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The map label for this gene is moaC

Identifier: 85374131

GI number: 85374131

Start: 1352191

End: 1352661

Strand: Direct

Name: moaC

Synonym: ELI_06520

Alternate gene names: 85374131

Gene position: 1352191-1352661 (Clockwise)

Preceding gene: 85374130

Following gene: 85374132

Centisome position: 44.3

GC content: 65.39

Gene sequence:

>471_bases
ATGAGCCAGCTGACCCACCTCGACGACTCAGGCGCTGCGCATATGGTCGATGTCGGCGGCAAGCCCGCGACCGAACGCCT
TGCGCGCGCTGGCGGGACGATCCGCATGAGCGCCGAAGCCCTCGCCGCGATCAAGGCAGGCGACGCACCCAAGGGCGATG
TGCTTGGCACGGCGCGCATCGCCGGGATCATGGCGGCCAAGAAGACCGGCGAGCTGATCCCGTTGTGCCATCCGCTTGCG
CTCGATGCGGTAGACGTCGCTTTCGAGTTCGGCGAGAGAGAAATCGCCGTTACTGCGACAGCATCGCTGACCGGCAAGAC
CGGTGTCGAGATGGAAGCGCTGACCGCGGCGAGCGTTGCCCTGCTTACGATCTACGACATGGCCAAGGCGCTCGACAAGG
GCATGGTGATCGAAGGCCTGCGCCTGCTGGAAAAGCGCGGCGGCAAGTCGGGGCACTGGATCGCGAAATGA

Upstream 100 bases:

>100_bases
GCCTCTCTGCCGGCCCGTTTTACGCCCGAATTGGGACCGCAGATTTTTCTGCCCCTGGACAGTGGTCCATGCGGTCCATG
TGTGCGGGAGCCGCGACGAA

Downstream 100 bases:

>100_bases
GCTTGCCGCACTTGAGTCTCGAGAATGCGCAGGCGCGGATGCTGGCGCTGCTGGAACCGTTGCCCATGGAGCGCGTGGCG
GTCGAGGCGGCGCTCGGACG

Product: molybdopterin cofactor biosynthesis MoaC region

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 156; Mature: 155

Protein sequence:

>156_residues
MSQLTHLDDSGAAHMVDVGGKPATERLARAGGTIRMSAEALAAIKAGDAPKGDVLGTARIAGIMAAKKTGELIPLCHPLA
LDAVDVAFEFGEREIAVTATASLTGKTGVEMEALTAASVALLTIYDMAKALDKGMVIEGLRLLEKRGGKSGHWIAK

Sequences:

>Translated_156_residues
MSQLTHLDDSGAAHMVDVGGKPATERLARAGGTIRMSAEALAAIKAGDAPKGDVLGTARIAGIMAAKKTGELIPLCHPLA
LDAVDVAFEFGEREIAVTATASLTGKTGVEMEALTAASVALLTIYDMAKALDKGMVIEGLRLLEKRGGKSGHWIAK
>Mature_155_residues
SQLTHLDDSGAAHMVDVGGKPATERLARAGGTIRMSAEALAAIKAGDAPKGDVLGTARIAGIMAAKKTGELIPLCHPLAL
DAVDVAFEFGEREIAVTATASLTGKTGVEMEALTAASVALLTIYDMAKALDKGMVIEGLRLLEKRGGKSGHWIAK

Specific function: Together with moaA, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z

COG id: COG0315

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moaC family

Homologues:

Organism=Escherichia coli, GI1787001, Length=155, Percent_Identity=58.7096774193548, Blast_Score=162, Evalue=9e-42,
Organism=Caenorhabditis elegans, GI32566331, Length=153, Percent_Identity=46.4052287581699, Blast_Score=136, Evalue=5e-33,
Organism=Drosophila melanogaster, GI28574490, Length=150, Percent_Identity=52.6666666666667, Blast_Score=148, Evalue=1e-36,
Organism=Drosophila melanogaster, GI28574492, Length=137, Percent_Identity=51.8248175182482, Blast_Score=134, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MOAC_ERYLH (Q2NA95)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458193.1
- STRING:   Q2NA95
- GeneID:   3870310
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_06520
- NMPDR:   fig|314225.3.peg.1751
- eggNOG:   COG0315
- HOGENOM:   HBG605231
- OMA:   PMCHPLM
- PhylomeDB:   Q2NA95
- ProtClustDB:   CLSK746416
- BioCyc:   ELIT314225:ELI_06520-MONOMER
- HAMAP:   MF_01224_B
- InterPro:   IPR023045
- InterPro:   IPR023046
- InterPro:   IPR002820
- Gene3D:   G3DSA:3.30.70.640
- TIGRFAMs:   TIGR00581

Pfam domain/function: PF01967 MoaC; SSF55040 MoaC

EC number: NA

Molecular weight: Translated: 16065; Mature: 15934

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: ACT_SITE 126-126

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQLTHLDDSGAAHMVDVGGKPATERLARAGGTIRMSAEALAAIKAGDAPKGDVLGTARI
CCCCCCCCCCCCEEEEECCCCCHHHHHHHCCCEEEECHHHHHHHHCCCCCCCCCCHHHHH
AGIMAAKKTGELIPLCHPLALDAVDVAFEFGEREIAVTATASLTGKTGVEMEALTAASVA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHH
LLTIYDMAKALDKGMVIEGLRLLEKRGGKSGHWIAK
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure 
SQLTHLDDSGAAHMVDVGGKPATERLARAGGTIRMSAEALAAIKAGDAPKGDVLGTARI
CCCCCCCCCCCEEEEECCCCCHHHHHHHCCCEEEECHHHHHHHHCCCCCCCCCCHHHHH
AGIMAAKKTGELIPLCHPLALDAVDVAFEFGEREIAVTATASLTGKTGVEMEALTAASVA
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEEEEEECCCCCCCCHHHHHHHHHH
LLTIYDMAKALDKGMVIEGLRLLEKRGGKSGHWIAK
HHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Involved in molybdopterin biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA