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The map label for this gene is lpxC [H]

Identifier: 84625255

GI number: 84625255

Start: 4070346

End: 4071257

Strand: Reverse

Name: lpxC [H]

Synonym: XOO_3598

Alternate gene names: 84625255

Gene position: 4071257-4070346 (Counterclockwise)

Preceding gene: 84625256

Following gene: 84625253

Centisome position: 82.41

GC content: 61.07

Gene sequence:

>912_bases
ATGACCCAGCAACGCACGCTCAAGAACACCATTCGCGCCACCGGCGTCGGCCTGCATAGCGGCGACAAGGTGTATATGAC
GCTACGACCGGCTCCGGTCGATCATGGCGTGGTGTTCCGACGTGTGGACCTGGAACCGATCGTCGAAGTCCCCGCCGATG
CCGAGCTGGTCACCGAAACCACGTTGTGCACCGGCCTGAGCTGCAACGGTGCCAAGATCCAGACCGTCGAACATCTGATG
TCCGCATTGGCGGGCTTGGGTGTGGACAATGTCATCGTCGAACTGTCCTCGGCCGAGTTGCCCATCATGGATGGTTCGTC
CGGCCCGTTCGTGTTCCTGCTGCAGTCGGCAGGTATCGTCGAACAGAGCAAGCCCAAGCGCTTCATCCGGATCAAGCAGA
CCGTGGAAGTGCGCGACGGCGACAAGGTGGCGCGCTTTGAGCCCTACGAGGGCTACAAGCTTGGTTTCACCATCGAATTC
AATCACCCGATGATCCCGGCCAAGCAGTCGCGCCAGGAAATCGATTTCTCCACGTCGGCGTACGTCACGGAAATTTCGCG
CGCGCGCACCTTCGGTTTCATGCGCGACCTCGAGTACATGCGCGAGCGCAATCTGGGCCTGGGCGGTTCAATGGACAACG
CCATCGTGCTGGACGAGTTCCGTGTGCTCAACGAAGACGGCCTGCGCTACACCAACGAATTCGTGCGGCACAAGATTCTG
GACGCCATTGGCGATCTGTATCTGGCTGGCGGCGCCATCCTGGGTGCTTACGAAGGCTTCAAATCCGGCCACGCCCTCAA
CAACAAACTGGTGCGTGCGTTGTTGGCCGACCAGGCCGCCTGGGAATGGGTGAGCTTCCCGGAAGGCACCGAGCAGCCGC
CGGTCACCTACGCCAGCCCTGTCTACGCGTAG

Upstream 100 bases:

>100_bases
GACAGTTTCCGTCACGCGCGACTTGTTAAAATACTGATAATCTCAGCGGGCCAGGCAGTCGATTCAGCGTCTGTCTGCAT
TGTTCAGCCAGACTTCGCAT

Downstream 100 bases:

>100_bases
TGTCAGGGAATGCCCTAGTTGGCACAGAAAGTGTGAATCAAGTTGTATTTTTTGTTCATTCTTAACATTTATCTAATAAT
TCCCTAACTCCTGCGGCCGA

Product: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase

Products: UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine; Acetate. [C]

Alternate protein names: UDP-3-O-acyl-GlcNAc deacetylase [H]

Number of amino acids: Translated: 303; Mature: 302

Protein sequence:

>303_residues
MTQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPIVEVPADAELVTETTLCTGLSCNGAKIQTVEHLM
SALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIVEQSKPKRFIRIKQTVEVRDGDKVARFEPYEGYKLGFTIEF
NHPMIPAKQSRQEIDFSTSAYVTEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKIL
DAIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASPVYA

Sequences:

>Translated_303_residues
MTQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPIVEVPADAELVTETTLCTGLSCNGAKIQTVEHLM
SALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIVEQSKPKRFIRIKQTVEVRDGDKVARFEPYEGYKLGFTIEF
NHPMIPAKQSRQEIDFSTSAYVTEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKIL
DAIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASPVYA
>Mature_302_residues
TQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPIVEVPADAELVTETTLCTGLSCNGAKIQTVEHLMS
ALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIVEQSKPKRFIRIKQTVEVRDGDKVARFEPYEGYKLGFTIEFN
HPMIPAKQSRQEIDFSTSAYVTEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKILD
AIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASPVYA

Specific function: Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell [H]

COG id: COG0774

COG function: function code M; UDP-3-O-acyl-N-acetylglucosamine deacetylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lpxC family [H]

Homologues:

Organism=Escherichia coli, GI1786285, Length=301, Percent_Identity=57.8073089700997, Blast_Score=375, Evalue=1e-105,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020568
- InterPro:   IPR004463
- InterPro:   IPR011334
- InterPro:   IPR015870 [H]

Pfam domain/function: PF03331 LpxC [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 33491; Mature: 33359

Theoretical pI: Translated: 5.23; Mature: 5.23

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPIVEVPADAELVTET
CCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCHHHCCCCCCHHHHHH
TLCTGLSCNGAKIQTVEHLMSALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIV
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEECCCCC
EQSKPKRFIRIKQTVEVRDGDKVARFEPYEGYKLGFTIEFNHPMIPAKQSRQEIDFSTSA
CCCCCCEEEEEEEEEEECCCCCEEEECCCCCEEEEEEEEECCCCCCCHHCHHHCCCCCHH
YVTEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKIL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHECCCCCCHHHHHHHHHHHH
DAIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASP
HHHHHHHHHCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VYA
CCC
>Mature Secondary Structure 
TQQRTLKNTIRATGVGLHSGDKVYMTLRPAPVDHGVVFRRVDLEPIVEVPADAELVTET
CCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCEEEEEECCCHHHCCCCCCHHHHHH
TLCTGLSCNGAKIQTVEHLMSALAGLGVDNVIVELSSAELPIMDGSSGPFVFLLQSAGIV
HHHCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEECCCCCEEEEEECCCCC
EQSKPKRFIRIKQTVEVRDGDKVARFEPYEGYKLGFTIEFNHPMIPAKQSRQEIDFSTSA
CCCCCCEEEEEEEEEEECCCCCEEEECCCCCEEEEEEEEECCCCCCCHHCHHHCCCCCHH
YVTEISRARTFGFMRDLEYMRERNLGLGGSMDNAIVLDEFRVLNEDGLRYTNEFVRHKIL
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEHHHECCCCCCHHHHHHHHHHHH
DAIGDLYLAGGAILGAYEGFKSGHALNNKLVRALLADQAAWEWVSFPEGTEQPPVTYASP
HHHHHHHHHCCCEEEHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VYA
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine; H2O [C]

Specific reaction: UDP-3-O-(3-Hydroxytetradecanoyl)-N- Acetylglucosamine + H2O = UDP-3-O-(3-Hydroxytetradecanoyl)- Glucosamine + Acetate. [C]

General reaction: Hydrolase; Acting on carbon-nitrogen bonds, other than peptide bonds; In linear amides [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]