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The map label for this gene is moaA [H]

Identifier: 84622616

GI number: 84622616

Start: 1050186

End: 1051217

Strand: Direct

Name: moaA [H]

Synonym: XOO_0959

Alternate gene names: 84622616

Gene position: 1050186-1051217 (Clockwise)

Preceding gene: 84622615

Following gene: 84622617

Centisome position: 21.26

GC content: 65.31

Gene sequence:

>1032_bases
ATGGGCGCCTTGCTGCTGCCGAATCTTGCCACGGCGCCGATGCAGGACCGCTATGGCCGTCCGCTGCGCGATCTGCGCCT
GTCGGTGATCGAGGCCTGCAATTTTCGCTGCGGGTACTGCATGCCGGCCGATCGCGTACCCGACGACTACGGGTTCGACT
CGCGGCAGCGGTTGAGTTTCGATCAGCTGGAAACCCTGGTGCGTGCCTTCGTGTCGGTCGGTGTGACCAAGGTGCGCCTG
ACCGGCGGCGAGCCGCTGCTGCGTCGCGATCTACCGAGCCTGATTGCGCGGCTGACTGCGATCGAGGGCATCGAAGATCT
GGCGCTGACCACCAACGGCACCTTGCTTGCGCGCCAGGCCGTCGCGCTGCGGCAGGCGGGGTTGCGCCGCATCACCGTCA
GCATGGATGCGCTGGAACCGGCATTGTTCAGACGCATGAACGGCGACCGCGGCGAGATTGCGCGGGTGCTGCCCGTCATC
GCCGCGGCCGAGCAGGCCGTCTTCCAGCGGCTGAAGATCAATTGCGTAGTGCAGCGTGGCGTCAACGAAGATCAGGTGCT
GCCGCTGGTGGAGCACTTCCGCGGCACCGGACACGTGCTGCGCTTTATCGAATTCATGGATGTGGGTAGCTGCAATGGCT
GGACGCCGGATGCGGTGGTGACCTCTGCGCAATTGCATGAACGCATCCATGCGCGCTGGCCGTTGGTGGCGCTGGACGCC
CATTACACCGGTGAAGTGGCGCAGCGCCACGCGTTCGCGGATGGCGCCGGCGAAGTGGGCTTCGTCAGTTCGGTCAGCGT
GCCGTTCTGCGGCGATTGCCAGCGTGCGCGCGTCTCGGCAGATGGGCATCTATATACCTGCCTGTTCGCCAGTCAGGGGC
ATGACCTGAAACCGGCACTGGCCAATGGCGAGCCTGCGCTGGCGACGCATCTATGGCAGTGCTGGAGTGTGCGTGGCGAC
CGCTACAGCGAAGTGCGCGCCTCGGTGCCACGGCGCGGCAAGCCGGTCGAGATGTTTTTAATCGGCGGATGA

Upstream 100 bases:

>100_bases
GCGACGCCGACGGCGATGTGCTGCGTGCGCGTGGCCACCGCGTCGCCGTGCCCGGTCAATACCTTGCGCTGGCGAACCCG
ACCGCAGCGACGGTGCCCTG

Downstream 100 bases:

>100_bases
GCTAGGGCGCGCTGCCGGTGCTGCTGCGCACGCTGGAACAGCGTCTGCGCGATCCGCAGCTGCGTGCCGATGTGCAGGTG
TTGGAGGCGTCGCTCGATCC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MGALLLPNLATAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSRQRLSFDQLETLVRAFVSVGVTKVRL
TGGEPLLRRDLPSLIARLTAIEGIEDLALTTNGTLLARQAVALRQAGLRRITVSMDALEPALFRRMNGDRGEIARVLPVI
AAAEQAVFQRLKINCVVQRGVNEDQVLPLVEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDA
HYTGEVAQRHAFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPALANGEPALATHLWQCWSVRGD
RYSEVRASVPRRGKPVEMFLIGG

Sequences:

>Translated_343_residues
MGALLLPNLATAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSRQRLSFDQLETLVRAFVSVGVTKVRL
TGGEPLLRRDLPSLIARLTAIEGIEDLALTTNGTLLARQAVALRQAGLRRITVSMDALEPALFRRMNGDRGEIARVLPVI
AAAEQAVFQRLKINCVVQRGVNEDQVLPLVEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDA
HYTGEVAQRHAFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPALANGEPALATHLWQCWSVRGD
RYSEVRASVPRRGKPVEMFLIGG
>Mature_342_residues
GALLLPNLATAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSRQRLSFDQLETLVRAFVSVGVTKVRLT
GGEPLLRRDLPSLIARLTAIEGIEDLALTTNGTLLARQAVALRQAGLRRITVSMDALEPALFRRMNGDRGEIARVLPVIA
AAEQAVFQRLKINCVVQRGVNEDQVLPLVEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDAH
YTGEVAQRHAFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPALANGEPALATHLWQCWSVRGDR
YSEVRASVPRRGKPVEMFLIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=293, Percent_Identity=35.8361774744027, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI116734668, Length=293, Percent_Identity=35.8361774744027, Blast_Score=190, Evalue=2e-48,
Organism=Escherichia coli, GI1786999, Length=291, Percent_Identity=35.0515463917526, Blast_Score=168, Evalue=5e-43,
Organism=Caenorhabditis elegans, GI17561210, Length=336, Percent_Identity=31.547619047619, Blast_Score=163, Evalue=1e-40,
Organism=Caenorhabditis elegans, GI32566329, Length=334, Percent_Identity=31.7365269461078, Blast_Score=159, Evalue=1e-39,
Organism=Caenorhabditis elegans, GI32566331, Length=293, Percent_Identity=33.4470989761092, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI28574488, Length=290, Percent_Identity=35.8620689655172, Blast_Score=185, Evalue=3e-47,
Organism=Drosophila melanogaster, GI28574490, Length=290, Percent_Identity=35.8620689655172, Blast_Score=184, Evalue=6e-47,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 37742; Mature: 37611

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGALLLPNLATAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSRQRLSF
CCCEECCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCH
DQLETLVRAFVSVGVTKVRLTGGEPLLRRDLPSLIARLTAIEGIEDLALTTNGTLLARQA
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHEEECCCHHHHHHH
VALRQAGLRRITVSMDALEPALFRRMNGDRGEIARVLPVIAAAEQAVFQRLKINCVVQRG
HHHHHCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
VNEDQVLPLVEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDA
CCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECC
HYTGEVAQRHAFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPAL
CCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHEECCCCCEEEEEEECCCCCCCCCC
ANGEPALATHLWQCWSVRGDRYSEVRASVPRRGKPVEMFLIGG
CCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECC
>Mature Secondary Structure 
GALLLPNLATAPMQDRYGRPLRDLRLSVIEACNFRCGYCMPADRVPDDYGFDSRQRLSF
CCEECCCCCCCCCHHHCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCHHCCCH
DQLETLVRAFVSVGVTKVRLTGGEPLLRRDLPSLIARLTAIEGIEDLALTTNGTLLARQA
HHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHEEECCCHHHHHHH
VALRQAGLRRITVSMDALEPALFRRMNGDRGEIARVLPVIAAAEQAVFQRLKINCVVQRG
HHHHHCCCEEEEEEHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEECC
VNEDQVLPLVEHFRGTGHVLRFIEFMDVGSCNGWTPDAVVTSAQLHERIHARWPLVALDA
CCCCHHHHHHHHCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCEEEECC
HYTGEVAQRHAFADGAGEVGFVSSVSVPFCGDCQRARVSADGHLYTCLFASQGHDLKPAL
CCCHHHHHHHHCCCCCCCCCEEEECCCCCCCCCCHHEECCCCCEEEEEEECCCCCCCCCC
ANGEPALATHLWQCWSVRGDRYSEVRASVPRRGKPVEMFLIGG
CCCCHHHHHHHHHHHHCCCCHHHHHHHCCCCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA