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The map label for this gene is hisI

Identifier: 85374004

GI number: 85374004

Start: 1217844

End: 1218221

Strand: Direct

Name: hisI

Synonym: ELI_05885

Alternate gene names: 85374004

Gene position: 1217844-1218221 (Clockwise)

Preceding gene: 85374003

Following gene: 85374005

Centisome position: 39.9

GC content: 58.2

Gene sequence:

>378_bases
ATGAGCGAGATTTCTGCCGAAGAGCGCGAAAGCGGAACGGTCTTCGCACCGAAATTCGATTCGGACGGCTTGCTGACAGC
GGTGGTGCAACATGTCGATACTCGCGAAGTTCTGATGGTGGCTTTCATGAATGCGGATGCGCTGGACGCAACCCGGAAGA
CGGGAATTGCGCATTTCTTTTCGCGATCGCGGCAGACATTGTGGAAGAAGGGCGGGACCTCGGGAAATACCTTGGCGGTC
AGCCAGGTGCTGGTCGATTGCGACCAGGATGCGGTCATTCTGCTGGTCGAACCGGCCGGGCCAGCTTGCCACACGGGGGC
GCGGACATGCTTCTATCGCGAACTGGATTGCGGCGCTCTCCAAGACGTAAGAACTTGA

Upstream 100 bases:

>100_bases
AGGGGGATTGCGCACCGCGTCCGATTTTGAGACCGAATTGTTGTGTTCGTGCAACAAAACTGTCGCATTGATCCAAGCCC
AGCAACGATGAGGCGAAAGC

Downstream 100 bases:

>100_bases
CCTTTACGTAAAGGGCATGTACCGATCGACGCATGGCAAACGTCGCATCGAAAGAATCGAGAGCGCATTCCGGCGCTCAT
CTCGAACGGCCGGACAAGCT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 125; Mature: 124

Protein sequence:

>125_residues
MSEISAEERESGTVFAPKFDSDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGNTLAV
SQVLVDCDQDAVILLVEPAGPACHTGARTCFYRELDCGALQDVRT

Sequences:

>Translated_125_residues
MSEISAEERESGTVFAPKFDSDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGNTLAV
SQVLVDCDQDAVILLVEPAGPACHTGARTCFYRELDCGALQDVRT
>Mature_124_residues
SEISAEERESGTVFAPKFDSDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFFSRSRQTLWKKGGTSGNTLAVS
QVLVDCDQDAVILLVEPAGPACHTGARTCFYRELDCGALQDVRT

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=49.4505494505495, Blast_Score=105, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_ERYLH (Q2NAM2)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_458066.1
- ProteinModelPortal:   Q2NAM2
- SMR:   Q2NAM2
- STRING:   Q2NAM2
- GeneID:   3870943
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_05885
- NMPDR:   fig|314225.3.peg.1887
- eggNOG:   COG0139
- HOGENOM:   HBG294308
- OMA:   TQYVHEV
- BioCyc:   ELIT314225:ELI_05885-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 13536; Mature: 13405

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSEISAEERESGTVFAPKFDSDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFF
CCCCCCCCCCCCCEECCCCCCCCHHHHHHHHCCHHHEEHHHHCCCCHHHHHHHHHHHHHH
SRSRQTLWKKGGTSGNTLAVSQVLVDCDQDAVILLVEPAGPACHTGARTCFYRELDCGAL
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCH
QDVRT
HCCCC
>Mature Secondary Structure 
SEISAEERESGTVFAPKFDSDGLLTAVVQHVDTREVLMVAFMNADALDATRKTGIAHFF
CCCCCCCCCCCCEECCCCCCCCHHHHHHHHCCHHHEEHHHHCCCCHHHHHHHHHHHHHH
SRSRQTLWKKGGTSGNTLAVSQVLVDCDQDAVILLVEPAGPACHTGARTCFYRELDCGAL
HHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCEEEEECCCCCCCCCCCCEEEEEECCCCCH
QDVRT
HCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA