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The map label for this gene is gyaR [H]

Identifier: 85374171

GI number: 85374171

Start: 1390487

End: 1391503

Strand: Direct

Name: gyaR [H]

Synonym: ELI_06720

Alternate gene names: 85374171

Gene position: 1390487-1391503 (Clockwise)

Preceding gene: 85374169

Following gene: 85374172

Centisome position: 45.55

GC content: 66.27

Gene sequence:

>1017_bases
ATGAGCGACCCAGAGAACACCACCGCCCGCCGGATCGAAGGCACACCCAAGGTCGTGGTGACGCGCCACCTGATGCCCTC
GGTCGAGGCGCGCATGCGCGAACTCTACGACGCAACGCTCAATCCCGACGATCACCCGATGAGCCGGGAGCAATTGGCCG
CCGCCATGGCCGATTGCGATGTTCTGGTTCCGACCGTGACCGACCGGATCGATGCCGATCTGATCGCCGGCGCAGGGGAG
CGGCTGAAACTGATCGCCAATTTCGGCGCGGGAACCGATCACATCGACCTCGCCGCAGCCGCCAAACGCAAGATCATGGT
CACCAACACGCCGAGCGTGTTCACCGACGACACCGCCGACATCGCGATGCTCGGCATTATCGGCGTGCCGCGACGGATTC
GCGAAGGCGTCGAACTGGTGCGCAGCGGCAAATGGACCGGCTGGGCACCATCGGGGATGCTGGGGCGAAAGATCGGCGGC
AAGGTGCTCGGCATCGTCGGCATGGGCCGGATCGGACAGGCGGTCGCGCACCGCGCCAAGGCCTTCGGGCTCGACATCGC
TTATCACAACCGCAAGCGCCTGCCCGAAGCGGTCGAGCGGATGCTGGGTGCCCGCTTTGTCGGCGACCTCGACACGCTGG
TCGCCGAAGCGGACATCCTCTCGCTGCATTGCCCCGCGACACAGGATACGATCGGCATGCTCGACGCGCGGCGGATCGGC
CTGATGAAGCCGGGGGCCAGCCTCATCAACACGGCGCGCGGGGAACTGGTCGATCAGGAGGCGCTGATCTCTGCGCTGGA
GCAAGGCCATCTCGCCGGGGCGGGTCTCGATGTATATCCCGACGAACCCAATGTCGACAAGCGACTGATCCGCCACCCCA
ATGTCATGACCCTGCCGCATATCGGCAGCGCCACTGCCGAAGGGCGCGAGGCCTCGGGCGAGAAAGTGATCGCCAACATC
CGCTTCTGGGCCGACGGCCACCGCCCGCCCGACCAGGTCCTCGACGCGCTGGTCTGA

Upstream 100 bases:

>100_bases
GACCATGATGCAGACAATTTATGGTAAATACCCCCTTCCCCGCAAGACTTTGCGCGCGCCGACTTGACCCAATTCGCGGC
TATGTCCAAGCACGGGACAG

Downstream 100 bases:

>100_bases
CATCCCCGCACCGCGCAACCGTCAAACTGCCGGATAACCGGCAGCATTCCGCTTGTGCGCGCGGTTAAACACGCCATAAC
CTTCGGCCGATATGCGCGCT

Product: D-isomer specific 2-hydroxyacid dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 338; Mature: 337

Protein sequence:

>338_residues
MSDPENTTARRIEGTPKVVVTRHLMPSVEARMRELYDATLNPDDHPMSREQLAAAMADCDVLVPTVTDRIDADLIAGAGE
RLKLIANFGAGTDHIDLAAAAKRKIMVTNTPSVFTDDTADIAMLGIIGVPRRIREGVELVRSGKWTGWAPSGMLGRKIGG
KVLGIVGMGRIGQAVAHRAKAFGLDIAYHNRKRLPEAVERMLGARFVGDLDTLVAEADILSLHCPATQDTIGMLDARRIG
LMKPGASLINTARGELVDQEALISALEQGHLAGAGLDVYPDEPNVDKRLIRHPNVMTLPHIGSATAEGREASGEKVIANI
RFWADGHRPPDQVLDALV

Sequences:

>Translated_338_residues
MSDPENTTARRIEGTPKVVVTRHLMPSVEARMRELYDATLNPDDHPMSREQLAAAMADCDVLVPTVTDRIDADLIAGAGE
RLKLIANFGAGTDHIDLAAAAKRKIMVTNTPSVFTDDTADIAMLGIIGVPRRIREGVELVRSGKWTGWAPSGMLGRKIGG
KVLGIVGMGRIGQAVAHRAKAFGLDIAYHNRKRLPEAVERMLGARFVGDLDTLVAEADILSLHCPATQDTIGMLDARRIG
LMKPGASLINTARGELVDQEALISALEQGHLAGAGLDVYPDEPNVDKRLIRHPNVMTLPHIGSATAEGREASGEKVIANI
RFWADGHRPPDQVLDALV
>Mature_337_residues
SDPENTTARRIEGTPKVVVTRHLMPSVEARMRELYDATLNPDDHPMSREQLAAAMADCDVLVPTVTDRIDADLIAGAGER
LKLIANFGAGTDHIDLAAAAKRKIMVTNTPSVFTDDTADIAMLGIIGVPRRIREGVELVRSGKWTGWAPSGMLGRKIGGK
VLGIVGMGRIGQAVAHRAKAFGLDIAYHNRKRLPEAVERMLGARFVGDLDTLVAEADILSLHCPATQDTIGMLDARRIGL
MKPGASLINTARGELVDQEALISALEQGHLAGAGLDVYPDEPNVDKRLIRHPNVMTLPHIGSATAEGREASGEKVIANIR
FWADGHRPPDQVLDALV

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=301, Percent_Identity=32.890365448505, Blast_Score=169, Evalue=3e-42,
Organism=Homo sapiens, GI6912396, Length=297, Percent_Identity=35.3535353535354, Blast_Score=165, Evalue=4e-41,
Organism=Homo sapiens, GI61743967, Length=248, Percent_Identity=36.2903225806452, Blast_Score=141, Evalue=8e-34,
Organism=Homo sapiens, GI4557497, Length=248, Percent_Identity=36.2903225806452, Blast_Score=141, Evalue=9e-34,
Organism=Homo sapiens, GI145580578, Length=248, Percent_Identity=36.6935483870968, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI4557499, Length=248, Percent_Identity=36.6935483870968, Blast_Score=140, Evalue=1e-33,
Organism=Homo sapiens, GI145580575, Length=248, Percent_Identity=36.6935483870968, Blast_Score=138, Evalue=8e-33,
Organism=Escherichia coli, GI87082289, Length=307, Percent_Identity=36.4820846905537, Blast_Score=179, Evalue=2e-46,
Organism=Escherichia coli, GI1789279, Length=282, Percent_Identity=34.3971631205674, Blast_Score=140, Evalue=8e-35,
Organism=Escherichia coli, GI1787645, Length=267, Percent_Identity=29.2134831460674, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI87081824, Length=237, Percent_Identity=27.8481012658228, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788660, Length=271, Percent_Identity=27.6752767527675, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17532191, Length=281, Percent_Identity=28.8256227758007, Blast_Score=147, Evalue=6e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=261, Percent_Identity=32.183908045977, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6324055, Length=258, Percent_Identity=34.4961240310078, Blast_Score=157, Evalue=3e-39,
Organism=Saccharomyces cerevisiae, GI6320925, Length=297, Percent_Identity=31.986531986532, Blast_Score=135, Evalue=9e-33,
Organism=Saccharomyces cerevisiae, GI6322116, Length=250, Percent_Identity=34.4, Blast_Score=133, Evalue=5e-32,
Organism=Saccharomyces cerevisiae, GI6324964, Length=325, Percent_Identity=31.3846153846154, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6325144, Length=154, Percent_Identity=33.7662337662338, Blast_Score=89, Evalue=1e-18,
Organism=Saccharomyces cerevisiae, GI6324980, Length=201, Percent_Identity=33.3333333333333, Blast_Score=86, Evalue=6e-18,
Organism=Saccharomyces cerevisiae, GI6321253, Length=245, Percent_Identity=27.3469387755102, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571528, Length=317, Percent_Identity=36.9085173501577, Blast_Score=174, Evalue=7e-44,
Organism=Drosophila melanogaster, GI45552429, Length=266, Percent_Identity=36.0902255639098, Blast_Score=164, Evalue=8e-41,
Organism=Drosophila melanogaster, GI24585514, Length=266, Percent_Identity=36.0902255639098, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI28574282, Length=266, Percent_Identity=36.0902255639098, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI45551003, Length=266, Percent_Identity=36.0902255639098, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI28574284, Length=266, Percent_Identity=36.0902255639098, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24646446, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24646448, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24646452, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI24646450, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=7e-36,
Organism=Drosophila melanogaster, GI62472511, Length=227, Percent_Identity=40.0881057268723, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI28574286, Length=269, Percent_Identity=32.3420074349442, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI19921140, Length=268, Percent_Identity=30.9701492537313, Blast_Score=134, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24585516, Length=262, Percent_Identity=30.1526717557252, Blast_Score=122, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 36364; Mature: 36233

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPENTTARRIEGTPKVVVTRHLMPSVEARMRELYDATLNPDDHPMSREQLAAAMADCD
CCCCCCCHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCC
VLVPTVTDRIDADLIAGAGERLKLIANFGAGTDHIDLAAAAKRKIMVTNTPSVFTDDTAD
EECCCHHHHHCHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEEEEECCCCCCCCCCHH
IAMLGIIGVPRRIREGVELVRSGKWTGWAPSGMLGRKIGGKVLGIVGMGRIGQAVAHRAK
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEECCCHHHHHHHHHHH
AFGLDIAYHNRKRLPEAVERMLGARFVGDLDTLVAEADILSLHCPATQDTIGMLDARRIG
HHEEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHC
LMKPGASLINTARGELVDQEALISALEQGHLAGAGLDVYPDEPNVDKRLIRHPNVMTLPH
CCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEECCC
IGSATAEGREASGEKVIANIRFWADGHRPPDQVLDALV
CCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHCC
>Mature Secondary Structure 
SDPENTTARRIEGTPKVVVTRHLMPSVEARMRELYDATLNPDDHPMSREQLAAAMADCD
CCCCCCHHHHCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCC
VLVPTVTDRIDADLIAGAGERLKLIANFGAGTDHIDLAAAAKRKIMVTNTPSVFTDDTAD
EECCCHHHHHCHHHHHCCCCEEEEEEECCCCCCCHHHHHHCCCEEEEECCCCCCCCCCHH
IAMLGIIGVPRRIREGVELVRSGKWTGWAPSGMLGRKIGGKVLGIVGMGRIGQAVAHRAK
HHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCEEEEEECCCHHHHHHHHHHH
AFGLDIAYHNRKRLPEAVERMLGARFVGDLDTLVAEADILSLHCPATQDTIGMLDARRIG
HHEEEEEECCHHCCHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCHHHHHHHHHHHC
LMKPGASLINTARGELVDQEALISALEQGHLAGAGLDVYPDEPNVDKRLIRHPNVMTLPH
CCCCCHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHCCCCEEECCC
IGSATAEGREASGEKVIANIRFWADGHRPPDQVLDALV
CCCCCCCCCCCCCCEEEEEEEEEECCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA