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The map label for this gene is typA [H]

Identifier: 85374631

GI number: 85374631

Start: 1835530

End: 1837365

Strand: Direct

Name: typA [H]

Synonym: ELI_09020

Alternate gene names: 85374631

Gene position: 1835530-1837365 (Clockwise)

Preceding gene: 85374628

Following gene: 85374634

Centisome position: 60.13

GC content: 64.32

Gene sequence:

>1836_bases
ATGTCCGCAGACCTTCGCAACGTGGCGATCATCGCCCACGTCGACCACGGCAAGACCACGCTTGTCGACCAGCTGTTCCG
CCAGTCCGGCACTTTCCGCGACAACCAGCGCGTGGAAGAACGCGCGATGGATTCCGGCGACCTGGAAAAAGAGCGCGGGA
TCACCATCCTCGCCAAATGCACGAGCGTCGAATGGGAGCACGAGGGTAAGACCACGCGAATCAACATCGTCGACACACCG
GGTCACGCCGATTTCGGCGCCGAGGTCGAGCGTATCCTCAGCATGGTCGACGGCGTCATCCTGCTGGTCGACAGCGCGGA
AGGCGCGATGCCGCAGACCAAGTTCGTCACCGGCAAGGCACTCGCGCTCGGCCTGCGTCCCATCGTCGTCGTCAATAAAA
TCGACCGCCCCGATGGCCGCCCGCAGGAAGTGCTCGACGAGGTGTTCGACCTTTTCGCAAGCCTCGATGCCAATGACGAC
CAGCTCGACTTCCCCTCGCTCTTCGCCTCGGGCCGCGATGGTTATGCCAGCGACGACGAAAGCGCGCGCGATGGGTCGCT
CGATCCCCTGTTCAAGCTGATCGTCGACCACGTCCCGCCCCCAGGCCTTGACACCTCGGGCAAGTTCAGCTTCCTCGCCA
CGCTGCTCGACCGCGACAACTTCATGGGCCGCGTGCTCACCGGCCGCGTCCAGTCGGGCACGGTCAGGATCAACGACCCG
ATCCATGCCATCGACAGCGATGGCAAGGTCGTAGAAACCGGCCGCGCGACCAAGTTGATGAGTTTCGACGGGCTCGAGCG
GGTCCCGGTCGAGAGCGCGCAGGCAGGTGACATCATCGCGCTGGCGGGTCTCGAAAAGGCCACCGTTGCCAACACCATCG
CCGACCCCTCCGTGACCGAGCCGATCGAAGCGCAGCCGATCGATCCGCCCACGCTCGCCATGCGCTTTGCCGTCAACGAC
AGCCCGCTGGCAGGCCGCGAGGGCGACAAGGTGACCAGCCGCATGATCCGCGACCGCCTGCTGCGCGAAGCGGAAACCAA
TGTCGCCATCCGCATCACAGAAAGCGCCGACAAGGACAGTTTCGAAGTCGCCGGGCGCGGCGAATTGCAGCTTGGCGTCC
TGATCGAAACCATGCGCCGCGAAGGCTTCGAACTCGGCATCAGCCGCCCGCGCGTGCTGTTCCGCGAGGGCGAGAGTGGC
CGCGAGGAACCGTACGAAACCGTCGTCATCGACGTGGACGACGAGCACTCCGGCACGGTCGTCGAGAAGATGCAGCGCCG
CAAGGCCGAGCTGGTCGAAATGCGCCCCAGCGGTCAGGGCAAGACCCGCATCACCTTCTCCGCCCCCAGCCGCGGCCTGA
TCGGCTATCACGGCGAATTCCTCTCCGACACGCGCGGCACCGGGATCATGAACCGCCTGTTCGAGAAATACGGCCCCTAC
AAGGGCAAGATCGAAGGCCGCCAGAACGGCGTGCTGATCTCCATGGTCGCCGGCGAAGCGGCGGCCTATGCCCTCAACAT
GCTGGAAGAACGCGGCGAACTGTTTATCGGCGCCAATGCCAAGATCTACGAAGGCATGGTGATCGGCGAGAACGCCAAGC
CCGACGACTTGGAAGTCAACCCGATGAAGTCCAAGCAGCTGACCAACTTCCGCAGCACCGGCAAGGACGACGCCATCCGC
CTCACCCCGCCCCGCGTGATGACGCTGGAACAGGCGATCGCCTATATCGACGACGATGAAATGGTCGAGGTAACGCCGCA
GAGCATCCGGCTGCGGAAAGCGATCCTGGACCCGCACGAGCGGAAACGGGCGAAGCGGGCGGCGGAAGTCGTTTGA

Upstream 100 bases:

>100_bases
CAGCGTGGACACAGTTGCCGTTTGCGCCCACTCCGGCTAGAGGCGCGCGCAACCGATGTTGCGGCGCACAAGGCGCCCGC
CCCCGACCCAAGAGAAAATC

Downstream 100 bases:

>100_bases
TGCTTCTTTGAAATATTGTCGCGCTATGTTTAAGTGATTCGGCTTGGCATCCAACCGGATCGGTTTACTTCCTCTGAAGG
GACGCGACTTAAAGACAGGG

Product: membrane GTPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 611; Mature: 610

Protein sequence:

>611_residues
MSADLRNVAIIAHVDHGKTTLVDQLFRQSGTFRDNQRVEERAMDSGDLEKERGITILAKCTSVEWEHEGKTTRINIVDTP
GHADFGAEVERILSMVDGVILLVDSAEGAMPQTKFVTGKALALGLRPIVVVNKIDRPDGRPQEVLDEVFDLFASLDANDD
QLDFPSLFASGRDGYASDDESARDGSLDPLFKLIVDHVPPPGLDTSGKFSFLATLLDRDNFMGRVLTGRVQSGTVRINDP
IHAIDSDGKVVETGRATKLMSFDGLERVPVESAQAGDIIALAGLEKATVANTIADPSVTEPIEAQPIDPPTLAMRFAVND
SPLAGREGDKVTSRMIRDRLLREAETNVAIRITESADKDSFEVAGRGELQLGVLIETMRREGFELGISRPRVLFREGESG
REEPYETVVIDVDDEHSGTVVEKMQRRKAELVEMRPSGQGKTRITFSAPSRGLIGYHGEFLSDTRGTGIMNRLFEKYGPY
KGKIEGRQNGVLISMVAGEAAAYALNMLEERGELFIGANAKIYEGMVIGENAKPDDLEVNPMKSKQLTNFRSTGKDDAIR
LTPPRVMTLEQAIAYIDDDEMVEVTPQSIRLRKAILDPHERKRAKRAAEVV

Sequences:

>Translated_611_residues
MSADLRNVAIIAHVDHGKTTLVDQLFRQSGTFRDNQRVEERAMDSGDLEKERGITILAKCTSVEWEHEGKTTRINIVDTP
GHADFGAEVERILSMVDGVILLVDSAEGAMPQTKFVTGKALALGLRPIVVVNKIDRPDGRPQEVLDEVFDLFASLDANDD
QLDFPSLFASGRDGYASDDESARDGSLDPLFKLIVDHVPPPGLDTSGKFSFLATLLDRDNFMGRVLTGRVQSGTVRINDP
IHAIDSDGKVVETGRATKLMSFDGLERVPVESAQAGDIIALAGLEKATVANTIADPSVTEPIEAQPIDPPTLAMRFAVND
SPLAGREGDKVTSRMIRDRLLREAETNVAIRITESADKDSFEVAGRGELQLGVLIETMRREGFELGISRPRVLFREGESG
REEPYETVVIDVDDEHSGTVVEKMQRRKAELVEMRPSGQGKTRITFSAPSRGLIGYHGEFLSDTRGTGIMNRLFEKYGPY
KGKIEGRQNGVLISMVAGEAAAYALNMLEERGELFIGANAKIYEGMVIGENAKPDDLEVNPMKSKQLTNFRSTGKDDAIR
LTPPRVMTLEQAIAYIDDDEMVEVTPQSIRLRKAILDPHERKRAKRAAEVV
>Mature_610_residues
SADLRNVAIIAHVDHGKTTLVDQLFRQSGTFRDNQRVEERAMDSGDLEKERGITILAKCTSVEWEHEGKTTRINIVDTPG
HADFGAEVERILSMVDGVILLVDSAEGAMPQTKFVTGKALALGLRPIVVVNKIDRPDGRPQEVLDEVFDLFASLDANDDQ
LDFPSLFASGRDGYASDDESARDGSLDPLFKLIVDHVPPPGLDTSGKFSFLATLLDRDNFMGRVLTGRVQSGTVRINDPI
HAIDSDGKVVETGRATKLMSFDGLERVPVESAQAGDIIALAGLEKATVANTIADPSVTEPIEAQPIDPPTLAMRFAVNDS
PLAGREGDKVTSRMIRDRLLREAETNVAIRITESADKDSFEVAGRGELQLGVLIETMRREGFELGISRPRVLFREGESGR
EEPYETVVIDVDDEHSGTVVEKMQRRKAELVEMRPSGQGKTRITFSAPSRGLIGYHGEFLSDTRGTGIMNRLFEKYGPYK
GKIEGRQNGVLISMVAGEAAAYALNMLEERGELFIGANAKIYEGMVIGENAKPDDLEVNPMKSKQLTNFRSTGKDDAIRL
TPPRVMTLEQAIAYIDDDEMVEVTPQSIRLRKAILDPHERKRAKRAAEVV

Specific function: Not known; probably interacts with the ribosomes in a GTP dependent manner [H]

COG id: COG1217

COG function: function code T; Predicted membrane GTPase involved in stress response

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding elongation factor family. TypA subfamily [H]

Homologues:

Organism=Homo sapiens, GI157426893, Length=312, Percent_Identity=30.7692307692308, Blast_Score=125, Evalue=9e-29,
Organism=Homo sapiens, GI94966754, Length=160, Percent_Identity=37.5, Blast_Score=120, Evalue=4e-27,
Organism=Homo sapiens, GI4503483, Length=146, Percent_Identity=36.986301369863, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI18390331, Length=149, Percent_Identity=36.241610738255, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI310132016, Length=113, Percent_Identity=38.0530973451327, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310110807, Length=113, Percent_Identity=38.0530973451327, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI310123363, Length=113, Percent_Identity=38.0530973451327, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI25306287, Length=136, Percent_Identity=36.7647058823529, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI19923640, Length=136, Percent_Identity=36.7647058823529, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI25306283, Length=136, Percent_Identity=36.7647058823529, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI217272892, Length=136, Percent_Identity=38.2352941176471, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI217272894, Length=136, Percent_Identity=38.2352941176471, Blast_Score=84, Evalue=4e-16,
Organism=Homo sapiens, GI94966752, Length=110, Percent_Identity=35.4545454545455, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI34147630, Length=277, Percent_Identity=27.0758122743682, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI48994988, Length=608, Percent_Identity=51.6447368421053, Blast_Score=636, Evalue=0.0,
Organism=Escherichia coli, GI1788922, Length=476, Percent_Identity=28.5714285714286, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI1789738, Length=151, Percent_Identity=36.4238410596026, Blast_Score=95, Evalue=1e-20,
Organism=Escherichia coli, GI1790835, Length=153, Percent_Identity=34.640522875817, Blast_Score=76, Evalue=6e-15,
Organism=Escherichia coli, GI1790412, Length=245, Percent_Identity=29.3877551020408, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1789737, Length=245, Percent_Identity=29.3877551020408, Blast_Score=67, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17557151, Length=323, Percent_Identity=29.1021671826625, Blast_Score=115, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI17556745, Length=148, Percent_Identity=35.8108108108108, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17533571, Length=148, Percent_Identity=40.5405405405405, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17506493, Length=179, Percent_Identity=32.9608938547486, Blast_Score=99, Evalue=7e-21,
Organism=Caenorhabditis elegans, GI71988819, Length=132, Percent_Identity=38.6363636363636, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI71988811, Length=132, Percent_Identity=38.6363636363636, Blast_Score=91, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17552882, Length=134, Percent_Identity=36.5671641791045, Blast_Score=86, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17556456, Length=284, Percent_Identity=26.7605633802817, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI25141371, Length=251, Percent_Identity=27.0916334661355, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6323320, Length=495, Percent_Identity=26.8686868686869, Blast_Score=126, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6324707, Length=162, Percent_Identity=36.4197530864198, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320593, Length=162, Percent_Identity=36.4197530864198, Blast_Score=109, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6323098, Length=149, Percent_Identity=36.9127516778523, Blast_Score=106, Evalue=9e-24,
Organism=Saccharomyces cerevisiae, GI6324166, Length=180, Percent_Identity=35.5555555555556, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6322359, Length=153, Percent_Identity=32.0261437908497, Blast_Score=84, Evalue=8e-17,
Organism=Saccharomyces cerevisiae, GI6324761, Length=280, Percent_Identity=27.8571428571429, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI78706572, Length=401, Percent_Identity=28.1795511221945, Blast_Score=120, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24582462, Length=149, Percent_Identity=37.5838926174497, Blast_Score=103, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24585711, Length=171, Percent_Identity=34.5029239766082, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585713, Length=171, Percent_Identity=34.5029239766082, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24585709, Length=171, Percent_Identity=34.5029239766082, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI28574573, Length=187, Percent_Identity=35.8288770053476, Blast_Score=98, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21357743, Length=190, Percent_Identity=34.7368421052632, Blast_Score=94, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221458488, Length=166, Percent_Identity=36.7469879518072, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI281363316, Length=246, Percent_Identity=32.520325203252, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI17864358, Length=246, Percent_Identity=32.520325203252, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI19921738, Length=245, Percent_Identity=31.8367346938775, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17137380, Length=258, Percent_Identity=26.3565891472868, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009022
- InterPro:   IPR000795
- InterPro:   IPR005225
- InterPro:   IPR000640
- InterPro:   IPR004161
- InterPro:   IPR009000
- InterPro:   IPR006298 [H]

Pfam domain/function: PF00679 EFG_C; PF00009 GTP_EFTU; PF03144 GTP_EFTU_D2 [H]

EC number: NA

Molecular weight: Translated: 67156; Mature: 67025

Theoretical pI: Translated: 4.74; Mature: 4.74

Prosite motif: PS00301 EFACTOR_GTP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADLRNVAIIAHVDHGKTTLVDQLFRQSGTFRDNQRVEERAMDSGDLEKERGITILAKC
CCCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHCCCEEEEEE
TSVEWEHEGKTTRINIVDTPGHADFGAEVERILSMVDGVILLVDSAEGAMPQTKFVTGKA
ECCCEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCEEECCHH
LALGLRPIVVVNKIDRPDGRPQEVLDEVFDLFASLDANDDQLDFPSLFASGRDGYASDDE
HEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCC
SARDGSLDPLFKLIVDHVPPPGLDTSGKFSFLATLLDRDNFMGRVLTGRVQSGTVRINDP
CCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECEECCCEEEECCC
IHAIDSDGKVVETGRATKLMSFDGLERVPVESAQAGDIIALAGLEKATVANTIADPSVTE
CEEECCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCC
PIEAQPIDPPTLAMRFAVNDSPLAGREGDKVTSRMIRDRLLREAETNVAIRITESADKDS
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
FEVAGRGELQLGVLIETMRREGFELGISRPRVLFREGESGREEPYETVVIDVDDEHSGTV
EEECCCCCEEHHHHHHHHHHCCCEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCHH
VEKMQRRKAELVEMRPSGQGKTRITFSAPSRGLIGYHGEFLSDTRGTGIMNRLFEKYGPY
HHHHHHHHHHHEEECCCCCCCEEEEECCCCCCCEEECCCHHCCCCCCHHHHHHHHHHCCC
KGKIEGRQNGVLISMVAGEAAAYALNMLEERGELFIGANAKIYEGMVIGENAKPDDLEVN
CCEECCCCCCEEEEEECCHHHHHHHHHHHHCCCEEECCCCEEEEEEEECCCCCCCCEECC
PMKSKQLTNFRSTGKDDAIRLTPPRVMTLEQAIAYIDDDEMVEVTPQSIRLRKAILDPHE
CCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCHHH
RKRAKRAAEVV
HHHHHHHHCCC
>Mature Secondary Structure 
SADLRNVAIIAHVDHGKTTLVDQLFRQSGTFRDNQRVEERAMDSGDLEKERGITILAKC
CCCCCEEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCHHHCCCEEEEEE
TSVEWEHEGKTTRINIVDTPGHADFGAEVERILSMVDGVILLVDSAEGAMPQTKFVTGKA
ECCCEECCCCEEEEEEEECCCCCCCHHHHHHHHHHHCCEEEEEECCCCCCCCCEEECCHH
LALGLRPIVVVNKIDRPDGRPQEVLDEVFDLFASLDANDDQLDFPSLFASGRDGYASDDE
HEECCCEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCC
SARDGSLDPLFKLIVDHVPPPGLDTSGKFSFLATLLDRDNFMGRVLTGRVQSGTVRINDP
CCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEECEECCCEEEECCC
IHAIDSDGKVVETGRATKLMSFDGLERVPVESAQAGDIIALAGLEKATVANTIADPSVTE
CEEECCCCCEEECCCCEEEEECCCCCCCCCCCCCCCCEEEEECCCHHHHHHHCCCCCCCC
PIEAQPIDPPTLAMRFAVNDSPLAGREGDKVTSRMIRDRLLREAETNVAIRITESADKDS
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCC
FEVAGRGELQLGVLIETMRREGFELGISRPRVLFREGESGREEPYETVVIDVDDEHSGTV
EEECCCCCEEHHHHHHHHHHCCCEECCCCCEEEEECCCCCCCCCCEEEEEEECCCCCCHH
VEKMQRRKAELVEMRPSGQGKTRITFSAPSRGLIGYHGEFLSDTRGTGIMNRLFEKYGPY
HHHHHHHHHHHEEECCCCCCCEEEEECCCCCCCEEECCCHHCCCCCCHHHHHHHHHHCCC
KGKIEGRQNGVLISMVAGEAAAYALNMLEERGELFIGANAKIYEGMVIGENAKPDDLEVN
CCEECCCCCCEEEEEECCHHHHHHHHHHHHCCCEEECCCCEEEEEEEECCCCCCCCEECC
PMKSKQLTNFRSTGKDDAIRLTPPRVMTLEQAIAYIDDDEMVEVTPQSIRLRKAILDPHE
CCCHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCHHH
RKRAKRAAEVV
HHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]