Click here to switch to the map view.

The map label for this gene is moeA [H]

Identifier: 85374132

GI number: 85374132

Start: 1352658

End: 1353836

Strand: Direct

Name: moeA [H]

Synonym: ELI_06525

Alternate gene names: 85374132

Gene position: 1352658-1353836 (Clockwise)

Preceding gene: 85374131

Following gene: 85374133

Centisome position: 44.31

GC content: 65.22

Gene sequence:

>1179_bases
ATGAGCTTGCCGCACTTGAGTCTCGAGAATGCGCAGGCGCGGATGCTGGCGCTGCTGGAACCGTTGCCCATGGAGCGCGT
GGCGGTCGAGGCGGCGCTCGGACGCTACCTGGCTGAGCCTCTCACCGCTGCGCGGACGCAACCCCCGGCGGACCTGTCGG
CCATGGATGGGTACGCCGTGGCCGGCCAAGGGCCGTGGCGCCTCAAAGGGGAAAGCCGGTGTGGCGAGCCGTTCGCGGGG
GCGATCCATGGCGGAGAATGCGTCCGCATTTCGACAGGCGCGGTCCTGCCGGAGGGTGCCGATCGCGTCCTGATCCAGGA
AGATGCGGACGTTTCAGGCGACACCGTAATCCACACCGAGGATCCGCCGGTCGGCAAGCATATTCGCCGGAAGGGCTTTG
AGTTCAGCCCCGGTCACACGCTGTTGGATGCCGGGACACGGATCGGACCCGCACATGTCGCGCTGATCCGCTCGGCAGGT
CATGCCGAGGTCGCGGTCCAGGCCAGGCCGACGCTTGCCATCTTCGACAGCGGAGATGAGCTCAATTCCGATCCGACTGC
CTGCGGCGTCCACGAAATCCCTGCCAGCAATGGCGCGATGCTGGCGGCACTGGCGGGCGCGCTGCCGTGCGACATCCACC
AGAGCGATCCCTTGCCCGACCGTCTCGATGACATTGTCGCCGCTTTGGAGGCGCATCGCGGGGCCGACCTGATGGTGCTG
ACAGGTGGTGCCTCGGTCGGCGACCATGATCTGGCAAAGCCTGCACTGGACGCGGTCGGGGCGCAACTGGATTTCTGGAA
GGTTGCCATGAAGCCTGGAAAACCGCTGATGGTCGCTCGGCGTGGCAAACAGCTTATCCTTGGCCTTCCCGGCAATCCCG
TATCCGCCTTCGTGACCGGTTTCCTGTTCATGCTTCCGGCGCTGCGCAAGCTGCTCGGCGCTCGCGACTGCTTACCGCAA
ACCATCCACCTGCCTCTCGCGACCGATTGTCCTGCTGGAGGACCAAGGCGAGAATTCATGCGCGGGTCGCTCGCTGAGGG
CGTCGTCCCCGCTCCGCAGCAAGACAGCAGTGCCCTCCTCACCCTCGCCCGATCAAATGTCCTGATCGACCGCCCCGCCC
ATGGCGACGAGGCGAAAGCGGGAACATCTGTTCCGTGCTTATTGTTGGAAATCCCCTGA

Upstream 100 bases:

>100_bases
CGATCTACGACATGGCCAAGGCGCTCGACAAGGGCATGGTGATCGAAGGCCTGCGCCTGCTGGAAAAGCGCGGCGGCAAG
TCGGGGCACTGGATCGCGAA

Downstream 100 bases:

>100_bases
ATTGCTTGACTTACGAAAATTGGTTCCTTAATTGTTCCACATTCGTTCGCATTCGCGCGCGAAGTTGGAACGGGCCATTT
GCGAGCCCAAAGAGGGAGCC

Product: molybdopterin biosynthesis protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 392; Mature: 391

Protein sequence:

>392_residues
MSLPHLSLENAQARMLALLEPLPMERVAVEAALGRYLAEPLTAARTQPPADLSAMDGYAVAGQGPWRLKGESRCGEPFAG
AIHGGECVRISTGAVLPEGADRVLIQEDADVSGDTVIHTEDPPVGKHIRRKGFEFSPGHTLLDAGTRIGPAHVALIRSAG
HAEVAVQARPTLAIFDSGDELNSDPTACGVHEIPASNGAMLAALAGALPCDIHQSDPLPDRLDDIVAALEAHRGADLMVL
TGGASVGDHDLAKPALDAVGAQLDFWKVAMKPGKPLMVARRGKQLILGLPGNPVSAFVTGFLFMLPALRKLLGARDCLPQ
TIHLPLATDCPAGGPRREFMRGSLAEGVVPAPQQDSSALLTLARSNVLIDRPAHGDEAKAGTSVPCLLLEIP

Sequences:

>Translated_392_residues
MSLPHLSLENAQARMLALLEPLPMERVAVEAALGRYLAEPLTAARTQPPADLSAMDGYAVAGQGPWRLKGESRCGEPFAG
AIHGGECVRISTGAVLPEGADRVLIQEDADVSGDTVIHTEDPPVGKHIRRKGFEFSPGHTLLDAGTRIGPAHVALIRSAG
HAEVAVQARPTLAIFDSGDELNSDPTACGVHEIPASNGAMLAALAGALPCDIHQSDPLPDRLDDIVAALEAHRGADLMVL
TGGASVGDHDLAKPALDAVGAQLDFWKVAMKPGKPLMVARRGKQLILGLPGNPVSAFVTGFLFMLPALRKLLGARDCLPQ
TIHLPLATDCPAGGPRREFMRGSLAEGVVPAPQQDSSALLTLARSNVLIDRPAHGDEAKAGTSVPCLLLEIP
>Mature_391_residues
SLPHLSLENAQARMLALLEPLPMERVAVEAALGRYLAEPLTAARTQPPADLSAMDGYAVAGQGPWRLKGESRCGEPFAGA
IHGGECVRISTGAVLPEGADRVLIQEDADVSGDTVIHTEDPPVGKHIRRKGFEFSPGHTLLDAGTRIGPAHVALIRSAGH
AEVAVQARPTLAIFDSGDELNSDPTACGVHEIPASNGAMLAALAGALPCDIHQSDPLPDRLDDIVAALEAHRGADLMVLT
GGASVGDHDLAKPALDAVGAQLDFWKVAMKPGKPLMVARRGKQLILGLPGNPVSAFVTGFLFMLPALRKLLGARDCLPQT
IHLPLATDCPAGGPRREFMRGSLAEGVVPAPQQDSSALLTLARSNVLIDRPAHGDEAKAGTSVPCLLLEIP

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=399, Percent_Identity=32.5814536340852, Blast_Score=154, Evalue=1e-37,
Organism=Homo sapiens, GI10880983, Length=399, Percent_Identity=32.5814536340852, Blast_Score=154, Evalue=1e-37,
Organism=Escherichia coli, GI1787049, Length=379, Percent_Identity=34.3007915567282, Blast_Score=172, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI25147659, Length=346, Percent_Identity=32.0809248554913, Blast_Score=154, Evalue=8e-38,
Organism=Caenorhabditis elegans, GI17562606, Length=301, Percent_Identity=25.2491694352159, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI17136978, Length=409, Percent_Identity=31.0513447432763, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24638841, Length=409, Percent_Identity=31.0513447432763, Blast_Score=124, Evalue=1e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 40956; Mature: 40824

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSLPHLSLENAQARMLALLEPLPMERVAVEAALGRYLAEPLTAARTQPPADLSAMDGYAV
CCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEE
AGQGPWRLKGESRCGEPFAGAIHGGECVRISTGAVLPEGADRVLIQEDADVSGDTVIHTE
ECCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEEEECC
DPPVGKHIRRKGFEFSPGHTLLDAGTRIGPAHVALIRSAGHAEVAVQARPTLAIFDSGDE
CCCCHHHHHHCCCCCCCCCEEECCCCCCCHHHEEEECCCCCCEEEEEECCEEEEEECCCC
LNSDPTACGVHEIPASNGAMLAALAGALPCDIHQSDPLPDRLDDIVAALEAHRGADLMVL
CCCCCCCCCCEECCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
TGGASVGDHDLAKPALDAVGAQLDFWKVAMKPGKPLMVARRGKQLILGLPGNPVSAFVTG
ECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEEECCCCHHHHHHHH
FLFMLPALRKLLGARDCLPQTIHLPLATDCPAGGPRREFMRGSLAEGVVPAPQQDSSALL
HHHHHHHHHHHHHHHHCCCCEEECCEECCCCCCCCHHHHHCCHHHCCCCCCCCCCCHHEE
TLARSNVLIDRPAHGDEAKAGTSVPCLLLEIP
EEECCCEEEECCCCCCCCCCCCCCCEEEEECC
>Mature Secondary Structure 
SLPHLSLENAQARMLALLEPLPMERVAVEAALGRYLAEPLTAARTQPPADLSAMDGYAV
CCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCEEE
AGQGPWRLKGESRCGEPFAGAIHGGECVRISTGAVLPEGADRVLIQEDADVSGDTVIHTE
ECCCCEEECCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEECCCCCCCCEEEECC
DPPVGKHIRRKGFEFSPGHTLLDAGTRIGPAHVALIRSAGHAEVAVQARPTLAIFDSGDE
CCCCHHHHHHCCCCCCCCCEEECCCCCCCHHHEEEECCCCCCEEEEEECCEEEEEECCCC
LNSDPTACGVHEIPASNGAMLAALAGALPCDIHQSDPLPDRLDDIVAALEAHRGADLMVL
CCCCCCCCCCEECCCCCCHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEE
TGGASVGDHDLAKPALDAVGAQLDFWKVAMKPGKPLMVARRGKQLILGLPGNPVSAFVTG
ECCCCCCCHHHHHHHHHHHCCCCEEEEEEECCCCEEEEEECCCEEEEECCCCHHHHHHHH
FLFMLPALRKLLGARDCLPQTIHLPLATDCPAGGPRREFMRGSLAEGVVPAPQQDSSALL
HHHHHHHHHHHHHHHHCCCCEEECCEECCCCCCCCHHHHHCCHHHCCCCCCCCCCCHHEE
TLARSNVLIDRPAHGDEAKAGTSVPCLLLEIP
EEECCCEEEECCCCCCCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]