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The map label for this gene is frmB [H]

Identifier: 84625302

GI number: 84625302

Start: 4122532

End: 4123362

Strand: Reverse

Name: frmB [H]

Synonym: XOO_3645

Alternate gene names: 84625302

Gene position: 4123362-4122532 (Counterclockwise)

Preceding gene: 84625303

Following gene: 84625301

Centisome position: 83.47

GC content: 61.37

Gene sequence:

>831_bases
ATGGAACGTATCGAACATCGTGCCTGTTTTGGCGGTTGGCAGGATGTCTACCGGCATCAGTCGCAGACCTTGGACTGCCG
CATGCACGTGGGCGTATACCTGCCGCCGCAGGCCGCCGATGGCCCGCTGCCGGTGCTGTACTGGCTGAGCGGTCTGACCT
GCACCGAGCAGAACTTCATCAGCAAGGCAGGGGCGCAGCGCTACGCCGCTGAGCATGGCGTGATCCTGGTGGCCCCCGAC
ACCAGCCCGCGTGGCGACGATATAGCGGATGCGGACGGCTACGATATCGGCAAGGGCGCGGGTTTCTACCTCGATGCCAC
ACAAGCGCCGTGGGCTGCGCATTACCGCATGTACGACTACGTGGTGAACGAGTTACCGGCGTTGATCGAAGCACACTTCG
CCACCACTGGCGTGCGTGCGATCAGCGGCCACTCGATGGGCGGGCATGGCGCCTTGACCATCGCATTGAAAAACCCGGGA
CGCTATCGCAGCGTGTCGGCGTTTTCGCCGATCGTGGCGCCCAGCCAGGTGCCATGGGGCGAGAAGGCGTTTAGCCAGTA
TCTGGGCGACGATCGCGCCACGTGGAACGCGTACGATGCTACGGCCTTGATCGCTGATGCTCAGGAACGCTTACCCTTGT
TGATCGATCAGGGAGACGCGGACGAGTTTCTTCAAAACCAGCTGAAAACAGTGTTGTTCGAAGATGCGGCCAAGGCAGCC
GGCTATCCGGTGACGGTGCGGCTGCAACCCGGTTACGACCACAGCTATTACTTCATCTCAAGCTTTATGGGCGAGCACAT
TGCGCATCATGCTGCGGCCTTGCGGGGATGA

Upstream 100 bases:

>100_bases
TGTCTGCGCATGTCGCGCGCAACAAGGGTCTGTTGCATTGATGGTCCAACCCTGCAGCCGGCGATCCGGCTGCGGGGTTT
TCTCTTCGTAAGGAATCTTC

Downstream 100 bases:

>100_bases
GCGTGGGCGGTTGTGGGCGCGACGTGGGATGAGCACGGCGGCTGATATTTGCGTGACATGGCGGCATCGGTCGCGACTAC
ACGCTGCTGCACCCGGGTGG

Product: esterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 276; Mature: 276

Protein sequence:

>276_residues
MERIEHRACFGGWQDVYRHQSQTLDCRMHVGVYLPPQAADGPLPVLYWLSGLTCTEQNFISKAGAQRYAAEHGVILVAPD
TSPRGDDIADADGYDIGKGAGFYLDATQAPWAAHYRMYDYVVNELPALIEAHFATTGVRAISGHSMGGHGALTIALKNPG
RYRSVSAFSPIVAPSQVPWGEKAFSQYLGDDRATWNAYDATALIADAQERLPLLIDQGDADEFLQNQLKTVLFEDAAKAA
GYPVTVRLQPGYDHSYYFISSFMGEHIAHHAAALRG

Sequences:

>Translated_276_residues
MERIEHRACFGGWQDVYRHQSQTLDCRMHVGVYLPPQAADGPLPVLYWLSGLTCTEQNFISKAGAQRYAAEHGVILVAPD
TSPRGDDIADADGYDIGKGAGFYLDATQAPWAAHYRMYDYVVNELPALIEAHFATTGVRAISGHSMGGHGALTIALKNPG
RYRSVSAFSPIVAPSQVPWGEKAFSQYLGDDRATWNAYDATALIADAQERLPLLIDQGDADEFLQNQLKTVLFEDAAKAA
GYPVTVRLQPGYDHSYYFISSFMGEHIAHHAAALRG
>Mature_276_residues
MERIEHRACFGGWQDVYRHQSQTLDCRMHVGVYLPPQAADGPLPVLYWLSGLTCTEQNFISKAGAQRYAAEHGVILVAPD
TSPRGDDIADADGYDIGKGAGFYLDATQAPWAAHYRMYDYVVNELPALIEAHFATTGVRAISGHSMGGHGALTIALKNPG
RYRSVSAFSPIVAPSQVPWGEKAFSQYLGDDRATWNAYDATALIADAQERLPLLIDQGDADEFLQNQLKTVLFEDAAKAA
GYPVTVRLQPGYDHSYYFISSFMGEHIAHHAAALRG

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=279, Percent_Identity=55.9139784946236, Blast_Score=317, Evalue=9e-87,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=60.3636363636364, Blast_Score=366, Evalue=1e-103,
Organism=Escherichia coli, GI1788477, Length=276, Percent_Identity=59.0579710144928, Blast_Score=346, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17510185, Length=280, Percent_Identity=48.5714285714286, Blast_Score=268, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6322393, Length=298, Percent_Identity=44.9664429530201, Blast_Score=230, Evalue=2e-61,
Organism=Drosophila melanogaster, GI45551932, Length=283, Percent_Identity=52.2968197879859, Blast_Score=283, Evalue=1e-76,
Organism=Drosophila melanogaster, GI24648347, Length=283, Percent_Identity=52.2968197879859, Blast_Score=281, Evalue=2e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30220; Mature: 30220

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MERIEHRACFGGWQDVYRHQSQTLDCRMHVGVYLPPQAADGPLPVLYWLSGLTCTEQNFI
CCCCHHHHHHCCHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHH
SKAGAQRYAAEHGVILVAPDTSPRGDDIADADGYDIGKGAGFYLDATQAPWAAHYRMYDY
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
VVNELPALIEAHFATTGVRAISGHSMGGHGALTIALKNPGRYRSVSAFSPIVAPSQVPWG
HHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCC
EKAFSQYLGDDRATWNAYDATALIADAQERLPLLIDQGDADEFLQNQLKTVLFEDAAKAA
HHHHHHHHCCCCCCCCCCCHHHEECCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHC
GYPVTVRLQPGYDHSYYFISSFMGEHIAHHAAALRG
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MERIEHRACFGGWQDVYRHQSQTLDCRMHVGVYLPPQAADGPLPVLYWLSGLTCTEQNFI
CCCCHHHHHHCCHHHHHHHCCCCEEEEEEEEEEECCCCCCCCCHHHHHHCCCCCCHHHHH
SKAGAQRYAAEHGVILVAPDTSPRGDDIADADGYDIGKGAGFYLDATQAPWAAHYRMYDY
HHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHH
VVNELPALIEAHFATTGVRAISGHSMGGHGALTIALKNPGRYRSVSAFSPIVAPSQVPWG
HHHHHHHHHHHHHHHHCCCEECCCCCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCC
EKAFSQYLGDDRATWNAYDATALIADAQERLPLLIDQGDADEFLQNQLKTVLFEDAAKAA
HHHHHHHHCCCCCCCCCCCHHHEECCHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHC
GYPVTVRLQPGYDHSYYFISSFMGEHIAHHAAALRG
CCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA