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The map label for this gene is trpC

Identifier: 85374130

GI number: 85374130

Start: 1351251

End: 1352036

Strand: Direct

Name: trpC

Synonym: ELI_06515

Alternate gene names: 85374130

Gene position: 1351251-1352036 (Clockwise)

Preceding gene: 85374129

Following gene: 85374131

Centisome position: 44.27

GC content: 62.98

Gene sequence:

>786_bases
ATGAACAAACTTGAAGAGATATGCGCCGCCAAGCTCGACGAAGTCGCGACGCGCAAGGCTGCGCTGTCGGATAGCGAATT
GGCCGATCGCATCGCAGCCCAATCCGCGCCGCGCGGGTTCGAAGCCGCTCTGCGTGCCAAGGCCGTAACCGACTTCGCAC
TGATTGCCGAGATCAAGAAAGCCTCACCGTCGAAGGGTCTCATCCGCGCAGACTTTCATCCCGCAGACCACGCCCGCGCC
TATGAGGCAGGCGGCGCGGCGTGCCTGTCCGTCCTGACCGATGAAGACTATTTCCAGGGCCACGCCGATTACCTGCGCGA
AGCGCGCGATGCGTGCACCCTCCCCGCCCTGCGCAAGGACTTCATGGTCGATCCGTGGCAATGCGCCGAAGCCCGGAGCA
TGGGTGCCGACGCGATCCTGATTATCGTTGCGGCACTCTCCAATGCGCAGATGCACGAGATCGAAGCTGCTGCGCTGGAG
CATCGGATGGATGCGCTGGTCGAAGTGCACGACGAAGAAGAAATGAGTCGCGCCCATGCGCTGCAATCGCGGCTGGTTGG
CGTCAATAATCGCGACTTGAAAACCTTCACCACCGATCTCGCGACCACCGAGCGCTTGGCTCCGCTGGCACCCGCAGGCG
CGCTTCTGGTCGGAGAAAGCGGTATCGACAACCACGCCGATTGCGTGCGGCTGTCGCAAGCGGGGGTCCAGACCTTCCTC
GTTGGTGAGAGCCTGATGCGGCAGGACGACGTCGAAGCCGCCACCCGCGAACTTCTCGGCGGTTAG

Upstream 100 bases:

>100_bases
GCAAAGCGTCTACGGCTGTCGTTTCCTGGAACACGCCCACCAGAAGTAAGTACAGGGCTTCGACAAGCTCAGCCCGAACG
GATTTTAGTGTGGTGAATAA

Downstream 100 bases:

>100_bases
GACTGTCCTACCCTGCGCAGTTCTGGCAGACCTGCGGCATGTTGGACCGATCAAGCCTCTCTGCCGGCCCGTTTTACGCC
CGAATTGGGACCGCAGATTT

Product: indole-3-glycerol-phosphate synthase

Products: NA

Alternate protein names: IGPS [H]

Number of amino acids: Translated: 261; Mature: 261

Protein sequence:

>261_residues
MNKLEEICAAKLDEVATRKAALSDSELADRIAAQSAPRGFEAALRAKAVTDFALIAEIKKASPSKGLIRADFHPADHARA
YEAGGAACLSVLTDEDYFQGHADYLREARDACTLPALRKDFMVDPWQCAEARSMGADAILIIVAALSNAQMHEIEAAALE
HRMDALVEVHDEEEMSRAHALQSRLVGVNNRDLKTFTTDLATTERLAPLAPAGALLVGESGIDNHADCVRLSQAGVQTFL
VGESLMRQDDVEAATRELLGG

Sequences:

>Translated_261_residues
MNKLEEICAAKLDEVATRKAALSDSELADRIAAQSAPRGFEAALRAKAVTDFALIAEIKKASPSKGLIRADFHPADHARA
YEAGGAACLSVLTDEDYFQGHADYLREARDACTLPALRKDFMVDPWQCAEARSMGADAILIIVAALSNAQMHEIEAAALE
HRMDALVEVHDEEEMSRAHALQSRLVGVNNRDLKTFTTDLATTERLAPLAPAGALLVGESGIDNHADCVRLSQAGVQTFL
VGESLMRQDDVEAATRELLGG
>Mature_261_residues
MNKLEEICAAKLDEVATRKAALSDSELADRIAAQSAPRGFEAALRAKAVTDFALIAEIKKASPSKGLIRADFHPADHARA
YEAGGAACLSVLTDEDYFQGHADYLREARDACTLPALRKDFMVDPWQCAEARSMGADAILIIVAALSNAQMHEIEAAALE
HRMDALVEVHDEEEMSRAHALQSRLVGVNNRDLKTFTTDLATTERLAPLAPAGALLVGESGIDNHADCVRLSQAGVQTFL
VGESLMRQDDVEAATRELLGG

Specific function: Bifunctional Enzyme That Catalyzes Two Sequential Steps Of Tryptophan Biosynthetic Pathway. The First Reaction Is Catalyzed By The Isomerase, Coded By The Trpf Domain; The Second Reaction Is Catalyzed By The Synthase, Coded By The Trpc Domain. [C]

COG id: COG0134

COG function: function code E; Indole-3-glycerol phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpC family [H]

Homologues:

Organism=Escherichia coli, GI87081863, Length=258, Percent_Identity=40.3100775193798, Blast_Score=161, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6322638, Length=214, Percent_Identity=39.2523364485981, Blast_Score=145, Evalue=8e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013798
- InterPro:   IPR001468
- InterPro:   IPR011060 [H]

Pfam domain/function: PF00218 IGPS [H]

EC number: =4.1.1.48 [H]

Molecular weight: Translated: 28080; Mature: 28080

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00436 PEROXIDASE_2 ; PS00614 IGPS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKLEEICAAKLDEVATRKAALSDSELADRIAAQSAPRGFEAALRAKAVTDFALIAEIKK
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASPSKGLIRADFHPADHARAYEAGGAACLSVLTDEDYFQGHADYLREARDACTLPALRKD
CCCCCCEEEECCCCCHHHHHHHCCCHHHHHHHCCCHHHCCHHHHHHHHHHHHCCHHHHHH
FMVDPWQCAEARSMGADAILIIVAALSNAQMHEIEAAALEHRMDALVEVHDEEEMSRAHA
HCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LQSRLVGVNNRDLKTFTTDLATTERLAPLAPAGALLVGESGIDNHADCVRLSQAGVQTFL
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
VGESLMRQDDVEAATRELLGG
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNKLEEICAAKLDEVATRKAALSDSELADRIAAQSAPRGFEAALRAKAVTDFALIAEIKK
CCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
ASPSKGLIRADFHPADHARAYEAGGAACLSVLTDEDYFQGHADYLREARDACTLPALRKD
CCCCCCEEEECCCCCHHHHHHHCCCHHHHHHHCCCHHHCCHHHHHHHHHHHHCCHHHHHH
FMVDPWQCAEARSMGADAILIIVAALSNAQMHEIEAAALEHRMDALVEVHDEEEMSRAHA
HCCCCHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
LQSRLVGVNNRDLKTFTTDLATTERLAPLAPAGALLVGESGIDNHADCVRLSQAGVQTFL
HHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHH
VGESLMRQDDVEAATRELLGG
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA