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The map label for this gene is obgE

Identifier: 85373198

GI number: 85373198

Start: 417156

End: 418214

Strand: Direct

Name: obgE

Synonym: ELI_01855

Alternate gene names: 85373198

Gene position: 417156-418214 (Clockwise)

Preceding gene: 85373197

Following gene: 85373199

Centisome position: 13.67

GC content: 62.98

Gene sequence:

>1059_bases
ATGCATTTCCTCGACCAGGCCAAGATCTATCTGAAATCGGGTGCGGGCGGACCGGGCGCGGTCTCGTTCCGGCGTGAGAA
GTATATCGAATACGGCGGGCCCGACGGCGGCAACGGCGGCAAGGGTGGCGATATCGTGTTCGAAGCCGTTCAGGGCCTCA
ATACGCTGATCGACTTTCGTTATGCCCAGCACTTCAAGGCCAAGCGCGGAGCACACGGGCAAGGCAAGGACCGCACAGGC
GCAGGCGCGCCCGATCTGGTGATCAAAGTGCCCGTCGGCACGCAGGTCCTTTCCGAAGACAAGGAAGAGGTGCTGGCGGA
CTTCACCGAGGTCGGCCAGCGCGTGACCTTTTTGGCAGGCGGTATGGGCGGACGCGGCAATGCGAGCTACAAATCCAGCA
CCAACCGCGCGCCGCGGCAGCACCAGCCGGGTCAAGCGGGCGAGGAAATGTGGGTGTGGTTGCGATTGAAGCTGCTGGCC
GATGTCGGCCTGTTGGGCCTGCCGAATGCGGGCAAGAGCACTTTCATCAACGCCGTTTCCAACGCCAAGGCCAAGGTCGG
GCATTACGCGTTTACGACACTCGTGCCCAAGCTTGGTGTCGTGAACCATAAAGGCCGCGAATTCGTGCTGGCGGATATTC
CGGGACTGATCGAAGGCGCGGCGGAAGGGGCCGGCATCGGTGATCGCTTCCTTGGCCATATCGAACGCTGCCGGGTGCTG
ATCCACCTGGTCGATATTTCCGGCGAGGACCCGGCCGAGGCGTTCCAGACCGTCAATGCCGAGCTGGAGGCTTACGGCGA
AGGGCTGGAGGACAAGCCGCAACTCGTCGCACTCAACAAGCTCGACCTGGCCGACGAAGAGCTGGTCGCGGGCTTTGCCG
AGGAATTGCTTGAAGCAGGCGCGGACGAGGTCTTCGCCGTGTCCGGTGCGACCGGCGCGGGTATCGAGCCATTGCTCGAT
GCCGTGCTGGGATATTTGCCGGACAGCACATCGACCGAGACCAAGGGGTCCGAAGTCGAGGAAGTCGACGAGGAGGGCGG
CGAGTGGTCGCCGATCTGA

Upstream 100 bases:

>100_bases
GACGATCCGCCAGAGGAATAGGCCCTGTCGCCGCACCGCACGGCGCGATAATGCGGCCACTCTCTGGCGCTTTGCCGCAT
AAGGCCTTACTTGGGCCGCC

Downstream 100 bases:

>100_bases
GCGATCTTGCCCGATCCCAGCGTCTTGTGGTCAAGGTTGGCAGCTCGCTGCTGGTCGAGCACGGCGAGGCGCGCGCGGAT
TGGCTGAAATCGCTGGCGCA

Product: GTPase ObgE

Products: NA

Alternate protein names: GTP-binding protein obg

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MHFLDQAKIYLKSGAGGPGAVSFRREKYIEYGGPDGGNGGKGGDIVFEAVQGLNTLIDFRYAQHFKAKRGAHGQGKDRTG
AGAPDLVIKVPVGTQVLSEDKEEVLADFTEVGQRVTFLAGGMGGRGNASYKSSTNRAPRQHQPGQAGEEMWVWLRLKLLA
DVGLLGLPNAGKSTFINAVSNAKAKVGHYAFTTLVPKLGVVNHKGREFVLADIPGLIEGAAEGAGIGDRFLGHIERCRVL
IHLVDISGEDPAEAFQTVNAELEAYGEGLEDKPQLVALNKLDLADEELVAGFAEELLEAGADEVFAVSGATGAGIEPLLD
AVLGYLPDSTSTETKGSEVEEVDEEGGEWSPI

Sequences:

>Translated_352_residues
MHFLDQAKIYLKSGAGGPGAVSFRREKYIEYGGPDGGNGGKGGDIVFEAVQGLNTLIDFRYAQHFKAKRGAHGQGKDRTG
AGAPDLVIKVPVGTQVLSEDKEEVLADFTEVGQRVTFLAGGMGGRGNASYKSSTNRAPRQHQPGQAGEEMWVWLRLKLLA
DVGLLGLPNAGKSTFINAVSNAKAKVGHYAFTTLVPKLGVVNHKGREFVLADIPGLIEGAAEGAGIGDRFLGHIERCRVL
IHLVDISGEDPAEAFQTVNAELEAYGEGLEDKPQLVALNKLDLADEELVAGFAEELLEAGADEVFAVSGATGAGIEPLLD
AVLGYLPDSTSTETKGSEVEEVDEEGGEWSPI
>Mature_352_residues
MHFLDQAKIYLKSGAGGPGAVSFRREKYIEYGGPDGGNGGKGGDIVFEAVQGLNTLIDFRYAQHFKAKRGAHGQGKDRTG
AGAPDLVIKVPVGTQVLSEDKEEVLADFTEVGQRVTFLAGGMGGRGNASYKSSTNRAPRQHQPGQAGEEMWVWLRLKLLA
DVGLLGLPNAGKSTFINAVSNAKAKVGHYAFTTLVPKLGVVNHKGREFVLADIPGLIEGAAEGAGIGDRFLGHIERCRVL
IHLVDISGEDPAEAFQTVNAELEAYGEGLEDKPQLVALNKLDLADEELVAGFAEELLEAGADEVFAVSGATGAGIEPLLD
AVLGYLPDSTSTETKGSEVEEVDEEGGEWSPI

Specific function: An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in t

COG id: COG0536

COG function: function code R; Predicted GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 G (guanine nucleotide-binding) domain

Homologues:

Organism=Homo sapiens, GI24308117, Length=319, Percent_Identity=38.2445141065831, Blast_Score=177, Evalue=2e-44,
Organism=Homo sapiens, GI111955139, Length=361, Percent_Identity=33.2409972299169, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI111955063, Length=260, Percent_Identity=34.6153846153846, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI4758796, Length=140, Percent_Identity=32.1428571428571, Blast_Score=76, Evalue=4e-14,
Organism=Homo sapiens, GI4557537, Length=117, Percent_Identity=35.042735042735, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI58761500, Length=135, Percent_Identity=30.3703703703704, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1789574, Length=334, Percent_Identity=51.7964071856287, Blast_Score=288, Evalue=5e-79,
Organism=Escherichia coli, GI1787454, Length=130, Percent_Identity=33.0769230769231, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17508313, Length=324, Percent_Identity=37.3456790123457, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17552324, Length=308, Percent_Identity=31.8181818181818, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17555344, Length=187, Percent_Identity=29.4117647058824, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17509631, Length=139, Percent_Identity=34.5323741007194, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI71981008, Length=159, Percent_Identity=27.6729559748428, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6321962, Length=172, Percent_Identity=41.8604651162791, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6319281, Length=122, Percent_Identity=32.7868852459016, Blast_Score=77, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6321612, Length=117, Percent_Identity=32.4786324786325, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI20129375, Length=323, Percent_Identity=38.390092879257, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI24585318, Length=238, Percent_Identity=39.9159663865546, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI17981711, Length=123, Percent_Identity=32.520325203252, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24640873, Length=175, Percent_Identity=30.8571428571429, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640877, Length=175, Percent_Identity=30.8571428571429, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24640875, Length=175, Percent_Identity=30.8571428571429, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21356473, Length=117, Percent_Identity=32.4786324786325, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): OBG_ERYLH (Q2NCX8)

Other databases:

- EMBL:   CP000157
- RefSeq:   YP_457260.1
- HSSP:   Q5SJ29
- ProteinModelPortal:   Q2NCX8
- STRING:   Q2NCX8
- GeneID:   3868856
- GenomeReviews:   CP000157_GR
- KEGG:   eli:ELI_01855
- NMPDR:   fig|314225.3.peg.2717
- eggNOG:   COG0536
- HOGENOM:   HBG716038
- OMA:   LIDYRFN
- PhylomeDB:   Q2NCX8
- ProtClustDB:   PRK12299
- BioCyc:   ELIT314225:ELI_01855-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01454
- InterPro:   IPR014100
- InterPro:   IPR006074
- InterPro:   IPR006073
- InterPro:   IPR006169
- InterPro:   IPR002917
- InterPro:   IPR005225
- Gene3D:   G3DSA:2.70.210.12
- PANTHER:   PTHR11702:SF3
- PIRSF:   PIRSF002401
- PRINTS:   PR00326
- TIGRFAMs:   TIGR02729
- TIGRFAMs:   TIGR00231

Pfam domain/function: PF01018 GTP1_OBG; PF01926 MMR_HSR1; SSF82051 GTP1_OBG_sub

EC number: NA

Molecular weight: Translated: 37197; Mature: 37197

Theoretical pI: Translated: 4.56; Mature: 4.56

Prosite motif: PS00905 GTP1_OBG

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFLDQAKIYLKSGAGGPGAVSFRREKYIEYGGPDGGNGGKGGDIVFEAVQGLNTLIDFR
CCCHHCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YAQHFKAKRGAHGQGKDRTGAGAPDLVIKVPVGTQVLSEDKEEVLADFTEVGQRVTFLAG
HHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHEEEEEEC
GMGGRGNASYKSSTNRAPRQHQPGQAGEEMWVWLRLKLLADVGLLGLPNAGKSTFINAVS
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
NAKAKVGHYAFTTLVPKLGVVNHKGREFVLADIPGLIEGAAEGAGIGDRFLGHIERCRVL
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHH
IHLVDISGEDPAEAFQTVNAELEAYGEGLEDKPQLVALNKLDLADEELVAGFAEELLEAG
HHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
ADEVFAVSGATGAGIEPLLDAVLGYLPDSTSTETKGSEVEEVDEEGGEWSPI
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MHFLDQAKIYLKSGAGGPGAVSFRREKYIEYGGPDGGNGGKGGDIVFEAVQGLNTLIDFR
CCCHHCCEEEEECCCCCCCCCCHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHH
YAQHFKAKRGAHGQGKDRTGAGAPDLVIKVPVGTQVLSEDKEEVLADFTEVGQRVTFLAG
HHHHHHHHCCCCCCCCCCCCCCCCCEEEECCCCHHHHHCCHHHHHHHHHHHHHEEEEEEC
GMGGRGNASYKSSTNRAPRQHQPGQAGEEMWVWLRLKLLADVGLLGLPNAGKSTFINAVS
CCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHH
NAKAKVGHYAFTTLVPKLGVVNHKGREFVLADIPGLIEGAAEGAGIGDRFLGHIERCRVL
CCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCHHHHHCCCCCCCHHHHHHHHHHHHHH
IHLVDISGEDPAEAFQTVNAELEAYGEGLEDKPQLVALNKLDLADEELVAGFAEELLEAG
HHEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCC
ADEVFAVSGATGAGIEPLLDAVLGYLPDSTSTETKGSEVEEVDEEGGEWSPI
CCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA