGCAAGGCCATGGCGAGCGCGCCGGGCTTCCTCGAAACGACCTTTCCGGGCACGAGCGATCCGGCGATCCGCGAAACCGA
CACGATGGACACTTTCATGTGCTCGTCGTGGTATGCCTGGCGCTATCTCGACGCGAAGAACGGCGAGCAGGCCTTCCGCG
AGAGCCGCGCCGAGGACTGGATGCCGATCGACTATTATGTCGGCGGGCTGGAGCATGCCTCGCAACACCTCATCTACTTC
CGCTTCATCAGCCATTTCCTGCATGCGATCGGGATGACCCCGACGTCGGAGCCGGTGAAGAACTTCCTCGACAACGGACT
GGTCAAGCTCGGCGGCGAGAAGATGTCCAAGTCCAAGGGGAATGTCGTGATCCCGACCGAAGCGGTCGACAAATACGGCG
CCGATGCACTGCGGCTCTATATCCTCGCCGATACGCCACTGCGGCGCGATATCGACTGGGACGACAGCGGGATTGAAGGC
AAGCAGCGCTTCCTCAGCCAGATCTGGACGCTGGCGGGCCAGATCGCCTCTGCGCCCGCGCTGGAGGGCGAGCCTGCGCC
GGGAACAGACGCCGAAAAGGCTGCGATGCGCGAGTTGGCGAAGATCGCGAAGGAAGTGGCGGAGGATCTCGAGGAACGCC
GCGGTTTCCACAACGCCATCGCCCGCCTGCACAGCTTCGTGGGCGAGCTGCGCCCGCTGGTGGCCGGTGCGAGCGATGCC
GAAAAGCCGCTGCTGCGCCATGTCATGGCCGAGTTCATGAAGGTGCTGGGAGTATTCGCCCCGCACATGGCCGAATACCT
CTGGCGCGAGGCCTTCGGCATGAGCGCCAGCCTGTTCAGCCAGCCATGGCCCGATCCGGGCGAGCAATACCTCGTAGCGG
ACGAGCTGACGATCTCGATCCAGGTCAACGGTAAGCTGCGTGCGACCGTATCCGTGCCCGCCGATGCAGGCGAGGAGCAG
GTCGTCGAAATCGCCAAGGCGGATGCGAAAGTGGCGGAGTATCTGGGCAGCGGCACCCTGCGGCGGACGATCTTCGTACC
CGGGCGGTTGGTGAATTTCGTGGTGGGGTAA

Upstream 100 bases:

>100_bases
TGTTGCTCCGCCGGTCGCTTGGGATTAGTGCGTGTCGCGTGCGGGCGGCTTCTCTTGCAGGGCCGCCTTTGTCGTTCATC
CCAGCAGACCAGATCGCCTC

Downstream 100 bases:

>100_bases
AAGAGGCTTTTGCCTGATTTCGTTTCAAATCGAAGGATTATTGAAAGGCGTTCAGTCGGTGTTGAAATTCGGAAAAATCG
CGATCGGGAAAATTCTCTGC

Product: leucyl-tRNA synthetase

Products: NA

Alternate protein names: Leucine--tRNA ligase; LeuRS [H]

Number of amino acids: Translated: 836; Mature: 835

Protein sequence:

>836_residues
MSETPETQSSGTLLDQPFRENFDAIEAYARDVWAAENVDACDLDSDKPKRYVLGMFPYPSGNAHMGHVRVYAISDAVARL
SRFRGFETLHPLGWDAFGLPAENAAIQNNADPAEWTQRNIATMKDEQFSRLGLSFDLDQEINSASPEFYKWTQWLFQTLY
DHDLVYRANGWVNWDPVDQTVLANEQVIDGKGWRSGAPVERRQLPQWYVRITRFAQSLWDGLDTLQGHWSDEAIAVQRGW
IGRSEGVEIEFPVLGEGGHTIRCYTTRADTIFGVTSITLAPEHPLVKDLAATEVQGKVEEYIAFATNRSELERETAERTG
VALGAKARNPLTGEDLPIYISEYVLGGYGTGAIMNVPAHDARDFDFARTNGLPIRQVILPAKDAPEGDLDEAYTDPGFMT
NSGQFDGMSTHEAKHAIIDHLVEQGLGTRKVNFRLRDWLISRQRFWGAPIPMVHSDEHGWAKAPDLPVMLPKDVDFSQGS
GKAMASAPGFLETTFPGTSDPAIRETDTMDTFMCSSWYAWRYLDAKNGEQAFRESRAEDWMPIDYYVGGLEHASQHLIYF
RFISHFLHAIGMTPTSEPVKNFLDNGLVKLGGEKMSKSKGNVVIPTEAVDKYGADALRLYILADTPLRRDIDWDDSGIEG
KQRFLSQIWTLAGQIASAPALEGEPAPGTDAEKAAMRELAKIAKEVAEDLEERRGFHNAIARLHSFVGELRPLVAGASDA
EKPLLRHVMAEFMKVLGVFAPHMAEYLWREAFGMSASLFSQPWPDPGEQYLVADELTISIQVNGKLRATVSVPADAGEEQ
VVEIAKADAKVAEYLGSGTLRRTIFVPGRLVNFVVG

Sequences:

>Translated_836_residues
MSETPETQSSGTLLDQPFRENFDAIEAYARDVWAAENVDACDLDSDKPKRYVLGMFPYPSGNAHMGHVRVYAISDAVARL
SRFRGFETLHPLGWDAFGLPAENAAIQNNADPAEWTQRNIATMKDEQFSRLGLSFDLDQEINSASPEFYKWTQWLFQTLY
DHDLVYRANGWVNWDPVDQTVLANEQVIDGKGWRSGAPVERRQLPQWYVRITRFAQSLWDGLDTLQGHWSDEAIAVQRGW
IGRSEGVEIEFPVLGEGGHTIRCYTTRADTIFGVTSITLAPEHPLVKDLAATEVQGKVEEYIAFATNRSELERETAERTG
VALGAKARNPLTGEDLPIYISEYVLGGYGTGAIMNVPAHDARDFDFARTNGLPIRQVILPAKDAPEGDLDEAYTDPGFMT
NSGQFDGMSTHEAKHAIIDHLVEQGLGTRKVNFRLRDWLISRQRFWGAPIPMVHSDEHGWAKAPDLPVMLPKDVDFSQGS
GKAMASAPGFLETTFPGTSDPAIRETDTMDTFMCSSWYAWRYLDAKNGEQAFRESRAEDWMPIDYYVGGLEHASQHLIYF
RFISHFLHAIGMTPTSEPVKNFLDNGLVKLGGEKMSKSKGNVVIPTEAVDKYGADALRLYILADTPLRRDIDWDDSGIEG
KQRFLSQIWTLAGQIASAPALEGEPAPGTDAEKAAMRELAKIAKEVAEDLEERRGFHNAIARLHSFVGELRPLVAGASDA
EKPLLRHVMAEFMKVLGVFAPHMAEYLWREAFGMSASLFSQPWPDPGEQYLVADELTISIQVNGKLRATVSVPADAGEEQ
VVEIAKADAKVAEYLGSGTLRRTIFVPGRLVNFVVG
>Mature_835_residues
SETPETQSSGTLLDQPFRENFDAIEAYARDVWAAENVDACDLDSDKPKRYVLGMFPYPSGNAHMGHVRVYAISDAVARLS
RFRGFETLHPLGWDAFGLPAENAAIQNNADPAEWTQRNIATMKDEQFSRLGLSFDLDQEINSASPEFYKWTQWLFQTLYD
HDLVYRANGWVNWDPVDQTVLANEQVIDGKGWRSGAPVERRQLPQWYVRITRFAQSLWDGLDTLQGHWSDEAIAVQRGWI
GRSEGVEIEFPVLGEGGHTIRCYTTRADTIFGVTSITLAPEHPLVKDLAATEVQGKVEEYIAFATNRSELERETAERTGV
ALGAKARNPLTGEDLPIYISEYVLGGYGTGAIMNVPAHDARDFDFARTNGLPIRQVILPAKDAPEGDLDEAYTDPGFMTN
SGQFDGMSTHEAKHAIIDHLVEQGLGTRKVNFRLRDWLISRQRFWGAPIPMVHSDEHGWAKAPDLPVMLPKDVDFSQGSG
KAMASAPGFLETTFPGTSDPAIRETDTMDTFMCSSWYAWRYLDAKNGEQAFRESRAEDWMPIDYYVGGLEHASQHLIYFR
FISHFLHAIGMTPTSEPVKNFLDNGLVKLGGEKMSKSKGNVVIPTEAVDKYGADALRLYILADTPLRRDIDWDDSGIEGK
QRFLSQIWTLAGQIASAPALEGEPAPGTDAEKAAMRELAKIAKEVAEDLEERRGFHNAIARLHSFVGELRPLVAGASDAE
KPLLRHVMAEFMKVLGVFAPHMAEYLWREAFGMSASLFSQPWPDPGEQYLVADELTISIQVNGKLRATVSVPADAGEEQV
VEIAKADAKVAEYLGSGTLRRTIFVPGRLVNFVVG

Specific function: Unknown

COG id: COG0495

COG function: function code J; Leucyl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I aminoacyl-tRNA synthetase family [H]

Homologues:

Organism=Homo sapiens, GI7661872, Length=854, Percent_Identity=33.9578454332553, Blast_Score=464, Evalue=1e-130,
Organism=Escherichia coli, GI1786861, Length=866, Percent_Identity=41.4549653579677, Blast_Score=642, Evalue=0.0,
Organism=Caenorhabditis elegans, GI71997510, Length=801, Percent_Identity=30.3370786516854, Blast_Score=356, Evalue=4e-98,
Organism=Caenorhabditis elegans, GI71997517, Length=781, Percent_Identity=30.4737516005122, Blast_Score=354, Evalue=9e-98,
Organism=Caenorhabditis elegans, GI212645227, Length=304, Percent_Identity=29.2763157894737, Blast_Score=124, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17554638, Length=274, Percent_Identity=28.4671532846715, Blast_Score=69, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17541896, Length=198, Percent_Identity=29.2929292929293, Blast_Score=66, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6323414, Length=724, Percent_Identity=37.8453038674033, Blast_Score=473, Evalue=1e-134,
Organism=Drosophila melanogaster, GI21355409, Length=883, Percent_Identity=33.5220838052095, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: 800 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001412
- InterPro:   IPR002300
- InterPro:   IPR002302
- InterPro:   IPR014729
- InterPro:   IPR009080
- InterPro:   IPR013155
- InterPro:   IPR009008 [H]

Pfam domain/function: PF08264 Anticodon_1; PF00133 tRNA-synt_1 [H]

EC number: =6.1.1.4 [H]

Molecular weight: Translated: 93042; Mature: 92911

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSETPETQSSGTLLDQPFRENFDAIEAYARDVWAAENVDACDLDSDKPKRYVLGMFPYPS
CCCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCC
GNAHMGHVRVYAISDAVARLSRFRGFETLHPLGWDAFGLPAENAAIQNNADPAEWTQRNI
CCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ATMKDEQFSRLGLSFDLDQEINSASPEFYKWTQWLFQTLYDHDLVYRANGWVNWDPVDQT
HHHCHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCH
VLANEQVIDGKGWRSGAPVERRQLPQWYVRITRFAQSLWDGLDTLQGHWSDEAIAVQRGW
HHCCCEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
IGRSEGVEIEFPVLGEGGHTIRCYTTRADTIFGVTSITLAPEHPLVKDLAATEVQGKVEE
CCCCCCCEEEEEEECCCCCEEEEEEECCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHH
YIAFATNRSELERETAERTGVALGAKARNPLTGEDLPIYISEYVLGGYGTGAIMNVPAHD
HHHHHCCHHHHHHHHHHHHCEEECCCCCCCCCCCCCCEEEEHHHHCCCCCCCEEECCCCC
ARDFDFARTNGLPIRQVILPAKDAPEGDLDEAYTDPGFMTNSGQFDGMSTHEAKHAIIDH
CCCCCCHHCCCCCHHHEEECCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LVEQGLGTRKVNFRLRDWLISRQRFWGAPIPMVHSDEHGWAKAPDLPVMLPKDVDFSQGS
HHHCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCEECCCCCCCCCCC
GKAMASAPGFLETTFPGTSDPAIRETDTMDTFMCSSWYAWRYLDAKNGEQAFRESRAEDW
CCEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCC
MPIDYYVGGLEHASQHLIYFRFISHFLHAIGMTPTSEPVKNFLDNGLVKLGGEKMSKSKG
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCHHHHCCCC
NVVIPTEAVDKYGADALRLYILADTPLRRDIDWDDSGIEGKQRFLSQIWTLAGQIASAPA
CEEEEHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
LEGEPAPGTDAEKAAMRELAKIAKEVAEDLEERRGFHNAIARLHSFVGELRPLVAGASDA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCH
EKPLLRHVMAEFMKVLGVFAPHMAEYLWREAFGMSASLFSQPWPDPGEQYLVADELTISI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEEEEEEEEE
QVNGKLRATVSVPADAGEEQVVEIAKADAKVAEYLGSGTLRRTIFVPGRLVNFVVG
EECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCC
>Mature Secondary Structure 
SETPETQSSGTLLDQPFRENFDAIEAYARDVWAAENVDACDLDSDKPKRYVLGMFPYPS
CCCCCCCCCCCCCCCHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEECCCCC
GNAHMGHVRVYAISDAVARLSRFRGFETLHPLGWDAFGLPAENAAIQNNADPAEWTQRNI
CCCCCCEEEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
ATMKDEQFSRLGLSFDLDQEINSASPEFYKWTQWLFQTLYDHDLVYRANGWVNWDPVDQT
HHHCHHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCEECCCCCCCH
VLANEQVIDGKGWRSGAPVERRQLPQWYVRITRFAQSLWDGLDTLQGHWSDEAIAVQRGW
HHCCCEEECCCCCCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCC
IGRSEGVEIEFPVLGEGGHTIRCYTTRADTIFGVTSITLAPEHPLVKDLAATEVQGKVEE
CCCCCCCEEEEEEECCCCCEEEEEEECCCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHH
YIAFATNRSELERETAERTGVALGAKARNPLTGEDLPIYISEYVLGGYGTGAIMNVPAHD
HHHHHCCHHHHHHHHHHHHCEEECCCCCCCCCCCCCCEEEEHHHHCCCCCCCEEECCCCC
ARDFDFARTNGLPIRQVILPAKDAPEGDLDEAYTDPGFMTNSGQFDGMSTHEAKHAIIDH
CCCCCCHHCCCCCHHHEEECCCCCCCCCCHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHH
LVEQGLGTRKVNFRLRDWLISRQRFWGAPIPMVHSDEHGWAKAPDLPVMLPKDVDFSQGS
HHHCCCCCEEEEHHHHHHHHHHHHHCCCCCCCEECCCCCCCCCCCCCEECCCCCCCCCCC
GKAMASAPGFLETTFPGTSDPAIRETDTMDTFMCSSWYAWRYLDAKNGEQAFRESRAEDW
CCEEECCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCEEEEEECCCHHHHHHHHHCCCC
MPIDYYVGGLEHASQHLIYFRFISHFLHAIGMTPTSEPVKNFLDNGLVKLGGEKMSKSKG
CCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCEEECCHHHHCCCC
NVVIPTEAVDKYGADALRLYILADTPLRRDIDWDDSGIEGKQRFLSQIWTLAGQIASAPA
CEEEEHHHHHHCCCCEEEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCC
LEGEPAPGTDAEKAAMRELAKIAKEVAEDLEERRGFHNAIARLHSFVGELRPLVAGASDA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCH
EKPLLRHVMAEFMKVLGVFAPHMAEYLWREAFGMSASLFSQPWPDPGEQYLVADELTISI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCEEEEEEEEEEE
QVNGKLRATVSVPADAGEEQVVEIAKADAKVAEYLGSGTLRRTIFVPGRLVNFVVG
EECCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA