Click here to switch to the map view.

The map label for this gene is norM [H]

Identifier: 84622190

GI number: 84622190

Start: 581807

End: 583183

Strand: Direct

Name: norM [H]

Synonym: XOO_0533

Alternate gene names: 84622190

Gene position: 581807-583183 (Clockwise)

Preceding gene: 84622188

Following gene: 84622191

Centisome position: 11.78

GC content: 67.25

Gene sequence:

>1377_bases
ATGTCTGTTTCTTCAGCCCCCCCGTCCGCGACGCCAGGCTTCGCCTCGGAAGTGCGTACCACCGGCCTGCTTGCGTTGCC
GCTGGTGCTCGGCCACGTCTCCACCGGCCTGATCGGGTTTGTCGACAACGTCATCGCCGGCCACCACGGCACTGCCACGC
TGGCCGCGGTGACCATCGGCACCTCGCTGTTGTGGCTGCCGATGCTGGTGCCGATCGGCACATTGATCTCATTGACCACC
TCGGTTTCGCAACTGATGGGCGCCGGCCGCGAGCGCGAGATCGGGCCGCTGTTCCGGCAGGCGCTGTGGCTGTCGCTGGG
GCTGAGTGCGCTGATGTTCGTGTTCCTGAGCGTGGTGCCGCCGTTGCTGCCCACCTTCGGGATTGCGCCGGACATCGTGC
CCGGCGCCACCGACTTTCTGCATACAGTGCGCTGGGGCGTGCCGGCGCTGACGTTCTACTTTTGCATGCGCTACCTCAGC
GAGGGCATGCACTGGACGCTGCCGACCATGCTGCTGGGCTTTGGCGGTTTGCTGGTCCTGGCACCGACGGGCTATGCGCT
GACCTATGGCAAGTTCGGCTTCGCCGAGCACGGTGCCGAAGGACTGGGCATGGCCTCGGCCATCACCCTGTGGGTGCAGG
CGAGCGTGTTTGCGCTGTACCTGTGGCGCGCGCGGCGCTTTGCGCATCTGCAATTGTTCACCCACCTGGAAGGCCCGCGC
TGGCGCGCCATTGGCGAGTTGCTGCGCACCGGCTTGCCGATCGGCATCACCGTGCTGATGGAAGGCGGGTTGTTTATCGT
CACCGCGTTGTTGATCGGCCGGCTGGGCTCCACCGAAGCGGCCGCGCACCAGATTGCGATCAACGTCGCGCAGCTGTGTT
TCATGATCCCGATGGGCGTGGCCGAGGCCACCACCGTGCGCGTCGGCCATGCGGTGGGGCGTGGCGATCCGCTGGGCATG
CGGCGCGCGGCCTGGGCCGGCTATGCGATCGTGCTGGGCACCCAAGCGCTGTCGGCCAGCGCACTGTTGCTGGGCCACGA
TGCCATCGTCGGCGTCTATACGGACGATGTGGCCGTGGCCGCGCTGGCCTCGGTCTTGCTGCTGTTTGCCGCCACATTCC
AGTTTCCCGATGGTATCCAGGTGCTCTCGGCCGGTGCGCTGCGCGGGCTCAAGGACACCCATGTGCCAATGTTCCTGGCA
ATGTTTTCGTACTGGGGCGTGGGCATGCCGATCGGCGCCGGGCTCGGCCTGGGGCTGGGCTGGGGGCCGCAGGGCATGTG
GGTAGGCCTGATTCTGGGCCTGACGGTGGCCTCGCTCCTGATGGGGCTGCGCTTTCGCCAGACCAGCCGGCGGGTGACCG
CCACCGCGACACCCTGA

Upstream 100 bases:

>100_bases
ACAAGGCCGCAGTCGGAAAGTAGGGGTAAGATAGCCGGCCCACGCGACCCGGTGCCAGCGCCTCCCGGCACGGCCGTAGT
CCACGCAGCAATTGGTTTTC

Downstream 100 bases:

>100_bases
CTTCCAGCGCATGCCGCGCGCGCTGCGCAGCCGGTATGCTGGGCACCATCGATTTGTATGCAGCGTCTTTCGACGGAGTT
TTCCATGAACCATCCCGTGC

Product: multidrug efflux protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MSVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIGTSLLWLPMLVPIGTLISLTT
SVSQLMGAGREREIGPLFRQALWLSLGLSALMFVFLSVVPPLLPTFGIAPDIVPGATDFLHTVRWGVPALTFYFCMRYLS
EGMHWTLPTMLLGFGGLLVLAPTGYALTYGKFGFAEHGAEGLGMASAITLWVQASVFALYLWRARRFAHLQLFTHLEGPR
WRAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGSTEAAAHQIAINVAQLCFMIPMGVAEATTVRVGHAVGRGDPLGM
RRAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVAALASVLLLFAATFQFPDGIQVLSAGALRGLKDTHVPMFLA
MFSYWGVGMPIGAGLGLGLGWGPQGMWVGLILGLTVASLLMGLRFRQTSRRVTATATP

Sequences:

>Translated_458_residues
MSVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIGTSLLWLPMLVPIGTLISLTT
SVSQLMGAGREREIGPLFRQALWLSLGLSALMFVFLSVVPPLLPTFGIAPDIVPGATDFLHTVRWGVPALTFYFCMRYLS
EGMHWTLPTMLLGFGGLLVLAPTGYALTYGKFGFAEHGAEGLGMASAITLWVQASVFALYLWRARRFAHLQLFTHLEGPR
WRAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGSTEAAAHQIAINVAQLCFMIPMGVAEATTVRVGHAVGRGDPLGM
RRAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVAALASVLLLFAATFQFPDGIQVLSAGALRGLKDTHVPMFLA
MFSYWGVGMPIGAGLGLGLGWGPQGMWVGLILGLTVASLLMGLRFRQTSRRVTATATP
>Mature_457_residues
SVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIGTSLLWLPMLVPIGTLISLTTS
VSQLMGAGREREIGPLFRQALWLSLGLSALMFVFLSVVPPLLPTFGIAPDIVPGATDFLHTVRWGVPALTFYFCMRYLSE
GMHWTLPTMLLGFGGLLVLAPTGYALTYGKFGFAEHGAEGLGMASAITLWVQASVFALYLWRARRFAHLQLFTHLEGPRW
RAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGSTEAAAHQIAINVAQLCFMIPMGVAEATTVRVGHAVGRGDPLGMR
RAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVAALASVLLLFAATFQFPDGIQVLSAGALRGLKDTHVPMFLAM
FSYWGVGMPIGAGLGLGLGWGPQGMWVGLILGLTVASLLMGLRFRQTSRRVTATATP

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI153792564, Length=421, Percent_Identity=25.1781472684086, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI38261960, Length=454, Percent_Identity=24.0088105726872, Blast_Score=94, Evalue=3e-19,
Organism=Homo sapiens, GI22907060, Length=435, Percent_Identity=27.816091954023, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI48994890, Length=443, Percent_Identity=36.7945823927765, Blast_Score=246, Evalue=2e-66,
Organism=Escherichia coli, GI226510954, Length=294, Percent_Identity=25.5102040816327, Blast_Score=62, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6320545, Length=446, Percent_Identity=23.7668161434978, Blast_Score=69, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48210; Mature: 48079

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIG
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TSLLWLPMLVPIGTLISLTTSVSQLMGAGREREIGPLFRQALWLSLGLSALMFVFLSVVP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLLPTFGIAPDIVPGATDFLHTVRWGVPALTFYFCMRYLSEGMHWTLPTMLLGFGGLLVL
HHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEE
APTGYALTYGKFGFAEHGAEGLGMASAITLWVQASVFALYLWRARRFAHLQLFTHLEGPR
ECCCCEEECCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
WRAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGSTEAAAHQIAINVAQLCFMIPMGV
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
AEATTVRVGHAVGRGDPLGMRRAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVA
CHHHHEEHHHHCCCCCCCCHHHHHHCCEEEEEECHHHHHHHHEEECCEEEEEECHHHHHH
ALASVLLLFAATFQFPDGIQVLSAGALRGLKDTHVPMFLAMFSYWGVGMPIGAGLGLGLG
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
WGPQGMWVGLILGLTVASLLMGLRFRQTSRRVTATATP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC
>Mature Secondary Structure 
SVSSAPPSATPGFASEVRTTGLLALPLVLGHVSTGLIGFVDNVIAGHHGTATLAAVTIG
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
TSLLWLPMLVPIGTLISLTTSVSQLMGAGREREIGPLFRQALWLSLGLSALMFVFLSVVP
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PLLPTFGIAPDIVPGATDFLHTVRWGVPALTFYFCMRYLSEGMHWTLPTMLLGFGGLLVL
HHHHHCCCCCCCCCCHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEEEE
APTGYALTYGKFGFAEHGAEGLGMASAITLWVQASVFALYLWRARRFAHLQLFTHLEGPR
ECCCCEEECCCCCCHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCH
WRAIGELLRTGLPIGITVLMEGGLFIVTALLIGRLGSTEAAAHQIAINVAQLCFMIPMGV
HHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCC
AEATTVRVGHAVGRGDPLGMRRAAWAGYAIVLGTQALSASALLLGHDAIVGVYTDDVAVA
CHHHHEEHHHHCCCCCCCCHHHHHHCCEEEEEECHHHHHHHHEEECCEEEEEECHHHHHH
ALASVLLLFAATFQFPDGIQVLSAGALRGLKDTHVPMFLAMFSYWGVGMPIGAGLGLGLG
HHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCC
WGPQGMWVGLILGLTVASLLMGLRFRQTSRRVTATATP
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]