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The map label for this gene is ubiA

Identifier: 85373412

GI number: 85373412

Start: 617220

End: 618140

Strand: Direct

Name: ubiA

Synonym: ELI_02925

Alternate gene names: 85373412

Gene position: 617220-618140 (Clockwise)

Preceding gene: 85373407

Following gene: 85373413

Centisome position: 20.22

GC content: 67.86

Gene sequence:

>921_bases
ATGCGCACAATGTCCGACATTGCGCCCAACATCGTCCCCGACACCGAACATCGCGGCCTCGTCGCGCGCTTGCCGCAAGT
GCCACGCGACCTCGCGCAGCTGGCGCGGTTCGACCGGCCGATCGGCTGGTGGCTGCTGTTCTGGCCGTGCGTGTGGGGCG
TATGGCTGACCGGCGCGGGGTGGCAGCTTGCGATGCTCGGCTGGCTGCTGCTCGGGAGCATCGCCATGCGCGGCGCGGGG
TGCGTCTATAACGATATCGTCGATGCCGATCTCGACCGGAAAGTCGCGCGCACTGCCAGTCGTCCGGTGGCGAGCGGGCG
GGTCTCGAAGAAATTGGCATGGGGCTGGCTGCTGGCCCTGTGCGCAATCGGCCTGTTGGTGCTGCTGCAATTGCGGCTCG
AGGCACAGGTGGTGGCGCTGGCGAGCCTTGCGCTGGTCGCCGCCTATCCGTTCATGAAGCGCATTACCTGGTGGCCGCAG
GCATGGCTGGGCATGGTCTTCACCTGGGGGCTGCTCGTCGGCTGGACGCAGTTCCGCACCGACAATCTCGACGCGCTGGC
GGCGCTCTATGCGGGCGCGGCGCTGTGGGTGATCGGCTACGACACGATCTACGCGCTGCAGGACCGCGAGGACGATGCGA
TGGTCGGCATCAAGTCGAGCGCGCTGCGGCTGGGAAGCAGCGTCAAGACCGGCGTGGCGCTATTCTACGGCGGCACCGTG
GCGCTGTGGGCGCTCGGCTTCTGGCTGCTGCGGGCGGACTGGATTGCGCTGCTGACGCTGGTGCCGGTTGCGGCCCATCT
GGCGTGGCAGGTGGCGACGCTCGATGCCGATGATCCGGTCAATCCGCTCGAGCGGTTTCGCTCCAATCGCTGGGCCGGTG
CGCTGATGGCGGCGGCGTGTTTCGTGGTGGGGACTGCGTAA

Upstream 100 bases:

>100_bases
CCACATCCGTCATCCCAGCGGAAGCTGGGATCTCGTGCAGCGAGGTCGGACGGTGCTGAGGAAGATCCCAGCTTTCGCTG
GGATGACGAGTTGGGTAGGG

Downstream 100 bases:

>100_bases
GACTGTGTGAGTCCCAGCGGAGGCTGGGACCTCAGGCAGGTTGAGCACATTGTCTTTCCGACCAGGTGGCCTGAGACCCC
AGCCTTCGCTGGGGCTCGCG

Product: 4-hydroxybenzoate polyprenyltransferase

Products: @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

Alternate protein names: 4-HB polyprenyltransferase [H]

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MRTMSDIAPNIVPDTEHRGLVARLPQVPRDLAQLARFDRPIGWWLLFWPCVWGVWLTGAGWQLAMLGWLLLGSIAMRGAG
CVYNDIVDADLDRKVARTASRPVASGRVSKKLAWGWLLALCAIGLLVLLQLRLEAQVVALASLALVAAYPFMKRITWWPQ
AWLGMVFTWGLLVGWTQFRTDNLDALAALYAGAALWVIGYDTIYALQDREDDAMVGIKSSALRLGSSVKTGVALFYGGTV
ALWALGFWLLRADWIALLTLVPVAAHLAWQVATLDADDPVNPLERFRSNRWAGALMAAACFVVGTA

Sequences:

>Translated_306_residues
MRTMSDIAPNIVPDTEHRGLVARLPQVPRDLAQLARFDRPIGWWLLFWPCVWGVWLTGAGWQLAMLGWLLLGSIAMRGAG
CVYNDIVDADLDRKVARTASRPVASGRVSKKLAWGWLLALCAIGLLVLLQLRLEAQVVALASLALVAAYPFMKRITWWPQ
AWLGMVFTWGLLVGWTQFRTDNLDALAALYAGAALWVIGYDTIYALQDREDDAMVGIKSSALRLGSSVKTGVALFYGGTV
ALWALGFWLLRADWIALLTLVPVAAHLAWQVATLDADDPVNPLERFRSNRWAGALMAAACFVVGTA
>Mature_306_residues
MRTMSDIAPNIVPDTEHRGLVARLPQVPRDLAQLARFDRPIGWWLLFWPCVWGVWLTGAGWQLAMLGWLLLGSIAMRGAG
CVYNDIVDADLDRKVARTASRPVASGRVSKKLAWGWLLALCAIGLLVLLQLRLEAQVVALASLALVAAYPFMKRITWWPQ
AWLGMVFTWGLLVGWTQFRTDNLDALAALYAGAALWVIGYDTIYALQDREDDAMVGIKSSALRLGSSVKTGVALFYGGTV
ALWALGFWLLRADWIALLTLVPVAAHLAWQVATLDADDPVNPLERFRSNRWAGALMAAACFVVGTA

Specific function: Synthesis of 3-octaprenyl-4-hydroxybenzoate [H]

COG id: COG0382

COG function: function code H; 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI260656052, Length=302, Percent_Identity=37.7483443708609, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI1790473, Length=265, Percent_Identity=33.5849056603774, Blast_Score=128, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI17553718, Length=284, Percent_Identity=43.3098591549296, Blast_Score=191, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI32565247, Length=283, Percent_Identity=40.6360424028269, Blast_Score=183, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17553720, Length=193, Percent_Identity=40.9326424870466, Blast_Score=125, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI32565245, Length=149, Percent_Identity=44.9664429530201, Blast_Score=104, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI32565243, Length=145, Percent_Identity=44.8275862068966, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6324370, Length=281, Percent_Identity=38.4341637010676, Blast_Score=159, Evalue=4e-40,
Organism=Drosophila melanogaster, GI21355567, Length=272, Percent_Identity=42.2794117647059, Blast_Score=203, Evalue=9e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006370
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.- [C]

Molecular weight: Translated: 33646; Mature: 33646

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTMSDIAPNIVPDTEHRGLVARLPQVPRDLAQLARFDRPIGWWLLFWPCVWGVWLTGAG
CCCHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
WQLAMLGWLLLGSIAMRGAGCVYNDIVDADLDRKVARTASRPVASGRVSKKLAWGWLLAL
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
CAIGLLVLLQLRLEAQVVALASLALVAAYPFMKRITWWPQAWLGMVFTWGLLVGWTQFRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
DNLDALAALYAGAALWVIGYDTIYALQDREDDAMVGIKSSALRLGSSVKTGVALFYGGTV
CCHHHHHHHHHHHHHEEEEHHHEEEECCCCCCHHCCCHHHHHHHCCCHHHCCHHHCCHHH
ALWALGFWLLRADWIALLTLVPVAAHLAWQVATLDADDPVNPLERFRSNRWAGALMAAAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCCHHHHHHHHHH
FVVGTA
HHHCCC
>Mature Secondary Structure
MRTMSDIAPNIVPDTEHRGLVARLPQVPRDLAQLARFDRPIGWWLLFWPCVWGVWLTGAG
CCCHHHHCCCCCCCCCCCCHHHHCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
WQLAMLGWLLLGSIAMRGAGCVYNDIVDADLDRKVARTASRPVASGRVSKKLAWGWLLAL
HHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHH
CAIGLLVLLQLRLEAQVVALASLALVAAYPFMKRITWWPQAWLGMVFTWGLLVGWTQFRT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCC
DNLDALAALYAGAALWVIGYDTIYALQDREDDAMVGIKSSALRLGSSVKTGVALFYGGTV
CCHHHHHHHHHHHHHEEEEHHHEEEECCCCCCHHCCCHHHHHHHCCCHHHCCHHHCCHHH
ALWALGFWLLRADWIALLTLVPVAAHLAWQVATLDADDPVNPLERFRSNRWAGALMAAAC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCCHHHHHHCCCHHHHHHHHHH
FVVGTA
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-Hydroxybenzoate; Farnesylfarnesylgeraniol [C]

Specific reaction: 4-Hydroxybenzoate + Farnesylfarnesylgeraniol = @OCTA07.txt*3-Octaprenyl-4-Hydroxybenzoate!. [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA