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The map label for this gene is hemC [H]

Identifier: 84625435

GI number: 84625435

Start: 4272370

End: 4273284

Strand: Reverse

Name: hemC [H]

Synonym: XOO_3778

Alternate gene names: 84625435

Gene position: 4273284-4272370 (Counterclockwise)

Preceding gene: 84625436

Following gene: 84625433

Centisome position: 86.5

GC content: 68.74

Gene sequence:

>915_bases
ATGACCACGCTCCGCATCGCTACCCGCAAAAGCCCGCTCGCCCTCTGGCAGAGCGAACACGTCGCCGCCGCGTTGCGTCA
GCACCACCCTGGACTGGAGGTGGTGCTGGTGCCGATGAGCACCCGTGGCGACGAAGTGCTGGACCGCTCGCTCGCGGCGA
TCGGTGGCAAGGGCCTGTTCTTGAAGGAACTGGAACTGGCGATGTTGCGCGGCGACGCCGATTGCGCCGTGCATTCGTTC
AAGGATGTGCCGATGGAACTGGACGACCCGTTCGTGCTGCCTGCGATCCTGGAACGCGGCGACCCGGCCGATGCGCTGGT
GTCCAACCTCTACGCCAGCCTGCAGGCGCTGCCGCTGGGCGCACGCGTGGGCACGTCTTCGCTGCGTCGCCAGGCGCAGT
TGCGCGCTGCGCGCCCGGACCTGGAATTGATCGACCTGCGCGGCAACGTCAACACGCGTCTGGCCAAGCTCGACAACGGC
GGCTACGACGCCATCGTGCTGGCCTGCGCCGGCCTGCAGCGGCTCGGGTTGGATGAACGCATCAGCGCGCGGCTGGATGC
ACCGGAGTGGTTGCCGGCGCCTGCACAAGGCGCGGTGGCGGTGGAATGCCGTGGCGACGACGCGCGCATCCACAGTCTGC
TGGCAGTGCTGGATGCCGGCCGCACGCGTGCCTGCGTGGAAGCCGAGCGGGCAATGAATCGCGCGCTGCACGGCAGCTGC
CATGTGCCGGTGGCCGCCCTTGCGCGCTGGGAAGGCGAGGGTCTGTTTCTGCAGGGCATGGTCGGCAGCGCCAGCGACGG
CCGCTTGATCCACGCCGACGCCCATGGCAGTGCCGACGACACTGAAGACCTGGGCCGCCGCGTTGCGCAAGGCCTGTTCG
ACAAGGGTGCCGCGCAGTTGCTGGCTGCGCTGTAA

Upstream 100 bases:

>100_bases
CGTACCGCAGACCCTGGAAGTGAGTCGGCGCTGTGTCGCCAGCCTGCGCGATCAATTACGCCAACTGTGAGTTCCGCGCC
GGCTCCGCGATAATGCTGGA

Downstream 100 bases:

>100_bases
CGCCGGGTCTGGAGAAGCGCGTTTGGCCGCAGAAGTCGGCGCGTGCAGACCCGTCGCCCCGAGAAAACCGCCGCCGCGCC
CGAAGGATCGATCCCGGTCA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 304; Mature: 303

Protein sequence:

>304_residues
MTTLRIATRKSPLALWQSEHVAAALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLFLKELELAMLRGDADCAVHSF
KDVPMELDDPFVLPAILERGDPADALVSNLYASLQALPLGARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNG
GYDAIVLACAGLQRLGLDERISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRACVEAERAMNRALHGSC
HVPVAALARWEGEGLFLQGMVGSASDGRLIHADAHGSADDTEDLGRRVAQGLFDKGAAQLLAAL

Sequences:

>Translated_304_residues
MTTLRIATRKSPLALWQSEHVAAALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLFLKELELAMLRGDADCAVHSF
KDVPMELDDPFVLPAILERGDPADALVSNLYASLQALPLGARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNG
GYDAIVLACAGLQRLGLDERISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRACVEAERAMNRALHGSC
HVPVAALARWEGEGLFLQGMVGSASDGRLIHADAHGSADDTEDLGRRVAQGLFDKGAAQLLAAL
>Mature_303_residues
TTLRIATRKSPLALWQSEHVAAALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLFLKELELAMLRGDADCAVHSFK
DVPMELDDPFVLPAILERGDPADALVSNLYASLQALPLGARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNGG
YDAIVLACAGLQRLGLDERISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRACVEAERAMNRALHGSCH
VPVAALARWEGEGLFLQGMVGSASDGRLIHADAHGSADDTEDLGRRVAQGLFDKGAAQLLAAL

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=334, Percent_Identity=40.1197604790419, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI66933009, Length=334, Percent_Identity=40.1197604790419, Blast_Score=197, Evalue=1e-50,
Organism=Escherichia coli, GI48994974, Length=301, Percent_Identity=54.1528239202658, Blast_Score=296, Evalue=9e-82,
Organism=Saccharomyces cerevisiae, GI6319996, Length=315, Percent_Identity=36.5079365079365, Blast_Score=179, Evalue=3e-46,
Organism=Drosophila melanogaster, GI20130425, Length=257, Percent_Identity=43.9688715953307, Blast_Score=187, Evalue=1e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 32378; Mature: 32247

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00533 PORPHOBILINOGEN_DEAM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLRIATRKSPLALWQSEHVAAALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLF
CCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCH
LKELELAMLRGDADCAVHSFKDVPMELDDPFVLPAILERGDPADALVSNLYASLQALPLG
HHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHCCCC
ARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNGGYDAIVLACAGLQRLGLDER
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHH
ISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRACVEAERAMNRALHGSC
HHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
HVPVAALARWEGEGLFLQGMVGSASDGRLIHADAHGSADDTEDLGRRVAQGLFDKGAAQL
CCCHHHHHEECCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
LAAL
HHCC
>Mature Secondary Structure 
TTLRIATRKSPLALWQSEHVAAALRQHHPGLEVVLVPMSTRGDEVLDRSLAAIGGKGLF
CEEEEECCCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCH
LKELELAMLRGDADCAVHSFKDVPMELDDPFVLPAILERGDPADALVSNLYASLQALPLG
HHHHHHHHHCCCCHHHHHHHCCCCCCCCCCEEHHHHHHCCCCHHHHHHHHHHHHHHCCCC
ARVGTSSLRRQAQLRAARPDLELIDLRGNVNTRLAKLDNGGYDAIVLACAGLQRLGLDER
CCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCHHHHHHHHHHHHCCCCHH
ISARLDAPEWLPAPAQGAVAVECRGDDARIHSLLAVLDAGRTRACVEAERAMNRALHGSC
HHHCCCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
HVPVAALARWEGEGLFLQGMVGSASDGRLIHADAHGSADDTEDLGRRVAQGLFDKGAAQL
CCCHHHHHEECCCCEEEEEECCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHH
LAAL
HHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]