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The map label for this gene is hrcA

Identifier: 85374030

GI number: 85374030

Start: 1244286

End: 1245326

Strand: Direct

Name: hrcA

Synonym: ELI_06015

Alternate gene names: 85374030

Gene position: 1244286-1245326 (Clockwise)

Preceding gene: 85374025

Following gene: 85374031

Centisome position: 40.76

GC content: 62.63

Gene sequence:

>1041_bases
ATGGCCGTACCACCCGTCACCGAACTGACCGACCGCGCCAGGGCGATCTTCCAGCTCGTGGTCGAGGGCTATCTCGAGAG
TGGGCAACCAGTCGGGTCGAAAACGTTATCGCAAGAGCAATCTCTGGATCTCTCACCCGCGTCGATCCGTTCGGTGCTGG
CCGATCTGGAATCGATTGGCCTGCTCGCAGCGCCGCATACCAGCGCCGGACGCATGCCGACGGAGACCGGACTGCGCCTC
TTCGTCGACGGGATGATGCAGGTTGCCGAACCCACGCGCGCAGAACGTGAGGCCATCGCTCAGCGCCTCAAGCGATCCGG
CCCGATAGAGCAGGCTCTGGAAGCGACAAGTTCGATGCTTTCCGATCTTTCAGGCGCCGCGGGGATGGTGATGGTCCCGA
GCCGGGAGCCGCGCTTGGCACAGATCAGCCTCGTGCCACTGGGGCAGGGTAAAGCACTGGCGGTGCTGGTCGGCGAAGAT
GGCGCGATCGAGAACCGCGTAATCGAGACGGGCGATACCCCGGCCCATGTGCTGGAGCAGGTCAGCAATTTCATCACGGC
GCGCCTCGCAGGACGTACGCTAGCCGAAGCGACAGCGGCGATGCGCAAAGAAATCGCAGACGGGAAATCGGCACTCGACA
CAGCCAGCCAGAATCTCGTCGAGCGCGGCCTCGCGGTCTGGACCGAAGATGCTGCGGAACGTCCGGTCCTCATCGTCCGC
GGGCAGGCCAATCTGCTGGATGAAAGTGCGCTGGAAGATCTCGACCGCGTGCGCTCGCTCCTTGACGATCTCGAGAACAA
GCAATCGGTCGCGGAATTGCTCGAAACCGCACGCGATGCCGAAGCGACGCGCATTTTCATCGGCAGCGAGAATCGTTTGT
TCGCCCTCAGCGGCTCTTCCGTCATCGCATCGCCCTATCGCGATCGCGAAGGGAAAGTCGTTGGTGTGCTGGGAGTCATA
GGCCCCACGCGGTTGAATTACGCGCGCGTCGTCCCCATGGTGGATTTCACGGCCCGTTCGCTGGGCAAACTGATCGGTTA
A

Upstream 100 bases:

>100_bases
TCCTCACTTCTTGAGCGGCGCTATAAGGAAGAACGGGACTTCGACAAGCTCAGGGCGAACGGAAAATTGAAACTTTGCCT
ATTCCAGCTAAGTGAGATCC

Downstream 100 bases:

>100_bases
CCGGAAAAATTTCAAAGCAATGAGCGACGATACCAAGAAGCAGGACACTGCGGCTGACGCAGAAGTCGAGAAGGAAATGG
AAGGCGTTCCCGAGCATCTA

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 345

Protein sequence:

>346_residues
MAVPPVTELTDRARAIFQLVVEGYLESGQPVGSKTLSQEQSLDLSPASIRSVLADLESIGLLAAPHTSAGRMPTETGLRL
FVDGMMQVAEPTRAEREAIAQRLKRSGPIEQALEATSSMLSDLSGAAGMVMVPSREPRLAQISLVPLGQGKALAVLVGED
GAIENRVIETGDTPAHVLEQVSNFITARLAGRTLAEATAAMRKEIADGKSALDTASQNLVERGLAVWTEDAAERPVLIVR
GQANLLDESALEDLDRVRSLLDDLENKQSVAELLETARDAEATRIFIGSENRLFALSGSSVIASPYRDREGKVVGVLGVI
GPTRLNYARVVPMVDFTARSLGKLIG

Sequences:

>Translated_346_residues
MAVPPVTELTDRARAIFQLVVEGYLESGQPVGSKTLSQEQSLDLSPASIRSVLADLESIGLLAAPHTSAGRMPTETGLRL
FVDGMMQVAEPTRAEREAIAQRLKRSGPIEQALEATSSMLSDLSGAAGMVMVPSREPRLAQISLVPLGQGKALAVLVGED
GAIENRVIETGDTPAHVLEQVSNFITARLAGRTLAEATAAMRKEIADGKSALDTASQNLVERGLAVWTEDAAERPVLIVR
GQANLLDESALEDLDRVRSLLDDLENKQSVAELLETARDAEATRIFIGSENRLFALSGSSVIASPYRDREGKVVGVLGVI
GPTRLNYARVVPMVDFTARSLGKLIG
>Mature_345_residues
AVPPVTELTDRARAIFQLVVEGYLESGQPVGSKTLSQEQSLDLSPASIRSVLADLESIGLLAAPHTSAGRMPTETGLRLF
VDGMMQVAEPTRAEREAIAQRLKRSGPIEQALEATSSMLSDLSGAAGMVMVPSREPRLAQISLVPLGQGKALAVLVGEDG
AIENRVIETGDTPAHVLEQVSNFITARLAGRTLAEATAAMRKEIADGKSALDTASQNLVERGLAVWTEDAAERPVLIVRG
QANLLDESALEDLDRVRSLLDDLENKQSVAELLETARDAEATRIFIGSENRLFALSGSSVIASPYRDREGKVVGVLGVIG
PTRLNYARVVPMVDFTARSLGKLIG

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_ERYLH (Q2NAJ6)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458092.1
- ProteinModelPortal:   Q2NAJ6
- SMR:   Q2NAJ6
- STRING:   Q2NAJ6
- GeneID:   3870754
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_06015
- NMPDR:   fig|314225.3.peg.1857
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   ELIT314225:ELI_06015-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 36872; Mature: 36740

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVPPVTELTDRARAIFQLVVEGYLESGQPVGSKTLSQEQSLDLSPASIRSVLADLESIG
CCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCC
LLAAPHTSAGRMPTETGLRLFVDGMMQVAEPTRAEREAIAQRLKRSGPIEQALEATSSML
EEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SDLSGAAGMVMVPSREPRLAQISLVPLGQGKALAVLVGEDGAIENRVIETGDTPAHVLEQ
HHHCCCCCEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHH
VSNFITARLAGRTLAEATAAMRKEIADGKSALDTASQNLVERGLAVWTEDAAERPVLIVR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
GQANLLDESALEDLDRVRSLLDDLENKQSVAELLETARDAEATRIFIGSENRLFALSGSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCC
VIASPYRDREGKVVGVLGVIGPTRLNYARVVPMVDFTARSLGKLIG
EEECCCCCCCCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
AVPPVTELTDRARAIFQLVVEGYLESGQPVGSKTLSQEQSLDLSPASIRSVLADLESIG
CCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCHHHHHHHHHHHHHCC
LLAAPHTSAGRMPTETGLRLFVDGMMQVAEPTRAEREAIAQRLKRSGPIEQALEATSSML
EEECCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SDLSGAAGMVMVPSREPRLAQISLVPLGQGKALAVLVGEDGAIENRVIETGDTPAHVLEQ
HHHCCCCCEEEECCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCCEEECCCCHHHHHHH
VSNFITARLAGRTLAEATAAMRKEIADGKSALDTASQNLVERGLAVWTEDAAERPVLIVR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEE
GQANLLDESALEDLDRVRSLLDDLENKQSVAELLETARDAEATRIFIGSENRLFALSGSS
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCC
VIASPYRDREGKVVGVLGVIGPTRLNYARVVPMVDFTARSLGKLIG
EEECCCCCCCCCEEEEEECCCCCCCCHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA